DE69824843D1 - Verfahren zur herstellung von modifizierten p-chiralen nucleotid-analoga - Google Patents

Verfahren zur herstellung von modifizierten p-chiralen nucleotid-analoga

Info

Publication number: DE69824843D1
Authority: DE; Germany
Prior art keywords: nucleotide analogs; producing modified; chiral; chiral nucleotide; modified
Prior art date: 1997-04-25
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE69824843T

Other languages

English (en)

Other versions

DE69824843T2 (de

Inventor

J Stec

A Wozniak

Arkadiusz Chworos

Jaroslaw Pyzowski

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Centrum Badan Molekularnych i Makromolekularnych PAN

Original Assignee

Centrum Badan Molekularnych i Makromolekularnych PAN

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-04-25

Filing date

1998-04-23

Publication date

2004-08-05

1998-04-23 Application filed by Centrum Badan Molekularnych i Makromolekularnych PAN filed Critical Centrum Badan Molekularnych i Makromolekularnych PAN

2004-08-05 Application granted granted Critical

2004-08-05 Publication of DE69824843D1 publication Critical patent/DE69824843D1/de

2005-07-21 Publication of DE69824843T2 publication Critical patent/DE69824843T2/de

2018-04-24 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Links

238000004519 manufacturing process Methods 0.000 title 1
239000002773 nucleotide Substances 0.000 title 1
238000000034 method Methods 0.000 abstract 2
108091034117 Oligonucleotide Proteins 0.000 abstract 1
JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 abstract 1
230000015572 biosynthetic process Effects 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
238000009396 hybridization Methods 0.000 abstract 1
125000003729 nucleotide group Chemical group 0.000 abstract 1
125000004437 phosphorous atom Chemical group 0.000 abstract 1
238000003786 synthesis reaction Methods 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Biochemistry (AREA)
Molecular Biology (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Biotechnology (AREA)
General Health & Medical Sciences (AREA)
Genetics & Genomics (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

DE69824843T 1997-04-25 1998-04-23 Verfahren zur herstellung von modifizierten p-chiralen nucleotid-analoga Expired - Fee Related DE69824843T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
PL97319677A PL184612B1 (pl)	1997-04-25	1997-04-25	Sposób wytwarzania modyfikowanych P chiralnych analogów nukleotydów
PL31967797		1997-04-25
PCT/PL1998/000014 WO1998049179A2 (en)	1997-04-25	1998-04-23	A process for the synthesis of modified p-chiral nucleotide analogues

Publications (2)

Publication Number	Publication Date
DE69824843D1 true DE69824843D1 (de)	2004-08-05
DE69824843T2 DE69824843T2 (de)	2005-07-21

Family

ID=20069747

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69824843T Expired - Fee Related DE69824843T2 (de)	1997-04-25	1998-04-23	Verfahren zur herstellung von modifizierten p-chiralen nucleotid-analoga

Country Status (8)

Country	Link
US (1)	US6407223B1 (de)
EP (1)	EP0977769B1 (de)
AT (1)	ATE270301T1 (de)
AU (1)	AU6934398A (de)
DE (1)	DE69824843T2 (de)
ES (1)	ES2224373T3 (de)
PL (1)	PL184612B1 (de)
WO (1)	WO1998049179A2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7592446B2 (en)	2001-03-22	2009-09-22	Georgia State University Research Foundation, Inc.	Synthesis of selenium-derivatized nucleosides, nucleotides, phosphoramidites, triphosphates and nucleic acids
PL216525B1 (pl) *	2006-10-17	2014-04-30	Ct Badań Molekularnych I Makromolekularnych Polskiej Akademii Nauk	5'-O-[(N-acylo)amidoditiofosforano] nukleozydy oraz sposób wytwarzania 5'-O-[(N-acylo)amidofosforano]-,5'-O-[(N-acylo)amidotiofosforano]-, 5'-O-[(N-acylo)amidoditiofosforano]nukleozydów
CN102282155B (zh)	2008-12-02	2017-06-09	日本波涛生命科学公司	磷原子修饰的核酸的合成方法
KR101885383B1 (ko)	2009-07-06	2018-08-03	웨이브 라이프 사이언시스 리미티드	신규한 핵산 프로드러그 및 그의 사용 방법
WO2012039448A1 (ja)	2010-09-24	2012-03-29	株式会社キラルジェン	不斉補助基
US9605019B2 (en)	2011-07-19	2017-03-28	Wave Life Sciences Ltd.	Methods for the synthesis of functionalized nucleic acids
US20150157655A1 (en) *	2012-06-29	2015-06-11	Sena Research, Inc.	Selenium containing nucleosides as nutritional supplements
KR101835401B1 (ko)	2012-07-13	2018-03-08	신 니뽄 바이오메디칼 라보라토리즈, 엘티디.	키랄 핵산 어쥬번트
SG10201912895PA (en)	2012-07-13	2020-02-27	Wave Life Sciences Ltd	Chiral control
AU2013288048A1 (en)	2012-07-13	2015-01-22	Wave Life Sciences Ltd.	Asymmetric auxiliary group
EP3095459A4 (de)	2014-01-15	2017-08-23	Shin Nippon Biomedical Laboratories, Ltd.	Chirales nukleinsäureadjuvans mit antitumorwirkung und antitumormittel
JPWO2015108046A1 (ja)	2014-01-15	2017-03-23	株式会社新日本科学	抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤
WO2015108047A1 (ja)	2014-01-15	2015-07-23	株式会社新日本科学	免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤
JP6382344B2 (ja)	2014-01-16	2018-08-29	ウェイブライフサイエンシズリミテッドＷａｖｅＬｉｆｅＳｃｉｅｎｃｅｓＬｔｄ．	キラルデザイン

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5635488A (en) *	1991-10-15	1997-06-03	Isis Pharmaceuticals, Inc.	Compounds having phosphorodithioate linkages of high chiral purity
US5852188A (en) *	1990-01-11	1998-12-22	Isis Pharmaceuticals, Inc.	Oligonucleotides having chiral phosphorus linkages
US5359052A (en) *	1991-08-05	1994-10-25	Polish Academy Of Sciences	Chalcophospholanes useful in the synthesis of oligonucleoside phosphorothioates, phosphorodithioates and related selenates
US5599797A (en) *	1991-10-15	1997-02-04	Isis Pharmaceuticals, Inc.	Oligonucleotides having phosphorothioate linkages of high chiral purity
US5661134A (en) *	1991-10-15	1997-08-26	Isis Pharmaceuticals, Inc.	Oligonucleotides for modulating Ha-ras or Ki-ras having phosphorothioate linkages of high chiral purity
US5955597A (en) *	1993-11-16	1999-09-21	Genta, Incorporated	Chirally enriched synthetic phosphate oligomers
US5703223A (en) *	1994-09-02	1997-12-30	Thomas Jefferson University	Solid phase synthesis of oligonucleotides with stereospecific substituted phosphonate linkages by pentavalent grignard coupling
CA2222048A1 (en) *	1995-05-26	1996-11-28	Polska Akademia Nauk	Compositions and methods for the synthesis of organophosphorus derivatives
CA2205218C (en) *	1995-10-20	1999-05-25	Hybridon, Inc.	Improved methods for h-phosphonate synthesis of mono- and oligonucleotides
US5734041A (en) *	1995-10-20	1998-03-31	Mcgill University	Preparation of chiral phosphorothioate oligomers
US5856465A (en) *	1996-05-24	1999-01-05	Polska Akademia Nauk Centrum Badan Molekularnych I Makromolekularnych	Compositions and methods for the synthesis of chirally pure organophosphorus nucleoside derivatives
US6117992A (en) *	1996-08-26	2000-09-12	Hybridon, Inc.	Reagents and process for synthesis of oligonucleotides containing phosphorodithioate internucleoside linkages

1997
- 1997-04-25 PL PL97319677A patent/PL184612B1/pl not_active IP Right Cessation
1998
- 1998-04-23 ES ES98915075T patent/ES2224373T3/es not_active Expired - Lifetime
- 1998-04-23 US US09/402,974 patent/US6407223B1/en not_active Expired - Fee Related
- 1998-04-23 WO PCT/PL1998/000014 patent/WO1998049179A2/en active IP Right Grant
- 1998-04-23 AU AU69343/98A patent/AU6934398A/en not_active Abandoned
- 1998-04-23 DE DE69824843T patent/DE69824843T2/de not_active Expired - Fee Related
- 1998-04-23 EP EP98915075A patent/EP0977769B1/de not_active Expired - Lifetime
- 1998-04-23 AT AT98915075T patent/ATE270301T1/de not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU6934398A (en)	1998-11-24
WO1998049179A3 (en)	1999-03-18
DE69824843T2 (de)	2005-07-21
ATE270301T1 (de)	2004-07-15
EP0977769A2 (de)	2000-02-09
US6407223B1 (en)	2002-06-18
PL319677A1 (en)	1998-10-26
PL184612B1 (pl)	2002-11-29
WO1998049179A2 (en)	1998-11-05
ES2224373T3 (es)	2005-03-01
EP0977769B1 (de)	2004-06-30

Publication	Publication Date	Title
ATE270301T1 (de)	2004-07-15	Verfahren zur herstellung von modifizierten p- chiralen nucleotid-analoga
ATE194142T1 (de)	2000-07-15	Verfahren zur herstellung von nukleotiden
ATE38386T1 (de)	1988-11-15	Verfahren zur herstellung von oligonucleotiden.
DE69835357D1 (de)	2006-09-07	Verfahren zur Herstellung von Synthesegas
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DE69636852D1 (de)	2007-03-08	Verfahren zur herstellung von nukleotid-5'-phosphat ester
DE69428912D1 (de)	2001-12-06	Verfahren zur herstellung von pentafluorethan
DE3675239D1 (de)	1990-12-06	Verfahren zur herstellung von aminopropylalkoxysilanen.
DE69105518D1 (de)	1995-01-12	Verfahren von hohem katalysatorgehalt zur herstellung von glucamide enthaltenden reinungsmitteln.
ATE268749T1 (de)	2004-06-15	Verfahren zur herstellung von iopamidol
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ATE321773T1 (de)	2006-04-15	Semisynthetisches verfahren zur herstellung von didemninanalogen
DE69613597D1 (de)	2001-08-09	Verfahren zur Herstellung von Cyclopentadienyl-Verbindungen und nach dem Verfahren hergestellte Verbindungen
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ATE294186T1 (de)	2005-05-15	Verfahren zur herstellung von nukleotiden oder oligonukleotiden phosphoramitiden
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DE69627472D1 (de)	2003-05-22	Verfahren zur Herstellung von Platin Verbindungen
ATE39698T1 (de)	1989-01-15	Verfahren zur herstellung von oligonucleosidphosphonaten.
DE60015563D1 (de)	2004-12-09	Verfahren zur herstellung von benzoperhydroisoindolen
ATE247129T1 (de)	2003-08-15	Biologisches verfahren zur herstellung von verbindungen auf der basis der dipeptiden
DE3679672D1 (de)	1991-07-11	Verfahren zur herstellung gesinterter siliziumcarbidartikel hoher dichte.
DE69104816D1 (de)	1994-12-01	Verfahren zur Herstellung von Ammoniak-Synthesegas.
DE69926223D1 (de)	2005-08-25	Verfahren zur herstellung von zwischenprodukten
ATE222885T1 (de)	2002-09-15	Verfahren zur herstellung von tetrabrombisphenol- a

Legal Events

Date	Code	Title	Description
2005-08-25	8364	No opposition during term of opposition
2009-02-19	8339	Ceased/non-payment of the annual fee