DE69520022D1 - Steroid-Verbindungen mit einer 17-Spiromethylen-Lakton- oder Lactol-Gruppe - Google Patents

Steroid-Verbindungen mit einer 17-Spiromethylen-Lakton- oder Lactol-Gruppe

Info

Publication number: DE69520022D1
Authority: DE; Germany
Prior art keywords: halogen; alkyl; optionally substituted; group; bond
Prior art date: 1994-10-27
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Fee Related

Application number

DE69520022T

Other languages

English (en)

Other versions

DE69520022T2 (de

Inventor

Johannes Antonius Mar Hamersma

Der Louw Jaap Van

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Akzo Nobel NV

Original Assignee

Akzo Nobel NV

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-10-27

Filing date

1995-10-24

Publication date

2001-03-08

1995-10-24 Application filed by Akzo Nobel NV filed Critical Akzo Nobel NV

2001-03-08 Application granted granted Critical

2001-03-08 Publication of DE69520022D1 publication Critical patent/DE69520022D1/de

2001-06-13 Publication of DE69520022T2 publication Critical patent/DE69520022T2/de

2015-10-25 Anticipated expiration legal-status Critical

Status Expired - Fee Related legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J19/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 by a lactone ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/006—Ketals at position 3
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0081—Substituted in position 17 alfa and 17 beta
- C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
- C07J1/0092—Alkenyl derivatives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/001—Lactones
- C07J21/003—Lactones at position 17
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
- C07J41/0016—Oximes
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Endocrinology (AREA)
Reproductive Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Gynecology & Obstetrics (AREA)
Engineering & Computer Science (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

DE69520022T 1994-10-27 1995-10-24 Steroid-Verbindungen mit einer 17-Spiromethylen-Lakton- oder Lactol-Gruppe Expired - Fee Related DE69520022T2 (de)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP94203117		1994-10-27

Publications (2)

Publication Number	Publication Date
DE69520022D1 true DE69520022D1 (de)	2001-03-08
DE69520022T2 DE69520022T2 (de)	2001-06-13

Family

ID=8217314

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE69520022T Expired - Fee Related DE69520022T2 (de)	1994-10-27	1995-10-24	Steroid-Verbindungen mit einer 17-Spiromethylen-Lakton- oder Lactol-Gruppe

Country Status (26)

Country	Link
US (1)	US5741786A (de)
EP (1)	EP0709394B1 (de)
JP (1)	JPH08225590A (de)
KR (1)	KR100402636B1 (de)
CN (1)	CN1052237C (de)
AT (1)	ATE199015T1 (de)
AU (1)	AU689642B2 (de)
BR (1)	BR9504576A (de)
CA (1)	CA2161490A1 (de)
CZ (1)	CZ287346B6 (de)
DE (1)	DE69520022T2 (de)
DK (1)	DK0709394T3 (de)
ES (1)	ES2157290T3 (de)
FI (1)	FI113542B (de)
GR (1)	GR3035713T3 (de)
HU (1)	HU221192B1 (de)
IL (1)	IL115659A (de)
NO (1)	NO305252B1 (de)
NZ (1)	NZ280325A (de)
PL (1)	PL187083B1 (de)
PT (1)	PT709394E (de)
RU (1)	RU2168516C2 (de)
SG (1)	SG33569A1 (de)
TR (1)	TR199501327A2 (de)
TW (1)	TW339337B (de)
ZA (1)	ZA958963B (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6407082B1 (en) *	1996-09-13	2002-06-18	New Life Pharmaceuticals Inc.	Prevention of ovarian cancer by administration of a vitamin D compound
US6511970B1 (en)	1996-09-13	2003-01-28	New Life Pharmaceuticals Inc.	Prevention of ovarian cancer by administration of products that induce transforming growth factor-beta and/or apoptosis in the ovarian epithelium
US6028064A (en)	1996-09-13	2000-02-22	New Life Pharmaceuticals Inc.	Prevention of ovarian cancer by administration of progestin products
US6034074A (en)	1996-09-13	2000-03-07	New Life Pharmaceuticals Inc.	Prevention of ovarian cancer by administration of a Vitamin D compound
US6765002B2 (en)	2000-03-21	2004-07-20	Gustavo Rodriguez	Prevention of ovarian cancer by administration of products that induce transforming growth factor-β and/or apoptosis in the ovarian epithelium
DE19651000A1 (de) *	1996-12-01	1998-06-04	Schering Ag	Oxyiminopregnancarbolactone
EP1079859B1 (de)	1998-05-22	2010-07-14	The Board Of Trustees Of The Leland Stanford Junior University	Bifunktionelle moleküle sowie darauf basierende therapien.
US6043235A (en) *	1999-07-21	2000-03-28	Research Triangle Institute	11β-aryl-17, 17-spirothiolane-substituted steroids
US20010044431A1 (en) *	2000-03-21	2001-11-22	Rodriguez Gustavo C.	Prevention of ovarian cancer by administration of products that induce biologic effects in the ovarian epithelium
JP4202250B2 (ja)	2001-07-25	2008-12-24	バイオマリンファーマシューティカルインコーポレイテッド	血液脳関門輸送を調節するための組成物および方法
CA2789262C (en)	2005-04-28	2016-10-04	Proteus Digital Health, Inc.	Pharma-informatics system
WO2007035716A2 (en)	2005-09-16	2007-03-29	Raptor Pharmaceutical Inc.	Compositions comprising receptor-associated protein (rap) variants specific for cr-containing proteins and uses thereof
ES2919563T3 (es)	2009-02-20	2022-07-27	Enhanx Biopharm Inc	Sistema de administración de medicamentos a base de glutatión
CN110075069A (zh)	2009-05-06	2019-08-02	实验室护肤股份有限公司	包含活性剂-磷酸钙颗粒复合物的皮肤递送组合物及其应用
CA3174401A1 (en) *	2020-04-03	2021-10-07	Daan De Kubber	Method of draining water

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2875199A (en) *	1958-04-22	1959-02-24	Searle & Co	Lactones of 17-carboxyalkylated estra-1, 3, 5(10)-triene-3, 17-diols and 3-ethers
US3547912A (en) *	1968-07-29	1970-12-15	American Home Prod	Derivatives of 2h-pyran-3(6h)-ones and preparation thereof
US3764596A (en) *	1971-06-22	1973-10-09	Sandoz Ag	17-dihydrofuranyl-substituted steroids
DE3306554A1 (de) *	1983-02-22	1984-08-23	Schering AG, 1000 Berlin und 4709 Bergkamen	Verfahren zur herstellung von 3-((delta)(pfeil hoch)4(pfeil hoch)-3-ketosteroid-17(alpha)-yl)-propionsaeurelactonen
DE3347510A1 (de) *	1983-12-27	1985-08-01	Schering AG, 1000 Berlin und 4709 Bergkamen	Verfahren zur herstellung von 3-oxo-17(alpha)-pregna-4,6-dien-21,17-carbolactonen
FR2596395B1 (fr) *	1986-03-26	1989-05-26	Roussel Uclaf	Nouveaux steroides comportant un cycle spirannique en position 17, leur procede de preparation, leur application comme medicaments et les compositions les renfermant
DE3878198T2 (de) *	1987-12-12	1993-06-24	Akzo Nv	11-arylsteroid-derivate.
FR2688004A1 (fr) *	1992-02-27	1993-09-03	Roussel Uclaf	Nouveaux sterouides comportant en position 17 un radical methylene lactone, leur procede et des intermediaires de preparation, leur application comme medicaments.

1995
- 1995-10-18 IL IL11565995A patent/IL115659A/xx not_active IP Right Cessation
- 1995-10-19 TW TW084111021A patent/TW339337B/zh active
- 1995-10-23 ZA ZA958963A patent/ZA958963B/xx unknown
- 1995-10-23 CZ CZ19952755A patent/CZ287346B6/cs not_active IP Right Cessation
- 1995-10-24 US US08/547,176 patent/US5741786A/en not_active Expired - Fee Related
- 1995-10-24 DE DE69520022T patent/DE69520022T2/de not_active Expired - Fee Related
- 1995-10-24 DK DK95202865T patent/DK0709394T3/da active
- 1995-10-24 PT PT95202865T patent/PT709394E/pt unknown
- 1995-10-24 AT AT95202865T patent/ATE199015T1/de not_active IP Right Cessation
- 1995-10-24 ES ES95202865T patent/ES2157290T3/es not_active Expired - Lifetime
- 1995-10-24 EP EP95202865A patent/EP0709394B1/de not_active Expired - Lifetime
- 1995-10-25 AU AU34457/95A patent/AU689642B2/en not_active Ceased
- 1995-10-25 NZ NZ280325A patent/NZ280325A/en unknown
- 1995-10-26 BR BR9504576A patent/BR9504576A/pt not_active Application Discontinuation
- 1995-10-26 KR KR1019950038035A patent/KR100402636B1/ko not_active Expired - Fee Related
- 1995-10-26 FI FI955108A patent/FI113542B/fi not_active IP Right Cessation
- 1995-10-26 CA CA002161490A patent/CA2161490A1/en not_active Abandoned
- 1995-10-26 PL PL95311135A patent/PL187083B1/pl not_active IP Right Cessation
- 1995-10-26 RU RU95118123/04A patent/RU2168516C2/ru not_active IP Right Cessation
- 1995-10-26 NO NO954293A patent/NO305252B1/no not_active IP Right Cessation
- 1995-10-26 HU HU9503068A patent/HU221192B1/hu not_active IP Right Cessation
- 1995-10-27 CN CN95120353A patent/CN1052237C/zh not_active Expired - Fee Related
- 1995-10-27 JP JP7280432A patent/JPH08225590A/ja active Pending
- 1995-10-27 TR TR95/01327A patent/TR199501327A2/xx unknown
- 1995-10-28 SG SG1995001675A patent/SG33569A1/en unknown
2001
- 2001-04-06 GR GR20010400563T patent/GR3035713T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
FI955108L (fi)	1996-04-28
JPH08225590A (ja)	1996-09-03
IL115659A (en)	2000-06-01
PT709394E (pt)	2001-06-29
US5741786A (en)	1998-04-21
CA2161490A1 (en)	1996-04-28
DE69520022T2 (de)	2001-06-13
DK0709394T3 (da)	2001-06-18
ZA958963B (en)	1996-05-23
CZ287346B6 (en)	2000-10-11
RU2168516C2 (ru)	2001-06-10
HUT73482A (en)	1996-08-28
HU221192B1 (en)	2002-08-28
CN1131158A (zh)	1996-09-18
EP0709394B1 (de)	2001-01-31
NO954293D0 (no)	1995-10-26
TR199501327A3 (de)	1996-06-21
TW339337B (en)	1998-09-01
KR960014152A (ko)	1996-05-22
PL311135A1 (en)	1996-04-29
IL115659A0 (en)	1996-01-19
NO305252B1 (no)	1999-04-26
CZ275595A3 (en)	1996-05-15
AU3445795A (en)	1996-05-09
EP0709394A2 (de)	1996-05-01
NO954293L (no)	1996-04-29
TR199501327A2 (tr)	1996-06-21
CN1052237C (zh)	2000-05-10
FI113542B (fi)	2004-05-14
FI955108A0 (fi)	1995-10-26
KR100402636B1 (ko)	2004-02-05
HU9503068D0 (en)	1995-12-28
EP0709394A3 (de)	1996-09-18
ES2157290T3 (es)	2001-08-16
PL187083B1 (pl)	2004-05-31
GR3035713T3 (en)	2001-07-31
ATE199015T1 (de)	2001-02-15
BR9504576A (pt)	1997-05-20
SG33569A1 (en)	1996-10-18
AU689642B2 (en)	1998-04-02
NZ280325A (en)	1997-03-24

Publication	Publication Date	Title
DE69520022D1 (de)	2001-03-08	Steroid-Verbindungen mit einer 17-Spiromethylen-Lakton- oder Lactol-Gruppe
ES417012A2 (es)	1976-04-16	Mejoras introducidas en el objeto de la patente principal, num. 399.057.
CA2152819A1 (en)	1994-07-21	New antiparasitic agents related to the milbemycins and avermectins
FI104178B1 (fi)	1999-11-30	17-spirofuran-3'-ylideenisteroidit
ATE179615T1 (de)	1999-05-15	Oxypurin-nukleoside und seine artverwandten, und acylderivate davon, zur verbesserung der hämatopoese
SE8000245L (sv)	1980-07-31	Medel mot glaukom
DE69902416D1 (de)	2002-09-12	Dihydro- oder Tetrahydronaphthalenderivate mit (anti)estrogenen Eigenschaften
YU49025B (sh)	2003-07-07	Novi derivati 17,20-epoksi pregnana, njihova primena u dobijanju kortizonskih derivata i intermedijera
HU9202100D0 (en)	1992-10-28	New 16-methyl-pregna-1,4-diene-3,20-dione derivatives
NZ208996A (en)	1989-08-29	5-substituted(1,2,4 triazpyrimidin-2-amine derivatives and pharmaceutical compositions
IL117497A (en)	1999-12-22	17-difluoromethylene estratriene derivatives and pharmaceutical compositions containing the same
ATE42957T1 (de)	1989-05-15	Waessrige kristallsuspension von steroidglykoestern.
IE811604L (en)	1982-01-16	11-alpha-amino androstanes
NZ218918A (en)	1989-04-26	4-oxo-1,4-dihydro-quinoline 3-carboxamides,their preparation and pharmaceutical compositions containing them
DE69305659D1 (de)	1996-12-05	17-Phenyl-substituierte Steroide mit cardiotonischer Wirksamkeit
DK164873C (da)	1993-01-11	3-keto-17alfa-mercapto-17beta-(substitueret thio)-androstenderivater med anvendelse som mellemprodukter ved fremstillingen af 17,17-bis(substitueret thio)-3-ketoandrostener samt fremgangsmaade til deres fremstilling
ATE174597T1 (de)	1999-01-15	Tan-1251-verbindung, ihre derivate, herstellung und verwendung
EP0273357A3 (en)	1989-11-02	Fluorine-containing macrolide compounds, pharmaceutical compositions comprising the same and their use for the manufacture of medicaments

Legal Events

Date	Code	Title	Description
2005-08-18	8339	Ceased/non-payment of the annual fee