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DE60310564D1 - Injizierbare depotformulierung enthaltend iloperidonkrystalle - Google Patents

Injizierbare depotformulierung enthaltend iloperidonkrystalle

Info

Publication number
DE60310564D1
DE60310564D1 DE60310564T DE60310564T DE60310564D1 DE 60310564 D1 DE60310564 D1 DE 60310564D1 DE 60310564 T DE60310564 T DE 60310564T DE 60310564 T DE60310564 T DE 60310564T DE 60310564 D1 DE60310564 D1 DE 60310564D1
Authority
DE
Germany
Prior art keywords
crystals
injectable depot
depot formulation
formulation containing
size
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60310564T
Other languages
English (en)
Other versions
DE60310564T2 (de
Inventor
Dierk Wieckhusen
Alexandra Glausch
Markus Ahlheim
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9940486&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60310564(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis AG filed Critical Novartis AG
Publication of DE60310564D1 publication Critical patent/DE60310564D1/de
Application granted granted Critical
Publication of DE60310564T2 publication Critical patent/DE60310564T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Psychiatry (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE60310564T 2002-07-15 2003-07-14 Injizierbare depotformulierung enthaltend iloperidonkrystalle Expired - Lifetime DE60310564T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0216416.8A GB0216416D0 (en) 2002-07-15 2002-07-15 Organic compounds
GB0216416 2002-07-15
PCT/EP2003/007619 WO2004006886A2 (en) 2002-07-15 2003-07-14 Injectable depot formulation comprising crystals of iloperidone

Publications (2)

Publication Number Publication Date
DE60310564D1 true DE60310564D1 (de) 2007-02-01
DE60310564T2 DE60310564T2 (de) 2007-10-04

Family

ID=9940486

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60310564T Expired - Lifetime DE60310564T2 (de) 2002-07-15 2003-07-14 Injizierbare depotformulierung enthaltend iloperidonkrystalle

Country Status (15)

Country Link
US (5) US20050250813A1 (de)
EP (1) EP1523335B1 (de)
JP (2) JP5392961B2 (de)
AT (1) ATE348635T1 (de)
AU (1) AU2003281154B2 (de)
CA (1) CA2492467C (de)
CY (1) CY1106305T1 (de)
DE (1) DE60310564T2 (de)
DK (1) DK1523335T3 (de)
ES (1) ES2279153T3 (de)
GB (1) GB0216416D0 (de)
NZ (1) NZ537598A (de)
PT (1) PT1523335E (de)
WO (1) WO2004006886A2 (de)
ZA (1) ZA200410323B (de)

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CA2582022C (en) 2004-09-30 2021-05-18 Vanda Pharmaceuticals, Inc. Methods for the administration of iloperidone
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US11918557B2 (en) 2012-01-26 2024-03-05 Vanda Pharmaceuticals Inc. Treatment of circadian rhythm disorders
CN102659771B (zh) * 2012-04-18 2013-11-27 吉林三善恩科技开发有限公司 一种伊潘立酮药物共晶及其制备方法
CN102633786B (zh) * 2012-04-18 2013-11-27 吉林三善恩科技开发有限公司 一种伊潘立酮药物共晶及其制备方法
KR101891299B1 (ko) 2012-05-18 2018-08-23 반다 파마슈티칼즈, 인코퍼레이티드. (1ｒ-트랜스)-ｎ-[[2-(2,3-디하이드로-4-벤조푸라닐)시클로프로필]메틸]프로판아미드의 대사 산물
EP3767297A1 (de) 2012-12-18 2021-01-20 Vanda Pharmaceuticals Inc. Behandlung von zirkadianen rhythmusstörungen
BR112015021870A2 (pt) * 2013-03-15 2017-07-18 Inotek Pharmaceuticals Corp formulações oftálmicas
US10376487B2 (en) 2013-11-12 2019-08-13 Vanda Pharmaceuticals Inc. Method of treatment
US11090285B2 (en) 2013-11-12 2021-08-17 Vanda Pharmaceuticals Inc Treatment of circadian rhythm disorders
CN103599074A (zh) * 2013-11-26 2014-02-26 重庆医药工业研究院有限责任公司 一种伊潘立酮缓释微球及其制备方法
CN116211857A (zh) 2015-02-17 2023-06-06 万达制药公司 用于治疗精神分裂症的伊潘立酮
US11071728B2 (en) 2015-12-11 2021-07-27 Vanda Pharmaceuticals Inc. Treatment of schizophrenia
CN106831741B (zh) * 2016-12-28 2019-08-23 北京医药集团有限责任公司 一种伊潘立酮超细粉体的制备方法
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US20200171018A1 (en) * 2018-12-04 2020-06-04 Vanda Pharmaceuticals Inc. Depot administration of iloperidone
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Also Published As

Publication number Publication date
AU2003281154B2 (en) 2006-10-12
GB0216416D0 (en) 2002-08-21
AU2003281154A1 (en) 2004-02-02
EP1523335B1 (de) 2006-12-20
US8227488B2 (en) 2012-07-24
JP2005533093A (ja) 2005-11-04
US20110212141A1 (en) 2011-09-01
DE60310564T2 (de) 2007-10-04
CY1106305T1 (el) 2011-10-12
WO2004006886A3 (en) 2004-02-19
ZA200410323B (en) 2006-06-28
EP1523335A2 (de) 2005-04-20
DK1523335T3 (da) 2007-01-29
NZ537598A (en) 2006-07-28
CA2492467C (en) 2010-03-16
ES2279153T3 (es) 2007-08-16
HK1076029A1 (en) 2006-01-06
US8614232B2 (en) 2013-12-24
JP2011016849A (ja) 2011-01-27
JP5670698B2 (ja) 2015-02-18
US8293765B2 (en) 2012-10-23
WO2004006886A2 (en) 2004-01-22
ATE348635T1 (de) 2007-01-15
JP5392961B2 (ja) 2014-01-22
CA2492467A1 (en) 2004-01-22
US20120156264A1 (en) 2012-06-21
US20050250813A1 (en) 2005-11-10
US20130012542A1 (en) 2013-01-10
PT1523335E (pt) 2007-02-28
US20090099232A1 (en) 2009-04-16

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8363 Opposition against the patent