DE69616651D1 - Antiidiotypische Antikörper die eine Immunantwort gegen den Rezeptor für epidermalen Wachstumsfaktor induzieren - Google Patents

Antiidiotypische Antikörper die eine Immunantwort gegen den Rezeptor für epidermalen Wachstumsfaktor induzieren

Info

Publication number: DE69616651D1
Authority: DE; Germany
Prior art keywords: induce; growth factor; immune response; epidermal growth; response against
Prior art date: 1995-05-26
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE69616651T

Other languages

English (en)

Inventor

Ana Carceller

Elisabet Rosell

Alicia Gomez

Jaume Adan

Jaume Piulats

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Merck Patent GmbH

Original Assignee

Merck Patent GmbH

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-05-26

Filing date

1996-05-14

Publication date

2001-12-13

1996-05-14 Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH

2001-12-13 Application granted granted Critical

2001-12-13 Publication of DE69616651D1 publication Critical patent/DE69616651D1/de

2016-05-15 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

230000028993 immune response Effects 0.000 title abstract 2
102000009024 Epidermal Growth Factor Human genes 0.000 title 1
101800003838 Epidermal growth factor Proteins 0.000 title 1
229940116977 epidermal growth factor Drugs 0.000 title 1
VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 title 1
102000001301 EGF receptor Human genes 0.000 abstract 2
108060006698 EGF receptor Proteins 0.000 abstract 2
239000000427 antigen Substances 0.000 abstract 2
102000036639 antigens Human genes 0.000 abstract 2
108091007433 antigens Proteins 0.000 abstract 2
206010028980 Neoplasm Diseases 0.000 abstract 1
230000003278 mimic effect Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
- C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
- C07K16/4258—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Immunology (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Biochemistry (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DE69616651T 1995-05-26 1996-05-14 Antiidiotypische Antikörper die eine Immunantwort gegen den Rezeptor für epidermalen Wachstumsfaktor induzieren Expired - Lifetime DE69616651D1 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP95107967		1995-05-26

Publications (1)

Publication Number	Publication Date
DE69616651D1 true DE69616651D1 (de)	2001-12-13

Family

ID=8219291

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69616651T Expired - Lifetime DE69616651D1 (de)	1995-05-26	1996-05-14	Antiidiotypische Antikörper die eine Immunantwort gegen den Rezeptor für epidermalen Wachstumsfaktor induzieren

Country Status (15)

Country	Link
US (1)	US5969107A (de)
JP (1)	JPH08325299A (de)
KR (1)	KR960040375A (de)
CN (1)	CN1142505A (de)
AT (1)	ATE208403T1 (de)
AU (1)	AU710159B2 (de)
CA (1)	CA2177328A1 (de)
CZ (1)	CZ289357B6 (de)
DE (1)	DE69616651D1 (de)
HU (1)	HUP9601392A3 (de)
MX (1)	MX9601930A (de)
NO (1)	NO962125L (de)
PL (1)	PL314414A1 (de)
SK (1)	SK67496A3 (de)
ZA (1)	ZA964207B (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6924359B1 (en)	1999-07-01	2005-08-02	Yale University	Neovascular-targeted immunoconjugates
EP1385959A2 (de) *	2001-02-07	2004-02-04	Wilex AG	Verfahren zur herstellung von rekombinanten antikörpern gegen tumoren
AU2003241398A1 (en) *	2002-05-06	2003-11-17	Washington University	Methods of treatment of glaucoma and other conditions mediated by nos-2 expression via inhibition of the egfr pathway
EP3679951A1 (de)	2003-06-27	2020-07-15	Amgen Fremont Inc.	Auf die deletionsmutanten des epidermalen wachstumsfaktorrezeptors gerichtete antikörper und verwendungen davon
RU2009128237A (ru) *	2006-12-22	2011-01-27	Новеликс Терапьютикс Гмбх (At)	Лечение диабета, по меньшей мере, одним антителом, специфичным к рецептору эпидермального фактора роста, или его производным
US20130059793A1 (en) *	2010-02-08	2013-03-07	Board Of Regents, The University Of Texas System	Egf receptor mimicking peptides
WO2012097313A2 (en)	2011-01-14	2012-07-19	The Regents Of The University Of California	Therapeutic antibodies against ror-1 protein and methods for use of same
CN109306010B (zh) *	2017-07-26	2022-07-19	石家庄以岭药业股份有限公司	表皮生长因子受体抗体及其用途

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0141783B2 (de) *	1983-11-07	1993-06-16	The Wistar Institute	Durch antiidiotype Antikörper induzierte immune Antwort zu Tumoren und Viren
US4699880A (en) *	1984-09-25	1987-10-13	Immunomedics, Inc.	Method of producing monoclonal anti-idiotype antibody
US4918164A (en) *	1987-09-10	1990-04-17	Oncogen	Tumor immunotherapy using anti-idiotypic antibodies
US5459061A (en) *	1990-01-26	1995-10-17	W. Alton Jones Cell Science Center, Inc.	Hybridomas producing monoclonal antibodies which specifically bind to continuous epitope on the human EGF receptor and compete with EGF for binding to the EGF receptor
ATE247168T1 (de) *	1991-03-06	2003-08-15	Merck Patent Gmbh	Humanisierte monoklonale antikörper
US5344760A (en) *	1991-06-03	1994-09-06	Ciba Corning Diagnostics Corp.	Method of cancer detection
PT586002E (pt) *	1992-08-18	2000-07-31	Centro Inmunologia Molecular	Anticorpos monoclonais que reconhecem o receptor do factor de crescimento epidermico, celulas e metodos para a sua producao e composicoes que os incluem

1996
- 1996-05-14 DE DE69616651T patent/DE69616651D1/de not_active Expired - Lifetime
- 1996-05-14 AT AT96107651T patent/ATE208403T1/de not_active IP Right Cessation
- 1996-05-21 AU AU52422/96A patent/AU710159B2/en not_active Ceased
- 1996-05-22 MX MX9601930A patent/MX9601930A/es unknown
- 1996-05-23 CN CN96108127A patent/CN1142505A/zh active Pending
- 1996-05-23 HU HU9601392A patent/HUP9601392A3/hu unknown
- 1996-05-23 SK SK674-96A patent/SK67496A3/sk unknown
- 1996-05-24 PL PL96314414A patent/PL314414A1/xx unknown
- 1996-05-24 JP JP8151798A patent/JPH08325299A/ja active Pending
- 1996-05-24 ZA ZA964207A patent/ZA964207B/xx unknown
- 1996-05-24 NO NO962125A patent/NO962125L/no not_active Application Discontinuation
- 1996-05-24 CA CA002177328A patent/CA2177328A1/en not_active Abandoned
- 1996-05-24 US US08/653,402 patent/US5969107A/en not_active Expired - Fee Related
- 1996-05-25 KR KR1019960017928A patent/KR960040375A/ko not_active Ceased
- 1996-05-27 CZ CZ19961525A patent/CZ289357B6/cs unknown

Also Published As

Publication number	Publication date
AU5242296A (en)	1996-12-05
AU710159B2 (en)	1999-09-16
JPH08325299A (ja)	1996-12-10
US5969107A (en)	1999-10-19
KR960040375A (ko)	1996-12-17
CZ289357B6 (cs)	2002-01-16
NO962125L (no)	1996-11-27
HUP9601392A2 (en)	1997-03-28
NO962125D0 (no)	1996-05-24
MX9601930A (es)	1997-01-31
CZ152596A3 (en)	1996-12-11
HU9601392D0 (en)	1996-07-29
PL314414A1 (en)	1996-12-09
ZA964207B (en)	1996-12-04
HUP9601392A3 (en)	2000-08-28
ATE208403T1 (de)	2001-11-15
CN1142505A (zh)	1997-02-12
CA2177328A1 (en)	1996-11-27
SK67496A3 (en)	1996-12-04

Publication	Publication Date	Title
DE69429095D1 (de)	2001-12-20	Humanisierte antikoerper
BR0315123A (pt)	2005-08-16	Composições farmacêuticas direcionadas a receptores erb-b1
MX9201016A (es)	1993-08-01	Anticuerpos monoclonales humanizados y quimericos
ATE377027T1 (de)	2007-11-15	Tetravalente antikörperkonstrukte
PT699237E (pt)	2003-07-31	Fvs de cadeia anti-egfr e anticorpos anti-egfr
ATE207080T1 (de)	2001-11-15	Multivalente antigen-bindende proteine
ATE233814T1 (de)	2003-03-15	Humaner neutralisierender monoklonaler antikörper gegen den die immunschwäche beim menschen hervorringenden virus
DE69616651D1 (de)	2001-12-13	Antiidiotypische Antikörper die eine Immunantwort gegen den Rezeptor für epidermalen Wachstumsfaktor induzieren
ATE173504T1 (de)	1998-12-15	Granulozytenbindende antikörperkonstrukte, ihre herstellung und verwendung
DE60216906T8 (de)	2008-01-17	Anti-pilyrosporum ovale igy und dessen verwendung
DE59207362D1 (de)	1996-11-21	Monoklonale Antikörper gegen den Plasmin-Antiplasmin Komplex, Verfahren zu ihrer Herstellung sowie ihre Verwendung
DE69024758D1 (de)	1996-02-22	Neuartige antiidiotypische monoklonale Antikörper
BR9702101A (pt)	1999-07-20	Hibridoma e anticorpo monoclonal
ATE283282T1 (de)	2004-12-15	Epitope des shigella-artigen toxins und ihre verwendung als impfstoff und in der diagnose
DE69941961D1 (de)	2010-03-11	Monoklonale Antikörper gegen humane Thymidylat-Synthase und Hybridomen zu derer Herstellung
ITTO911003A0 (it)	1991-12-20	Metodo rapido per l'identificazione dello s.aureus, kit diagnostico per l'esecuzione di tale metodo, anticorpi monoclonali contro la glucosaminidasi dello s. aureus e ibridoma per la produzione di tali anticorpi.
RU96109830A (ru)	1998-08-10	Антиидиотипические антитела, которые индуцируют иммунный ответ против рецептора эпидермального фактора роста

Legal Events

Date	Code	Title	Description
2002-07-04	8332	No legal effect for de