DE69730332D1 - Alkyldextran-polyalcohol Arzneimittel-Komplexe - Google Patents
Alkyldextran-polyalcohol Arzneimittel-KomplexeInfo
- Publication number
- DE69730332D1 DE69730332D1 DE69730332T DE69730332T DE69730332D1 DE 69730332 D1 DE69730332 D1 DE 69730332D1 DE 69730332 T DE69730332 T DE 69730332T DE 69730332 T DE69730332 T DE 69730332T DE 69730332 D1 DE69730332 D1 DE 69730332D1
- Authority
- DE
- Germany
- Prior art keywords
- alkyldextran
- polyalcohol
- spacer
- drug
- drug complexes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP14442196 | 1996-06-06 | ||
| JP14442196 | 1996-06-06 | ||
| PCT/JP1997/001914 WO1997046260A1 (fr) | 1996-06-06 | 1997-06-05 | Complexes medicamenteux |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69730332D1 true DE69730332D1 (de) | 2004-09-23 |
| DE69730332T2 DE69730332T2 (de) | 2005-09-22 |
Family
ID=15361795
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69730332T Expired - Lifetime DE69730332T2 (de) | 1996-06-06 | 1997-06-05 | Alkyldextran-polyalcohol Arzneimittel-Komplexe |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US6436912B1 (de) |
| EP (1) | EP0916348B1 (de) |
| JP (1) | JP4137183B2 (de) |
| KR (1) | KR20000016558A (de) |
| CN (1) | CN1227499A (de) |
| AT (1) | ATE273715T1 (de) |
| AU (1) | AU723392B2 (de) |
| CA (1) | CA2257245A1 (de) |
| DE (1) | DE69730332T2 (de) |
| DK (1) | DK0916348T3 (de) |
| EA (1) | EA001550B1 (de) |
| ES (1) | ES2229354T3 (de) |
| ID (1) | ID18298A (de) |
| NO (1) | NO985666L (de) |
| PT (1) | PT916348E (de) |
| TW (1) | TW527183B (de) |
| WO (1) | WO1997046260A1 (de) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH071238U (ja) * | 1993-06-11 | 1995-01-10 | 株式会社大井製作所 | ドアロック操作用のロッド連結装置 |
| TW527183B (en) * | 1996-06-06 | 2003-04-11 | Daiichi Seiyaku Co | Drug complex |
| TW409058B (en) | 1996-06-06 | 2000-10-21 | Daiichi Seiyaku Co | Method for preparation of a drug complex |
| AU3733399A (en) * | 1998-05-22 | 1999-12-13 | Daiichi Pharmaceutical Co., Ltd. | Drug composites |
| CN1191093C (zh) * | 1998-10-30 | 2005-03-02 | 第一制药株式会社 | Dds化合物及其测定方法 |
| EP1221445B1 (de) * | 1999-10-15 | 2008-08-20 | Daiichi Sankyo Company, Limited | Pentacyclische taxan-verbindungen |
| US6677456B2 (en) | 1999-10-15 | 2004-01-13 | Daiichi Pharmaceutical Co., Ltd. | Pentacyclic taxan compound |
| KR20030031502A (ko) * | 2000-06-29 | 2003-04-21 | 다이이찌 세이야꾸 가부시기가이샤 | 디디에스 화합물 및 그의 제조방법 |
| US6815435B2 (en) * | 2000-07-13 | 2004-11-09 | Daiichi Pharmaceutical Co., Ltd. | Pharmaceutical compositions containing DDS compounds |
| US20030092608A1 (en) * | 2001-08-21 | 2003-05-15 | Takayuki Kawaguchi | Pharmaceutical composition for inhibiting the metastasis or preventing the recurrence of malignant tumor |
| TWI313609B (en) * | 2001-08-21 | 2009-08-21 | Mitsubishi Tanabe Pharma Corp | Pharmaceutical composition for inhibiting the metastasis or preventing the recurrence of malignant tumor |
| US7585491B2 (en) * | 2002-12-13 | 2009-09-08 | Immunomedics, Inc. | Immunoconjugates with an intracellularly-cleavable linkage |
| TW200306314A (en) * | 2002-04-16 | 2003-11-16 | Tanabe Seiyaku Co | Liquid preparation comprising camptothecin derivative and pharmaceutical composition producible by lyophilizing the preparation |
| BR122018071808B8 (pt) * | 2003-11-06 | 2020-06-30 | Seattle Genetics Inc | conjugado |
| JPWO2006088245A1 (ja) * | 2005-02-18 | 2008-07-10 | 国立大学法人徳島大学 | ポリオキシアルキレン鎖含有脂質誘導体及び該誘導体を含有する脂質膜構造体 |
| CN100516067C (zh) | 2006-01-10 | 2009-07-22 | 上海恒瑞医药有限公司 | 具有抗肿瘤活性的紫杉酚衍生物 |
| US9895449B2 (en) | 2010-05-25 | 2018-02-20 | Syndevrx, Inc. | Polymer-conjugated MetAP2 inhibitors, and therapeutic methods of use thereof |
| DK2576638T3 (da) | 2010-05-25 | 2021-03-15 | Syndevrx Inc | Polymerkonjugerede metap2-inhibitorer og terapeutiske fremgangsmåder til anvendelse deraf |
| MX364484B (es) | 2012-10-11 | 2019-04-29 | Daiichi Sankyo Co Ltd | Conjugado de anticuerpo-fármaco. |
| ES2782248T3 (es) | 2012-10-19 | 2020-09-11 | Daiichi Sankyo Co Ltd | Conjugado de anticuerpo y fármaco producido por la unión a través de un enlazador que tiene estructura hidrófila |
| US9173956B2 (en) | 2013-04-10 | 2015-11-03 | Syndevrx, Inc. | METAP2 inhibitors and methods of treating obesity |
| WO2015071841A1 (en) | 2013-11-12 | 2015-05-21 | Druggability Technologies Holdings Limited | Complexes of dabigatran and its derivatives, process for the preparation thereof and pharmaceutical compositions containing them |
| HRP20250673T1 (hr) | 2013-12-25 | 2025-08-01 | Daiichi Sankyo Company, Limited | Postupak za proizvodnju konjugata anti-trop2 antitijelo-lijek |
| KR102314913B1 (ko) | 2014-01-31 | 2021-10-19 | 다이이찌 산쿄 가부시키가이샤 | 항-her2 항체-약물 접합체 |
| KR102186027B1 (ko) | 2014-04-10 | 2020-12-03 | 다이이치 산쿄 유럽 게엠베하 | 항her3 항체-약물 콘주게이트 |
| ES2754348T3 (es) | 2014-04-10 | 2020-04-17 | Daiichi Sankyo Co Ltd | Conjugado de (anticuerpo anti-HER2)-fármaco |
| AU2016286898B2 (en) | 2015-06-29 | 2022-12-08 | Daiichi Sankyo Company, Limited | Method for selectively manufacturing antibody-drug conjugate |
| ES2893749T3 (es) | 2015-12-10 | 2022-02-10 | Syndevrx Inc | Derivados de fumagilol y polimorfos de los mismos |
| CA3008960C (en) | 2016-01-11 | 2024-07-02 | Syndevrx, Inc. | TREATMENT OF TUMORS INDUCED BY METABOLIC DYSFUNCTION |
| SG10201912173RA (en) | 2016-10-07 | 2020-02-27 | Daiichi Sankyo Co Ltd | Therapy for drug-resistant cancer by administration of anti-her2 antibody/drug conjugate |
| KR20250040100A (ko) | 2016-12-12 | 2025-03-21 | 다이이찌 산쿄 가부시키가이샤 | 항체-약물 콘주게이트와 면역 체크 포인트 저해제의 조합 |
| CA3050668C (en) | 2017-01-17 | 2023-08-15 | Daiichi Sankyo Company, Limited | Anti-gpr20 antibody and anti-gpr20 antibody-drug conjugate |
| TW202532106A (zh) | 2017-05-15 | 2025-08-16 | 日商第一三共股份有限公司 | 抗體－藥物結合物之製造方法 |
| JP7248578B2 (ja) | 2017-08-31 | 2023-03-29 | 第一三共株式会社 | 抗体－薬物コンジュゲートの新規製造方法 |
| KR102816741B1 (ko) | 2017-08-31 | 2025-06-04 | 다이이찌 산쿄 가부시키가이샤 | 항체-약물 콘주게이트의 개량 제조 방법 |
| HUE067382T2 (hu) | 2018-05-18 | 2024-10-28 | Daiichi Sankyo Co Ltd | Anti-MUC1-exatecan antitest-hatóanyag konjugátum |
| WO2020022475A1 (ja) | 2018-07-27 | 2020-01-30 | 第一三共株式会社 | 抗体－薬物コンジュゲートの薬物部位を認識する蛋白質 |
| CN112805036A (zh) | 2018-07-31 | 2021-05-14 | 第一三共株式会社 | 通过施用抗体-药物缀合物对转移性脑肿瘤的治疗 |
| WO2020087077A1 (en) | 2018-10-26 | 2020-04-30 | Syndevrx,Inc. | Biomarkers of metap2 inhibitors and applications thereof |
| CN114302744B (zh) | 2019-07-10 | 2025-08-26 | 赛博克萨3公司 | 作为治疗剂的微管靶向剂的肽缀合物 |
| US11634508B2 (en) | 2019-07-10 | 2023-04-25 | Cybrexa 2, Inc. | Peptide conjugates of cytotoxins as therapeutics |
| US11806405B1 (en) | 2021-07-19 | 2023-11-07 | Zeno Management, Inc. | Immunoconjugates and methods |
| AU2023306832A1 (en) | 2022-07-11 | 2025-02-13 | Pinotbio, Inc. | Ddx5 protein-binding camptothecin derivatives and prodrugs thereof |
| WO2025185559A1 (zh) * | 2024-03-04 | 2025-09-12 | 杭州中美华东制药有限公司 | 抗FGFR2b抗体、其抗体药物偶联物及其用途 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS59220197A (ja) | 1983-05-30 | 1984-12-11 | Snow Brand Milk Prod Co Ltd | 新規な含窒素多糖体およびその製造方法 |
| JP2604930B2 (ja) | 1990-12-14 | 1997-04-30 | 株式会社ディ・ディ・エス研究所 | ヒアルロン酸およびコンドロイチン誘導体 |
| WO1992014759A1 (fr) | 1991-02-21 | 1992-09-03 | Drug Delivery System Institute, Ltd. | Carboxymethylmannoglucane et derive |
| JP3359955B2 (ja) | 1992-07-16 | 2002-12-24 | 第一製薬株式会社 | 抗腫瘍剤 |
| WO1994019376A1 (fr) | 1993-02-26 | 1994-09-01 | Drug Delivery System Institute, Ltd. | Derive de polysaccharide et vehicule de medicament |
| JPH0784481A (ja) | 1993-06-26 | 1995-03-31 | Ricoh Co Ltd | 画像形成装置 |
| US5811510A (en) * | 1995-04-14 | 1998-09-22 | General Hospital Corporation | Biodegradable polyacetal polymers and methods for their formation and use |
| SG50747A1 (en) * | 1995-08-02 | 1998-07-20 | Tanabe Seiyaku Co | Comptothecin derivatives |
| TW527183B (en) * | 1996-06-06 | 2003-04-11 | Daiichi Seiyaku Co | Drug complex |
| TW409058B (en) | 1996-06-06 | 2000-10-21 | Daiichi Seiyaku Co | Method for preparation of a drug complex |
| AU3733399A (en) | 1998-05-22 | 1999-12-13 | Daiichi Pharmaceutical Co., Ltd. | Drug composites |
| CN1191093C (zh) | 1998-10-30 | 2005-03-02 | 第一制药株式会社 | Dds化合物及其测定方法 |
-
1997
- 1997-05-31 TW TW086107455A patent/TW527183B/zh not_active IP Right Cessation
- 1997-06-05 AU AU29787/97A patent/AU723392B2/en not_active Ceased
- 1997-06-05 ID IDP971928A patent/ID18298A/id unknown
- 1997-06-05 WO PCT/JP1997/001914 patent/WO1997046260A1/ja not_active Ceased
- 1997-06-05 DK DK97924325T patent/DK0916348T3/da active
- 1997-06-05 AT AT97924325T patent/ATE273715T1/de not_active IP Right Cessation
- 1997-06-05 ES ES97924325T patent/ES2229354T3/es not_active Expired - Lifetime
- 1997-06-05 JP JP50042198A patent/JP4137183B2/ja not_active Expired - Fee Related
- 1997-06-05 CA CA002257245A patent/CA2257245A1/en not_active Abandoned
- 1997-06-05 CN CN97197008A patent/CN1227499A/zh active Pending
- 1997-06-05 KR KR1019980710148A patent/KR20000016558A/ko not_active Abandoned
- 1997-06-05 US US09/147,342 patent/US6436912B1/en not_active Expired - Fee Related
- 1997-06-05 PT PT97924325T patent/PT916348E/pt unknown
- 1997-06-05 EA EA199900004A patent/EA001550B1/ru not_active IP Right Cessation
- 1997-06-05 EP EP97924325A patent/EP0916348B1/de not_active Expired - Lifetime
- 1997-06-05 DE DE69730332T patent/DE69730332T2/de not_active Expired - Lifetime
-
1998
- 1998-12-04 NO NO985666A patent/NO985666L/no not_active Application Discontinuation
-
2002
- 2002-05-28 US US10/155,170 patent/US6838450B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| ID18298A (id) | 1998-03-26 |
| EA199900004A1 (ru) | 1999-06-24 |
| ATE273715T1 (de) | 2004-09-15 |
| WO1997046260A1 (fr) | 1997-12-11 |
| JP4137183B2 (ja) | 2008-08-20 |
| DE69730332T2 (de) | 2005-09-22 |
| US20030171262A1 (en) | 2003-09-11 |
| CN1227499A (zh) | 1999-09-01 |
| EP0916348A4 (de) | 2000-11-29 |
| EA001550B1 (ru) | 2001-04-23 |
| NO985666L (no) | 1999-02-04 |
| NO985666D0 (no) | 1998-12-04 |
| PT916348E (pt) | 2004-10-29 |
| ES2229354T3 (es) | 2005-04-16 |
| TW527183B (en) | 2003-04-11 |
| AU2978797A (en) | 1998-01-05 |
| KR20000016558A (ko) | 2000-03-25 |
| CA2257245A1 (en) | 1997-12-11 |
| DK0916348T3 (da) | 2004-12-06 |
| US6436912B1 (en) | 2002-08-20 |
| US6838450B2 (en) | 2005-01-04 |
| AU723392B2 (en) | 2000-08-24 |
| EP0916348A1 (de) | 1999-05-19 |
| EP0916348B1 (de) | 2004-08-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: DAIICHI SANKYO CO., LTD., TOKYO, JP |