DE69801764D1 - Verfahren zur herstellung von citalopram - Google Patents

Verfahren zur herstellung von citalopram

Info

Publication number: DE69801764D1
Authority: DE; Germany
Prior art keywords: citalopram; compound; halogen; formula; grignard reagent
Prior art date: 1997-07-08
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69801764T

Other languages

English (en)

Other versions

DE69801764T2 (de

Inventor

Hans Petersen

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

H Lundbeck AS

Original Assignee

H Lundbeck AS

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-07-08

Filing date

1998-03-03

Publication date

2001-10-25

1998-03-03 Application filed by H Lundbeck AS filed Critical H Lundbeck AS

2001-10-25 Publication of DE69801764D1 publication Critical patent/DE69801764D1/de

2002-07-04 Application granted granted Critical

2002-07-04 Publication of DE69801764T2 publication Critical patent/DE69801764T2/de

2018-03-04 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/84—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/28—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton
- C07C237/30—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a non-condensed six-membered aromatic ring of the carbon skeleton having the nitrogen atom of the carboxamide group bound to hydrogen atoms or to acyclic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
- C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Neurology (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Psychiatry (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Steroid Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Furan Compounds (AREA)

DE69801764T 1997-07-08 1998-03-03 Verfahren zur herstellung von citalopram Expired - Lifetime DE69801764T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US5278897P	1997-07-08	1997-07-08
DK82697		1997-07-08
PCT/DK1998/000081 WO1998019513A2 (en)	1997-07-08	1998-03-03	Method for the preparation of citalopram

Publications (2)

Publication Number	Publication Date
DE69801764D1 true DE69801764D1 (de)	2001-10-25
DE69801764T2 DE69801764T2 (de)	2002-07-04

Family

ID=26064729

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DE69801764T Expired - Lifetime DE69801764T2 (de)	1997-07-08	1998-03-03	Verfahren zur herstellung von citalopram
DE1015416T Pending DE1015416T1 (de)	1997-07-08	1998-03-03	Verfahren zur herstellung von citalopram

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DE1015416T Pending DE1015416T1 (de)	1997-07-08	1998-03-03	Verfahren zur herstellung von citalopram

Country Status (23)

Country	Link
US (1)	US6229026B1 (de)
EP (1)	EP1015416B1 (de)
JP (1)	JP3526581B2 (de)
KR (1)	KR100357975B1 (de)
CN (1)	CN1206207C (de)
AT (1)	ATE205824T1 (de)
AU (1)	AU737610B2 (de)
BG (1)	BG64823B1 (de)
CA (1)	CA2291067C (de)
CZ (1)	CZ291440B6 (de)
DE (2)	DE69801764T2 (de)
DK (1)	DK1015416T3 (de)
EA (1)	EA001728B1 (de)
ES (1)	ES2148120T3 (de)
HU (1)	HU228744B1 (de)
IL (2)	IL133511A (de)
IS (1)	IS2023B (de)
NO (1)	NO322146B1 (de)
NZ (1)	NZ501737A (de)
PT (1)	PT1015416E (de)
SK (1)	SK283309B6 (de)
TR (1)	TR200000066T2 (de)
WO (1)	WO1998019513A2 (de)

Families Citing this family (52)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
UA62985C2 (en)	1997-11-10	2004-01-15	Lunnbeck As H	A method for the preparation of citalopram
HU228576B1 (en) *	1998-10-20	2013-04-29	Lundbeck & Co As H	Method for the preparation of citalopram
NZ512073A (en)	1998-12-23	2003-10-31	H	Method for the preparation of 5-cyanophthalide and citalopram
AR022329A1 (es) *	1999-01-29	2002-09-04	Lundbeck & Co As H	Metodo para la preparacion de 5-cianoftalida
PT1173431E (pt)	1999-04-14	2003-09-30	Lundbeck & Co As H	Metodo de preparacao do citalopram
US6245782B1 (en)	1999-05-17	2001-06-12	Heartdrug Research L.L.C.	Methods of inhibiting platelet activation with selective serotonin reuptake inhibitors
ITMI991579A1 (it)	1999-06-25	2001-01-15	Lundbeck & Co As H	Metodo per la preparazione di citalopram
ITMI991581A1 (it) *	1999-06-25	2001-01-15	Lundbeck & Co As H	Metodo per la preparazione di citalopram
ITMI991486A1 (it) *	1999-07-06	2001-01-06	Vis Farmaceutici S P A	Processo per la sintesi di citalopram
HRP20020344B1 (hr)	1999-10-25	2010-10-31	H. Lundbeck A/S	Način priprave citaloprama
WO2000012044A2 (en)	1999-10-25	2000-03-09	H. Lundbeck A/S	Method for the preparation of citalopram
AR026063A1 (es)	1999-11-01	2002-12-26	Lundbeck & Co As H	Metodo para la preparacion de 5-carboxiftalida.
MXPA02006503A (es)	1999-12-28	2002-12-09	Lundbeck & Co As H	Metodo para la preparacion de citalopram.
WO2001049672A1 (en) *	1999-12-30	2001-07-12	H. Lundbeck A/S	Method for the preparation of citalopram
KR100660802B1 (ko)	2000-01-14	2006-12-26	하. 룬트벡 아크티에 셀스카브	5-시아노프탈리드의 제조 방법
IT1317729B1 (it) *	2000-01-18	2003-07-15	Norpharma S P A	Procedimento per la preparazione della 5-carbossiftalide.
FR2805812A1 (fr)	2000-02-24	2001-09-07	Lundbeck & Co As H	Procede de preparation du citalopram
IES20010157A2 (en)	2000-03-03	2002-03-06	Lundbeck & Co As H	Method for the preparation of citalopram
GB0005477D0 (en)	2000-03-07	2000-04-26	Resolution Chemicals Limited	Process for the preparation of citalopram
IES20010206A2 (en)	2000-03-13	2002-03-06	Lundbeck & Co As H	Method for the preparation of citalopram
GB2357762B (en) *	2000-03-13	2002-01-30	Lundbeck & Co As H	Crystalline base of citalopram
CA2402388A1 (en)	2000-03-13	2001-09-20	Hans Petersen	Method for the preparation of citalopram
WO2001068629A1 (en)	2000-03-13	2001-09-20	H. Lundbeck A/S	Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
AU2001239213A1 (en)	2000-03-14	2001-09-24	H Lundbeck A/S	Method for the preparation of citalopram
SK14812002A3 (sk) *	2000-03-16	2003-02-04	H. Lundbeck A/S	Spôsob prípravy 5-kyano-1-(4-fluórfenyl)-1,3-dihydrobenzofuránov a antidepresívny farmaceutický prostriedok
AR032455A1 (es)	2000-05-12	2003-11-12	Lundbeck & Co As H	Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
IL144816A (en) *	2000-08-18	2005-09-25	Lundbeck & Co As H	Method for the preparation of citalopram
IT1319686B1 (it) *	2000-12-12	2003-10-23	C D Farmasint S R L	Procedimento di preparazione di citalopram.
HK1048812B (zh)	2000-12-22	2007-06-01	H‧隆德贝克有限公司	制备纯西酞普兰的方法
DE10112828C1 (de) *	2000-12-28	2002-11-21	Lundbeck & Co As H	Verfahren zur Herstellung von Citalopram
AU3920201A (en) *	2000-12-28	2001-07-09	H. Lundbeck A/S	Process for the preparation of pure citalopram
CA2435925A1 (en)	2001-01-30	2002-08-08	Orion Corporation Fermion	Process for the preparation of 1-(3-dimethylaminopropyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile
BG65271B1 (bg) *	2001-06-18	2007-11-30	H. Lundbeck A/S	Метод за получаване на циталопрам
IN192057B (de) *	2001-07-19	2004-02-14	Ranbaxy Lab Ltd
EP1522539B1 (de)	2001-07-31	2007-01-24	H. Lundbeck A/S	Kristalline Zusammensetzung enthaltend Escitalopram
PT1281707E (pt) *	2001-08-02	2005-04-29	Infosint Sa	Processo para a preparacao de isobenzofuranos 5-substituidos
GR1004635B (el) *	2001-08-14	2004-07-14	H@Αlundbeckαa@Sαα	Μεθοδοσαπαρασκευησατησασιταλοπραμης@αα
EP1288211A1 (de) *	2001-08-28	2003-03-05	Sekhsaria Chemicals Ltd.	Verbessertes Verfahren zur Herstellung von Citalopram-Hydrobromid aus 5-Bromphthalid
WO2003057132A2 (en)	2002-01-07	2003-07-17	Sun Pharmaceutical Industries Limited	Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)- 1,3-dihydro-5-isobenzofuran carbonitrile
GB2387596B (en) *	2002-02-27	2004-02-11	Matrix Lab Ltd	Process
HU0200980D0 (de) *	2002-03-14	2002-05-29	Gabor S Pal Dr
BG65515B1 (bg) *	2002-07-26	2008-10-31	H. Lundbeck A/S	Метод за получаване на 5-цианофталид
AU2002330730A1 (en) *	2002-08-14	2004-03-03	Natco Pharma Limited	Process for the preparation of high purity citalopram and its pharmaceutically acceptable salts
US6812355B2 (en)	2002-10-22	2004-11-02	Sekhsaria Chemicals Limited	Process for the manufacture of citalopram hydrobromide from 5-bromophthalide
ITMI20030479A1 (it) *	2003-03-13	2004-09-14	Adorkem Technology S P A	Procedimento per la preparazione di un ciano-isobenzofurano.
EP1611118A2 (de) *	2003-03-21	2006-01-04	H. Lundbeck A/S	Zwischenverbindungen zur herstellung von citalopram und escitalopram
EP1486492A3 (de)	2003-06-10	2005-02-23	Sun Pharmaceuticals Industries Ltd.	Ein Verfahren zur Hydrogenolyse von [1-(3-dimethylamino)propyl)]-1-(4-fluorophenyl)-1,3-dihydro-5-halo-isobenzofuran
EP1506963B1 (de) *	2003-10-28	2005-04-13	Adorkem Technology SpA	Verfahren zur Herstellung von Citalopram
ES2285972T1 (es)	2004-08-23	2007-12-01	Sun Pharmaceutical Industries Limited	Procedimiento de fabricacion de citalopram y enantiomeros.
US7834201B2 (en)	2005-06-22	2010-11-16	H. Lundbeck A/S	Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
TWI347942B (en)	2005-06-22	2011-09-01	Lundbeck & Co As H	Crystalline base of escitalopram and orodispersible tablets comprising escitalopram base
WO2009111031A2 (en) *	2008-03-04	2009-09-11	Intra-Cellular Therapies, Inc.	Methods of treating vasomotor symptoms

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1143703A (de)	1965-03-18
GB1526331A (en) *	1976-01-14	1978-09-27	Kefalas As	Phthalanes
GB8419963D0 (en) *	1984-08-06	1984-09-12	Lundbeck & Co As H	Intermediate compound and method
DK213290D0 (da) *	1990-09-06	1990-09-06	Lundbeck & Co As H	Treatment of cerebrovascular disorders
NZ243065A (en)	1991-06-13	1995-07-26	Lundbeck & Co As H	Piperidine derivatives and pharmaceutical compositions

1998
- 1998-03-03 DE DE69801764T patent/DE69801764T2/de not_active Expired - Lifetime
- 1998-03-03 CN CNB2003101164072A patent/CN1206207C/zh not_active Expired - Fee Related
- 1998-03-03 CZ CZ200062A patent/CZ291440B6/cs not_active IP Right Cessation
- 1998-03-03 AT AT98905125T patent/ATE205824T1/de active
- 1998-03-03 CA CA002291067A patent/CA2291067C/en not_active Expired - Fee Related
- 1998-03-03 ES ES98905125T patent/ES2148120T3/es not_active Expired - Lifetime
- 1998-03-03 AU AU66098/98A patent/AU737610B2/en not_active Ceased
- 1998-03-03 SK SK3-2000A patent/SK283309B6/sk not_active IP Right Cessation
- 1998-03-03 TR TR2000/00066T patent/TR200000066T2/xx unknown
- 1998-03-03 WO PCT/DK1998/000081 patent/WO1998019513A2/en not_active Ceased
- 1998-03-03 IL IL13351198A patent/IL133511A/en not_active IP Right Cessation
- 1998-03-03 PT PT98905125T patent/PT1015416E/pt unknown
- 1998-03-03 DE DE1015416T patent/DE1015416T1/de active Pending
- 1998-03-03 JP JP52097198A patent/JP3526581B2/ja not_active Expired - Fee Related
- 1998-03-03 EA EA200000102A patent/EA001728B1/ru not_active IP Right Cessation
- 1998-03-03 KR KR1020007000063A patent/KR100357975B1/ko not_active Expired - Fee Related
- 1998-03-03 NZ NZ501737A patent/NZ501737A/en unknown
- 1998-03-03 DK DK98905125T patent/DK1015416T3/da active
- 1998-03-03 EP EP98905125A patent/EP1015416B1/de not_active Expired - Lifetime
- 1998-03-03 HU HU0003177A patent/HU228744B1/hu not_active IP Right Cessation
1999
- 1999-12-14 IS IS5300A patent/IS2023B/is unknown
2000
- 2000-01-03 NO NO20000008A patent/NO322146B1/no not_active IP Right Cessation
- 2000-01-07 US US09/479,832 patent/US6229026B1/en not_active Expired - Lifetime
- 2000-01-31 BG BG104116A patent/BG64823B1/bg unknown
2002
- 2002-11-27 IL IL153125A patent/IL153125A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
NZ501737A (en)	2001-10-26
IL153125A (en)	2008-11-03
BG64823B1 (bg)	2006-05-31
NO20000008L (no)	2000-01-03
CZ200062A3 (cs)	2000-07-12
BG104116A (en)	2000-12-29
IS2023B (is)	2005-08-15
JP3526581B2 (ja)	2004-05-17
EA200000102A1 (ru)	2000-06-26
CA2291067A1 (en)	1998-05-14
US6229026B1 (en)	2001-05-08
NO322146B1 (no)	2006-08-21
CN1206207C (zh)	2005-06-15
KR100357975B1 (ko)	2002-10-25
WO1998019513A2 (en)	1998-05-14
JP2002509526A (ja)	2002-03-26
SK283309B6 (sk)	2003-05-02
WO1998019513A3 (en)	2000-05-04
ATE205824T1 (de)	2001-10-15
DK1015416T3 (da)	2001-11-05
NO20000008D0 (no)	2000-01-03
ES2148120T3 (es)	2002-01-16
IL133511A (en)	2004-05-12
CN1495157A (zh)	2004-05-12
KR20010021516A (ko)	2001-03-15
PT1015416E (pt)	2002-03-28
AU6609898A (en)	1998-05-29
HU228744B1 (en)	2013-05-28
ES2148120T1 (es)	2000-10-16
DE69801764T2 (de)	2002-07-04
DE1015416T1 (de)	2000-10-05
HUP0003177A2 (hu)	2001-04-28
IL133511A0 (en)	2001-04-30
SK32000A3 (en)	2000-07-11
EP1015416A2 (de)	2000-07-05
TR200000066T2 (tr)	2000-11-21
HUP0003177A3 (en)	2002-12-28
EA001728B1 (ru)	2001-08-27
AU737610B2 (en)	2001-08-23
IS5300A (is)	1999-12-14
CA2291067C (en)	2002-07-30
CZ291440B6 (cs)	2003-03-12
EP1015416B1 (de)	2001-09-19

Publication	Publication Date	Title
ATE205824T1 (de)	2001-10-15	Verfahren zur herstellung von citalopram
DE69714480D1 (de)	2002-09-05	Verfahren zur Herstellung von Citalopram
NO932870L (no)	1994-02-14	Ny fremgangsmaate for fremstilling av 9-amino-6-demetyl-6-deoksyetracykliner
ATE153332T1 (de)	1997-06-15	Verfahren zur herstellung von oxetanonen
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ATE519747T1 (de)	2011-08-15	Verfahren zur herstellung von cyclopentaägüchinazolin-derivaten
DE69707341D1 (de)	2001-11-22	Verfahren zur Herstellung von 4-Aryl-3-Hydroxymethyl-piperidinen
DE60105441D1 (de)	2004-10-14	Verfahren zur herstellung von pantoprazol und zwischenprodukte dieses verfahrens
ATE310735T1 (de)	2005-12-15	Verfahren zur herstellung von spirocyclischen tetronsäurederivaten
ES541544A0 (es)	1986-06-16	Un metodo de preparar bestatinas
DK0768296T3 (da)	2001-09-03	Fremgangsmåde til fremstilling af alfa, beta-umættede beta-trifluormethylcarboxylater
DE59803194D1 (de)	2002-04-04	Verfahren zur herstellung von 1,3-disubstituierten 2-nitroguanidinen
DE69729631D1 (de)	2004-07-29	Verfahren zur herstellung von granisetron
DE60014103D1 (de)	2004-10-28	Verfahren zur herstellung von debromohymenialdisin und deren analogen
ATE165824T1 (de)	1998-05-15	Verfahren zur herstellung von 2-perfluoroalkyl-3- oxazolin-5-one
DE59908757D1 (de)	2004-04-08	Verfahren zur herstellung von atropasäureethylester
WO2001018231A3 (de)	2001-09-13	VERFAHREN ZUR HERSTELLUNG VON (R)- ODER (S)-HYDROXY-η-BUTYROLACTON
DE69919132D1 (de)	2004-09-09	Verfahren zur herstellung von s-alkylcysteinen
ATE225762T1 (de)	2002-10-15	Verfahren zur herstellung von trifluoromethyl- acetophenon
DE69915081D1 (de)	2004-04-01	Verfahren zur herstellung von c-4-deacetyltaxanen
DE3778765D1 (de)	1992-06-11	Verfahren zur herstellung von antibiotika.
BR9810499A (pt)	2001-03-13	Método e processo para preparação de citalopram; intermediário para tal preparação e sua composição farmacêutica antidepressiva
ATE206109T1 (de)	2001-10-15	Verfahren zur herstellung von carbamoylmethylharnstoff-derivaten
KR850005842A (ko)	1985-09-26	질소-함유 포화 삼중환 디온

Legal Events

Date	Code	Title	Description
2002-10-17	8364	No opposition during term of opposition