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DE60330407D1 - Synthese von Epothilonen, Zwischenprodukte davon, Analoga und ihre Verwendung - Google Patents

Synthese von Epothilonen, Zwischenprodukte davon, Analoga und ihre Verwendung

Info

Publication number
DE60330407D1
DE60330407D1 DE60330407T DE60330407T DE60330407D1 DE 60330407 D1 DE60330407 D1 DE 60330407D1 DE 60330407 T DE60330407 T DE 60330407T DE 60330407 T DE60330407 T DE 60330407T DE 60330407 D1 DE60330407 D1 DE 60330407D1
Authority
DE
Germany
Prior art keywords
epothilones
analogs
intermediates
synthesis
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60330407T
Other languages
English (en)
Inventor
Samuel J Danishefsky
Alexey Rivkin
Fumihiko Yoshimura
Ortega Ana Esther Gabarda
Young Shin Cho
Ting-Chao Chou
Huajin Dong
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Memorial Sloan Kettering Cancer Center
Original Assignee
Memorial Sloan Kettering Cancer Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/402,004 external-priority patent/US6921769B2/en
Priority claimed from US10/435,408 external-priority patent/US7649006B2/en
Application filed by Memorial Sloan Kettering Cancer Center filed Critical Memorial Sloan Kettering Cancer Center
Application granted granted Critical
Publication of DE60330407D1 publication Critical patent/DE60330407D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D419/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms
    • C07D419/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D419/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
DE60330407T 2002-08-23 2003-08-22 Synthese von Epothilonen, Zwischenprodukte davon, Analoga und ihre Verwendung Expired - Lifetime DE60330407D1 (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US40582302P 2002-08-23 2002-08-23
US40858902P 2002-09-06 2002-09-06
US42312902P 2002-11-01 2002-11-01
US45615903P 2003-03-20 2003-03-20
US10/402,004 US6921769B2 (en) 2002-08-23 2003-03-28 Synthesis of epothilones, intermediates thereto and analogues thereof
US10/435,408 US7649006B2 (en) 2002-08-23 2003-05-09 Synthesis of epothilones, intermediates thereto and analogues thereof
US49674103P 2003-08-21 2003-08-21

Publications (1)

Publication Number Publication Date
DE60330407D1 true DE60330407D1 (de) 2010-01-14

Family

ID=31950966

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60310916T Expired - Lifetime DE60310916T2 (de) 2002-08-23 2003-08-22 Synthese von epothilonen, zwischenprodukte dafür, analoga und deren verwendungen
DE60330407T Expired - Lifetime DE60330407D1 (de) 2002-08-23 2003-08-22 Synthese von Epothilonen, Zwischenprodukte davon, Analoga und ihre Verwendung

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE60310916T Expired - Lifetime DE60310916T2 (de) 2002-08-23 2003-08-22 Synthese von epothilonen, zwischenprodukte dafür, analoga und deren verwendungen

Country Status (18)

Country Link
US (1) US7875638B2 (de)
EP (3) EP2186811A1 (de)
JP (2) JP4791183B2 (de)
KR (1) KR101173510B1 (de)
CN (2) CN1759115A (de)
AT (2) ATE350383T1 (de)
AU (1) AU2003260002B2 (de)
CA (1) CA2496477C (de)
DE (2) DE60310916T2 (de)
DK (2) DK1506203T3 (de)
ES (2) ES2336937T3 (de)
IL (1) IL167046A (de)
MX (1) MXPA05002113A (de)
NZ (1) NZ538522A (de)
PH (1) PH12012501351A1 (de)
PT (2) PT1767535E (de)
SI (1) SI1767535T1 (de)
WO (1) WO2004018478A2 (de)

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CN106470705B (zh) 2014-08-08 2020-03-31 美国政府(由卫生和人类服务部的部长所代表) 在体内和在体外的靶标的光控移除
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US11505573B2 (en) 2018-03-28 2022-11-22 Hoffmann-La Roche Inc. Peptide macrocycles against Acinetobacter baumannii
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KR20220031054A (ko) 2019-07-02 2022-03-11 더 유나이티드 스테이츠 오브 어메리카, 애즈 리프리젠티드 바이 더 세크러테리, 디파트먼트 오브 헬쓰 앤드 휴먼 서비씨즈 Egfrviii에 결합하는 단일클론 항체 및 이의 용도
WO2021154705A1 (en) 2020-01-27 2021-08-05 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Rab13 and net1 antisense oligonucleotides to treat metastatic cancer
PE20231175A1 (es) 2020-11-19 2023-08-01 Kalivir Immunotherapeutics Inc Inmunoterapia oncolitica por remodelacion del microambiente tumoral
EP4284439A1 (de) 2021-01-29 2023-12-06 The United States of America, as represented by the Secretary, Department of Health and Human Services Nahinfrarot-photoimmuntherapie-kombinationstherapie (nir-pit) zur behandlung von krebs
IL308018B2 (en) 2021-04-30 2025-04-01 Kalivir Immunotherapeutics Inc Oncolytic viruses for altered MHC expression
US20240108579A1 (en) * 2021-12-31 2024-04-04 Chengdu Biostar Pharmaceuticals, Ltd. Utidelone liposome composition, and preparation method therefor and use thereof
WO2024006965A1 (en) 2022-06-30 2024-01-04 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Cd25-specific antibodies and uses thereof
WO2025014896A1 (en) 2023-07-07 2025-01-16 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Humanized 40h3 antibody

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US20090149516A1 (en) 2009-06-11
EP1506203B1 (de) 2007-01-03
DE60310916T2 (de) 2007-11-15
CN1759115A (zh) 2006-04-12
ATE350383T1 (de) 2007-01-15

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