[go: up one dir, main page]

DE69740144D1 - Verfahren zur Trennung organischer Verbindungen unter Verwendung fluorierter Trennungssysteme - Google Patents

Verfahren zur Trennung organischer Verbindungen unter Verwendung fluorierter Trennungssysteme

Info

Publication number
DE69740144D1
DE69740144D1 DE69740144T DE69740144T DE69740144D1 DE 69740144 D1 DE69740144 D1 DE 69740144D1 DE 69740144 T DE69740144 T DE 69740144T DE 69740144 T DE69740144 T DE 69740144T DE 69740144 D1 DE69740144 D1 DE 69740144D1
Authority
DE
Germany
Prior art keywords
fluorous
organic
separation
reaction component
phase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69740144T
Other languages
English (en)
Inventor
Dennis P Curran
Ruah Sabine Hadida
Masahide Hashino
Armido Studer
Peter Wipf
Patrick Jeger
Sun-Young Kim
Rafael Ferritto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Pittsburgh
Original Assignee
University of Pittsburgh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Pittsburgh filed Critical University of Pittsburgh
Priority claimed from PCT/US1997/011215 external-priority patent/WO1998000376A1/en
Application granted granted Critical
Publication of DE69740144D1 publication Critical patent/DE69740144D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B61/00—Other general methods
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B63/00—Purification; Separation; Stabilisation; Use of additives
    • C07B63/02—Purification; Separation; Stabilisation; Use of additives by treatment giving rise to a chemical modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/10—Preparation of carboxylic acid amides from compounds not provided for in groups C07C231/02 - C07C231/08
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/12—Organo silicon halides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/12—Organo silicon halides
    • C07F7/121—Preparation or treatment not provided for in C07F7/14, C07F7/16 or C07F7/20
    • C07F7/123—Preparation or treatment not provided for in C07F7/14, C07F7/16 or C07F7/20 by reactions involving the formation of Si-halogen linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1872—Preparation; Treatments not provided for in C07F7/20
    • C07F7/188—Preparation; Treatments not provided for in C07F7/20 by reactions involving the formation of Si-O linkages
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/22—Tin compounds
    • C07F7/2208—Compounds having tin linked only to carbon, hydrogen and/or halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/22—Tin compounds
    • C07F7/2284—Compounds with one or more Sn-N linkages
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B50/00—Methods of creating libraries, e.g. combinatorial synthesis
    • C40B50/08—Liquid phase synthesis, i.e. wherein all library building blocks are in liquid phase or in solution during library creation; Particular methods of cleavage from the liquid support
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/582—Recycling of unreacted starting or intermediate materials

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Structural Engineering (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69740144T 1996-06-28 1997-06-26 Verfahren zur Trennung organischer Verbindungen unter Verwendung fluorierter Trennungssysteme Expired - Lifetime DE69740144D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/671,945 US5777121A (en) 1996-06-28 1996-06-28 Fluorous reaction systems
US08/690,491 US5859247A (en) 1996-06-28 1996-07-31 Fluorous reaction and separation systems
PCT/US1997/011215 WO1998000376A1 (en) 1996-06-28 1997-06-26 Fluorous reaction and separation systems

Publications (1)

Publication Number Publication Date
DE69740144D1 true DE69740144D1 (de) 2011-04-21

Family

ID=24696521

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69740144T Expired - Lifetime DE69740144D1 (de) 1996-06-28 1997-06-26 Verfahren zur Trennung organischer Verbindungen unter Verwendung fluorierter Trennungssysteme

Country Status (3)

Country Link
US (2) US5777121A (de)
AT (1) ATE501102T1 (de)
DE (1) DE69740144D1 (de)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3581897A (en) * 1996-06-28 1998-01-21 University Of Pittsburgh Fluorous reaction and separation systems
US6706839B1 (en) 1999-02-10 2004-03-16 University Of Pittsburgh Chemical partitioning agents and methods of using same
US6749756B1 (en) 2000-02-18 2004-06-15 University Of Pittsburgh Reaction and separation methods
US6825043B1 (en) * 2000-05-05 2004-11-30 University Of Pittsburgh Fluorous tagging compounds and methods of increasing the fluorous nature of compounds
US6673539B1 (en) 2000-05-31 2004-01-06 University Of Pittsburgh Fluorous tagging compounds and methods of use thereof
US6861544B1 (en) * 2000-06-22 2005-03-01 University Of Pittsburgh Fluorous tin compounds an methods of using fluorous tin compounds
EP1307287A2 (de) * 2000-07-12 2003-05-07 MERCK PATENT GmbH An funktionalisierte plastikkugeln oder sio2 angelagerter katalysator für die zweiphasenkatalyse mit fluorhaltigem lösungsmittel
WO2002081486A1 (en) 2001-04-05 2002-10-17 University Of Pittsburgh Fluorous phosphines and phosphine oxides
US7404943B2 (en) * 2001-05-30 2008-07-29 The Regents Of The University Of California Methods for solubilizing and recovering fluorinated compounds
US7214819B2 (en) * 2001-06-08 2007-05-08 Fluorous Technologies, Inc. Fluorous triphasic reaction and separation processes for the generation of enantioenriched alcohols, amines, carboxylic acids and related compounds
US6897331B2 (en) * 2001-06-08 2005-05-24 University Of Pittsburgh Fluorous triphase and other multiphase systems
US6734318B2 (en) * 2001-06-08 2004-05-11 University Of Pittsburgh Fluorous triphase and other multiphase systems
US6806357B1 (en) 2001-08-20 2004-10-19 University Of Pittsburgh Fluorous nucleophilic substitution of alcohols and reagents for use therein
EP1323747A1 (de) * 2001-12-19 2003-07-02 Borealis Technology Oy Herstellung von Katalysatoren für die Olefinpolymerisation
WO2004007407A2 (en) * 2002-07-11 2004-01-22 Fluorous Technologies Incorporated Fluorous tagging and scavenging reactants and methods of synthesis and use thereof
AU2003268452A1 (en) * 2002-09-06 2004-03-29 University Of Pittsburgh N-vinylformamide derivatives, polymers formed therefrom and synthesis thereof
US7875752B2 (en) * 2002-09-17 2011-01-25 Fluorous Technologies Incorporated Recovery method for catalysts, reagents and co-products
AU2003301432B2 (en) * 2002-10-18 2008-11-06 Mcmaster University Methods for purifying radiolabelled compounds
US7790037B2 (en) * 2003-06-25 2010-09-07 University of Pittsburgh—of the Commonwealth System of Higher Education Separation of compounds using tagging moieties including varying numbers of repeat units
US7612166B2 (en) 2004-05-21 2009-11-03 Trustees Of Tufts College Fluorous capping reagents and methods for peptide purification
US7364908B2 (en) * 2004-06-17 2008-04-29 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Separation of fluorous compounds
US20060094866A1 (en) * 2004-11-02 2006-05-04 Gladysz John A Methods, processes and materials for dispensing and recovering supported fluorous reaction components
US20060178507A1 (en) * 2004-12-30 2006-08-10 Berry & Associates, Inc. Fluorous oligonucleotide reagents and affinity purification of oligonucleotides
WO2007139182A1 (ja) * 2006-05-31 2007-12-06 National University Corporation Hokkaido University パーフルオロアルキル基を有するフルオロアミン、その製造方法及びそれを用いるフッ素化方法、並びにパーフルオロアルキル基を有するアミドの回収方法
US7977102B2 (en) * 2007-06-15 2011-07-12 Los Alamos National Security, Llc Isotopically labeled compositions and method
GB0713187D0 (en) * 2007-07-06 2007-08-15 Cambridge Entpr biomolecule binding ligands
EP2502674A1 (de) * 2011-03-22 2012-09-26 Koninklijke Philips Electronics N.V. Verfahren zur Durchführung molekularer Reaktionen durch die Verwendung von unmischbaren Zwischenflüssigkeiten
EP2841944B1 (de) 2012-04-25 2019-11-06 Ms² Array LLC Mikroarray aus fluorierten peptiden, detektionsverfahren mit dem mikroarray aus fluorierten peptiden sowie verfahren zur formung des mikroarrays aus fluorierten peptiden
US9637791B2 (en) 2013-12-20 2017-05-02 Roche Molecular Systems, Inc. Multiplexed nucleic acid target identification by strucutre based probe cleavage
US10758895B2 (en) 2014-09-30 2020-09-01 University of Pittsburgh—of the Commonwealth System of Higher Education Cu(I)-catalyzed azide-alkyne cycloadditions (CuAAC) ligands and methods for carrying out Cu(I)-catalyzed azide-alkyne cycloaddition reactions
US10443093B2 (en) 2014-10-14 2019-10-15 Ms² Array Llc Fluorous oligonucleotide microarray

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5463082A (en) * 1993-07-08 1995-10-31 Exxon Research And Engineering Company Fluorous multiphase systems
FR2720744A1 (fr) * 1994-06-01 1995-12-08 Dow Corning Procédé de préparation de silanes fluorés inertes.

Also Published As

Publication number Publication date
US5859247A (en) 1999-01-12
US5777121A (en) 1998-07-07
ATE501102T1 (de) 2011-03-15

Similar Documents

Publication Publication Date Title
DE69740144D1 (de) Verfahren zur Trennung organischer Verbindungen unter Verwendung fluorierter Trennungssysteme
DE69430909T2 (de) Dns-sequenzbestimmung durch massenspektrometrie auf dem weg des abbaus mit exonuklease
Hays et al. Organotin Hydride-Catalyzed Conjugate Reduction of α, β-Unsaturated Ketones
US6074823A (en) DNA sequencing by mass spectrometry via exonuclease degradation
PL318157A1 (en) Method of isolating compounds from each other
DE69107656D1 (de) Chemische Abscheidemethoden unter Verwendung überkritischer Lösungen.
EP0902034A3 (de) Synthese von immobilisierten Peptiden in grossem Massstab
DE3483389D1 (de) Reaktor und suszeptor fuer ein verfahren zur chemischen dampfphasenabscheidung.
DE69532255D1 (de) Verfahren zum Nachweis von einer Zielsubstanz in einer Probe mit Hilfe von Pyryliumverbindung
AU5119690A (en) Method and device for improved reaction kinetics in nucleic acid hybridizations
Lee et al. Synthesis of symmetric fluorescently labeled poly (ethylene glycols) using phosphoramidites of pyrenebutanol and their characterization by MALDI mass spectrometry
Anderson et al. Hydrolysis of phosphotriesters: determination of transition states in parallel reactions by heavy-atom isotope effects
ATE37045T1 (de) Verfahren zur entfernung von arsen aus arsen enthaltenden saeureloesungen.
DE69425340D1 (de) Verfahren zur Verbesserung der Selektivität von Kohlenstoffmembranen durch chemische Kohlenstoffdampfabscheidung
Rhlalou et al. Facilitated transport of sugars by a resorcinarene through a supported liquid membrane
AU551143B2 (en) Analytical element and method of preventing reagents migration
EP1107470A3 (de) Verfahren zum Synchronisieren eines Empfängers in einem Positionssystem
DE68906802D1 (de) Verfahren zur bildung eines funktionellen aufgedampften films aus gruppe -iii- und -v-atomen als hauptkomponentenatome durch chemisches mikrowellen-plasma-aufdampfverfahren.
US4908135A (en) Moiety for selective separation
DE69737563D1 (de) Verfahren zur chemischen gasphasenabscheidung
DE3881582D1 (de) Verfahren zur kontinuierlichen herstellung von oximinosilanen.
SE9700207D0 (sv) A method of preventing evaporation from liquid samples in small volumes
Rosenkranz et al. The behaviour of different organometallic compounds in the presence of inorganic mercury (II): transalkylation of mercury species and their analysis by the GC–MIP–PED system
KR970015552A (ko) 펜텐알의 제조방법
DE69736561D1 (de) Acyltransfer mit einem stabilisierten übergangskomplex unter verwendung eines katalysators mit einer katalytischen imidazolfunktion (z.b. histidin)