DE602004016162D1 - Indol-derivate, die durch einen thiazol ring substoren - Google Patents
Indol-derivate, die durch einen thiazol ring substorenInfo
- Publication number
- DE602004016162D1 DE602004016162D1 DE602004016162T DE602004016162T DE602004016162D1 DE 602004016162 D1 DE602004016162 D1 DE 602004016162D1 DE 602004016162 T DE602004016162 T DE 602004016162T DE 602004016162 T DE602004016162 T DE 602004016162T DE 602004016162 D1 DE602004016162 D1 DE 602004016162D1
- Authority
- DE
- Germany
- Prior art keywords
- sup
- substores
- indol derivatives
- thiazol ring
- thiazol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical class C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 title 1
- FZWLAAWBMGSTSO-UHFFFAOYSA-N Thiazole Chemical group C1=CSC=N1 FZWLAAWBMGSTSO-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 102000023984 PPAR alpha Human genes 0.000 abstract 1
- 108010015181 PPAR delta Proteins 0.000 abstract 1
- 239000000556 agonist Substances 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 108091008725 peroxisome proliferator-activated receptors alpha Proteins 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Biomedical Technology (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Child & Adolescent Psychology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Reproductive Health (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03014476 | 2003-07-02 | ||
| EP04100157 | 2004-01-20 | ||
| PCT/EP2004/006924 WO2005005423A1 (en) | 2003-07-02 | 2004-06-25 | Indolyl derivatives substituted with a thiazole ring and their use as ppar modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602004016162D1 true DE602004016162D1 (de) | 2008-10-09 |
Family
ID=33553804
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004016162T Expired - Lifetime DE602004016162D1 (de) | 2003-07-02 | 2004-06-25 | Indol-derivate, die durch einen thiazol ring substoren |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7235572B2 (de) |
| EP (1) | EP1644368B1 (de) |
| JP (1) | JP4627298B2 (de) |
| KR (1) | KR100796093B1 (de) |
| CN (1) | CN1816550B (de) |
| AT (1) | ATE406369T1 (de) |
| AU (1) | AU2004255580B2 (de) |
| BR (1) | BRPI0412236A (de) |
| CA (1) | CA2530452C (de) |
| DE (1) | DE602004016162D1 (de) |
| ES (1) | ES2313022T3 (de) |
| MX (1) | MXPA06000235A (de) |
| RU (1) | RU2344135C2 (de) |
| WO (1) | WO2005005423A1 (de) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005060958A1 (en) * | 2003-12-19 | 2005-07-07 | Kalypsys, Inc. | (5- (2-phenyl)-thiazol-5-ylmethoxy)-indol-1-yl) -acetic acid derivatives and related compounds as modulators of the human ppar-delta receptor for the treatment of metabolic disorders such as type 2 diabetes |
| KR100989093B1 (ko) | 2008-01-18 | 2010-10-25 | 한화제약주식회사 | 생강나무 가지의 추출물을 포함하는 심혈관계 질환의 예방 및 치료용 조성물 |
| US9227969B2 (en) | 2013-08-14 | 2016-01-05 | Novartis Ag | Compounds and compositions as inhibitors of MEK |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1299176C (en) | 1985-07-02 | 1992-04-21 | Guy Dominic Diana | Process for preparing isoxazole and furan derivatives |
| SK280914B6 (sk) * | 1994-03-08 | 2000-09-12 | American Home Products Corporation | Tiazolidíndiónové deriváty, farmaceutický prostriedok s ich obsahom a ich použitie |
| GB9604242D0 (en) | 1996-02-28 | 1996-05-01 | Glaxo Wellcome Inc | Chemical compounds |
| US6531609B2 (en) | 2000-04-14 | 2003-03-11 | Hoffmann-La Roche Inc. | Process for the preparation of thiazolidinedione derivatives |
| GB0024362D0 (en) | 2000-10-05 | 2000-11-22 | Glaxo Group Ltd | Medicaments |
| AU2002211901A1 (en) * | 2000-10-10 | 2002-04-22 | Smithkline Beecham Corporation | Substituted indoles, pharmaceutical compositions containing such indoles and their use as PPAR-gamma binding agents |
| GB0031107D0 (en) | 2000-12-20 | 2001-01-31 | Glaxo Group Ltd | Chemical compounds |
| EP1405848B1 (de) * | 2001-06-18 | 2008-05-07 | Ono Pharmaceutical Co., Ltd. | Tetrahydrochinolinderivatverbindung und die verbindung als wirkstoff enthaltendes arzneimittel |
| PL369569A1 (en) * | 2001-08-29 | 2005-05-02 | Warner-Lambert Company Llc | Oral antidiabetic agents |
| US6867224B2 (en) * | 2002-03-07 | 2005-03-15 | Warner-Lambert Company | Compounds that modulate PPAR activity and methods of preparation |
| EP1581521A1 (de) * | 2003-01-06 | 2005-10-05 | Eli Lilly And Company | Kondensierte heterocyclische verbindungen als ppar modulatoren |
| BRPI0416238A (pt) * | 2003-11-05 | 2007-01-02 | Hoffmann La Roche | compostos, processo para a sua preparação, composição farmacêutica que compreende os mesmos, uso dos compostos e métodos para o tratamento e/ou a prevenção de doenças que são moduladas por ppar(delta) e/ou agonistas ppar(alfa) |
-
2004
- 2004-06-25 ES ES04740332T patent/ES2313022T3/es not_active Expired - Lifetime
- 2004-06-25 DE DE602004016162T patent/DE602004016162D1/de not_active Expired - Lifetime
- 2004-06-25 WO PCT/EP2004/006924 patent/WO2005005423A1/en not_active Ceased
- 2004-06-25 RU RU2006102866/04A patent/RU2344135C2/ru not_active IP Right Cessation
- 2004-06-25 BR BRPI0412236-4A patent/BRPI0412236A/pt not_active IP Right Cessation
- 2004-06-25 JP JP2006518042A patent/JP4627298B2/ja not_active Expired - Fee Related
- 2004-06-25 KR KR1020057025397A patent/KR100796093B1/ko not_active Expired - Fee Related
- 2004-06-25 MX MXPA06000235A patent/MXPA06000235A/es active IP Right Grant
- 2004-06-25 AU AU2004255580A patent/AU2004255580B2/en not_active Ceased
- 2004-06-25 CN CN2004800188566A patent/CN1816550B/zh not_active Expired - Fee Related
- 2004-06-25 EP EP04740332A patent/EP1644368B1/de not_active Expired - Lifetime
- 2004-06-25 CA CA2530452A patent/CA2530452C/en not_active Expired - Fee Related
- 2004-06-25 AT AT04740332T patent/ATE406369T1/de active
- 2004-06-28 US US10/878,473 patent/US7235572B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP4627298B2 (ja) | 2011-02-09 |
| ATE406369T1 (de) | 2008-09-15 |
| EP1644368A1 (de) | 2006-04-12 |
| AU2004255580B2 (en) | 2009-10-08 |
| CA2530452A1 (en) | 2005-01-20 |
| BRPI0412236A (pt) | 2006-09-12 |
| JP2009501693A (ja) | 2009-01-22 |
| CA2530452C (en) | 2011-07-26 |
| AU2004255580A1 (en) | 2005-01-20 |
| US20050004187A1 (en) | 2005-01-06 |
| EP1644368B1 (de) | 2008-08-27 |
| ES2313022T3 (es) | 2009-03-01 |
| KR100796093B1 (ko) | 2008-01-21 |
| WO2005005423A1 (en) | 2005-01-20 |
| CN1816550A (zh) | 2006-08-09 |
| US7235572B2 (en) | 2007-06-26 |
| RU2344135C2 (ru) | 2009-01-20 |
| RU2006102866A (ru) | 2007-08-20 |
| CN1816550B (zh) | 2010-04-28 |
| MXPA06000235A (es) | 2006-04-11 |
| KR20060027830A (ko) | 2006-03-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |