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DE69615354D1 - Heterocyclische verbindungen für diabetebehandlung - Google Patents

Heterocyclische verbindungen für diabetebehandlung

Info

Publication number
DE69615354D1
DE69615354D1 DE69615354T DE69615354T DE69615354D1 DE 69615354 D1 DE69615354 D1 DE 69615354D1 DE 69615354 T DE69615354 T DE 69615354T DE 69615354 T DE69615354 T DE 69615354T DE 69615354 D1 DE69615354 D1 DE 69615354D1
Authority
DE
Germany
Prior art keywords
treatment
diabete
heterocyclic compounds
hyperalgesic
painful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69615354T
Other languages
English (en)
Inventor
Peter Madsen
Erik Andersen
Zaragossa Doerwald
Krogh Jorgensen
Sune Andersen
Rolf Hohlweg
Bang Olsen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Application granted granted Critical
Publication of DE69615354D1 publication Critical patent/DE69615354D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D223/00Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C07D223/28Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a single bond between positions 10 and 11
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/52Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C229/54Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C229/56Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in ortho-position
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00Systems containing at least three condensed rings
    • C07C2603/02Ortho- or ortho- and peri-condensed systems
    • C07C2603/04Ortho- or ortho- and peri-condensed systems containing three rings
    • C07C2603/30Ortho- or ortho- and peri-condensed systems containing three rings containing seven-membered rings
    • C07C2603/32Dibenzocycloheptenes; Hydrogenated dibenzocycloheptenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pain & Pain Management (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE69615354T 1995-04-07 1996-04-01 Heterocyclische verbindungen für diabetebehandlung Expired - Lifetime DE69615354D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DK40795 1995-04-07
DK100295 1995-09-11
PCT/DK1996/000141 WO1996031481A1 (en) 1995-04-07 1996-04-01 Novel heterocyclic compounds

Publications (1)

Publication Number Publication Date
DE69615354D1 true DE69615354D1 (de) 2001-10-25

Family

ID=26063934

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69615354T Expired - Lifetime DE69615354D1 (de) 1995-04-07 1996-04-01 Heterocyclische verbindungen für diabetebehandlung

Country Status (9)

Country Link
US (1) US5962449A (de)
EP (1) EP0820443B1 (de)
JP (1) JPH11503129A (de)
AT (1) ATE205833T1 (de)
AU (1) AU5270696A (de)
CA (1) CA2217198A1 (de)
DE (1) DE69615354D1 (de)
IL (1) IL117812A0 (de)
WO (1) WO1996031481A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005020913A2 (en) * 2003-08-25 2005-03-10 Combinatorx, Incorporated Formulations, conjugates, and combinations of drugs for the treatment of neoplasms
CN103864765B (zh) * 2014-03-05 2016-02-10 天津药物研究院 含有五元杂环的苯并氮杂卓类衍生物、其制备方法和用途

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2860137A (en) * 1958-11-11 Xcoxz
DE1084266B (de) * 1958-06-25 1960-06-30 Cassella Farbwerke Mainkur Ag Verfahren zur Herstellung von in 10-Stellung basisch substituierten Phenthiazinderivaten
CH385833A (de) * 1961-03-14 1964-12-31 Geigy Ag J R Verfahren zur Herstellung von neuen Aminen
NL138423C (de) * 1966-07-14
US4383999A (en) 1981-05-26 1983-05-17 Smithkline Beckman Corporation Inhibition of GABA uptake by N-substituted azaheterocyclic carboxylic acids and their esters
US4514414A (en) 1982-10-25 1985-04-30 Smithkline Beckman Corporation N-Substituted pyrrolidineacetic acids and their esters
DK704488D0 (da) 1988-12-19 1988-12-19 Novo Industri As Nye n-substituerede azaheterocykliske carboxylsyrer
DK288385D0 (da) 1985-06-26 1985-06-26 Novo Industri As Aminosyrederivater
FI864246A7 (fi) 1985-11-08 1987-05-09 Warner Lambert Co N-substituerade 3-piperidin- eller 3-pyridinkarboxylsyror samt deras derivat.
DK165692C (da) 1986-01-07 1993-11-08 Novo Nordisk As Phenylbutenderivater, fremgangsmaade til fremstilling heraf, farmaceutisk praeparat indeholdende disse, samt anvendelse af disse til fremstilling af et medikament nyttigt til inhibering af gaba-optagelse i mennesker
DK270488D0 (da) 1988-05-18 1988-05-18 Novo Industri As Hidtil ukendte o-substituerede ketoximer
DK588189D0 (da) 1989-11-22 1989-11-22 Novo Nordisk As Nye heterocykliske carboxylsyrer
GB9001694D0 (en) * 1990-01-25 1990-03-28 Therapeutic Antibodies Inc Immunogenic compositions
JPH0578292A (ja) * 1991-04-05 1993-03-30 Hokuriku Seiyaku Co Ltd 三環系化合物
TW198008B (de) * 1991-04-08 1993-01-11 Green Cross Corp
DK93791D0 (da) 1991-05-17 1991-05-17 Novo Nordisk As Nye heterocykliske carboxylsyrer
MY113463A (en) 1994-01-04 2002-03-30 Novo Nordisk As Novel heterocyclic compounds

Also Published As

Publication number Publication date
AU5270696A (en) 1996-10-23
EP0820443A1 (de) 1998-01-28
US5962449A (en) 1999-10-05
CA2217198A1 (en) 1996-10-10
EP0820443B1 (de) 2001-09-19
ATE205833T1 (de) 2001-10-15
WO1996031481A1 (en) 1996-10-10
JPH11503129A (ja) 1999-03-23
IL117812A0 (en) 1996-08-04

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Legal Events

Date Code Title Description
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