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DE60323766D1 - En konjugate mit biomolekülen für fluoreszenzdiagnose - Google Patents

En konjugate mit biomolekülen für fluoreszenzdiagnose

Info

Publication number
DE60323766D1
DE60323766D1 DE60323766T DE60323766T DE60323766D1 DE 60323766 D1 DE60323766 D1 DE 60323766D1 DE 60323766 T DE60323766 T DE 60323766T DE 60323766 T DE60323766 T DE 60323766T DE 60323766 D1 DE60323766 D1 DE 60323766D1
Authority
DE
Germany
Prior art keywords
dyes
biomolecules
conjugates
relates
fluorescent diagnosis
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60323766T
Other languages
English (en)
Inventor
Kai Licha
Christin Perlitz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Bayer Schering Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2003102787 external-priority patent/DE10302787A1/de
Application filed by Bayer Schering Pharma AG filed Critical Bayer Schering Pharma AG
Application granted granted Critical
Publication of DE60323766D1 publication Critical patent/DE60323766D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0008—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0008—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain
    • C09B23/0025—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain the substituent being bound through an oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0008—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain
    • C09B23/005—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain the substituent being a COOH and/or a functional derivative thereof
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0066—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain being part of a carbocyclic ring,(e.g. benzene, naphtalene, cyclohexene, cyclobutenene-quadratic acid)
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
    • C09B23/086—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines more than five >CH- groups
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/531—Production of immunochemical test materials
    • G01N33/532—Production of labelled immunochemicals
    • G01N33/533—Production of labelled immunochemicals with fluorescent label
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
DE60323766T 2003-01-24 2003-11-14 En konjugate mit biomolekülen für fluoreszenzdiagnose Expired - Fee Related DE60323766D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE2003102787 DE10302787A1 (de) 2003-01-24 2003-01-24 Hydrophile, Thiol-reaktive Cyaninfarbstoffe und deren Konjugate mit Biomolekülen für die Fluoreszenzdiagnostik
US44319703P 2003-01-29 2003-01-29
PCT/EP2003/012735 WO2004065491A1 (en) 2003-01-24 2003-11-14 Hydrophilic, thiol-reactive cyanine dyes and conjugates thereof with biomolecules for fluorescence diagnosis

Publications (1)

Publication Number Publication Date
DE60323766D1 true DE60323766D1 (de) 2008-11-06

Family

ID=32773159

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60323766T Expired - Fee Related DE60323766D1 (de) 2003-01-24 2003-11-14 En konjugate mit biomolekülen für fluoreszenzdiagnose

Country Status (17)

Country Link
US (1) US20040260072A1 (de)
EP (1) EP1585791B1 (de)
JP (1) JP2006513293A (de)
KR (1) KR20050103907A (de)
AT (1) ATE409209T1 (de)
AU (1) AU2003292019A1 (de)
BR (1) BR0318028A (de)
CA (1) CA2514131A1 (de)
CR (1) CR7925A (de)
DE (1) DE60323766D1 (de)
EA (1) EA009386B1 (de)
EC (1) ECSP055975A (de)
ES (1) ES2311736T3 (de)
MX (1) MXPA05007668A (de)
NZ (1) NZ541414A (de)
PL (1) PL376459A1 (de)
WO (1) WO2004065491A1 (de)

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US7597878B2 (en) * 2000-09-19 2009-10-06 Li-Cor, Inc. Optical fluorescent imaging
ATE374367T1 (de) * 2004-07-22 2007-10-15 Bayer Schering Pharma Ag Verwendung von cyanin-farbstoffen zur diagnose von krankheiten, welche mit angiogenese assoziert sind
EP1679082A1 (de) * 2005-01-07 2006-07-12 Schering AG Benutzung von Cyaninfarbstoffen für die Diagnose von proliferierenden Krankheiten
FR2889700B1 (fr) 2005-08-11 2012-11-23 Synthinnove Lab Marqueurs, leur procede de fabrication et leurs applications
EP1760467A1 (de) * 2005-09-02 2007-03-07 Schering AG Optisch fluoreszierende Nanopartikel
ES2606333T3 (es) 2005-11-28 2017-03-23 Dako Denmark A/S Colorantes de cianina y métodos para detectar una diana usando dichos colorantes
JPWO2007091661A1 (ja) * 2006-02-08 2009-07-02 独立行政法人産業技術総合研究所 分子イメージングに適した糖鎖修飾リポソームならびにその利用および製造
EP2118206B9 (de) 2007-02-09 2018-08-29 Visen Medical, Inc. Polycyclofarbstoffe und verwendung davon
WO2009023813A1 (en) * 2007-08-15 2009-02-19 Applied Soil Water Technologies Llc Metals recovery from mining heap leach ore
US20090214436A1 (en) 2008-02-18 2009-08-27 Washington University Dichromic fluorescent compounds
KR101043407B1 (ko) * 2009-02-19 2011-06-22 한국과학기술연구원 암 표적성이 우수한 단백질 복합체 및 이의 제조방법
JP2011046663A (ja) 2009-08-28 2011-03-10 Fujifilm Corp 近赤外蛍光造影剤
KR101228147B1 (ko) * 2010-08-13 2013-01-31 국립암센터 방사성 동위원소가 표지되고 근적외선 영역의 형광색소 및 가시광선 영역의 색소가 결합된 알부민을 포함하는 감시림프절 표지자
WO2012054749A1 (en) 2010-10-20 2012-04-26 Li-Cor, Inc. Cyanine dyes and their conjugates
EP3029027B1 (de) 2010-12-21 2018-06-27 Pierce Biotechnology, Inc. Fluoreszierende verbindungen
US8889884B1 (en) 2011-07-14 2014-11-18 Pierce Biotechnology, Inc. Phosphine derivatives of fluorescent compounds
US9249307B2 (en) 2011-08-16 2016-02-02 Pierce Biotechnology, Inc. Benzocyanine compounds
CA2847887A1 (en) * 2011-09-23 2013-03-28 Li-Cor, Inc. Application of reduced dyes in imaging
EP3553075B1 (de) 2012-01-23 2025-01-08 Washington University Brillenbildgebungssysteme und -verfahren
US9751868B2 (en) 2012-02-28 2017-09-05 Pierce Biotechnology, Inc. Benzocyanine compounds
US20140072515A9 (en) 2012-03-02 2014-03-13 Greg Hermanson Cyanine compounds
JP6101782B2 (ja) 2012-03-27 2017-03-22 ヴェンタナ メディカル システムズ， インク． シグナリングコンジュゲート及び使用法
US9676787B2 (en) 2012-08-28 2017-06-13 Pierce Biotechnology, Inc. Benzopyrylium compounds
US10442836B2 (en) 2013-08-12 2019-10-15 Genentech, Inc. 1-(chloromethyl)-2,3-dihydro-1H-benzo[E]indole dimer antibody-drug conjugate compounds, and methods of use and treatment
JP6980384B2 (ja) 2013-12-16 2021-12-15 ジェネンテック， インコーポレイテッド １−（クロロメチル）−２，３−ジヒドロ−１ｈ−ベンゾ［ｅ］インドール二量体抗体−薬物コンジュゲート化合物、並びに使用及び処置の方法
PE20170935A1 (es) 2014-09-12 2017-07-13 Genentech Inc Anticuerpos anti-her2 e inmunoconjugados
EP3001197A1 (de) * 2014-09-23 2016-03-30 Universität Heidelberg Fluoreszenzproteinflecken
US10806804B2 (en) 2015-05-06 2020-10-20 Washington University Compounds having RD targeting motifs and methods of use thereof
JP6752582B2 (ja) * 2016-02-08 2020-09-09 キヤノン株式会社 光音響イメージング用造影剤
EP3646032B1 (de) * 2017-06-27 2024-08-07 Coriolis Pharma Research GmbH Quantifizierung von polysorbate
CN107955392B (zh) * 2017-12-05 2019-04-16 大连理工大学 一类具有长寿命三重激发态的近红外氨基菁染料及其制备方法
CN108624081B (zh) 2018-05-29 2020-03-10 苏州百源基因技术有限公司 一种荧光染料及其制备方法与应用
EP4072598A4 (de) 2019-12-13 2024-02-21 Washington University Nahinfrarot-fluoreszierende farbstoffe, formulierungen und zugehörige verfahren
CA3167456A1 (en) * 2020-02-10 2021-08-19 C-Biomex Co., Ltd. Amphoteric fluorescent substance capable of being attached to biomaterials
CN116209722B (zh) 2020-06-23 2025-06-27 伯拉考成像股份公司 近红外花青染料及其缀合物
CN117460789A (zh) * 2021-06-18 2024-01-26 富士胶片株式会社 化合物及使用了该化合物的标记生物物质
JPWO2022265043A1 (de) * 2021-06-18 2022-12-22

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DE4445065A1 (de) * 1994-12-07 1996-06-13 Diagnostikforschung Inst Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung
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WO2002038190A2 (en) * 2000-10-27 2002-05-16 Beth Israel Deaconess Medical Center Non-isotopic detection of osteoblastic activity in vivo using modified bisphosphonates
US20040022731A1 (en) * 2002-04-26 2004-02-05 Alexei Bogdanov In vivo imaging of apoptosis

Also Published As

Publication number Publication date
MXPA05007668A (es) 2005-09-30
ECSP055975A (es) 2006-01-16
EA200501064A1 (ru) 2006-02-24
CR7925A (es) 2006-02-06
EP1585791B1 (de) 2008-09-24
US20040260072A1 (en) 2004-12-23
ATE409209T1 (de) 2008-10-15
EP1585791A1 (de) 2005-10-19
JP2006513293A (ja) 2006-04-20
EA009386B1 (ru) 2007-12-28
WO2004065491A1 (en) 2004-08-05
KR20050103907A (ko) 2005-11-01
BR0318028A (pt) 2005-12-06
AU2003292019A1 (en) 2004-08-13
CA2514131A1 (en) 2004-08-05
NZ541414A (en) 2007-12-21
PL376459A1 (en) 2005-12-27
ES2311736T3 (es) 2009-02-16

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