DE69703294D1 - Zusammensetzungen die konjugate von cis-docosahexaenoic-säure und taxotere enthalten - Google Patents
Zusammensetzungen die konjugate von cis-docosahexaenoic-säure und taxotere enthaltenInfo
- Publication number
- DE69703294D1 DE69703294D1 DE69703294T DE69703294T DE69703294D1 DE 69703294 D1 DE69703294 D1 DE 69703294D1 DE 69703294 T DE69703294 T DE 69703294T DE 69703294 T DE69703294 T DE 69703294T DE 69703294 D1 DE69703294 D1 DE 69703294D1
- Authority
- DE
- Germany
- Prior art keywords
- taxotere
- compositions
- docosahexaenoic acid
- conjugate containing
- containing cis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65142996A | 1996-05-22 | 1996-05-22 | |
| PCT/US1997/008866 WO1997044026A1 (en) | 1996-05-22 | 1997-05-22 | Compositions comprising conjugates of cis-docosahexaenoic acid and taxotere |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69703294D1 true DE69703294D1 (de) | 2000-11-16 |
| DE69703294T2 DE69703294T2 (de) | 2001-05-17 |
Family
ID=24612833
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69703294T Expired - Lifetime DE69703294T2 (de) | 1996-05-22 | 1997-05-22 | Zusammensetzungen die konjugate von cis-docosahexaenoic-säure und taxotere enthalten |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6080877A (de) |
| EP (1) | EP0914116B1 (de) |
| JP (1) | JP4172726B2 (de) |
| AT (1) | ATE196844T1 (de) |
| CA (1) | CA2255615C (de) |
| DE (1) | DE69703294T2 (de) |
| DK (1) | DK0914116T3 (de) |
| ES (1) | ES2151277T3 (de) |
| WO (1) | WO1997044026A1 (de) |
Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| US6576636B2 (en) * | 1996-05-22 | 2003-06-10 | Protarga, Inc. | Method of treating a liver disorder with fatty acid-antiviral agent conjugates |
| US5795909A (en) | 1996-05-22 | 1998-08-18 | Neuromedica, Inc. | DHA-pharmaceutical agent conjugates of taxanes |
| EP0870510A3 (de) * | 1997-04-11 | 1999-09-15 | Eli Lilly And Company | Synergistische Zusammensetzung enthaltend Cryptophycinderivate und synergistische mikrotubuli Mitteln |
| US7288665B1 (en) * | 1997-08-18 | 2007-10-30 | Florida State University | Process for selective derivatization of taxanes |
| GB9803448D0 (en) | 1998-02-18 | 1998-04-15 | Pharma Mar Sa | Pharmaceutical formulation |
| GB9804361D0 (en) * | 1998-03-02 | 1998-04-22 | Scotia Holdings Plc | Cancer treatment |
| US20030130316A1 (en) * | 2000-03-20 | 2003-07-10 | Steiner Mitchell S. | Method for chemoprevention of prostate cancer |
| US20040176470A1 (en) * | 1998-05-07 | 2004-09-09 | Steiner Mitchell S. | Method for treatment and chemoprevention of prostate cancer |
| US20040092602A1 (en) * | 1998-05-07 | 2004-05-13 | Steiner Mitchell S. | Method for treatment and chemoprevention of prostate cancer |
| US6413533B1 (en) * | 1998-05-07 | 2002-07-02 | The University Of Tennessee Research Corporation | Method for chemoprevention of prostate cancer |
| US6632447B1 (en) * | 1998-05-07 | 2003-10-14 | The University Of Tennessee Research Corporation | Method for chemoprevention of prostate cancer |
| US6207660B1 (en) * | 1998-06-05 | 2001-03-27 | Jonathan L. Sessler | Texaphyrin conjugates and uses thereof |
| GB9904386D0 (en) * | 1999-02-25 | 1999-04-21 | Pharmacia & Upjohn Spa | Antitumour synergistic composition |
| US7235583B1 (en) | 1999-03-09 | 2007-06-26 | Luitpold Pharmaceuticals, Inc., | Fatty acid-anticancer conjugates and uses thereof |
| KR20020000147A (ko) * | 1999-03-09 | 2002-01-04 | 니겔 엘. 웹 | 지방산-항암제 결합체 및 그의 용도 |
| WO2000067802A1 (en) * | 1999-05-10 | 2000-11-16 | Protarga, Inc. | Fatty acid-n-substituted indol-3-glyoxyl-amide compositions and uses thereof |
| CA2391502A1 (en) * | 1999-11-15 | 2001-05-25 | Pharma Mar S.A | Aplidine treatment of cancers |
| CA2388063C (en) | 1999-11-24 | 2010-06-08 | Immunogen, Inc. | Cytotoxic agents comprising taxanes and their therapeutic use |
| CO5280224A1 (es) * | 2000-02-02 | 2003-05-30 | Univ Florida State Res Found | Taxanos sustituidos con ester en c7, utiles como agentes antitumorales y composiciones farmaceuticas que los contienen |
| BR0104354A (pt) * | 2000-02-02 | 2002-01-02 | Univ Florida State Res Found | Taxanos substituìdos com éster c10 |
| US6649632B2 (en) | 2000-02-02 | 2003-11-18 | Fsu Research Foundation, Inc. | C10 ester substituted taxanes |
| GB0003201D0 (en) * | 2000-02-11 | 2000-04-05 | Pharmacia & Upjohn Spa | Method to potentiate the therapeutic efficacy of taxane and derivatives thereof |
| EP2275557A1 (de) | 2000-04-12 | 2011-01-19 | Human Genome Sciences, Inc. | Albuminfusionsproteine |
| US20050100991A1 (en) * | 2001-04-12 | 2005-05-12 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| CA2410632A1 (en) | 2000-06-22 | 2001-12-27 | David S. Garvey | Nitrosated and nitrosylated taxanes, compositions and methods of use |
| US6881420B2 (en) * | 2000-06-23 | 2005-04-19 | Teva Pharmaceutical Industries Ltd. | Compositions and dosage forms for gastric delivery of irinotecan and methods of treatment that use it to inhibit cancer cell proliferation |
| UA76718C2 (uk) * | 2000-06-30 | 2006-09-15 | Фарма Мар, С.А. | Протипухлинні похідні аплідину |
| US6624317B1 (en) | 2000-09-25 | 2003-09-23 | The University Of North Carolina At Chapel Hill | Taxoid conjugates as antimitotic and antitumor agents |
| BR0114604A (pt) * | 2000-10-12 | 2003-10-14 | Pharma Mar Sa | Tratamento de cnceres |
| JP4634694B2 (ja) * | 2001-03-23 | 2011-02-16 | ルイトポルド・ファーマシューティカルズ・インコーポレーテッド | 脂肪アルコール薬物複合体 |
| JP2005500988A (ja) * | 2001-03-23 | 2005-01-13 | ルイトポルド・ファーマシューティカルズ・インコーポレーテッド | 脂肪族アミン薬物複合体 |
| US6825166B2 (en) | 2001-03-23 | 2004-11-30 | Tapestry Pharmaceuticals, Inc. | Molecular conjugates for use in treatment of cancer |
| CA2446739A1 (en) * | 2001-05-25 | 2002-12-05 | Human Genome Sciences, Inc. | Chemokine beta-1 fusion proteins |
| CA2354471A1 (en) * | 2001-07-31 | 2003-01-31 | Florida State University Research Foundation, Inc. | C10 ester substituted taxanes |
| CA2354486A1 (en) * | 2001-07-31 | 2003-01-31 | Florida State University Research Foundation, Inc. | C7 ester substituted taxanes |
| SG125889A1 (en) * | 2001-08-01 | 2006-10-30 | Univ Florida State Res Found | C7 ester subsituted taxanes |
| SG129990A1 (en) * | 2001-08-01 | 2007-03-20 | Univ Florida State Res Found | C10 ester substituted taxanes |
| AU2002336206B2 (en) * | 2001-10-19 | 2007-11-29 | Pharma Mar, S.A. | Use of aplidine for the treatment of pancreatic cancer |
| US20080249183A1 (en) * | 2001-11-29 | 2008-10-09 | Steiner Mitchell S | Treatment of androgen-deprivation induced osteoporosis |
| EP2990417A1 (de) | 2001-12-21 | 2016-03-02 | Human Genome Sciences, Inc. | Albumin-insulin-fusionsprotein |
| MXPA05001390A (es) | 2002-08-02 | 2005-07-29 | Immunogen Inc | Agentes citotoxicos que contienen taxanos potentes novedosos y su uso terapeutico. |
| US7390898B2 (en) | 2002-08-02 | 2008-06-24 | Immunogen Inc. | Cytotoxic agents containing novel potent taxanes and their therapeutic use |
| EP1594530A4 (de) | 2003-01-22 | 2006-10-11 | Human Genome Sciences Inc | Albuminfusionsproteine |
| WO2004080477A1 (en) * | 2003-03-12 | 2004-09-23 | Dana-Farber Cancer Institute, Inc. | Aplidine for multiple myeloma treatment |
| WO2004103409A1 (ja) * | 2003-05-26 | 2004-12-02 | Hiroshi Maeda | 抗腫瘍剤及びその製造方法 |
| US20050148534A1 (en) * | 2003-09-22 | 2005-07-07 | Castellino Angelo J. | Small molecule compositions and methods for increasing drug efficiency using compositions thereof |
| RU2340616C2 (ru) * | 2003-10-29 | 2008-12-10 | Сонус Фармасьютикалз, Инк. | Токоферол-модифицированные терапевтические лекарственные соединения |
| DE602004027936D1 (de) | 2003-10-29 | 2010-08-12 | Sonus Pharmaceutical Inc | Tocopherolmodifizierte therapeutische arzneimittelverbindung |
| CA2544128A1 (en) * | 2003-10-30 | 2005-05-12 | The Research Foundation Of State University Of New York | Taxoid-fatty acid conjugates and pharmaceutical compositions thereof |
| PE20050693A1 (es) | 2004-02-13 | 2005-09-27 | Univ Florida State Res Found | Taxanos sustituidos con esteres de ciclopentilo en c10 |
| US7160919B2 (en) | 2004-03-05 | 2007-01-09 | Florida State University Research Foundation, Inc. | C7 lactyloxy-substituted taxanes |
| US20100009929A1 (en) | 2004-03-29 | 2010-01-14 | Cheng Jin Q | Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof |
| US20100028339A1 (en) | 2004-03-29 | 2010-02-04 | Cheng Jin Q | Compositions including triciribine and trastuzumab and methods of use thereof |
| US20110008327A1 (en) | 2004-03-29 | 2011-01-13 | Cheng Jin Q | Compositions including triciribine and epidermal growth factor receptor inhibitor compounds or salts thereof and methods of use thereof |
| US20100009928A1 (en) | 2004-03-29 | 2010-01-14 | Cheng Jin Q | Compositions including triciribine and taxanes and methods of use thereof |
| EP1737472B1 (de) | 2004-03-29 | 2014-08-13 | University Of South Florida | Wirksame Behandlung von Tumoren und Krebs mit Triciribin |
| US20100173864A1 (en) | 2004-03-29 | 2010-07-08 | Cheng Jin Q | Compositions including triciribine and one or more platinum compounds and methods of use thereof |
| US20060216767A1 (en) * | 2005-03-22 | 2006-09-28 | Saladax Biomedical Inc. | Docetaxel immunoassay |
| US20060270641A1 (en) * | 2005-05-31 | 2006-11-30 | Steiner Mitchell S | Method for chemoprevention of prostate cancer |
| WO2008021242A2 (en) * | 2006-08-10 | 2008-02-21 | The Research Foundation Of State University Of New York | Fluorotaxoid-fatty acid conjugates and pharmaceutical compositions thereof |
| US20080051380A1 (en) | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods and compositions for treating cancer |
| US8399420B2 (en) * | 2007-09-26 | 2013-03-19 | Mount Sanai School of Medicine | Azacytidine analogues and uses thereof |
| EP2276755A4 (de) | 2008-03-31 | 2011-05-04 | Univ Florida State Res Found | C(10)-ethylester- und c(10)-cyclopropylester-substituierte taxane |
| GB201604316D0 (en) | 2016-03-14 | 2016-04-27 | Avexxin As | Combination therapy |
| CN109310771A (zh) * | 2016-06-03 | 2019-02-05 | 埃维克辛公司 | 包含多不饱和酮与皮质甾类化合物的联合疗法 |
| GB201609735D0 (en) * | 2016-06-03 | 2016-07-20 | Avexxin As | Combination therapy |
| RS66574B1 (sr) | 2016-07-29 | 2025-03-31 | Janssen Pharmaceutica Nv | Niraparib za upotrebu u postupku lečenja raka prostate |
| WO2018055062A1 (en) | 2016-09-21 | 2018-03-29 | Avexxin As | Pharmaceutical composition |
Family Cites Families (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4351831A (en) * | 1977-11-02 | 1982-09-28 | Massachusetts Institute Of Technology | Process and composition for treating disorders by administering isoxsurpine and choline |
| IT7927748A0 (it) * | 1979-11-30 | 1979-11-30 | Simes | Derivati dell'acido 6,6'-diapopsi psicarotenedioico e relativi procedimenti di preparazione. |
| US4346085A (en) * | 1980-02-29 | 1982-08-24 | Massachusetts Institute Of Technology | Process and composition for treating disorders by administering amphetamine and choline |
| US4636494A (en) * | 1981-01-30 | 1987-01-13 | Massachusetts Institute Of Technology | Process and composition for treating disorders by administering amphetamine and choline |
| JPS58177953A (ja) * | 1982-04-13 | 1983-10-18 | Eisai Co Ltd | ポリプレニルカルボン酸アミドおよびその製造方法 |
| JPS5925327A (ja) * | 1982-07-31 | 1984-02-09 | Hidematsu Hirai | 抗腫瘍性複合体の製造方法 |
| EP0133795B1 (de) * | 1983-08-01 | 1989-01-18 | THE McLEAN HOSPITAL CORPORATION | Gaba-Ester und gaba-analoge Ester |
| US4550109A (en) * | 1984-05-31 | 1985-10-29 | The Board Of Regents, The University Of Texas System | Lipoidal biopterin compounds |
| US4684646A (en) * | 1984-06-26 | 1987-08-04 | Merck & Co., Inc. | 2-acylaminomethyl-1,4-benzodiazepine derivatives as CCK-antagonists |
| US4554272A (en) * | 1985-01-25 | 1985-11-19 | Merck & Co., Inc. | Substituted quinazolino-1,4-benzodiazepin-6,9-diones and their preparation |
| US5223263A (en) * | 1988-07-07 | 1993-06-29 | Vical, Inc. | Liponucleotide-containing liposomes |
| US5246726A (en) * | 1986-03-21 | 1993-09-21 | Efamol Ltd. | Iron-containing composition and method for treatment of cancer |
| FR2601675B1 (fr) * | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Derives du taxol, leur preparation et les compositions pharmaceutiques qui les contiennent |
| FR2601676B1 (fr) * | 1986-07-17 | 1988-09-23 | Rhone Poulenc Sante | Procede de preparation du taxol et du desacetyl-10 taxol |
| US4968672A (en) * | 1987-01-02 | 1990-11-06 | The United States Of America As Represented By The Department Of Health And Human Services | Adenosine receptor prodrugs |
| GB8716305D0 (en) * | 1987-07-10 | 1987-08-19 | Raychem Ltd | Electrical wire |
| JPH01153629A (ja) * | 1987-12-11 | 1989-06-15 | Nippon Oil & Fats Co Ltd | 制癌剤 |
| JPH01203331A (ja) * | 1988-02-05 | 1989-08-16 | Rikagaku Kenkyusho | 制癌剤 |
| US4933324A (en) * | 1988-02-26 | 1990-06-12 | Shashoua Victor E | Fatty acid-neuroactive drug conjugate as a prodrug |
| US4939174A (en) * | 1988-02-26 | 1990-07-03 | Shashoua Victor E | Appetite suppression with dopamine-fatty acid conjugates |
| JPH01287022A (ja) * | 1988-05-12 | 1989-11-17 | Nippon Oil & Fats Co Ltd | 抗癌剤耐性克服剤 |
| GB8813766D0 (en) * | 1988-06-10 | 1988-07-13 | Efamol Holdings | Essential fatty acid compositions |
| CH676909A5 (de) * | 1988-12-23 | 1991-03-28 | Nestle Sa | |
| HU207287B (en) * | 1989-01-17 | 1993-03-29 | Biosignal Kutato Fejlesztoe Kf | Polyene fatty acid derivatives of tyrozine-quinaze inhibiting activity and pharmaceutical composition containing them as active component |
| US5411947A (en) * | 1989-06-28 | 1995-05-02 | Vestar, Inc. | Method of converting a drug to an orally available form by covalently bonding a lipid to the drug |
| US5194654A (en) * | 1989-11-22 | 1993-03-16 | Vical, Inc. | Lipid derivatives of phosphonoacids for liposomal incorporation and method of use |
| GB8918294D0 (en) * | 1989-08-10 | 1989-09-20 | Efamol Holdings | Pharmaceutical compositions |
| GB9001121D0 (en) * | 1990-01-18 | 1990-03-21 | Efamol Holdings | Efa compositions and therapy |
| MX9102128A (es) * | 1990-11-23 | 1992-07-08 | Rhone Poulenc Rorer Sa | Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene |
| IT1254515B (it) * | 1992-03-06 | 1995-09-25 | Indena Spa | Tassani di interesse oncologico, loro metodo di preparazione ed uso |
| IT1254517B (it) * | 1992-03-06 | 1995-09-25 | Indena Spa | 14-beta idrossi-10-deacetil-baccatina iii, suoi derivati, loro prepazione ed impiego terapeutico |
| GB9213077D0 (en) * | 1992-06-19 | 1992-08-05 | Erba Carlo Spa | Polymerbound taxol derivatives |
| JPH0616548A (ja) * | 1992-06-30 | 1994-01-25 | Sagami Chem Res Center | 組織異常増殖抑制剤 |
| US5453521A (en) * | 1992-10-05 | 1995-09-26 | Rhone-Poulenc Rorer S.A. | Process for obtaining 10-deacetylbaccatin III |
| FR2696461B1 (fr) * | 1992-10-05 | 1994-11-10 | Rhone Poulenc Rorer Sa | Nouveaux dérivés d'analogues du taxol, leur préparation et les compositions qui les contiennent. |
| US5356928A (en) * | 1992-11-06 | 1994-10-18 | Hauser Chemical Research, Inc. | Cytotoxic agents |
| FR2697841B1 (fr) * | 1992-11-12 | 1995-01-13 | Rhone Poulenc Rorer Sa | Nouveaux dérivés du taxane, leur préparation et les compositions pharmaceutiques qui les contiennent. |
| GB9224809D0 (en) * | 1992-11-26 | 1993-01-13 | Scotia Holdings Plc | Schizophrenia |
| CA2150470A1 (en) * | 1992-11-30 | 1994-06-09 | S.P.I. Synthetic Peptides Incorporated | Polyunsaturated fatty acyl-peptide composition |
| FR2698871B1 (fr) * | 1992-12-09 | 1995-02-24 | Rhone Poulenc Rorer Sa | Nouveau taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent. |
| US5643909A (en) * | 1993-04-19 | 1997-07-01 | Syntex (U.S.A.) Inc. | 10,11-Methanodibenzosuberane derivatives |
| US5336684A (en) * | 1993-04-26 | 1994-08-09 | Hauser Chemical Research, Inc. | Oxidation products of cephalomannine |
| FR2707293A1 (fr) * | 1993-07-08 | 1995-01-13 | Rhone Poulenc Rorer Sa | Nouveaux taxoides, leur préparation et les compositions pharmaceutiques qui les contiennent. |
| FR2712288B1 (fr) * | 1993-11-08 | 1996-01-05 | Rhone Poulenc Rorer Sa | Nouveaux taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent. |
| FR2712289B1 (fr) * | 1993-11-08 | 1996-01-05 | Rhone Poulenc Rorer Sa | Nouveaux dérivés de taxicine, leur préparation et les compositions pharmaceutiques qui les contiennent. |
| US5447936A (en) * | 1993-12-22 | 1995-09-05 | Bionumerik Pharmaceuticals, Inc. | Lactone stable formulation of 10-hydroxy 7-ethyl camptothecin and methods for uses thereof |
| US5468754A (en) * | 1994-04-19 | 1995-11-21 | Bionumerik Pharmaceuticals, Inc. | 11,7 substituted camptothecin derivatives and formulations of 11,7 substituted camptothecin derivatives and methods for uses thereof |
| FR2721023B1 (fr) * | 1994-06-09 | 1996-07-12 | Rhone Poulenc Rorer Sa | Nouveaux Taxoïdes, leur préparation et les compositions pharmaceutiques qui les contiennent. |
| FR2721928A1 (fr) * | 1994-07-04 | 1996-01-05 | Rhone Poulenc Rorer Sa | Nouveaux taxoides, leur preparation et les compositions pharmaceutiques qui les contiennent |
| JPH0827010A (ja) * | 1994-07-19 | 1996-01-30 | Nichinichi Seiyaku Kk | 制癌免疫療法剤 |
| JPH08163991A (ja) * | 1994-12-15 | 1996-06-25 | Mitsui Petrochem Ind Ltd | タキサン型ジテルペンの製造方法 |
| US5580899A (en) * | 1995-01-09 | 1996-12-03 | The Liposome Company, Inc. | Hydrophobic taxane derivatives |
| GB9508823D0 (en) * | 1995-05-01 | 1995-06-21 | Scotia Holdings Plc | Drug Derivatives |
| JPH0925231A (ja) * | 1995-07-13 | 1997-01-28 | Sagami Chem Res Center | 癌転移抑制剤 |
| US5795909A (en) * | 1996-05-22 | 1998-08-18 | Neuromedica, Inc. | DHA-pharmaceutical agent conjugates of taxanes |
-
1997
- 1997-05-22 AT AT97926722T patent/ATE196844T1/de not_active IP Right Cessation
- 1997-05-22 DK DK97926722T patent/DK0914116T3/da active
- 1997-05-22 WO PCT/US1997/008866 patent/WO1997044026A1/en not_active Ceased
- 1997-05-22 ES ES97926722T patent/ES2151277T3/es not_active Expired - Lifetime
- 1997-05-22 CA CA002255615A patent/CA2255615C/en not_active Expired - Fee Related
- 1997-05-22 DE DE69703294T patent/DE69703294T2/de not_active Expired - Lifetime
- 1997-05-22 EP EP97926722A patent/EP0914116B1/de not_active Expired - Lifetime
- 1997-05-22 JP JP54281097A patent/JP4172726B2/ja not_active Expired - Fee Related
- 1997-06-03 US US08/868,476 patent/US6080877A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| ATE196844T1 (de) | 2000-10-15 |
| CA2255615A1 (en) | 1997-11-27 |
| JP2000511188A (ja) | 2000-08-29 |
| WO1997044026A1 (en) | 1997-11-27 |
| DE69703294T2 (de) | 2001-05-17 |
| US6080877A (en) | 2000-06-27 |
| AU722912B2 (en) | 2000-08-17 |
| EP0914116A1 (de) | 1999-05-12 |
| DK0914116T3 (da) | 2000-11-20 |
| EP0914116B1 (de) | 2000-10-11 |
| ES2151277T3 (es) | 2000-12-16 |
| JP4172726B2 (ja) | 2008-10-29 |
| AU3142497A (en) | 1997-12-09 |
| CA2255615C (en) | 2006-08-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE69703294D1 (de) | Zusammensetzungen die konjugate von cis-docosahexaenoic-säure und taxotere enthalten | |
| ATE208382T1 (de) | Konjugate von cis-docosahexaensäure und paclitaxel | |
| TR200101481T2 (tr) | Doğal bitkisel zaruri yağlar kullanan kanser tedavi kompozisyonu ve yöntemi. | |
| TR200000927T2 (tr) | Prostaglandin agonistleri ve kemik bozukluklarının tedavisi | |
| TR199903331T2 (xx) | Farnesil protein transferas engelleyicileri. | |
| ATE556706T1 (de) | Fettalkohol-arzneimittel-konjugate | |
| DK1039912T3 (da) | Angiostatiske midler og præparater til behandling af GLC1A-glaukom | |
| DE69830072D1 (de) | Radioaktive zusammensetzungen zur behandlung von prostatatumoren | |
| DE69838177D1 (de) | Androgensyntheseinhibitoren | |
| ATE314844T1 (de) | Verfahren und zusammensetzungen zur verabreichung von taxanen | |
| DE69830336D1 (de) | Ein kovalentes konjugat von clozapine und einer fettsäure und dessen verwendung zur behandlung von schizophrenie | |
| DK0705100T3 (da) | Terapeutiske substituerede guanidiner | |
| ATE239509T1 (de) | Konjugate zur behandlung von prostatakrebs | |
| BR9912327A (pt) | Inibidores da uroquinase | |
| PT1109571E (pt) | Metodos de tratamento da hipertensao e composicoes para utilizacao nesses metodos | |
| BG100930A (bg) | Фармацевтични състави и лекарствени средства за профилактика и лечение на ендотелиални нарушения | |
| DE69918413D1 (de) | Auswahlverfahren von hla-g exprimierenden tumoren, die durch antikrebsmittel behandelbar sind, und deren verwendungen | |
| TR200101756T2 (tr) | Protein kinaz inhibitörleri olarak 4,5-pirazinoksindoller. | |
| ATE381327T1 (de) | Cethylmyristat und cetylpalmitat zurbehandlung von ekzemen und/oder psoriasis | |
| ATE196083T1 (de) | Verwendung von ferrioxamin-b zur behandlung septischen schocks | |
| ES2088128T3 (es) | Aminosulfonilureas inhibidoras de acat. | |
| BR9915955A (pt) | Composição cosmética para cuidado com a pele, processo cosmético para tratar uma pele envelhecida e uso de 4- cromanona | |
| WO2000053231A3 (en) | Fatty acid-anticancer conjugates and uses thereof | |
| NO994631D0 (no) | Fremgangsmaater og sammensetninger for behandling av eggstokkreft | |
| BG100248A (bg) | Инхибитори на скваленсинтетаза |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8327 | Change in the person/name/address of the patent owner |
Owner name: LUITPOLD PHARMACEUTICALS, INC., SHIRLEY, N.Y., US |