DE69907675D1 - Ein substituiertes triazolo-pyridazin-derivat, davon hergestellte arzneimittel - Google Patents

Ein substituiertes triazolo-pyridazin-derivat, davon hergestellte arzneimittel

Info

Publication number: DE69907675D1
Authority: DE; Germany
Prior art keywords: pyridazine derivative; medicament manufactured; substituted triazolo; triazolo; substituted
Prior art date: 1998-06-24
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69907675T

Other languages

English (en)

Other versions

DE69907675T2 (de

Inventor

William Robert Carling

Pineiro Jose Luis Castro

Cameron John Cowden

Antony John Davies

Andrew Madin

James Francis Mccabe

Gareth Edward Stephen Pearce

Leslie Joseph Street

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Organon Pharma UK Ltd

Original Assignee

Merck Sharp and Dohme Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-06-24

Filing date

1999-06-15

Publication date

2003-06-12

1999-06-15 Application filed by Merck Sharp and Dohme Ltd filed Critical Merck Sharp and Dohme Ltd

2003-06-12 Publication of DE69907675D1 publication Critical patent/DE69907675D1/de

2004-03-04 Application granted granted Critical

2004-03-04 Publication of DE69907675T2 publication Critical patent/DE69907675T2/de

2019-06-16 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Chemical Kinetics & Catalysis (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurology (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DE69907675T 1998-06-24 1999-06-15 Ein substituiertes triazolo-pyridazin-derivat, davon hergestellte arzneimittel Expired - Lifetime DE69907675T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB9813576		1998-06-24
GBGB9813576.7A GB9813576D0 (en)	1998-06-24	1998-06-24	Therapeutic agents
PCT/GB1999/001897 WO1999067245A1 (en)	1998-06-24	1999-06-15	A substituted triazolo-pyridazine derivative, pharmaceutical compositions made therefrom

Publications (2)

Publication Number	Publication Date
DE69907675D1 true DE69907675D1 (de)	2003-06-12
DE69907675T2 DE69907675T2 (de)	2004-03-04

Family

ID=10834265

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69907675T Expired - Lifetime DE69907675T2 (de)	1998-06-24	1999-06-15	Ein substituiertes triazolo-pyridazin-derivat, davon hergestellte arzneimittel

Country Status (35)

Country	Link
US (1)	US6630471B1 (de)
EP (1)	EP1090004B1 (de)
JP (1)	JP4749545B2 (de)
KR (1)	KR100604108B1 (de)
CN (1)	CN1138779C (de)
AR (1)	AR018925A1 (de)
AT (1)	ATE239730T1 (de)
AU (1)	AU757315B2 (de)
BG (1)	BG64989B1 (de)
BR (1)	BR9911563A (de)
CA (1)	CA2335328C (de)
CO (1)	CO5031239A1 (de)
CZ (1)	CZ291409B6 (de)
DE (1)	DE69907675T2 (de)
EA (1)	EA003332B1 (de)
EE (1)	EE200000767A (de)
ES (1)	ES2196824T3 (de)
GB (1)	GB9813576D0 (de)
GE (1)	GEP20033143B (de)
HR (1)	HRP20000879A2 (de)
HU (1)	HUP0102894A3 (de)
ID (1)	ID27771A (de)
IL (2)	IL139775A0 (de)
IS (1)	IS2258B (de)
MY (1)	MY124341A (de)
NO (1)	NO317992B1 (de)
NZ (1)	NZ508290A (de)
PE (1)	PE20000710A1 (de)
PL (1)	PL204650B1 (de)
RS (1)	RS49746B (de)
SK (1)	SK285307B6 (de)
TR (1)	TR200003789T2 (de)
TW (1)	TWI222449B (de)
WO (1)	WO1999067245A1 (de)
ZA (1)	ZA200007485B (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB2345443A (en) *	1999-01-08	2000-07-12	Merck Sharp & Dohme	Use of triazolo-pyridazines for treating premenstrual syndrome
US20050042194A1 (en)	2000-05-11	2005-02-24	A.P. Pharma, Inc.	Semi-solid delivery vehicle and pharmaceutical compositions
GB0111191D0 (en) *	2001-05-08	2001-06-27	Merck Sharp & Dohme	Therapeutic agents
KR101075812B1 (ko)	2002-12-18	2011-10-25	버텍스 파마슈티칼스 인코포레이티드	단백질 키나제 억제제로서의 트리아졸로피리다진
WO2006061428A2 (en) *	2004-12-10	2006-06-15	Universität Zürich	Gaba-a alpha 2 and alpha 3 receptor agonists for treating neuropathic, inflammatory and migraine associated pain
US8501738B2 (en) *	2009-06-23	2013-08-06	Concert Pharmaceuticals, Inc.	Substituted triazolo-pyridazine derivatives
WO2011011712A1 (en) *	2009-07-24	2011-01-27	Concert Pharmaceuticals, Inc.	Substituted imidazotriazines
US8278460B2 (en)	2009-10-15	2012-10-02	Concert Pharmaceuticals, Inc.	Substituted benzimidazoles
PH12012501361A1 (en)	2009-12-31	2012-10-22	Centro Nac De Investigaciones Oncologicas Cnio	Tricyclic compounds for use as kinase inhibitors
WO2012098387A1 (en) *	2011-01-18	2012-07-26	Centro Nacional De Investigaciones Oncológicas (Cnio)	6, 7-ring-fused triazolo [4, 3 - b] pyridazine derivatives as pim inhibitors
CN104024259B (zh)	2011-09-27	2017-09-26	基恩菲特公司	作为Rev‑Erb激动剂的6‑取代的三唑并哒嗪类衍生物
MX388862B (es)	2016-01-27	2025-03-20	Univ Zuerich	Uso de moduladores de receptores de gabaa para el tratamiento de picor.
EP3781566A4 (de) *	2018-04-18	2022-06-22	Neurocycle Therapeutics, Inc.	Positive allosterische gabaa-modulatorverbindungen, verfahren zu ihrer herstellung und ihre verwendungen
PL3849976T3 (pl) *	2018-09-13	2023-02-27	Saniona A/S	Ligand receptora gaba a
HU231223B1 (hu)	2018-09-28	2022-01-28	Richter Gedeon Nyrt.	GABAA A5 receptor modulátor hatású biciklusos vegyületek
WO2021191837A1 (en)	2020-03-26	2021-09-30	Richter Gedeon Nyrt.	1,3-dihydro-2h-pyrrolo[3,4-c]pyridine derivatives as gabaa α5 receptor modulators
WO2025141131A1 (en)	2023-12-27	2025-07-03	Saniona A/S	A gabaa receptor ligand and the use thereof in medicine, in particular in the treatment of epilepsy

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2194205T3 (es) *	1996-07-25	2003-11-16	Merck Sharp & Dohme	Derivados de triazolo-piridazina sustituidos como ligandos para los receptores gaba.

1998
- 1998-06-24 GB GBGB9813576.7A patent/GB9813576D0/en not_active Ceased
1999
- 1999-06-15 ES ES99929508T patent/ES2196824T3/es not_active Expired - Lifetime
- 1999-06-15 AU AU46301/99A patent/AU757315B2/en not_active Ceased
- 1999-06-15 JP JP2000555898A patent/JP4749545B2/ja not_active Expired - Fee Related
- 1999-06-15 EE EEP200000767A patent/EE200000767A/xx unknown
- 1999-06-15 KR KR1020007014680A patent/KR100604108B1/ko not_active Expired - Fee Related
- 1999-06-15 PL PL345332A patent/PL204650B1/pl not_active IP Right Cessation
- 1999-06-15 SK SK1955-2000A patent/SK285307B6/sk not_active IP Right Cessation
- 1999-06-15 US US09/719,184 patent/US6630471B1/en not_active Expired - Lifetime
- 1999-06-15 IL IL13977599A patent/IL139775A0/xx active IP Right Grant
- 1999-06-15 GE GEAP19995726A patent/GEP20033143B/en unknown
- 1999-06-15 WO PCT/GB1999/001897 patent/WO1999067245A1/en active IP Right Grant
- 1999-06-15 CA CA002335328A patent/CA2335328C/en not_active Expired - Fee Related
- 1999-06-15 CZ CZ20004872A patent/CZ291409B6/cs not_active IP Right Cessation
- 1999-06-15 HU HU0102894A patent/HUP0102894A3/hu unknown
- 1999-06-15 EA EA200100071A patent/EA003332B1/ru not_active IP Right Cessation
- 1999-06-15 TR TR2000/03789T patent/TR200003789T2/xx unknown
- 1999-06-15 EP EP99929508A patent/EP1090004B1/de not_active Expired - Lifetime
- 1999-06-15 CN CNB998078352A patent/CN1138779C/zh not_active Expired - Fee Related
- 1999-06-15 DE DE69907675T patent/DE69907675T2/de not_active Expired - Lifetime
- 1999-06-15 NZ NZ508290A patent/NZ508290A/en unknown
- 1999-06-15 AT AT99929508T patent/ATE239730T1/de not_active IP Right Cessation
- 1999-06-15 ID IDW20002717A patent/ID27771A/id unknown
- 1999-06-15 BR BR9911563-8A patent/BR9911563A/pt not_active Application Discontinuation
- 1999-06-15 HR HR20000879A patent/HRP20000879A2/hr not_active Application Discontinuation
- 1999-06-15 RS YUP-778/00A patent/RS49746B/sr unknown
- 1999-06-16 MY MYPI99002465A patent/MY124341A/en unknown
- 1999-06-18 CO CO99038282A patent/CO5031239A1/es unknown
- 1999-06-22 PE PE1999000557A patent/PE20000710A1/es not_active Application Discontinuation
- 1999-06-23 AR ARP990103008A patent/AR018925A1/es active IP Right Grant
- 1999-06-28 TW TW088110866A patent/TWI222449B/zh active
2000
- 2000-11-20 IL IL139775A patent/IL139775A/en not_active IP Right Cessation
- 2000-11-24 IS IS5730A patent/IS2258B/is unknown
- 2000-12-14 ZA ZA200007485A patent/ZA200007485B/en unknown
- 2000-12-21 NO NO20006576A patent/NO317992B1/no not_active IP Right Cessation
2001
- 2001-01-15 BG BG105152A patent/BG64989B1/bg unknown

Also Published As

Publication number	Publication date
EP1090004A1 (de)	2001-04-11
BG105152A (en)	2001-10-31
TR200003789T2 (tr)	2001-04-20
EA200100071A1 (ru)	2001-06-25
ATE239730T1 (de)	2003-05-15
AR018925A1 (es)	2001-12-12
CZ291409B6 (cs)	2003-03-12
KR20010053136A (ko)	2001-06-25
IS2258B (is)	2007-06-15
BG64989B1 (bg)	2006-11-30
ZA200007485B (en)	2002-01-07
ES2196824T3 (es)	2003-12-16
JP2002518501A (ja)	2002-06-25
PL204650B1 (pl)	2010-01-29
MY124341A (en)	2006-06-30
EE200000767A (et)	2002-06-17
DE69907675T2 (de)	2004-03-04
AU4630199A (en)	2000-01-10
HRP20000879A2 (en)	2001-06-30
KR100604108B1 (ko)	2006-07-26
CN1307579A (zh)	2001-08-08
ID27771A (id)	2001-04-26
YU77800A (sh)	2003-10-31
CO5031239A1 (es)	2001-04-27
AU757315B2 (en)	2003-02-13
JP4749545B2 (ja)	2011-08-17
HUP0102894A2 (hu)	2001-11-28
WO1999067245A1 (en)	1999-12-29
TWI222449B (en)	2004-10-21
NO20006576D0 (no)	2000-12-21
BR9911563A (pt)	2001-03-20
PE20000710A1 (es)	2000-08-14
IL139775A0 (en)	2002-02-10
NO317992B1 (no)	2005-01-17
EP1090004B1 (de)	2003-05-07
RS49746B (sr)	2008-04-04
IL139775A (en)	2007-02-11
IS5730A (is)	2000-11-24
GEP20033143B (en)	2003-12-25
GB9813576D0 (en)	1998-08-19
CA2335328A1 (en)	1999-12-29
CZ20004872A3 (cs)	2001-07-11
SK19552000A3 (sk)	2001-08-06
EA003332B1 (ru)	2003-04-24
NO20006576L (no)	2001-02-14
NZ508290A (en)	2003-09-26
CA2335328C (en)	2007-11-27
US6630471B1 (en)	2003-10-07
PL345332A1 (en)	2001-12-17
HUP0102894A3 (en)	2003-03-28
SK285307B6 (sk)	2006-10-05
CN1138779C (zh)	2004-02-18

Publication	Publication Date	Title
DE69908021D1 (de)	2003-06-26	Ziprasidonhaltige Arzneimittel
DE60037455D1 (de)	2008-01-24	Kinaseinhibitoren als arzneimittel
DE60117362D1 (de)	2006-04-27	Parenteral anzuwendendes bisphosphonathaltiges arzneimittel
TR200000520A3 (tr)	2001-06-21	4-Fenil-piridin türevleri.
ATE187063T1 (de)	1999-12-15	Arzneimittel
NO20004348D0 (no)	2000-09-01	Ultraliten kondensatorgruppe
ATE367150T1 (de)	2007-08-15	Arzneimittel
DE69907675D1 (de)	2003-06-12	Ein substituiertes triazolo-pyridazin-derivat, davon hergestellte arzneimittel
IT1318317B1 (it)	2003-07-28	Dispensatore a doppia funzione
PT1070708E (pt)	2004-05-31	Derivados de triazol
MA26673A1 (fr)	2004-12-20	Composes pharmaceutiques
EE00297U1 (et)	2002-07-15	Kaubakapp
DK1466615T3 (da)	2009-08-31	Farmaceutisk præparat
PT1237857E (pt)	2004-10-29	Novos derivados fenalquiloxi-fenilo
NO20022606L (no)	2002-07-11	Farmasöytiske kombinasjoner
NO20014926D0 (no)	2001-10-10	Farmasöytiske forbindelser
DK1178990T3 (da)	2003-05-26	Imidazodiazepinderivat.
FR2788409B1 (fr)	2002-10-11	Gateau hyperprotidique hypocalorique
DE59805373D1 (de)	2002-10-10	Nephroprotektive Arzneimittel
NO20015397L (no)	2001-11-05	1,5-Benzodiazepin-derivater
FI973784A7 (fi)	1999-03-26	Ksylitolikaramelli, erityisesti kovakaramelli
ES1037825Y (es)	1998-11-01	Cajon modular de medicamentos perfeccionado.
ES1044951Y (es)	2000-12-16	Tabique perfeccionado.
ES1043697Y (es)	2001-02-01	Contenedor-expositor perfeccionado.
ES1044451Y (es)	2000-09-01	Gavion perfeccionado.

Legal Events

Date	Code	Title	Description
2004-06-03	8364	No opposition during term of opposition