DE69915965D1 - Stereoselektives Verfahren zur Herstellung vom 22R Epimer von Budesonid - Google Patents

Stereoselektives Verfahren zur Herstellung vom 22R Epimer von Budesonid

Info

Publication number: DE69915965D1
Authority: DE; Germany
Prior art keywords: budesonide; alpha; epimer; iodo; bromo
Prior art date: 1998-10-13
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE69915965T

Other languages

English (en)

Other versions

DE69915965T2 (de

Inventor

Loggia Filippo La

Pierfranco Dotti

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Farmabios SpA

Original Assignee

Farmabios SpA

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-13

Filing date

1999-10-12

Publication date

2004-05-06

1999-10-12 Application filed by Farmabios SpA filed Critical Farmabios SpA

2004-05-06 Application granted granted Critical

2004-05-06 Publication of DE69915965D1 publication Critical patent/DE69915965D1/de

2005-03-17 Publication of DE69915965T2 publication Critical patent/DE69915965T2/de

2019-10-13 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

229960004436 budesonide Drugs 0.000 title abstract 6
230000000707 stereoselective effect Effects 0.000 title abstract 3
VOVIALXJUBGFJZ-KWVAZRHASA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-KWVAZRHASA-N 0.000 title abstract 2
238000000034 method Methods 0.000 title abstract 2
ZTQSAGDEMFDKMZ-UHFFFAOYSA-N Butyraldehyde Chemical compound CCCC=O ZTQSAGDEMFDKMZ-UHFFFAOYSA-N 0.000 abstract 2
HEPIBRLGCSXTQU-JNQJZLCISA-N (1S,2S,4R,8S,9S,11S,12R,13S)-12-bromo-11-hydroxy-8-(2-hydroxyacetyl)-6,6,9,13-tetramethyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-16-one Chemical compound CC1(C)O[C@@H]2C[C@H]3[C@@H]4CCC5=CC(=O)C=C[C@]5(C)[C@@]4(Br)[C@@H](O)C[C@]3(C)[C@@]2(O1)C(=O)CO HEPIBRLGCSXTQU-JNQJZLCISA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
239000003795 chemical substances by application Substances 0.000 abstract 1
229960003662 desonide Drugs 0.000 abstract 1
HGBOYTHUEUWSSQ-UHFFFAOYSA-N valeric aldehyde Natural products CCCCC=O HGBOYTHUEUWSSQ-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/0026—Oxygen-containing hetero ring cyclic ketals
- C07J71/0031—Oxygen-containing hetero ring cyclic ketals at positions 16, 17
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Rheumatology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Pain & Pain Management (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DE69915965T 1998-10-13 1999-10-12 Stereoselektives Verfahren zur Herstellung vom 22R Epimer von Budesonid Expired - Fee Related DE69915965T2 (de)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
ITMI982196		1998-10-13
IT1998MI002196A IT1302657B1 (it)	1998-10-13	1998-10-13	Processo stereoselettivo per la preparazione di budesonide nella formadi epimero 22-r.

Publications (2)

Publication Number	Publication Date
DE69915965D1 true DE69915965D1 (de)	2004-05-06
DE69915965T2 DE69915965T2 (de)	2005-03-17

Family

ID=11380860

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69915965T Expired - Fee Related DE69915965T2 (de)	1998-10-13	1999-10-12	Stereoselektives Verfahren zur Herstellung vom 22R Epimer von Budesonid

Country Status (8)

Country	Link
EP (1)	EP0994119B1 (de)
JP (1)	JP2000128897A (de)
AT (1)	ATE263184T1 (de)
DE (1)	DE69915965T2 (de)
DK (1)	DK0994119T3 (de)
ES (1)	ES2218929T3 (de)
IT (1)	IT1302657B1 (de)
PT (1)	PT994119E (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0012260D0 (en) *	2000-05-19	2000-07-12	Astrazeneca Ab	Novel composition
US20100331539A1 (en) *	2008-03-13	2010-12-30	Farmabios S.P.A.	Process for the preparation of pregnane derivatives
CN111018932B (zh) *	2019-11-28	2021-07-02	奥锐特药业股份有限公司	一种甾体化合物9-位脱卤的方法
IT202000006442A1 (it) *	2020-03-27	2021-09-27	Genetic S P A	Budesonide 21-phosphate salts and pharmaceutical compositions containing the same

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1196142B (it) *	1984-06-11	1988-11-10	Sicor Spa	Procedimento per la preparazione di 16,17-acetali di derivati pregnanici e nuovi composti ottenuti
SE8604059D0 (sv) *	1986-09-25	1986-09-25	Astra Pharma Prod	A method of controlling the epimeric distribution in the preparation of 16,17-acetals of pregnane derivatives
FR2675146A1 (fr) *	1991-04-10	1992-10-16	Roussel Uclaf	Nouveaux derives sterouides de la pregna-1,4-diene-3,20-dione, leur preparation, leur application a la preparation de derives 16,17-methylene dioxy substitues et nouveaux intermediaires.
IT1291288B1 (it) *	1997-04-30	1999-01-07	Farmabios Srl	Processo per la preparazione di 16,17 acetali di derivati pregnanici con controllo della distribuzione epimerica al c-22.

1998
- 1998-10-13 IT IT1998MI002196A patent/IT1302657B1/it active IP Right Grant
1999
- 1999-10-12 EP EP99120330A patent/EP0994119B1/de not_active Expired - Lifetime
- 1999-10-12 ES ES99120330T patent/ES2218929T3/es not_active Expired - Lifetime
- 1999-10-12 PT PT99120330T patent/PT994119E/pt unknown
- 1999-10-12 DE DE69915965T patent/DE69915965T2/de not_active Expired - Fee Related
- 1999-10-12 DK DK99120330T patent/DK0994119T3/da active
- 1999-10-12 AT AT99120330T patent/ATE263184T1/de not_active IP Right Cessation
- 1999-10-13 JP JP11291384A patent/JP2000128897A/ja active Pending

Also Published As

Publication number	Publication date
JP2000128897A (ja)	2000-05-09
ITMI982196A1 (it)	2000-04-13
ATE263184T1 (de)	2004-04-15
EP0994119B1 (de)	2004-03-31
DE69915965T2 (de)	2005-03-17
ES2218929T3 (es)	2004-11-16
EP0994119A1 (de)	2000-04-19
DK0994119T3 (da)	2004-08-02
IT1302657B1 (it)	2000-09-29
PT994119E (pt)	2004-08-31

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Legal Events

Date	Code	Title	Description
2005-04-28	8364	No opposition during term of opposition
2005-08-18	8339	Ceased/non-payment of the annual fee