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DE60329194D1 - Nachweis der rezeptoroligomerisierung - Google Patents

Nachweis der rezeptoroligomerisierung

Info

Publication number
DE60329194D1
DE60329194D1 DE60329194T DE60329194T DE60329194D1 DE 60329194 D1 DE60329194 D1 DE 60329194D1 DE 60329194 T DE60329194 T DE 60329194T DE 60329194 T DE60329194 T DE 60329194T DE 60329194 D1 DE60329194 D1 DE 60329194D1
Authority
DE
Germany
Prior art keywords
probes
binding
molecules
probe includes
cleaving
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60329194T
Other languages
English (en)
Inventor
Po-Ying Chan-Hui
Yining Shi
Sailaja Pidaparthi
Rajiv Dua
Sharat Singh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monogram Biosciences Inc
Original Assignee
Aclara Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aclara Biosciences Inc filed Critical Aclara Biosciences Inc
Application granted granted Critical
Publication of DE60329194D1 publication Critical patent/DE60329194D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566—Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
    • G01N33/542—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase with steric inhibition or signal modification, e.g. fluorescent quenching
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/71—Assays involving receptors, cell surface antigens or cell surface determinants for growth factors; for growth regulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72—Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/726—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Steroid Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE60329194T 2002-07-25 2003-07-17 Nachweis der rezeptoroligomerisierung Expired - Lifetime DE60329194D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39872402P 2002-07-25 2002-07-25
PCT/US2003/022611 WO2004011900A2 (en) 2002-07-25 2003-07-17 Detecting receptor oligomerization

Publications (1)

Publication Number Publication Date
DE60329194D1 true DE60329194D1 (de) 2009-10-22

Family

ID=31188464

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60329194T Expired - Lifetime DE60329194D1 (de) 2002-07-25 2003-07-17 Nachweis der rezeptoroligomerisierung

Country Status (13)

Country Link
US (2) US7105308B2 (de)
EP (1) EP1540347B1 (de)
JP (2) JP4443407B2 (de)
KR (1) KR20050025669A (de)
CN (1) CN1672054A (de)
AT (1) ATE442589T1 (de)
AU (1) AU2003259175B2 (de)
CA (1) CA2490654C (de)
DE (1) DE60329194D1 (de)
ES (1) ES2332310T3 (de)
NO (1) NO20050916L (de)
PL (1) PL374875A1 (de)
WO (1) WO2004011900A2 (de)

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US20040091850A1 (en) * 2002-11-08 2004-05-13 Travis Boone Single cell analysis of membrane molecules
US8017323B2 (en) * 2003-03-26 2011-09-13 President And Fellows Of Harvard College Free reactant use in nucleic acid-templated synthesis
AU2004225439A1 (en) 2003-04-01 2004-10-14 Monogram Biosciences, Inc. Intracellular complexes as biomarkers
CA2525286C (en) * 2003-05-20 2012-09-11 The University Court Of The University Of Glasgow Materials and methods relating to g-protein coupled receptor oligomers
US20100291594A1 (en) * 2003-07-17 2010-11-18 Laboratory Corporation Of America Holdings ErbB Surface Receptor Complexes as Biomarkers
US7402398B2 (en) 2003-07-17 2008-07-22 Monogram Biosciences, Inc. Measuring receptor homodimerization
WO2005019470A2 (en) 2003-08-11 2005-03-03 Monogram Biosciences, Inc. Detecting and profiling molecular complexes
EP1681983A4 (de) * 2003-10-14 2008-12-10 Monogram Biosciences Inc Rezeptor-tyrosin-kinase-signalpfad-analyse für diagnose und therapie
US8282921B2 (en) 2004-08-02 2012-10-09 Paul Glidden tRNA synthetase fragments
US7939267B2 (en) 2004-11-04 2011-05-10 Laboratory Corporation Of America Holdings Detection of activation of endothelial cells as surrogate marker for angiogenesis
US20060204999A1 (en) * 2005-03-14 2006-09-14 Stephen Macevicz Detecting molecular complexes
AR056857A1 (es) 2005-12-30 2007-10-24 U3 Pharma Ag Anticuerpos dirigidos hacia her-3 (receptor del factor de crecimiento epidérmico humano-3) y sus usos
WO2008064884A1 (en) 2006-11-28 2008-06-05 U3 Pharma Gmbh Activated her3 as a marker for predicting therapeutic efficacy
CA2706763C (en) 2007-11-27 2013-07-30 Laboratory Corporation Of America Holdings Enhanced method for detecting and/or quantifying an analyte in a sample
US10416162B2 (en) 2007-12-20 2019-09-17 Monogram Biosciences, Inc. Her2 diagnostic methods
EP2438442B1 (de) 2008-12-01 2017-08-09 Laboratory Corporation of America Holdings Verfahren und tests zur messung von p95 und/oder p95-komlexen in einer probe und für p95 spezifische antikörper
EP2387717B1 (de) * 2009-01-15 2014-12-10 Laboratory Corporation of America Holdings Verfahren zur bestimmung von patientenreaktionen durch messung der her-2-expression
JP5746051B2 (ja) 2009-01-15 2015-07-08 ラボラトリー コーポレイション オブ アメリカ ホールディングス Ｈｅｒ−３の測定による患者の反応を判定する方法
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TW201302793A (zh) 2010-09-03 2013-01-16 Glaxo Group Ltd 新穎之抗原結合蛋白
SG194609A1 (en) 2011-05-19 2013-12-30 Lab Corp America Holdings Methods for determining the likelihood of survival and for predicting likelihood of metastasis in cancer patients
US9442098B2 (en) * 2012-08-02 2016-09-13 Waters Technologies Corporation Chromatographic system quality control reference materials
CN103012193B (zh) * 2012-12-14 2015-08-19 无锡中德伯尔生物技术有限公司 隐色孔雀石绿半抗原、人工抗原及制备方法
JP6402173B2 (ja) * 2013-04-05 2018-10-10 ラボラトリー コーポレイション オブ アメリカ ホールディングス Ｈｅｒ３の検出に基づく癌の診断、予後予測、および処置を容易にするためのシステムおよび方法
WO2015038799A1 (en) * 2013-09-11 2015-03-19 Moy Ronald L Systems and methods for the molecular quantification of skin damage in skin
CN104458708A (zh) * 2013-09-12 2015-03-25 中国药科大学 一种筛选乙酰胆碱酯酶抑制剂高通量筛选方法
EP3050886A1 (de) * 2015-02-02 2016-08-03 Bürkert Werke GmbH Fluoreszenzfarbstoffe und Farbstoffvorläufer
JP2019515252A (ja) 2016-03-15 2019-06-06 ラボラトリー コーポレイション オブ アメリカ ホールディングス 細胞間のタンパク質相互作用を評価する方法
CN105891347B (zh) * 2016-03-18 2018-02-13 宁波大学 一种胶束电动毛细管电泳法测定γ‑氨基丁酸含量的方法
EP3736324A1 (de) 2016-09-30 2020-11-11 The Governing Council Of The University Of Toronto System zur identifizierung und zum targeting einzelner zellen in einer heterogenen population zur selektiven extraktion von zellgehalt
CN111276385B (zh) * 2020-02-13 2020-12-08 清华大学 质谱仪的离子激发检测方法
JP7686748B2 (ja) 2020-09-28 2025-06-02 メルス ナムローゼ フェンノートシャップ 細胞表面部分の発現又はクラスター化を検出するための方法

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Also Published As

Publication number Publication date
AU2003259175A1 (en) 2004-02-16
JP2009271087A (ja) 2009-11-19
US20040126818A1 (en) 2004-07-01
US20040197835A1 (en) 2004-10-07
JP4443407B2 (ja) 2010-03-31
US7105308B2 (en) 2006-09-12
ATE442589T1 (de) 2009-09-15
AU2003259175B2 (en) 2010-08-12
ES2332310T3 (es) 2010-02-02
CA2490654C (en) 2012-02-07
EP1540347B1 (de) 2009-09-09
CN1672054A (zh) 2005-09-21
EP1540347A2 (de) 2005-06-15
KR20050025669A (ko) 2005-03-14
PL374875A1 (en) 2005-11-14
EP1540347A4 (de) 2006-09-20
WO2004011900A3 (en) 2004-06-10
US7135300B2 (en) 2006-11-14
JP2005534030A (ja) 2005-11-10
NO20050916L (no) 2005-04-14
WO2004011900A2 (en) 2004-02-05
CA2490654A1 (en) 2004-02-05

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Legal Events

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8327 Change in the person/name/address of the patent owner

Owner name: MONOGRAM BIOSCIENCES, INC. (N. D. GES. D. STAA, US