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DE69507614D1 - 3-amino-2-oxo-piperidinessigsäurederivate, die eine argininnachahmende verbindung, mit enzyminhibitorischen wirkung enthalten - Google Patents

3-amino-2-oxo-piperidinessigsäurederivate, die eine argininnachahmende verbindung, mit enzyminhibitorischen wirkung enthalten

Info

Publication number
DE69507614D1
DE69507614D1 DE69507614T DE69507614T DE69507614D1 DE 69507614 D1 DE69507614 D1 DE 69507614D1 DE 69507614 T DE69507614 T DE 69507614T DE 69507614 T DE69507614 T DE 69507614T DE 69507614 D1 DE69507614 D1 DE 69507614D1
Authority
DE
Germany
Prior art keywords
piperidinessigic
enzyminhibitoric
arginine
oxo
compatible
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69507614T
Other languages
English (en)
Inventor
Joseph E Semple
Odile E Levy
Ruth F Nutt
William C Ripka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dendreon San Diego LLC
Dendreon Pharmaceuticals LLC
Original Assignee
Dendreon San Diego LLC
Corvas International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/261,498 external-priority patent/US5714499A/en
Application filed by Dendreon San Diego LLC, Corvas International Inc filed Critical Dendreon San Diego LLC
Application granted granted Critical
Publication of DE69507614D1 publication Critical patent/DE69507614D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06191—Dipeptides containing heteroatoms different from O, S, or N

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Peptides Or Proteins (AREA)
DE69507614T 1994-06-17 1995-06-19 3-amino-2-oxo-piperidinessigsäurederivate, die eine argininnachahmende verbindung, mit enzyminhibitorischen wirkung enthalten Expired - Lifetime DE69507614D1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/261,498 US5714499A (en) 1994-06-17 1994-06-17 3-amino-2-oxo-1-piperidineacetic derivatives containing an arginine mimic as enzyme inhibitors
US35683194A 1994-12-13 1994-12-13
US08/482,117 US5932733A (en) 1994-06-17 1995-06-07 3-amino-2-oxo-1-piperidineacetic derivatives containing an arginine mimic as enzyme inhibitors
PCT/US1995/007832 WO1995035313A1 (en) 1994-06-17 1995-06-19 3-amino-2-oxo-1-piperidineacetic derivatives containing an arginine mimic as enzyme inhibitors

Publications (1)

Publication Number Publication Date
DE69507614D1 true DE69507614D1 (de) 1999-03-11

Family

ID=27401415

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69507614T Expired - Lifetime DE69507614D1 (de) 1994-06-17 1995-06-19 3-amino-2-oxo-piperidinessigsäurederivate, die eine argininnachahmende verbindung, mit enzyminhibitorischen wirkung enthalten

Country Status (8)

Country Link
US (1) US5932733A (de)
EP (1) EP0765339B1 (de)
JP (1) JPH10503177A (de)
AT (1) ATE176241T1 (de)
AU (1) AU2905495A (de)
CA (1) CA2192211A1 (de)
DE (1) DE69507614D1 (de)
WO (1) WO1995035313A1 (de)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6011158A (en) * 1994-12-13 2000-01-04 Corvas International, Inc. Aromatic heterocyclic derivatives as enzyme inhibitors
US6342504B1 (en) 1994-12-13 2002-01-29 Corvas International, Inc. Aromatic heterocyclic derivatives as enzyme inhibitors
CA2176414A1 (en) * 1995-05-18 1996-11-19 S. David Kimball Acyl guanidine and amidine prodrugs
AU4172397A (en) * 1996-09-06 1998-03-26 Biochem Pharma Inc. Lactam inhibitors of thrombin
US6063794A (en) 1996-10-11 2000-05-16 Cor Therapeutics Inc. Selective factor Xa inhibitors
US6262047B1 (en) 1996-10-11 2001-07-17 Cor Therapeutics, Inc. Selective factor Xa inhibitors
AU743544B2 (en) * 1996-10-11 2002-01-31 Millennium Pharmaceuticals, Inc. Selective factor Xa inhibitors
US6369080B2 (en) 1996-10-11 2002-04-09 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6194435B1 (en) 1996-10-11 2001-02-27 Cor Therapeutics, Inc. Lactams as selective factor Xa inhibitors
NZ500353A (en) 1997-04-14 2002-02-01 Cor Therapeutics Inc Cyclic diaza compounds that are selective inhibitors of factor Xa
NZ500351A (en) * 1997-04-14 2001-10-26 Cor Therapeutics Inc Cyclic diaza compounds as selective factor Xa inhibitors
EP0977773A1 (de) * 1997-04-14 2000-02-09 Cor Therapeutics, Inc. Selektive faktor xa-inhibitoren
US7109326B2 (en) 1997-04-15 2006-09-19 Genentech, Inc. Halo-alkoxycarbonyl prodrugs
US6333321B1 (en) 1997-08-11 2001-12-25 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6218382B1 (en) 1997-08-11 2001-04-17 Cor Therapeutics, Inc Selective factor Xa inhibitors
US6228854B1 (en) 1997-08-11 2001-05-08 Cor Therapeutics, Inc. Selective factor Xa inhibitors
US6204384B1 (en) 1997-11-26 2001-03-20 Corvas International, Inc. Substituted 3-amino-2-hydroxyphenylacetamide derivatives as enzyme inhibitors (II)
US6011047A (en) * 1997-11-26 2000-01-04 Corvas International Inc. Substituted 3-amino-2-hydroxyphenylacetamide derivatives as enzyme inhibitors
AU1605699A (en) * 1997-11-26 1999-06-15 Corvas International, Inc. Substituted 3-amino-2-hydroxyphenylacetamide derivatives as enzyme inhibitors (ii)
WO2000047207A1 (en) 1999-02-09 2000-08-17 Bristol-Myers Squibb Company LACTAM INHIBITORS OF FXa AND METHOD
US6344450B1 (en) * 1999-02-09 2002-02-05 Bristol-Myers Squibb Company Lactam compounds and their use as inhibitors of serine proteases and method
US6677473B1 (en) 1999-11-19 2004-01-13 Corvas International Inc Plasminogen activator inhibitor antagonists
US6541467B1 (en) * 2000-04-14 2003-04-01 Corvas International, Inc. Thrombin inhibitors having a lactam at P3
US6511973B2 (en) 2000-08-02 2003-01-28 Bristol-Myers Squibb Co. Lactam inhibitors of FXa and method
EP1411929B1 (de) 2001-01-26 2011-05-11 Chugai Seiyaku Kabushiki Kaisha Malonyl coa-decarboxylase inhibitoren als stoffwechselmodulatoren
JP4267920B2 (ja) 2001-01-26 2009-05-27 中外製薬株式会社 代謝調節剤として有用なマロニル−ＣｏＡ脱炭酸酵素阻害剤
ATE359773T1 (de) 2001-01-26 2007-05-15 Chugai Pharmaceutical Co Ltd Verfahren zur behandlung von erkrankungen mit malonyl coa-decarboxylase-inhibitoren
WO2002060894A2 (en) * 2001-01-30 2002-08-08 Bristol-Myers Squibb Company Sulfonamide lactam inhibitors of factor xa
JP4159361B2 (ja) 2001-02-20 2008-10-01 中外製薬株式会社 マロニル−ＣｏＡ脱炭酸酵素阻害剤を用いた代謝性疾患の治療法
US7709510B2 (en) 2001-02-20 2010-05-04 Chugai Seiyaku Kabushiki Kaisha Azoles as malonyl-CoA decarboxylase inhibitors useful as metabolic modulators
US6777431B2 (en) 2001-07-13 2004-08-17 Corvas International, Inc. Non-convalent thrombin inhibitors
GB0127568D0 (en) * 2001-11-16 2002-01-09 Glaxo Group Ltd Chemical compounds
CA2533763C (en) 2003-08-01 2012-11-20 Chugai Seiyaku Kabushiki Kaisha Cyanoamide compounds useful as malonyl-coa decarboxylase inhibitors
DE602004030017D1 (de) 2003-08-01 2010-12-23 Chugai Pharmaceutical Co Ltd Heterocyclische verbindungen als nützliche malonyl-coa decarboxylase-hemmer
CA2533881C (en) 2003-08-01 2012-07-10 Chugai Seiyaku Kabushiki Kaisha Cyanoguanidine-based azole compounds useful as malonyl-coa decarboxylase inhibitors
CA2533749C (en) 2003-08-01 2012-07-10 Chugai Seiyaku Kabushiki Kaisha Piperidine compounds useful as malonyl-coa decarboxylase inhibitors
CA2547064A1 (en) * 2003-12-18 2005-06-30 Astrazeneca Ab New 5,6-dihydropyrin-2-one compounds useful as inhibitors of thrombin
CN119859160A (zh) * 2024-12-20 2025-04-22 中国科学院长春应用化学研究所 一种功能性己内酰胺、本征型阻燃尼龙材料及其制备方法和应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5754157A (en) * 1980-09-19 1982-03-31 Nippon Kayaku Co Ltd L-argininal derivative and its preparation
HU184368B (en) * 1981-01-13 1984-08-28 Gyogyszerkutato Intezet Process for preparing d-phenyl-alanyl-l-propyl-l-arginine-ald ehyde-shulphate
US4433152A (en) * 1981-05-25 1984-02-21 Nippon Chemiphar Co., Ltd. Amidinopiperidine derivatives
CA2075154A1 (en) * 1991-08-06 1993-02-07 Neelakantan Balasubramanian Peptide aldehydes as antithrombotic agents
US5424334A (en) * 1991-12-19 1995-06-13 G. D. Searle & Co. Peptide mimetic compounds useful as platelet aggregation inhibitors
US5492895A (en) * 1992-02-14 1996-02-20 Corvas International, Inc. Inhibitors of thrombosis
US5371072A (en) * 1992-10-16 1994-12-06 Corvas International, Inc. Asp-Pro-Arg α-keto-amide enzyme inhibitors

Also Published As

Publication number Publication date
EP0765339B1 (de) 1999-01-27
JPH10503177A (ja) 1998-03-24
EP0765339A1 (de) 1997-04-02
CA2192211A1 (en) 1995-12-28
AU2905495A (en) 1996-01-15
ATE176241T1 (de) 1999-02-15
WO1995035313A1 (en) 1995-12-28
US5932733A (en) 1999-08-03

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Legal Events

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8332 No legal effect for de