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DE60330159D1 - Bittergeschmack-rezeptoren - Google Patents

Bittergeschmack-rezeptoren

Info

Publication number
DE60330159D1
DE60330159D1 DE60330159T DE60330159T DE60330159D1 DE 60330159 D1 DE60330159 D1 DE 60330159D1 DE 60330159 T DE60330159 T DE 60330159T DE 60330159 T DE60330159 T DE 60330159T DE 60330159 D1 DE60330159 D1 DE 60330159D1
Authority
DE
Germany
Prior art keywords
bitter taste
taste receptors
receptors
bitter
taste
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60330159T
Other languages
English (en)
Inventor
Bernd Bufe
Thomas Hofmann
Dietmar Krautwurst
Christina Kuhn
Wolfgang Meyerhof
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Deutsches Institut fuer Ernaehrungsforschung Potsdam Rehbruecke
Original Assignee
Deutsches Institut fuer Ernaehrungsforschung Potsdam Rehbruecke
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deutsches Institut fuer Ernaehrungsforschung Potsdam Rehbruecke filed Critical Deutsches Institut fuer Ernaehrungsforschung Potsdam Rehbruecke
Application granted granted Critical
Publication of DE60330159D1 publication Critical patent/DE60330159D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L27/00—Spices; Flavouring agents or condiments; Artificial sweetening agents; Table salts; Dietetic salt substitutes; Preparation or treatment thereof
    • A23L27/86—Addition of bitterness inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/04—Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Toxicology (AREA)
  • Polymers & Plastics (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • General Preparation And Processing Of Foods (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE60330159T 2002-09-25 2003-09-25 Bittergeschmack-rezeptoren Expired - Lifetime DE60330159D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41329802P 2002-09-25 2002-09-25
PCT/EP2003/010691 WO2004029087A2 (en) 2002-09-25 2003-09-25 Bitter taste receptors

Publications (1)

Publication Number Publication Date
DE60330159D1 true DE60330159D1 (de) 2009-12-31

Family

ID=32043229

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60330159T Expired - Lifetime DE60330159D1 (de) 2002-09-25 2003-09-25 Bittergeschmack-rezeptoren

Country Status (5)

Country Link
US (3) US7413867B2 (de)
EP (12) EP1543122B1 (de)
AU (1) AU2003267411A1 (de)
DE (1) DE60330159D1 (de)
WO (1) WO2004029087A2 (de)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2403003A1 (en) * 2000-04-07 2001-10-18 Senomyx, Inc. T2r taste receptors and genes encoding same
US8030008B2 (en) 2001-04-05 2011-10-04 Senomyx, Inc. Identification of bitter ligands that specifically activate human T2R receptors and related assays for identifying human bitter taste modulators
US7883856B2 (en) * 2001-04-05 2011-02-08 Senomyx Inc. Identification of bitter ligands that specifically activate human T2R receptors and related assays for identifying human bitter taste modulators
US7314725B2 (en) 2001-07-20 2008-01-01 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Phenylthiocarbamide (PTC) taste receptor
EP1644528A2 (de) 2003-06-19 2006-04-12 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, the Department of Health and Human Services, Varianten menschlicher geschmacksrezeptorgene
KR20070053659A (ko) 2004-04-20 2007-05-25 도이체스 인스티튜트 퓌어 에른에룬그스포슝 쓴맛 수용체의 작용제 및 그의 용도
EP1815015B1 (de) 2004-11-18 2012-05-23 Deutsches Institut für Ernährungsforschung Potsdam -Rehbrücke Stiftung des Öffentlichen Rechts Agonisten des bittergeschmacksrezeptors sowie deren verwendung
EP2064226A4 (de) 2006-09-05 2010-03-31 Senomyx Inc Neuartiger haplotyp des menschlichen t2r-rezeptors ht2r50 und seine verwendung in assays zur identifikation menschlicher modulatoren bitteren geschmacks
EP1975612A1 (de) * 2007-03-29 2008-10-01 Deutsches Institut für Ernährungsforschung Potsdam -Rehbrücke-Stiftung des öffentlichen Rechts- Vertreten durch den Stiftungsvorstand Agonisten von Bittergeschmackrezeptoren und ihre Verwendung
EP1975611A1 (de) 2007-03-29 2008-10-01 Deutsches Institut für Ernährungsforschung Potsdam -Rehbrücke-Stiftung des öffentlichen Rechts- Vertreten durch den Stiftungsvorstand Agonisten von Bittergeschmackrezeptoren und ihre Verwendung
US8409649B2 (en) 2007-03-30 2013-04-02 Givaudan S.A. Off-note blocking sensory organic compounds
EP2137322B1 (de) 2007-03-30 2013-02-27 Givaudan SA Verfahren zur identifizierung von tas2r modulatoren
EP1983342A1 (de) * 2007-04-18 2008-10-22 Deutsches Institut für Ernährungsforschung Potsdam -Rehbrücke-Stiftung des öffentlichen Rechts- Vertreten durch den Stiftungsvorstand Antagonisten von Bittergeschmacksrezeptoren und Verwendungen davon
KR20100122491A (ko) * 2008-02-01 2010-11-22 크로모셀 코포레이션 세포주 및 이의 제조 및 사용 방법
KR101751074B1 (ko) * 2009-02-02 2017-06-26 크로모셀 코포레이션 신규한 세포주와 방법
EP2460010A1 (de) * 2009-07-28 2012-06-06 Deutsches Institut für Ernährungsforschung Potsdam-Rehbrücke Agonisten und antagonisten des menschlichen bittergeschmacksrezeptors tasr49 und seine verwendung
CN106213416B (zh) 2010-04-15 2018-05-11 卓莫赛尔公司 用于减小或消除苦味的化合物、组合物和方法
WO2013022948A1 (en) 2011-08-08 2013-02-14 The Coca-Cola Company Cell lines comprising endogenous taste receptors and their uses
CN103998933B (zh) 2011-10-20 2016-12-14 卓莫赛尔公司 鉴定调节苦味的化合物的测定
NZ623729A (en) 2011-10-20 2016-09-30 Kraft Foods Group Brands Llc Compounds, compositions, and methods for reducing or eliminating bitter taste
WO2013072332A1 (en) 2011-11-14 2013-05-23 Givaudan Sa Methods of using antagonists of bitter taste receptors
EP2946208A1 (de) 2013-01-17 2015-11-25 Universität Wien Verfahren zur identifizierung von bittergeschmacksverbindungen und bittergeschmack-modulierende verbindungen
EP2767829A1 (de) 2013-02-18 2014-08-20 Universität Wien Verfahren zur Identifizierung von Bitterstoffen und bittermodulierenden Stoffen
US9169311B2 (en) 2013-03-15 2015-10-27 Applied Food Biotechnology, Inc. Feline bitter taste receptors and methods
BR112015023737A2 (pt) 2013-03-15 2017-10-24 Applied Food Biotech Inc polipeptídeo do receptor felino tas2r isolado (ftas2r), composição, polinucleotídeo isolado, par de iniciadores, vetor de expressão, célula hospedeira, cultura celular, oligonucleotídeo, anticorpo isolado ou um fragmento desse, método para identificar um composto que interage com um polipeptídeo do receptor felino tas2r, método para identificar um composto que modula um polipeptídeo do receptor felino tas2r, método para preparar uma composição comestível, método para formular uma composição comestível com palatabilidade intensificada, método para administrar um composto amargo a um animal que necessita desse, método para preparar uma composição comestível para controlar a palatabilidade da composição comestível para um animal, método para produzir uma composição de sabor para revestimento ou incorporação em uma composição comestível a ser administrada para um animal, e composição de sabor para revestimento ou incorporação em uma composição comestível a ser administrada para um animal
CN105358983B (zh) 2013-04-24 2018-08-03 卓莫赛尔公司 用于鉴定调节苦味的化合物的测定
US10301275B2 (en) 2017-03-17 2019-05-28 Altria Client Services Llc Sweet taste modulators
WO2023205647A1 (en) * 2022-04-19 2023-10-26 Firmenich Incorporated Reduction of bitter taste of active pharmaceutical ingredients and related assays and screening methods

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2384777A1 (en) * 1999-09-10 2001-03-15 Charles S. Zuker T2r taste receptor family
JP2003520033A (ja) * 1999-11-05 2003-07-02 ヒューマン ジノーム サイエンシーズ， インコーポレイテッド ２２個のヒト分泌タンパク質
CA2403003A1 (en) * 2000-04-07 2001-10-18 Senomyx, Inc. T2r taste receptors and genes encoding same
WO2002057309A1 (fr) * 2001-01-18 2002-07-25 Takeda Chemical Industries, Ltd. Nouvelle proteine receptrice couplee a la proteine g et adn de cette proteine
US7314725B2 (en) * 2001-07-20 2008-01-01 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Phenylthiocarbamide (PTC) taste receptor
JP2005522187A (ja) * 2001-10-12 2005-07-28 ザ レジェンツ オブ ザ ユニバーシティー オブ カリフォルニア サン ディエゴ 胃腸化学感覚受容体
EP1644528A2 (de) * 2003-06-19 2006-04-12 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, the Department of Health and Human Services, Varianten menschlicher geschmacksrezeptorgene

Also Published As

Publication number Publication date
EP2270153A3 (de) 2011-08-10
EP1543122B1 (de) 2009-11-18
EP2270156A3 (de) 2011-08-10
WO2004029087A2 (en) 2004-04-08
EP2270157A2 (de) 2011-01-05
US20060248602A1 (en) 2006-11-02
AU2003267411A8 (en) 2004-04-19
EP2267129A3 (de) 2011-08-03
EP2267128A3 (de) 2011-08-10
EP2272957A2 (de) 2011-01-12
WO2004029087A3 (en) 2004-07-01
EP2270154A2 (de) 2011-01-05
EP2163623A3 (de) 2010-05-26
US7413867B2 (en) 2008-08-19
EP2270158A3 (de) 2011-08-03
EP2267129A2 (de) 2010-12-29
US20080287364A1 (en) 2008-11-20
EP2163623A2 (de) 2010-03-17
EP2267130A3 (de) 2011-08-03
AU2003267411A1 (en) 2004-04-19
US8709737B2 (en) 2014-04-29
EP2267128A2 (de) 2010-12-29
EP2270153A2 (de) 2011-01-05
EP2270158A2 (de) 2011-01-05
EP2270156A2 (de) 2011-01-05
US7955808B2 (en) 2011-06-07
EP2267130A2 (de) 2010-12-29
US20110177085A1 (en) 2011-07-21
EP1543122A2 (de) 2005-06-22
EP2270155A3 (de) 2011-08-10
EP2270154A3 (de) 2011-08-10
EP2270155A2 (de) 2011-01-05
EP2267129B1 (de) 2015-03-25
EP2270157A3 (de) 2011-08-03
EP2272957A3 (de) 2011-08-03

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Legal Events

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