DE69615354D1 - Heterocyclische verbindungen für diabetebehandlung - Google Patents
Heterocyclische verbindungen für diabetebehandlungInfo
- Publication number
- DE69615354D1 DE69615354D1 DE69615354T DE69615354T DE69615354D1 DE 69615354 D1 DE69615354 D1 DE 69615354D1 DE 69615354 T DE69615354 T DE 69615354T DE 69615354 T DE69615354 T DE 69615354T DE 69615354 D1 DE69615354 D1 DE 69615354D1
- Authority
- DE
- Germany
- Prior art keywords
- treatment
- diabete
- heterocyclic compounds
- hyperalgesic
- painful
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 206010012601 diabetes mellitus Diseases 0.000 title 1
- 150000002391 heterocyclic compounds Chemical class 0.000 title 1
- -1 N-substituted amino Chemical class 0.000 abstract 1
- 208000007920 Neurogenic Inflammation Diseases 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 230000000917 hyperalgesic effect Effects 0.000 abstract 1
- 230000004968 inflammatory condition Effects 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 208000004296 neuralgia Diseases 0.000 abstract 1
- 230000001991 pathophysiological effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000547 substituted alkyl group Chemical group 0.000 abstract 1
- 210000001170 unmyelinated nerve fiber Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
- C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
- C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
- C07D223/28—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom having a single bond between positions 10 and 11
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
- C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C229/56—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in ortho-position
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/30—Ortho- or ortho- and peri-condensed systems containing three rings containing seven-membered rings
- C07C2603/32—Dibenzocycloheptenes; Hydrogenated dibenzocycloheptenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pain & Pain Management (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK40795 | 1995-04-07 | ||
| DK100295 | 1995-09-11 | ||
| PCT/DK1996/000141 WO1996031481A1 (en) | 1995-04-07 | 1996-04-01 | Novel heterocyclic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE69615354D1 true DE69615354D1 (de) | 2001-10-25 |
Family
ID=26063934
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69615354T Expired - Lifetime DE69615354D1 (de) | 1995-04-07 | 1996-04-01 | Heterocyclische verbindungen für diabetebehandlung |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5962449A (de) |
| EP (1) | EP0820443B1 (de) |
| JP (1) | JPH11503129A (de) |
| AT (1) | ATE205833T1 (de) |
| AU (1) | AU5270696A (de) |
| CA (1) | CA2217198A1 (de) |
| DE (1) | DE69615354D1 (de) |
| IL (1) | IL117812A0 (de) |
| WO (1) | WO1996031481A1 (de) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005020913A2 (en) * | 2003-08-25 | 2005-03-10 | Combinatorx, Incorporated | Formulations, conjugates, and combinations of drugs for the treatment of neoplasms |
| CN103864765B (zh) * | 2014-03-05 | 2016-02-10 | 天津药物研究院 | 含有五元杂环的苯并氮杂卓类衍生物、其制备方法和用途 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2860137A (en) * | 1958-11-11 | Xcoxz | ||
| DE1084266B (de) * | 1958-06-25 | 1960-06-30 | Cassella Farbwerke Mainkur Ag | Verfahren zur Herstellung von in 10-Stellung basisch substituierten Phenthiazinderivaten |
| CH385833A (de) * | 1961-03-14 | 1964-12-31 | Geigy Ag J R | Verfahren zur Herstellung von neuen Aminen |
| NL138423C (de) * | 1966-07-14 | |||
| US4383999A (en) | 1981-05-26 | 1983-05-17 | Smithkline Beckman Corporation | Inhibition of GABA uptake by N-substituted azaheterocyclic carboxylic acids and their esters |
| US4514414A (en) | 1982-10-25 | 1985-04-30 | Smithkline Beckman Corporation | N-Substituted pyrrolidineacetic acids and their esters |
| DK704488D0 (da) | 1988-12-19 | 1988-12-19 | Novo Industri As | Nye n-substituerede azaheterocykliske carboxylsyrer |
| DK288385D0 (da) | 1985-06-26 | 1985-06-26 | Novo Industri As | Aminosyrederivater |
| FI864246A7 (fi) | 1985-11-08 | 1987-05-09 | Warner Lambert Co | N-substituerade 3-piperidin- eller 3-pyridinkarboxylsyror samt deras derivat. |
| DK165692C (da) | 1986-01-07 | 1993-11-08 | Novo Nordisk As | Phenylbutenderivater, fremgangsmaade til fremstilling heraf, farmaceutisk praeparat indeholdende disse, samt anvendelse af disse til fremstilling af et medikament nyttigt til inhibering af gaba-optagelse i mennesker |
| DK270488D0 (da) | 1988-05-18 | 1988-05-18 | Novo Industri As | Hidtil ukendte o-substituerede ketoximer |
| DK588189D0 (da) | 1989-11-22 | 1989-11-22 | Novo Nordisk As | Nye heterocykliske carboxylsyrer |
| GB9001694D0 (en) * | 1990-01-25 | 1990-03-28 | Therapeutic Antibodies Inc | Immunogenic compositions |
| JPH0578292A (ja) * | 1991-04-05 | 1993-03-30 | Hokuriku Seiyaku Co Ltd | 三環系化合物 |
| TW198008B (de) * | 1991-04-08 | 1993-01-11 | Green Cross Corp | |
| DK93791D0 (da) | 1991-05-17 | 1991-05-17 | Novo Nordisk As | Nye heterocykliske carboxylsyrer |
| MY113463A (en) | 1994-01-04 | 2002-03-30 | Novo Nordisk As | Novel heterocyclic compounds |
-
1996
- 1996-03-28 US US08/623,447 patent/US5962449A/en not_active Expired - Fee Related
- 1996-04-01 JP JP8529870A patent/JPH11503129A/ja active Pending
- 1996-04-01 AT AT96909078T patent/ATE205833T1/de not_active IP Right Cessation
- 1996-04-01 DE DE69615354T patent/DE69615354D1/de not_active Expired - Lifetime
- 1996-04-01 CA CA002217198A patent/CA2217198A1/en not_active Abandoned
- 1996-04-01 AU AU52706/96A patent/AU5270696A/en not_active Abandoned
- 1996-04-01 EP EP96909078A patent/EP0820443B1/de not_active Expired - Lifetime
- 1996-04-01 WO PCT/DK1996/000141 patent/WO1996031481A1/en not_active Ceased
- 1996-04-03 IL IL11781296A patent/IL117812A0/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU5270696A (en) | 1996-10-23 |
| EP0820443A1 (de) | 1998-01-28 |
| US5962449A (en) | 1999-10-05 |
| CA2217198A1 (en) | 1996-10-10 |
| EP0820443B1 (de) | 2001-09-19 |
| ATE205833T1 (de) | 2001-10-15 |
| WO1996031481A1 (en) | 1996-10-10 |
| JPH11503129A (ja) | 1999-03-23 |
| IL117812A0 (en) | 1996-08-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8332 | No legal effect for de |