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DE69414554D1 - Heterocyclische verbindungen und ihre herstellung und verwendung - Google Patents

Heterocyclische verbindungen und ihre herstellung und verwendung

Info

Publication number
DE69414554D1
DE69414554D1 DE69414554T DE69414554T DE69414554D1 DE 69414554 D1 DE69414554 D1 DE 69414554D1 DE 69414554 T DE69414554 T DE 69414554T DE 69414554 T DE69414554 T DE 69414554T DE 69414554 D1 DE69414554 D1 DE 69414554D1
Authority
DE
Germany
Prior art keywords
compounds
production
heterocyclic compounds
forebrain
hippocampus
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69414554T
Other languages
English (en)
Other versions
DE69414554T2 (de
Inventor
Per Sauerberg
Preben Olesen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Publication of DE69414554D1 publication Critical patent/DE69414554D1/de
Application granted granted Critical
Publication of DE69414554T2 publication Critical patent/DE69414554T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69414554T 1993-03-05 1994-03-04 Heterocyclische verbindungen und ihre herstellung und verwendung Expired - Fee Related DE69414554T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/026,943 US5418240A (en) 1990-08-21 1993-03-05 Heterocyclic compounds and their preparation and use
PCT/DK1994/000092 WO1994020496A1 (en) 1993-03-05 1994-03-04 Heterocyclic compounds and their preparation and use

Publications (2)

Publication Number Publication Date
DE69414554D1 true DE69414554D1 (de) 1998-12-17
DE69414554T2 DE69414554T2 (de) 1999-06-17

Family

ID=21834696

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69414554T Expired - Fee Related DE69414554T2 (de) 1993-03-05 1994-03-04 Heterocyclische verbindungen und ihre herstellung und verwendung

Country Status (21)

Country Link
US (1) US5418240A (de)
EP (1) EP0687266B1 (de)
JP (1) JP3411923B2 (de)
KR (1) KR100344329B1 (de)
CN (1) CN1046722C (de)
AT (1) ATE173257T1 (de)
AU (1) AU694415B2 (de)
CZ (1) CZ290639B6 (de)
DE (1) DE69414554T2 (de)
DK (1) DK0687266T3 (de)
ES (1) ES2126099T3 (de)
FI (1) FI954130L (de)
HU (1) HUT72443A (de)
IL (1) IL108865A (de)
NO (1) NO312676B1 (de)
NZ (1) NZ262372A (de)
PH (1) PH31394A (de)
SK (1) SK281005B6 (de)
TW (1) TW350846B (de)
WO (1) WO1994020496A1 (de)
ZA (1) ZA941542B (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5641791A (en) * 1991-08-13 1997-06-24 Novo Nordisk A.S Heterocyclic compounds and their preparation and use
MX9300875A (es) 1992-02-20 1993-08-31 Smithkline Beecham Plc Procedimiento para la preparacion de compuestos azabiciclicos.
US6281233B1 (en) 1993-08-19 2001-08-28 Novo Nordisk A/S Method of treating gastrointestinal motility disorders
KR960703908A (ko) * 1993-08-19 1996-08-31 안네 세커 정신병 치료방법(Antipsychotic method)
US5663182A (en) * 1993-08-19 1997-09-02 Bymaster; Franklin Porter Antipsychotic method
US6265419B1 (en) * 1993-12-21 2001-07-24 Novo Nordisk A/S Method of treating gastrointestinal motility disorders
GB9409705D0 (en) * 1994-05-14 1994-07-06 Smithkline Beecham Plc Novel compounds
US5998404A (en) 1994-10-24 1999-12-07 Eli Lilly And Company Heterocyclic compounds and their use
US5605908A (en) * 1994-10-24 1997-02-25 Eli Lilly And Company Heterocyclic compounds and their use
US5821371A (en) * 1994-10-24 1998-10-13 Eli Lilly And Comany Heterocyclic compounds and their preparation and use
US5726193A (en) * 1994-10-31 1998-03-10 Eli Lilly And Company Method for treating anxiety
US5488056A (en) * 1994-10-31 1996-01-30 Eli Lilly And Company Method for treating anxiety
US5612351A (en) * 1994-11-08 1997-03-18 Novo Nordisk A/S Method of treating urinary bladder dysfunctions
WO1997011073A1 (en) * 1995-09-22 1997-03-27 Novo Nordisk A/S Novel substituted azacyclic or azabicyclic compounds
CA2233541C (en) * 1995-10-13 2002-04-30 Neurosearch A/S 8-azabicyclo[3.2.1]oct-2-ene derivatives, their preparation and use
US5998434A (en) * 1995-12-06 1999-12-07 Eli Lilly And Company Composition for treating pain
JP2000501709A (ja) * 1995-12-07 2000-02-15 イーライ・リリー・アンド・カンパニー 疼痛治療用組成物
WO1997025043A1 (en) * 1996-01-04 1997-07-17 Novo Nordisk A/S A method of treating hypercholesterolemia and related disorders
US5914338A (en) 1996-04-02 1999-06-22 Novo Nordisk Heterocyclic compounds and their preparation and use
CA2250472A1 (en) * 1996-04-23 1997-10-30 Steven James Quimby Heterocyclic compounds
CA2252563A1 (en) * 1996-04-24 1997-10-30 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
US5733912A (en) * 1997-02-19 1998-03-31 Abbott Laboratories 7A-heterocycle substituted hexahydro-1H-pyrrolizine compounds useful in controlling chemical synaptic transmission
AU6966998A (en) * 1997-04-11 1998-11-11 Eli Lilly And Company Composition for treating pain
AU7107998A (en) * 1997-04-11 1998-11-11 Eli Lilly And Company Method for treating schizophrenia
US6015813A (en) * 1997-04-22 2000-01-18 Novo Nordisk A/S Heterocyclic compounds and their preparation and use
EP0977755B1 (de) * 1997-04-22 2005-07-13 Novo Nordisk A/S Heterozyklische verbindungen, ihre herstellung und ihre anwendung
CA2291157A1 (en) * 1997-05-29 1998-12-03 Eli Lilly And Company Process for preparing heterocyclic compounds
EP1098883A4 (de) * 1997-05-29 2001-11-14 Lilly Co Eli Verfahren zur herstellung heterozyklischer verbindungen
US6465467B1 (en) * 1999-05-21 2002-10-15 Biovitrum Ab Certain aryl-aliphatic and heteroaryl-aliphatic piperazinyl pyrazines and their use in the treatment of serotonin-related diseases
US20050131051A1 (en) * 2000-08-21 2005-06-16 Shaomeng Wang 2-3-disubstituted quinuclidiness as modulators of monoamine transporters and theraperutic and diagnostic methods based thereon
US20110294835A1 (en) 2008-05-15 2011-12-01 The Board Of Trustees Of The University Of Illinois Muscarinic Agonists as Cognitive Enhancers
WO2012149524A1 (en) 2011-04-29 2012-11-01 The University Of Toledo Muscarinic agonists as enhancers of working memory and cognitive flexibility

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ219646A (en) * 1986-03-27 1990-10-26 Merck Sharp & Dohme Oxadiazole derivatives of azacyclics for treating cns disorders
GB8610432D0 (en) * 1986-04-29 1986-06-04 Akzo Nv Amino-thiazole & oxazole derivatives
GB8714789D0 (en) * 1987-06-24 1987-07-29 Lundbeck & Co As H Heterocyclic compounds
GB8717446D0 (en) * 1987-07-23 1987-08-26 Merck Sharp & Dohme Chemical compounds
NZ225999A (en) * 1987-09-10 1992-04-28 Merck Sharp & Dohme Azacyclic- or azabicyclic-substituted thiadiazole derivatives and pharmaceutical compositions
IL88156A (en) * 1987-11-13 1997-02-18 Novo Nordisk As Azacyclic compounds their preparation and pharmaceutical compositions containing them
EP0322182A3 (de) * 1987-12-22 1992-01-02 Beecham Group Plc Azabicyclische-Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
NZ227841A (en) * 1988-02-12 1991-08-27 Merck Sharp & Dohme Heterocyclic compounds with at least two non-condensed five membered rings and pharmaceutical compositions
DK162892C (da) * 1988-07-04 1992-05-11 Novo Nordisk As 1,2,5,6-tetrahydropyridinforbindelser, deres fremstilling og farmaceutiske praeparater indeholdende disse
US5043345A (en) * 1989-02-22 1991-08-27 Novo Nordisk A/S Piperidine compounds and their preparation and use
EP0459568A3 (en) * 1990-05-31 1992-09-30 Merck Sharp & Dohme Ltd. Substituted oxadiazoles and thiadiazoles for use in the treatment of glaucoma and novel compounds having such use
DK198590D0 (da) * 1990-08-21 1990-08-21 Novo Nordisk As Heterocykliske forbindelser, deres fremstilling og anvendelse

Also Published As

Publication number Publication date
KR100344329B1 (ko) 2002-11-30
EP0687266B1 (de) 1998-11-11
ATE173257T1 (de) 1998-11-15
US5418240A (en) 1995-05-23
NO953491L (no) 1995-09-05
HUT72443A (en) 1996-04-29
SK281005B6 (sk) 2000-10-09
NO953491D0 (no) 1995-09-05
NZ262372A (en) 1997-07-27
TW350846B (en) 1999-01-21
ZA941542B (en) 1995-09-04
FI954130A0 (fi) 1995-09-04
JP3411923B2 (ja) 2003-06-03
CZ290639B6 (cs) 2002-09-11
IL108865A0 (en) 1994-06-24
EP0687266A1 (de) 1995-12-20
AU6202794A (en) 1994-09-26
FI954130A7 (fi) 1995-10-27
CZ225195A3 (en) 1996-04-17
JPH08507499A (ja) 1996-08-13
ES2126099T3 (es) 1999-03-16
CN1121349A (zh) 1996-04-24
KR960701049A (ko) 1996-02-24
PH31394A (en) 1998-10-29
WO1994020496A1 (en) 1994-09-15
SK110195A3 (en) 1996-10-02
AU694415B2 (en) 1998-07-23
DE69414554T2 (de) 1999-06-17
IL108865A (en) 2000-07-16
DK0687266T3 (da) 1999-07-26
CN1046722C (zh) 1999-11-24
FI954130L (fi) 1995-10-27
NO312676B1 (no) 2002-06-17
HU9502588D0 (en) 1995-11-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee