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DE69927668D1 - Massenfingerabdrucken und seiner verwendung zur identifizierung von protein-affinitätsliganden - Google Patents

Massenfingerabdrucken und seiner verwendung zur identifizierung von protein-affinitätsliganden

Info

Publication number
DE69927668D1
DE69927668D1 DE69927668T DE69927668T DE69927668D1 DE 69927668 D1 DE69927668 D1 DE 69927668D1 DE 69927668 T DE69927668 T DE 69927668T DE 69927668 T DE69927668 T DE 69927668T DE 69927668 D1 DE69927668 D1 DE 69927668D1
Authority
DE
Germany
Prior art keywords
affinity ligands
protein affinity
proteins
protein
massenfingerprints
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69927668T
Other languages
English (en)
Other versions
DE69927668T2 (de
Inventor
Roy Pennington
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University College Dublin
Original Assignee
University College Dublin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University College Dublin filed Critical University College Dublin
Application granted granted Critical
Publication of DE69927668D1 publication Critical patent/DE69927668D1/de
Publication of DE69927668T2 publication Critical patent/DE69927668T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2550/00—Electrophoretic profiling, e.g. for proteome analysis
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Genetics & Genomics (AREA)
  • Peptides Or Proteins (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Paper (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
DE69927668T 1998-01-08 1999-01-08 Massenfingerabdrucken und seiner verwendung zur identifizierung von protein-affinitätsliganden Expired - Fee Related DE69927668T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9800378 1998-01-08
GBGB9800378.3A GB9800378D0 (en) 1998-01-08 1998-01-08 Proteome analysis
PCT/GB1999/000071 WO1999035502A1 (en) 1998-01-08 1999-01-08 Use of mass fingerprinting for identification of protein affinity ligands

Publications (2)

Publication Number Publication Date
DE69927668D1 true DE69927668D1 (de) 2006-02-23
DE69927668T2 DE69927668T2 (de) 2006-06-29

Family

ID=10825008

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69927668T Expired - Fee Related DE69927668T2 (de) 1998-01-08 1999-01-08 Massenfingerabdrucken und seiner verwendung zur identifizierung von protein-affinitätsliganden

Country Status (7)

Country Link
EP (1) EP1046038B1 (de)
JP (1) JP2002501176A (de)
AT (1) ATE306671T1 (de)
DE (1) DE69927668T2 (de)
ES (1) ES2251171T3 (de)
GB (1) GB9800378D0 (de)
WO (1) WO1999035502A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19943743C2 (de) * 1999-09-03 2002-02-07 Jerini Biotools Gmbh Verfahren zur Identifizierung von Bindungspartnern mit positions-spezifischen Arrays
WO2002048716A2 (en) 2000-12-14 2002-06-20 Paul Stroobant Differential phage capture proteomics
JP2002333430A (ja) * 2001-05-09 2002-11-22 Japan Science & Technology Corp プロテオーム解析方法
WO2003049602A2 (en) 2001-12-11 2003-06-19 University Of Medicine And Dentistry Of New Jersey Diagnostic methods for protein profiling
CA2490522A1 (en) * 2002-06-20 2003-12-31 Paul Stroobant Improved methods for performing differential capture proteomics
JP2007309689A (ja) * 2006-05-16 2007-11-29 Hitachi High-Technologies Corp タンパク質結合部位同定技術
CN106778032B (zh) * 2016-12-14 2019-06-04 南京邮电大学 药物设计中配体分子海量特征筛选方法
US20220034902A1 (en) * 2018-12-11 2022-02-03 Merck Sharp & Dohme Corp. Method for identifying high affinity monoclonal antibody heavy and light chain pairs from high throughput screens of b-cell and hybridoma libraries

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6124107A (en) * 1988-06-10 2000-09-26 Merck & Co., Inc. Assay for marker of human polymorphonuclear leukocyte elastase activity
US5244816A (en) * 1989-10-11 1993-09-14 Akzo N.V. Method for purifying chelator conjugated compounds
JPH07101998A (ja) * 1993-08-09 1995-04-18 Sumitomo Electric Ind Ltd Ｐａｆ受容体に特異的に反応するモノクローナル抗体、その製造方法、及び該抗体を産生するハイブリドーマ
US6017693A (en) * 1994-03-14 2000-01-25 University Of Washington Identification of nucleotides, amino acids, or carbohydrates by mass spectrometry
US5599668A (en) * 1994-09-22 1997-02-04 Abbott Laboratories Light scattering optical waveguide method for detecting specific binding events
GB9502112D0 (en) * 1995-02-03 1995-03-22 British Biocell Int Assay device and method
GB9507366D0 (en) * 1995-04-08 1995-05-31 Zeneca Ltd Assay
US5834318A (en) * 1995-05-10 1998-11-10 Bayer Corporation Screening of combinatorial peptide libraries for selection of peptide ligand useful in affinity purification of target proteins
JP2001510328A (ja) * 1996-10-04 2001-07-31 ミカエル マルヴァニー 高血圧マーカー

Also Published As

Publication number Publication date
EP1046038B1 (de) 2005-10-12
ATE306671T1 (de) 2005-10-15
DE69927668T2 (de) 2006-06-29
JP2002501176A (ja) 2002-01-15
EP1046038A1 (de) 2000-10-25
ES2251171T3 (es) 2006-04-16
WO1999035502A1 (en) 1999-07-15
GB9800378D0 (en) 1998-03-04

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee