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DE69733493D1 - Dermatandisulfat,ein hemmer von thrombinerzeugung und komplementaktivierung - Google Patents

Dermatandisulfat,ein hemmer von thrombinerzeugung und komplementaktivierung

Info

Publication number
DE69733493D1
DE69733493D1 DE69733493T DE69733493T DE69733493D1 DE 69733493 D1 DE69733493 D1 DE 69733493D1 DE 69733493 T DE69733493 T DE 69733493T DE 69733493 T DE69733493 T DE 69733493T DE 69733493 D1 DE69733493 D1 DE 69733493D1
Authority
DE
Germany
Prior art keywords
thrombin generation
activation
dermatandisulfat
complemental
inhibitor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69733493T
Other languages
English (en)
Other versions
DE69733493T2 (de
Inventor
Gorp L Van
J Brister
R Buchanan
J Linhardt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Celsus Biopharmaceuticals Inc
Original Assignee
Celsus Biopharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25164665&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69733493(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Celsus Biopharmaceuticals Inc filed Critical Celsus Biopharmaceuticals Inc
Application granted granted Critical
Publication of DE69733493D1 publication Critical patent/DE69733493D1/de
Publication of DE69733493T2 publication Critical patent/DE69733493T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L33/00—Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
    • A61L33/06—Use of macromolecular materials
    • A61L33/08—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials Engineering (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Polymers & Plastics (AREA)
  • Biochemistry (AREA)
  • Surgery (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69733493T 1997-02-06 1997-07-03 Dermatandisulfat,ein hemmer von thrombinerzeugung und komplementaktivierung Expired - Fee Related DE69733493T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/795,099 US5922690A (en) 1996-04-25 1997-02-06 Dermatan disulfate, an inhibitor of thrombin generation and activation
US795099 1997-02-06
PCT/US1997/011750 WO1998034959A1 (en) 1997-02-06 1997-07-03 Dermatan disulfate, an inhibitor of thrombin generation and complement activation

Publications (2)

Publication Number Publication Date
DE69733493D1 true DE69733493D1 (de) 2005-07-14
DE69733493T2 DE69733493T2 (de) 2006-03-23

Family

ID=25164665

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69733493T Expired - Fee Related DE69733493T2 (de) 1997-02-06 1997-07-03 Dermatandisulfat,ein hemmer von thrombinerzeugung und komplementaktivierung

Country Status (10)

Country Link
US (1) US5922690A (de)
EP (1) EP0983304B1 (de)
JP (1) JP2003512807A (de)
AT (1) ATE297412T1 (de)
AU (1) AU734112C (de)
CA (1) CA2279535C (de)
DE (1) DE69733493T2 (de)
ES (1) ES2242980T3 (de)
PT (1) PT983304E (de)
WO (1) WO1998034959A1 (de)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9711443D0 (en) * 1997-06-03 1997-07-30 Leo Pharm Prod Ltd Chemical suppositions
IL127826A0 (en) * 1998-12-29 1999-10-28 Laster Gail Restenosis drug therapy
DE19913707A1 (de) 1999-03-26 2000-10-05 Privates Inst Bioserv Gmbh Immunadsorber zur Sepsistherapie
US6409987B1 (en) 1999-04-07 2002-06-25 Intimax Corporation Targeted agents useful for diagnostic and therapeutic applications
AU782661B2 (en) * 1999-06-30 2005-08-18 Hamilton Civic Hospitals Research Development, Inc. Heparin compositions that inhibit clot associated coagulation factors
US6518244B2 (en) * 2000-03-09 2003-02-11 Intimax Corporation Combinations of heparin cofactor II agonist and platelet IIb/IIIa antagonist, and uses thereof
JP2002080371A (ja) * 2000-06-23 2002-03-19 Seikagaku Kogyo Co Ltd プラスミノーゲンアクチベーター活性促進剤
HUP0300939A2 (hu) * 2000-09-08 2003-09-29 Hamilton Civic Hospitals Research Development, Inc. Antitrombotikus készítmények
WO2002058633A2 (en) * 2001-01-23 2002-08-01 Massachusetts Institute Of Technology Solid- and solution -phase synthesis of heparin and other glycosaminoglycans
JP4915888B2 (ja) * 2001-08-01 2012-04-11 株式会社ジャパンエコロジーシンキング 豚皮抽出物よりのデルマタン硫酸の製造方法
DE10307205A1 (de) * 2003-02-20 2004-09-09 Jostra Ag Blutverträgliche Beschichtung von Kunststoffoberflächen
US20050261241A1 (en) * 2004-05-19 2005-11-24 Celsus Biopharmaceuticals, Inc. Use of dermatan sulfates and/or desulfated heparins to treat or prevent heparinoid-induced autoimmune responses
WO2006105313A2 (en) * 2005-03-29 2006-10-05 Massachusetts Institute Of Technology Compositions of and methods of using oversulfated glycosaminoglycans
US9114194B2 (en) * 2006-05-12 2015-08-25 W. L. Gore & Associates, Inc. Immobilized biologically active entities having high biological activity following mechanical manipulation
US8021677B2 (en) 2006-05-12 2011-09-20 Gore Enterprise Holdings, Inc. Immobilized biologically active entities having a high degree of biological activity
US8986713B2 (en) * 2006-05-12 2015-03-24 W. L. Gore & Associates, Inc. Medical device capable of being compacted and expanded having anti-thrombin III binding activity
US8496953B2 (en) * 2006-05-12 2013-07-30 W. L. Gore & Associates, Inc. Immobilized biologically active entities having a high degree of biological activity following sterilization
US20080279909A1 (en) * 2006-05-12 2008-11-13 Cleek Robert L Immobilized Biologically Active Entities Having A High Degree of Biological Activity Following Sterilization
CA3154415A1 (en) 2006-10-10 2008-04-17 Regenesance B.V. Anti-sense oligonucleotide for use in facilitating axonal regeneration
US8617820B2 (en) * 2007-08-28 2013-12-31 Ortho-Clinical Diagnostics, Inc. Use of glycosaminoglycans to reduce non-specific binding in immunoassays
DE102008045127A1 (de) 2008-09-01 2010-03-04 Heinrich, Hans-Werner, Prof. Dr. Filtersystem zur extrakorporalen Abreicherung von aktivierten Polymorphkernigen Granuloyzten (Polymorphonuclear leukocytes-PMNs)
US8591932B2 (en) * 2009-09-17 2013-11-26 W. L. Gore & Associates, Inc. Heparin entities and methods of use
KR101933237B1 (ko) 2011-03-11 2018-12-27 더블유.엘. 고어 앤드 어소시에이트스, 인코포레이티드 고정화된 생물학적 실체의 개선
WO2013006906A1 (en) * 2011-07-11 2013-01-17 Commonwealth Scientific And Industrial Research Organisation Dermatan sulphate, pharmaceutical compositions and process for producing same
CN106188341B (zh) * 2016-07-27 2019-09-17 河北常山生化药业股份有限公司 肝素钠下脚料制备高纯度硫酸皮肤素工艺
CN106146688A (zh) * 2016-07-27 2016-11-23 河北常山生化药业股份有限公司 肝素钠下脚料制备类肝素工艺
JP7623953B2 (ja) * 2019-11-29 2025-01-29 マルホ株式会社 医薬品または化粧品用組成物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA795325A (en) * 1962-08-06 1968-09-24 Roussel-Uclaf Procede de preparation de nouveaux derives de l'heparine
SE306597B (de) * 1964-12-17 1968-12-02 Incentive Ab
FR2482603A1 (fr) * 1980-05-14 1981-11-20 Pharmindustrie Nouveaux esters d'heparine utilisables pour la preparation de medicaments, et procedes pour leur preparation
DE3124384C2 (de) * 1981-06-22 1985-05-15 Herbert Prof. Dr. 1000 Berlin Voß Dermatanpolysulfat, Verfahren zu dessen Herstellung und dieses enthaltendes virushemmendes Mittel
FR2538404B1 (de) * 1982-12-28 1985-08-23 Anic Spa
FR2584728B1 (fr) * 1985-07-12 1987-11-20 Choay Sa Procede de sulfatation de glycosaminoglycanes et de leurs fragments
US4745106A (en) * 1986-08-20 1988-05-17 Griffin Charles C Heparin derivatives having improved anti-Xa specificity
CA2000650A1 (en) * 1989-10-13 1991-04-13 Louis Jaques Product and process for the treatment and prevention of intravascular thrombi and atherosclerosis
US5362755A (en) * 1990-01-05 1994-11-08 Sepracor, Inc. Method for treating asthma using optically pure (R)-albuterol
JP2855307B2 (ja) * 1992-02-05 1999-02-10 生化学工業株式会社 光反応性グリコサミノグリカン、架橋グリコサミノグリカン及びそれらの製造方法

Also Published As

Publication number Publication date
AU734112C (en) 2002-03-28
PT983304E (pt) 2005-09-30
DE69733493T2 (de) 2006-03-23
ATE297412T1 (de) 2005-06-15
CA2279535C (en) 2006-10-03
WO1998034959A1 (en) 1998-08-13
ES2242980T3 (es) 2005-11-16
US5922690A (en) 1999-07-13
EP0983304A1 (de) 2000-03-08
JP2003512807A (ja) 2003-04-02
AU3880797A (en) 1998-08-26
AU734112B2 (en) 2001-06-07
CA2279535A1 (en) 1998-08-13
EP0983304B1 (de) 2005-06-08

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee