DE60336734D1 - Sidasen - Google Patents
SidasenInfo
- Publication number
- DE60336734D1 DE60336734D1 DE60336734T DE60336734T DE60336734D1 DE 60336734 D1 DE60336734 D1 DE 60336734D1 DE 60336734 T DE60336734 T DE 60336734T DE 60336734 T DE60336734 T DE 60336734T DE 60336734 D1 DE60336734 D1 DE 60336734D1
- Authority
- DE
- Germany
- Prior art keywords
- compounds
- methylthioadenosine
- phosphorylases
- infections
- purine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 150000001875 compounds Chemical class 0.000 abstract 3
- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical compound N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 abstract 2
- 102000010722 N-Glycosyl Hydrolases Human genes 0.000 abstract 2
- 108010063372 N-Glycosyl Hydrolases Proteins 0.000 abstract 2
- 102100034187 S-methyl-5'-thioadenosine phosphorylase Human genes 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- WUUGFSXJNOTRMR-IOSLPCCCSA-N 5'-S-methyl-5'-thioadenosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CSC)O[C@H]1N1C2=NC=NC(N)=C2N=C1 WUUGFSXJNOTRMR-IOSLPCCCSA-N 0.000 abstract 1
- 108010034457 5'-methylthioadenosine phosphorylase Proteins 0.000 abstract 1
- 101710185027 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase Proteins 0.000 abstract 1
- 101710081557 Aminodeoxyfutalosine nucleosidase Proteins 0.000 abstract 1
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102000009097 Phosphorylases Human genes 0.000 abstract 1
- 108010073135 Phosphorylases Proteins 0.000 abstract 1
- 206010037075 Protozoal infections Diseases 0.000 abstract 1
- 101710136206 S-methyl-5'-thioadenosine phosphorylase Proteins 0.000 abstract 1
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 108010091901 purine phosphoribosyltransferase Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/28—Oxygen atom
- C07D473/30—Oxygen atom attached in position 6, e.g. hypoxanthine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/23—Heterocyclic radicals containing two or more heterocyclic rings condensed among themselves or condensed with a common carbocyclic ring system, not provided for in groups C07H19/14 - C07H19/22
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Genetics & Genomics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyrane Compounds (AREA)
- Seal Device For Vehicle (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NZ52091902 | 2002-08-21 | ||
| PCT/NZ2003/000186 WO2004018496A1 (en) | 2002-08-21 | 2003-08-21 | Inhibitors of nucleoside phosphorylases and nucleosidases |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60336734D1 true DE60336734D1 (de) | 2011-05-26 |
Family
ID=31944950
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60336734T Expired - Lifetime DE60336734D1 (de) | 2002-08-21 | 2003-08-21 | Sidasen |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US7553839B2 (de) |
| EP (1) | EP1539783B1 (de) |
| JP (1) | JP4682314B2 (de) |
| KR (1) | KR101081226B1 (de) |
| CN (1) | CN100379750C (de) |
| AT (1) | ATE505474T1 (de) |
| AU (1) | AU2003258911B2 (de) |
| BR (1) | BRPI0313664B8 (de) |
| CA (1) | CA2496698C (de) |
| CY (1) | CY1111700T1 (de) |
| DE (1) | DE60336734D1 (de) |
| DK (1) | DK1539783T3 (de) |
| ES (1) | ES2363766T3 (de) |
| PT (1) | PT1539783E (de) |
| RU (1) | RU2330042C2 (de) |
| SI (1) | SI1539783T1 (de) |
| WO (1) | WO2004018496A1 (de) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5985848A (en) | 1997-10-14 | 1999-11-16 | Albert Einstein College Of Medicine Of Yeshiva University | Inhibitors of nucleoside metabolism |
| DE60041757D1 (de) * | 1999-04-08 | 2009-04-23 | Ind Res Ltd | Verfahren zur zubereitung von inhibitoren des nukleosid-metabolismus |
| ES2363766T3 (es) | 2002-08-21 | 2011-08-16 | Albert Einstein College Of Medicine Of Yeshiva University | Inhibidores de nucleosidasas y fosforilasas de nucleosidos. |
| NZ523970A (en) * | 2003-02-04 | 2005-02-25 | Ind Res Ltd | Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases |
| US7557113B2 (en) | 2003-08-26 | 2009-07-07 | Teijin Pharma Limited | Substituted pyrrolo[3,2-d]pyrimidine derivatives |
| CA2536887C (en) * | 2003-08-26 | 2012-03-06 | Teijin Pharma Limited | Pyrrolopyrimidinone derivatives |
| NZ533360A (en) * | 2004-06-04 | 2007-02-23 | Ind Res Ltd | Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds |
| JP2008508287A (ja) * | 2004-07-27 | 2008-03-21 | バイオクリスト・フアーマシユーテイカルズ・インコーポレイテツド | ５’−メチルチオアデノシンホスホリラーゼ及び５’メチルチオアデノシン／ｓ−アデノシルホモシステインヌクレオシダーゼの阻害剤 |
| NZ540160A (en) * | 2005-05-20 | 2008-03-28 | Einstein Coll Med | Inhibitors of nucleoside phosphorylases |
| CA2615549A1 (en) * | 2005-07-27 | 2007-02-08 | Albert Einstein College Of Medicine Of Yeshiva University | Transition state structure of 5'-methylthioadenosine/s-adenosylhomocysteine nucleosidases |
| NZ544187A (en) * | 2005-12-15 | 2008-07-31 | Ind Res Ltd | Deazapurine analogs of 1'-aza-l-nucleosides |
| US20090053221A1 (en) * | 2006-01-17 | 2009-02-26 | Cheung Nai-Kong V | Immune response enhancing glucan |
| US8394950B2 (en) * | 2006-02-22 | 2013-03-12 | Industrial Research Limited | Analogues of coformycin and their use for treating protozoan parasite infections |
| AU2006200809B2 (en) * | 2006-02-24 | 2013-11-07 | Albert Einstein College Of Medicine Of Yeshiva University | Methods of treating cancer |
| CA2643056A1 (en) * | 2006-02-24 | 2007-08-30 | Industrial Research Limited | Methods of treating diseases using inhibitors of nucleoside phosphorylases and nucleosidases |
| JP2009527550A (ja) * | 2006-02-24 | 2009-07-30 | アルバート アインシュタイン カレッジ オブ メディシン オブ イエシバ ユニバーシティ | 癌を処置する方法 |
| CN101094080B (zh) * | 2006-06-22 | 2012-06-20 | 华为技术有限公司 | 一种即按即通系统中的计费方法 |
| AU2007293773B2 (en) | 2006-09-07 | 2013-01-31 | Albert Einstein College Of Medicine, Inc. | Acyclic amine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase |
| AU2007293774C1 (en) | 2006-09-07 | 2014-12-18 | Albert Einstein College Of Medicine, Inc. | Acyclic amine inhibitors of nucleoside phosphorylases and hydrolases |
| KR20090101278A (ko) * | 2006-12-22 | 2009-09-24 | 인더스트리얼 리서치 리미티드 | 누클레오시다제 및 포스포릴라제 억제제의 아제티딘 유사체 |
| WO2009082247A1 (en) * | 2007-12-21 | 2009-07-02 | Industrial Research Limited | Process for preparing immucillins having a methylene link |
| UA103195C2 (uk) | 2008-08-11 | 2013-09-25 | Глаксосмитклайн Ллк | Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань |
| US20110190265A1 (en) * | 2008-09-22 | 2011-08-04 | Schramm Vern L | Methods and compositions for treating bacterial infections by inhibiting quorum sensing |
| KR101763672B1 (ko) * | 2009-03-24 | 2017-08-01 | 바이오크리스트파마슈티컬즈,인코포레이티드 | 7―［（3ｒ,4ｒ）―3―하이드록시―4―하이드록시메틸―피롤리딘―1―일메틸］―3,5―디하이드로―피롤로［3,2―ｄ］피리미딘―4―온의 유용한 약학적 염 |
| ES2687168T3 (es) | 2009-07-17 | 2018-10-24 | Albert Einstein College Of Medicine, Inc. | Inhibidores de 3-hidroxipirrolidina de 5'-metiltioadenosina fosforilasa y nucleosidasa |
| WO2012074912A1 (en) * | 2010-11-29 | 2012-06-07 | Albert Einstein College Of Medicine Of Yeshiva University | Methods, assays and compounds for treating bacterial infections by inhibiting methylthioinosine phosphorylase |
| WO2012122532A2 (en) * | 2011-03-09 | 2012-09-13 | Biocryst Pharmaceuticals, Inc. | Compositions and methods for treatment of hyperuricemia |
| CA2841361A1 (en) | 2011-07-22 | 2013-01-31 | Glaxosmithkline Llc | Composition for the treatment of allergic diseases and inflammatory conditions |
| WO2014025842A1 (en) * | 2012-08-07 | 2014-02-13 | Albert Einstein College Of Medicine Of Yeshiva University | Treatment of helicobacter pylori infections |
| AR092198A1 (es) * | 2012-08-24 | 2015-04-08 | Glaxosmithkline Llc | Derivados de pirazolopirimidinas |
| JP6587252B2 (ja) * | 2012-11-12 | 2019-10-09 | ヴィクトリア リンク リミテッドＶｉｃｔｏｒｉａ Ｌｉｎｋ Ｌｉｍｉｔｅｄ | （３ｒ，４ｓ）−ｌ−（（４−アミノ−５ｈ−ピロロ［３，２−ｄ］ピリミジン−７−イル）メチル）−４−（メチルチオメチル）ピロリジン−３−オール（ｍｔｄｉａ）の塩及び多形形態 |
| RU2643371C2 (ru) | 2012-11-20 | 2018-02-01 | ГЛАКСОСМИТКЛАЙН ЭлЭлСи | Новые соединения |
| CN104780923B (zh) | 2012-11-20 | 2017-03-15 | 葛兰素史克有限责任公司 | 干扰素诱导剂化合物 |
| PE20151086A1 (es) | 2012-11-20 | 2015-08-20 | Glaxosmithkline Llc | COMPUESTOS DERIVADOS DE 5H-PIRROLO-[3,2-d]PIRIMIDIN-4-AMINA 2,6,7 TRISUSTITUIDOS O 2,7 DISUSTITUIDOS COMO INDUCTORES DEL INTERFERON HUMANO |
| EP3010507A4 (de) | 2013-06-22 | 2017-06-07 | Nitor Therapeutics | Zusammensetzungen und verfahren zur verstärkung der immunreaktion zur behandlung von infektionskrankheiten und krebs |
| SG11201606595RA (en) | 2014-02-12 | 2016-09-29 | Einstein Coll Med | Treatment of h. pylori infections using mtan inhibitors |
| EP2913333A1 (de) * | 2014-02-27 | 2015-09-02 | Laboratoire Biodim | 3H-Thieno[3,4]pyrimidin-4-on und Pyrrolopyrimidon-Verbindungen als Gram-Positive Antibakteria |
| CN108794628A (zh) * | 2018-05-28 | 2018-11-13 | 广东工业大学 | 一种抗幽门螺杆菌的卵黄抗体制备方法及应用 |
| GB202110403D0 (en) | 2021-07-20 | 2021-09-01 | Laevoroc Immunology | Ulodesine Salt |
| GB202218782D0 (en) | 2022-12-13 | 2023-01-25 | Mehrling Thomas | Purine nucleoside phosphorylase inhibitor for metabolic syndrome |
| CN117777134B (zh) * | 2022-12-19 | 2025-02-25 | 艾立康药业股份有限公司 | 作为mat2a抑制剂的多环类化合物 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2866478B2 (ja) * | 1989-10-31 | 1999-03-08 | バイオクリスト・ファーマシューティカルズ・インコーポレイテッド | プリンヌクレオシドホスホリラーゼの阻害剤 |
| JPH07242668A (ja) * | 1994-03-08 | 1995-09-19 | Nippon Kayaku Co Ltd | 新規なアゼチジン誘導体 |
| FI971413A7 (fi) * | 1994-10-05 | 1997-04-04 | Darwin Discovery Ltd | Puriini- ja guaniiniyhdisteet PNP:n estäjinä |
| EP0763529B1 (de) | 1995-03-29 | 2003-07-23 | Taiho Pharmaceutical Company Limited | Uracilderivate und diese enthaltende antitumoreffekt-verstärker sowie antitumormittel |
| WO1997031008A1 (en) | 1996-02-23 | 1997-08-28 | Industrial Research Limited | Enzyme detection/assay method and substrates |
| RU2183639C2 (ru) * | 1996-10-16 | 2002-06-20 | Ай-Си-Эн Фармасьютикалз, Инк. | Пуриновые l-нуклеозиды, их аналоги и применение |
| US5985848A (en) | 1997-10-14 | 1999-11-16 | Albert Einstein College Of Medicine Of Yeshiva University | Inhibitors of nucleoside metabolism |
| DE60041757D1 (de) | 1999-04-08 | 2009-04-23 | Ind Res Ltd | Verfahren zur zubereitung von inhibitoren des nukleosid-metabolismus |
| US6448799B1 (en) * | 1999-09-30 | 2002-09-10 | Hitachi Electronics Engineering Co., Ltd. | Timing adjustment method and apparatus for semiconductor IC tester |
| JP4110347B2 (ja) | 1999-11-05 | 2008-07-02 | 大鵬薬品工業株式会社 | 抗ｈｉｖ剤 |
| US7109331B2 (en) | 2000-08-29 | 2006-09-19 | Industrial Research Limited | 5H-pyrrolo[3,2-d]pyrimidine nucleoside metabolism inhibitors |
| US6458799B1 (en) | 2000-08-31 | 2002-10-01 | Biocryst Pharmaceuticals, Inc. | Deazaguanine analog, preparation thereof and use thereof |
| US7098334B2 (en) | 2002-03-25 | 2006-08-29 | Industrial Research Limited | 4-amino-5H-pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases |
| ES2363766T3 (es) | 2002-08-21 | 2011-08-16 | Albert Einstein College Of Medicine Of Yeshiva University | Inhibidores de nucleosidasas y fosforilasas de nucleosidos. |
| NZ523970A (en) | 2003-02-04 | 2005-02-25 | Ind Res Ltd | Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases |
| NZ533360A (en) | 2004-06-04 | 2007-02-23 | Ind Res Ltd | Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds |
| JP2008508287A (ja) | 2004-07-27 | 2008-03-21 | バイオクリスト・フアーマシユーテイカルズ・インコーポレイテツド | ５’−メチルチオアデノシンホスホリラーゼ及び５’メチルチオアデノシン／ｓ−アデノシルホモシステインヌクレオシダーゼの阻害剤 |
| NZ540160A (en) | 2005-05-20 | 2008-03-28 | Einstein Coll Med | Inhibitors of nucleoside phosphorylases |
| CA2615549A1 (en) | 2005-07-27 | 2007-02-08 | Albert Einstein College Of Medicine Of Yeshiva University | Transition state structure of 5'-methylthioadenosine/s-adenosylhomocysteine nucleosidases |
| NZ544187A (en) | 2005-12-15 | 2008-07-31 | Ind Res Ltd | Deazapurine analogs of 1'-aza-l-nucleosides |
| JP2009527550A (ja) | 2006-02-24 | 2009-07-30 | アルバート アインシュタイン カレッジ オブ メディシン オブ イエシバ ユニバーシティ | 癌を処置する方法 |
| CA2643056A1 (en) | 2006-02-24 | 2007-08-30 | Industrial Research Limited | Methods of treating diseases using inhibitors of nucleoside phosphorylases and nucleosidases |
| AU2007293773B2 (en) | 2006-09-07 | 2013-01-31 | Albert Einstein College Of Medicine, Inc. | Acyclic amine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase |
| AU2007293774C1 (en) | 2006-09-07 | 2014-12-18 | Albert Einstein College Of Medicine, Inc. | Acyclic amine inhibitors of nucleoside phosphorylases and hydrolases |
| US20100062995A1 (en) | 2006-09-26 | 2010-03-11 | Schramm Vern L | Transition state structure of human 5'methylthioadenosine phosphorylase |
| KR20090101278A (ko) | 2006-12-22 | 2009-09-24 | 인더스트리얼 리서치 리미티드 | 누클레오시다제 및 포스포릴라제 억제제의 아제티딘 유사체 |
| WO2009082247A1 (en) | 2007-12-21 | 2009-07-02 | Industrial Research Limited | Process for preparing immucillins having a methylene link |
| US20110190265A1 (en) | 2008-09-22 | 2011-08-04 | Schramm Vern L | Methods and compositions for treating bacterial infections by inhibiting quorum sensing |
| ES2687168T3 (es) | 2009-07-17 | 2018-10-24 | Albert Einstein College Of Medicine, Inc. | Inhibidores de 3-hidroxipirrolidina de 5'-metiltioadenosina fosforilasa y nucleosidasa |
-
2003
- 2003-08-21 ES ES03792904T patent/ES2363766T3/es not_active Expired - Lifetime
- 2003-08-21 DK DK03792904.9T patent/DK1539783T3/da active
- 2003-08-21 EP EP03792904A patent/EP1539783B1/de not_active Expired - Lifetime
- 2003-08-21 CA CA2496698A patent/CA2496698C/en not_active Expired - Lifetime
- 2003-08-21 AU AU2003258911A patent/AU2003258911B2/en not_active Expired
- 2003-08-21 DE DE60336734T patent/DE60336734D1/de not_active Expired - Lifetime
- 2003-08-21 JP JP2004530687A patent/JP4682314B2/ja not_active Expired - Lifetime
- 2003-08-21 PT PT03792904T patent/PT1539783E/pt unknown
- 2003-08-21 BR BRPI0313664A patent/BRPI0313664B8/pt active IP Right Grant
- 2003-08-21 US US10/524,995 patent/US7553839B2/en not_active Expired - Lifetime
- 2003-08-21 KR KR1020057002959A patent/KR101081226B1/ko not_active Expired - Lifetime
- 2003-08-21 AT AT03792904T patent/ATE505474T1/de active
- 2003-08-21 SI SI200332011T patent/SI1539783T1/sl unknown
- 2003-08-21 WO PCT/NZ2003/000186 patent/WO2004018496A1/en not_active Ceased
- 2003-08-21 CN CNB038243547A patent/CN100379750C/zh not_active Expired - Lifetime
- 2003-08-21 RU RU2005107714/04A patent/RU2330042C2/ru active
-
2009
- 2009-06-03 US US12/455,537 patent/US8173662B2/en not_active Expired - Lifetime
-
2011
- 2011-07-12 CY CY20111100673T patent/CY1111700T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0313664B8 (pt) | 2021-05-25 |
| EP1539783A1 (de) | 2005-06-15 |
| CN100379750C (zh) | 2008-04-09 |
| AU2003258911B2 (en) | 2009-11-19 |
| KR20050093756A (ko) | 2005-09-23 |
| US20090239885A1 (en) | 2009-09-24 |
| HK1085219A1 (zh) | 2006-08-18 |
| JP4682314B2 (ja) | 2011-05-11 |
| DK1539783T3 (da) | 2011-06-20 |
| CA2496698A1 (en) | 2004-03-04 |
| BR0313664A (pt) | 2005-07-12 |
| CN1692120A (zh) | 2005-11-02 |
| US8173662B2 (en) | 2012-05-08 |
| RU2330042C2 (ru) | 2008-07-27 |
| JP2006501239A (ja) | 2006-01-12 |
| SI1539783T1 (sl) | 2011-08-31 |
| KR101081226B1 (ko) | 2011-11-07 |
| EP1539783B1 (de) | 2011-04-13 |
| AU2003258911A1 (en) | 2004-03-11 |
| CA2496698C (en) | 2012-01-24 |
| US20060160765A1 (en) | 2006-07-20 |
| RU2005107714A (ru) | 2006-01-20 |
| CY1111700T1 (el) | 2015-10-07 |
| PT1539783E (pt) | 2011-06-01 |
| US7553839B2 (en) | 2009-06-30 |
| BRPI0313664B1 (pt) | 2021-03-23 |
| EP1539783A4 (de) | 2010-05-19 |
| WO2004018496A1 (en) | 2004-03-04 |
| ES2363766T3 (es) | 2011-08-16 |
| ATE505474T1 (de) | 2011-04-15 |
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