DE69923676D1 - Bestimmte heteroaryl substituierte thiol inhibitoren von endothelin wechselnden enzymen - Google Patents

Bestimmte heteroaryl substituierte thiol inhibitoren von endothelin wechselnden enzymen

Info

Publication number: DE69923676D1
Authority: DE; Germany
Prior art keywords: endothelin; metabolizing enzymes; substituted thiol; certain heteroaryl; thiol inhibitors
Prior art date: 1998-04-23
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE69923676T

Other languages

English (en)

Other versions

DE69923676T2 (de

Inventor

Anne Fink

Fariborz Firooznia

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Novartis AG

Original Assignee

Novartis AG

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-23

Filing date

1999-04-21

Publication date

2005-03-17

1999-04-21 Application filed by Novartis AG filed Critical Novartis AG

2005-03-17 Application granted granted Critical

2005-03-17 Publication of DE69923676D1 publication Critical patent/DE69923676D1/de

2006-01-12 Publication of DE69923676T2 publication Critical patent/DE69923676T2/de

2019-04-22 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

102000002045 Endothelin Human genes 0.000 title 1
108050009340 Endothelin Proteins 0.000 title 1
102000004190 Enzymes Human genes 0.000 title 1
108090000790 Enzymes Proteins 0.000 title 1
ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 title 1
239000003774 sulfhydryl reagent Substances 0.000 title 1
125000003396 thiol group Chemical class [H]S* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Biochemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Engineering & Computer Science (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Plural Heterocyclic Compounds (AREA)
Enzymes And Modification Thereof (AREA)

DE69923676T 1998-04-23 1999-04-21 Bestimmte heteroaryl substituierte thiol inhibitoren von endothelin wechselnden enzymen Expired - Fee Related DE69923676T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US6497998A	1998-04-23	1998-04-23
US64979		1998-04-23
PCT/EP1999/002694 WO1999055723A1 (en)	1998-04-23	1999-04-21	Certain heteroaryl substituted thiol inhibitors of endothelin-converting enzyme

Publications (2)

Publication Number	Publication Date
DE69923676D1 true DE69923676D1 (de)	2005-03-17
DE69923676T2 DE69923676T2 (de)	2006-01-12

Family

ID=22059547

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69923676T Expired - Fee Related DE69923676T2 (de)	1998-04-23	1999-04-21	Bestimmte heteroaryl substituierte thiol inhibitoren von endothelin wechselnden enzymen

Country Status (11)

Country	Link
EP (1)	EP1080104B1 (de)
JP (1)	JP3646062B2 (de)
AT (1)	ATE288922T1 (de)
AU (1)	AU750048B2 (de)
CA (1)	CA2324251A1 (de)
DE (1)	DE69923676T2 (de)
ES (1)	ES2237917T3 (de)
IL (1)	IL138688A0 (de)
PT (1)	PT1080104E (de)
WO (1)	WO1999055723A1 (de)
ZA (1)	ZA200004679B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6423727B1 (en)	1998-04-23	2002-07-23	Novartis Ag	Certain thiol inhibitors of endothelin-converting enzyme
US6426354B1 (en)	1998-04-23	2002-07-30	Novartis Ag	Certain heteroaryl substituted thiol inhibitors of endothelin-converting enzyme
JP4603646B2 (ja) *	1999-11-15	2010-12-22	富士フイルムファインケミカルズ株式会社	新規なジピリジル誘導体
NL1014353C2 (nl) *	2000-02-11	2001-08-15	Dsm Nv	Werkwijze voor de bereiding van (R) -2-broom-3-fenylpropaanzuur.
US20020028799A1 (en) *	2000-07-06	2002-03-07	Naylor Alasdair Mark	Treatment of male sexual dysfunction
US6670479B2 (en) *	2001-03-07	2003-12-30	Advanced Research And Technology Institute, Inc.	Amination process
US6777443B2 (en)	2001-05-15	2004-08-17	Novartis Ag	Dipeptide derivatives
BR0212899A (pt) *	2001-09-21	2004-11-03	Novartis Ag	Compostos orgânicos
WO2003066563A1 (en) *	2002-02-04	2003-08-14	Kaneka Corporation	Process for production of optically active 2-halogeno- carboxylic acids
AR038377A1 (es)	2002-02-08	2005-01-12	Merck & Co Inc	Derivados de n-bifenil-aminocicloalcancarboxamida (con sustitucion con metilo)
WO2003065789A2 (en)	2002-02-08	2003-08-14	Merck & Co., Inc.	N-biphenylmethyl aminocycloalkanecarboxamide derivatives
AU2007205578B2 (en) *	2006-01-11	2012-06-28	Seikagaku Corporation	Cycloalkylcarbonylamino acid ester derivative and process for producing the same
JP4047365B2 (ja)	2006-01-11	2008-02-13	生化学工業株式会社	シクロアルカンカルボキサミド誘導体及びその製造方法
JP3975226B2 (ja)	2006-01-11	2007-09-12	生化学工業株式会社	シクロアルキルカルボニルアミノ酸誘導体及びその製造方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5432186A (en) *	1993-11-16	1995-07-11	Ciba-Geigy Corporation	Cyclic amino acid derivatives
FR2745571B1 (fr) *	1996-03-04	1998-06-19	Inst Nat Sante Rech Med	Nouveaux derives soufres comportant une liaison amide, leur procede de preparation, leur application a titre de medicaments, et les compositions pharmaceutiques les renfermant
FR2745570B1 (fr) *	1996-03-04	1998-06-19	Roussel Uclaf	Nouveaux derives soufres comportant une liaison retroamide, leur procede et intermediaires de preparation, leur application a titre de medicaments, et les compositions pharmaceutiques les renfermant

1999
- 1999-04-21 CA CA002324251A patent/CA2324251A1/en not_active Abandoned
- 1999-04-21 AT AT99923433T patent/ATE288922T1/de not_active IP Right Cessation
- 1999-04-21 WO PCT/EP1999/002694 patent/WO1999055723A1/en not_active Ceased
- 1999-04-21 PT PT99923433T patent/PT1080104E/pt unknown
- 1999-04-21 EP EP99923433A patent/EP1080104B1/de not_active Expired - Lifetime
- 1999-04-21 JP JP2000545881A patent/JP3646062B2/ja not_active Expired - Fee Related
- 1999-04-21 ES ES99923433T patent/ES2237917T3/es not_active Expired - Lifetime
- 1999-04-21 AU AU40319/99A patent/AU750048B2/en not_active Ceased
- 1999-04-21 DE DE69923676T patent/DE69923676T2/de not_active Expired - Fee Related
- 1999-04-21 IL IL13868899A patent/IL138688A0/xx unknown
2000
- 2000-09-06 ZA ZA200004679A patent/ZA200004679B/en unknown

Also Published As

Publication number	Publication date
ZA200004679B (en)	2002-04-24
AU4031999A (en)	1999-11-16
ATE288922T1 (de)	2005-02-15
EP1080104A1 (de)	2001-03-07
IL138688A0 (en)	2001-10-31
DE69923676T2 (de)	2006-01-12
JP2002513029A (ja)	2002-05-08
AU750048B2 (en)	2002-07-11
PT1080104E (pt)	2005-06-30
JP3646062B2 (ja)	2005-05-11
CA2324251A1 (en)	1999-11-04
EP1080104B1 (de)	2005-02-09
WO1999055723A1 (en)	1999-11-04
ES2237917T3 (es)	2005-08-01

Publication	Publication Date	Title
BR9900177A (pt)	2000-04-11	Inibidores de metaloprotease.
MY136789A (en)	2008-11-28	Metalloproteinase inhibitors
PL372926A1 (en)	2005-08-08	Piperidine-pyridazones and phthalazones as pde4 inhibitors
TR200100605T2 (tr)	2001-08-21	Arilpiperazinler ve bunların metaloproteinaz inhibe edici maddeler (MMP) olarak kullanımı
UY27972A1 (es)	2004-04-30	Derivados de hidantoína
DE69923676D1 (de)	2005-03-17	Bestimmte heteroaryl substituierte thiol inhibitoren von endothelin wechselnden enzymen
NO20011174D0 (no)	2001-03-07	Nye heteroaromatiske inhibitorer av fruktose-1,6-bisfosfotase
BR0209149A (pt)	2004-07-13	Ftalazinonas
DK1042319T3 (da)	2004-06-01	Dihydrobenzofuraner
SE0103710D0 (sv)	2001-11-07	Compounds
MY128164A (en)	2007-01-31	Compounds
EA200000628A1 (ru)	2001-02-26	Ингибиторы металлопротеаз матрикса
SE9903290D0 (sv)	1999-09-15	Novel compounds
ATE356114T1 (de)	2007-03-15	Inhibitoren von metalloproteinasen
DK1377574T3 (da)	2005-04-25	6-phenylbenzonaphtyridiner
HRP20050382A2 (en)	2006-12-31	Novel pyrimidine-4,6-dicarboxamides for the selective inhibition of collagenases
NO20023951L (no)	2002-08-20	Arylpiperaziner og arylpiperidiner og deres anvendelse som metalloproteinaseinhiberende midler
MXPA06003345A (es)	2006-06-08	Derivados de aminopiridina como inhibidores de la no-sintasa inducible.
ATE268322T1 (de)	2004-06-15	Inhibitoren der tryptase
NO20061316L (no)	2006-03-23	Imidazopyndinderivater som induserbare NO-syntaseinhibitorer
DE59803066D1 (de)	2002-03-21	Substituierte benzyloxyimino-verbindungen
ATE238791T1 (de)	2003-05-15	Verwendung von 2-methyl-thiazolidin-2,4- dicarbonsäure als mukolytikum
ID27656A (id)	2001-04-19	Turunan azabisikloheptana n-tersubstitusi, pembuatan dan penggunaannya
ATE238781T1 (de)	2003-05-15	Verwendung von katecholderivaten als proteinaseinhibitoren
AP2001002047A0 (en)	2001-03-31	Isoquinoliness as urokinase inhibitors.

Legal Events

Date	Code	Title	Description
2006-04-13	8364	No opposition during term of opposition
2010-05-20	8328	Change in the person/name/address of the agent	Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336
2012-01-31	R082	Change of representative	Ref document number: 1080104 Country of ref document: EP Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN, DE
2012-08-20	R119	Application deemed withdrawn, or ip right lapsed, due to non-payment of renewal fee	Ref document number: 1080104 Country of ref document: EP