DE60135862D1 - Aliphatische stickstoffhaltige fünfgliedrige ringverbindungen - Google Patents

Aliphatische stickstoffhaltige fünfgliedrige ringverbindungen

Info

Publication number: DE60135862D1
Authority: DE; Germany
Prior art keywords: alk; con; aliphatic nitrogen; ring compounds; group
Prior art date: 2000-10-06
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60135862T

Other languages

English (en)

Inventor

Kosuke Yasuda

Hiroshi Morimoto

Saburo Kawanami

Masataka Hikota

Takeshi Matsumoto

Kenji Arakawa

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Mitsubishi Tanabe Pharma Corp

Original Assignee

Mitsubishi Tanabe Pharma Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-10-06

Filing date

2001-10-05

Publication date

2008-10-30

2001-10-05 Application filed by Mitsubishi Tanabe Pharma Corp filed Critical Mitsubishi Tanabe Pharma Corp

2008-10-30 Application granted granted Critical

2008-10-30 Publication of DE60135862D1 publication Critical patent/DE60135862D1/de

2021-10-06 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
- C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/40—2,5-Pyrrolidine-diones
- C07D207/416—2,5-Pyrrolidine-diones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Obesity (AREA)
Endocrinology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Hydrogenated Pyridines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Peptides Or Proteins (AREA)
Investigating Or Analysing Biological Materials (AREA)
Glass Compositions (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

DE60135862T 2000-10-06 2001-10-05 Aliphatische stickstoffhaltige fünfgliedrige ringverbindungen Expired - Lifetime DE60135862D1 (de)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
JP2000308528		2000-10-06
JP2000312562		2000-10-12
JP2001099251		2001-03-30
PCT/JP2001/008803 WO2002030891A1 (en)	2000-10-06	2001-10-05	Aliphatic nitrogenous five-membered ring compounds

Publications (1)

Publication Number	Publication Date
DE60135862D1 true DE60135862D1 (de)	2008-10-30

Family

ID=27344889

Family Applications (2)

Application Number	Title	Priority Date	Filing Date
DE60135862T Expired - Lifetime DE60135862D1 (de)	2000-10-06	2001-10-05	Aliphatische stickstoffhaltige fünfgliedrige ringverbindungen
DE60135764T Expired - Lifetime DE60135764D1 (de)	2000-10-06	2001-10-05	Stickstoffhaltige, fünfgliedrige ringverbindungen

Family Applications After (1)

Application Number	Title	Priority Date	Filing Date
DE60135764T Expired - Lifetime DE60135764D1 (de)	2000-10-06	2001-10-05	Stickstoffhaltige, fünfgliedrige ringverbindungen

Country Status (20)

Country	Link
US (5)	US7138397B2 (de)
EP (2)	EP1323710B1 (de)
KR (2)	KR100526091B1 (de)
CN (2)	CN1280269C (de)
AT (2)	ATE407924T1 (de)
AU (4)	AU2001294196B2 (de)
BR (1)	BR0114436A (de)
CA (2)	CA2424964C (de)
DE (2)	DE60135862D1 (de)
DK (2)	DK1323710T3 (de)
ES (2)	ES2312471T3 (de)
HU (1)	HUP0303391A3 (de)
IL (2)	IL154893A0 (de)
MX (2)	MXPA03003006A (de)
NO (1)	NO324519B1 (de)
NZ (2)	NZ524974A (de)
PL (1)	PL362545A1 (de)
PT (2)	PT1323710E (de)
TW (1)	TWI290919B (de)
WO (2)	WO2002030891A1 (de)

Families Citing this family (124)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10123163A1 (de) *	2001-05-09	2003-01-16	Gruenenthal Gmbh	Substituierte Cyclohexan-1,4-diaminderivate
US7196201B2 (en)	2001-06-27	2007-03-27	Smithkline Beecham Corporation	Pyrrolidines as dipeptidyl peptidase inhibitors
US7183290B2 (en)	2001-06-27	2007-02-27	Smithkline Beecham Corporation	Fluoropyrrolidines as dipeptidyl peptidase inhibitors
ES2296979T3 (es)	2001-06-27	2008-05-01	Smithkline Beecham Corporation	Fluoropirrolidinas como inhibidores de dipeptidil peptidasa.
US6861440B2 (en) *	2001-10-26	2005-03-01	Hoffmann-La Roche Inc.	DPP IV inhibitors
DE60304911D1 (de)	2002-02-25	2006-06-08	Eisai Co Ltd	Xanthin-Derivate als DPP-IV-Inhibitoren
DE60217186T2 (de) *	2002-02-28	2007-09-27	Prosidion Ltd.	Dpiv-inhibitoren auf glutaminbasis
HUP0200849A2 (hu) *	2002-03-06	2004-08-30	Sanofi-Synthelabo	N-aminoacetil-2-ciano-pirrolidin-származékok, e vegyületeket tartalmazó gyógyszerkészítmények és eljárás előállításukra
DE10213051B4 (de) *	2002-03-23	2013-03-07	Grünenthal GmbH	Substituierte 4-Aminocyclohexanole
HUP0202001A2 (hu) *	2002-06-14	2005-08-29	Sanofi-Aventis	DDP-IV gátló hatású azabiciklooktán- és nonánszármazékok
AU2003248259A1 (en) *	2002-07-10	2004-02-02	Yamanouchi Pharmaceutical Co., Ltd.	Novel azetidine derivative or salt thereof
TW200401635A (en)	2002-07-23	2004-02-01	Yamanouchi Pharma Co Ltd	2-Cyano-4-fluoropyrrolidine derivative or salt thereof
US7238724B2 (en)	2002-09-19	2007-07-03	Abbott Laboratories	Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV)
US7262207B2 (en)	2002-09-19	2007-08-28	Abbott Laboratories	Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV)
EP1556040A1 (de) *	2002-10-24	2005-07-27	Sterix Limited	Inhibitoren der 11-beta-hydroxy-steroid-dehydrogenase des typs 1 und des typ 2
GB0224830D0 (en)	2002-10-24	2002-12-04	Sterix Ltd	Compound
DE10252666A1 (de)	2002-11-11	2004-08-05	Grünenthal GmbH	N-Piperidyl-cyclohexan-Derivate
KR20050122220A (ko) *	2003-03-25	2005-12-28	다케다 샌디에고, 인코포레이티드	디펩티딜 펩티다제 억제제
EP1464335A3 (de) *	2003-03-31	2007-05-09	Taisho Pharmaceutical Co. Ltd.	Chinolin-, Tetrahydrochinolin- und Pyrimidinderivate als MCH Antagonisten
CN100451004C (zh) *	2003-03-31	2009-01-14	大正制药株式会社	嘧啶衍生物
US20090137658A1 (en) *	2003-05-06	2009-05-28	Tanabe Seiyaku Co.,Ltd.	Benzenesulfonic acid salt compounds
GB0310593D0 (en) *	2003-05-08	2003-06-11	Leuven K U Res & Dev	Peptidic prodrugs
EP1625122A1 (de)	2003-05-14	2006-02-15	Takeda San Diego, Inc.	Dipeptidylpeptidase-hemmer
DK1638970T3 (da)	2003-06-20	2011-01-03	Hoffmann La Roche	Pyrid (2, 1-A)-isoquinolinderivater som DPP-IV-inhibitorer
AU2004251829B2 (en)	2003-06-20	2009-12-17	F. Hoffmann-La Roche Ag	Hexahydropyridoisoqinolines as DPP-IV inhibitors
US7678909B1 (en)	2003-08-13	2010-03-16	Takeda Pharmaceutical Company Limited	Dipeptidyl peptidase inhibitors
KR20060041309A (ko) *	2003-08-13	2006-05-11	다케다 야쿠힌 고교 가부시키가이샤	４-피리미돈 유도체 및 펩티딜 펩티다제 저해제로서의 그의용도
US7169926B1 (en)	2003-08-13	2007-01-30	Takeda Pharmaceutical Company Limited	Dipeptidyl peptidase inhibitors
HU227684B1 (en) *	2003-08-29	2011-11-28	Sanofi Aventis	Adamantane and azabicyclo-octane and nonane derivatives and their use as dpp-iv inhibitors
US7205409B2 (en)	2003-09-04	2007-04-17	Abbott Laboratories	Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV)
EP1697342A2 (de) *	2003-09-08	2006-09-06	Takeda Pharmaceutical Company Limited	Dipeptidyl peptidase inhibitoren
US7790734B2 (en) *	2003-09-08	2010-09-07	Takeda Pharmaceutical Company Limited	Dipeptidyl peptidase inhibitors
US7291744B2 (en)	2003-11-13	2007-11-06	Bristol-Myers Squibb Company	N-ureidoalkyl-amino compounds as modulators of chemokine receptor activity
KR20140089408A (ko)	2003-11-17	2014-07-14	노파르티스 아게	디펩티딜 펩티다제 ⅳ 억제제의 용도
KR101146849B1 (ko)	2003-12-11	2012-05-16	미쓰비시 타나베 파마 코퍼레이션	α-아미노산 유도체 및 그 의약 용도
WO2005058894A1 (en) *	2003-12-19	2005-06-30	Altana Pharma Ag	Intermediates for the preparation of tricyclic dihydropyrano -imidazo -pyridines derivatives
SI1715893T1 (sl)	2004-01-20	2009-12-31	Novartis Pharma Ag	Direktna kompresijska formulacija in postopek
CA2554493C (en) *	2004-02-05	2012-06-26	Kyorin Pharmaceutical Co., Ltd.	Bicycloester derivative
AU2005214167B2 (en)	2004-02-13	2008-08-07	Warner-Lambert Company Llc	Androgen receptor modulators
EP1717225A4 (de) *	2004-02-18	2009-10-21	Kyorin Seiyaku Kk	Bicyclische amidderivate
US7514571B2 (en) *	2004-02-27	2009-04-07	Kyorin Pharmaceutical Co., Ltd.	Bicyclo derivative
US7348346B2 (en)	2004-03-08	2008-03-25	Abbott Laboratories	Pharmaceutical compositions as inhibitors of dipeptidyl peptidase-IV (DPP-IV)
US7732446B1 (en)	2004-03-11	2010-06-08	Takeda Pharmaceutical Company Limited	Dipeptidyl peptidase inhibitors
EA013427B1 (ru)	2004-03-15	2010-04-30	Такеда Фармасьютикал Компани Лимитед	Ингибиторы дипептидилпептидазы
CN101693695A (zh) *	2004-03-30	2010-04-14	大正制药株式会社	嘧啶衍生物以及与其应用有关的治疗方法
JP2007532621A (ja)	2004-04-13	2007-11-15	ワーナー−ランバートカンパニーリミテッドライアビリティーカンパニー	アンドロゲンモジュレータ
EP1740533A1 (de)	2004-04-22	2007-01-10	Warner-Lambert Company LLC	Androgenmodulatoren
TW200604167A (en) *	2004-04-27	2006-02-01	Astellas Pharma Inc	Pyrrolidine derivatives
DE102004023635A1 (de)	2004-05-10	2006-04-13	Grünenthal GmbH	Heteroarylsubstituierte Cyclohexyl-1,4-diamin-Derivate
DE102004023507A1 (de) *	2004-05-10	2005-12-01	Grünenthal GmbH	Substituierte Cyclohexylessigsäure-Derivate
DE102004023632A1 (de) *	2004-05-10	2005-12-08	Grünenthal GmbH	Substituierte Cyclohexylcarbonsäure-Derivate
JP2008501714A (ja) *	2004-06-04	2008-01-24	武田薬品工業株式会社	ジペプチジルペプチダーゼインヒビター
WO2006006065A1 (en)	2004-07-08	2006-01-19	Warner-Lambert Company Llc	Androgen modulators
WO2006019965A2 (en)	2004-07-16	2006-02-23	Takeda San Diego, Inc.	Dipeptidyl peptidase inhibitors
EP1794120B1 (de)	2004-07-23	2012-04-11	Nuada, LLC	Peptidaseinhibitoren
WO2006012441A1 (en) *	2004-07-23	2006-02-02	Susan Marie Royalty	Peptidase inhibitors
WO2006011035A1 (en) *	2004-07-23	2006-02-02	Glenmark Pharmaceuticals Ltd.	Novel dipeptidyl peptidase iv inhibitors; process for their preparation and compositions containing them
US20080090863A1 (en) *	2004-09-30	2008-04-17	Taisho Pharmaceutical Co., Ltd.	Pyridine Derivatives and Their Use as Medicaments for Treating Diseases Related to Mch Receptor
CN101087757B (zh) *	2004-10-12	2013-01-02	格兰马克药品股份有限公司	二肽基肽酶ⅳ抑制剂、含有它们的药用组合物及其制备方法
AP2007003973A0 (en)	2004-10-12	2007-07-30	Glenmark Pharmaceuticals Sa	Novel dideptidyl peptidase IV inhibitors, pharmaceutical compositions containing them, and proces for their preparation
EP1828192B1 (de) *	2004-12-21	2014-12-03	Takeda Pharmaceutical Company Limited	Dipeptidylpeptidasehemmer
DOP2006000008A (es) *	2005-01-10	2006-08-31	Arena Pharm Inc	Terapia combinada para el tratamiento de la diabetes y afecciones relacionadas y para el tratamiento de afecciones que mejoran mediante un incremento de la concentración sanguínea de glp-1
WO2006113261A2 (en) *	2005-04-14	2006-10-26	Bristol-Myers Squibb Company	Inhibitors of 11-beta hydroxysteroid dehydrogenase type i
JP4568361B2 (ja)	2005-04-22	2010-10-27	アラントス・ファーマシューティカルズ・ホールディング・インコーポレーテッド	ジペプチジルペプチダーゼ−ｉｖ阻害剤
TW200724139A (en)	2005-05-05	2007-07-01	Warner Lambert Co	Androgen modulators
US7521557B2 (en)	2005-05-20	2009-04-21	Bristol-Myers Squibb Company	Pyrrolopyridine-based inhibitors of dipeptidyl peptidase IV and methods
US20090287710A1 (en) *	2005-05-31	2009-11-19	Koninklijke Philips Electronics, N.V.	Portable storage media, host device and method of accessing the content of the portable storage media by the host device
EP2356997A1 (de)	2005-06-06	2011-08-17	Georgetown University	Zusammensetzungen und Verfahren zur Fettmodulation
MY152185A (en)	2005-06-10	2014-08-29	Novartis Ag	Modified release 1-[(3-hydroxy-adamant-1-ylamino)-acetyl]-pyrrolidine-2(s)-carbonitrile formulation
EP1760076A1 (de)	2005-09-02	2007-03-07	Ferring B.V.	FAP Inhibitoren
PT1942898E (pt) *	2005-09-14	2011-12-20	Takeda Pharmaceutical	Inibidores da dipeptidilpeptidase para o tratamento da diabetes
GEP20135791B (en) *	2005-09-14	2013-03-25	Takeda Pharmaceutical	Use of dipeptidyl peptidase inhibitors
TW200745080A (en) *	2005-09-16	2007-12-16	Takeda Pharmaceuticals Co	Polymorphs of tartrate salt of 2-[2-(3-(R)-amino-piperidin-1-yl)-5-fluoro-6-oxo-6H-pyrimidin-1-ylmethyl]-benzonitrile and methods of use therefor
TW200745079A (en) *	2005-09-16	2007-12-16	Takeda Pharmaceuticals Co	Polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile and methods of use therefor
CN101360723A (zh)	2005-09-16	2009-02-04	武田药品工业株式会社	制备嘧啶二酮衍生物的方法
GB0526291D0 (en)	2005-12-23	2006-02-01	Prosidion Ltd	Therapeutic method
CN101395131B (zh) *	2006-03-08	2012-11-14	杏林制药株式会社	氨基乙酰基吡咯烷甲腈衍生物的制备方法及其制备中间体
WO2007112347A1 (en)	2006-03-28	2007-10-04	Takeda Pharmaceutical Company Limited	Dipeptidyl peptidase inhibitors
EP1999108A1 (de) *	2006-03-28	2008-12-10	Takeda Pharmaceutical Company Limited	Herstellung von (r)-3-aminopiperidin-dihydrochlorid
PE20071221A1 (es)	2006-04-11	2007-12-14	Arena Pharm Inc	Agonistas del receptor gpr119 en metodos para aumentar la masa osea y para tratar la osteoporosis y otras afecciones caracterizadas por masa osea baja, y la terapia combinada relacionada a estos agonistas
AU2007238805B2 (en) *	2006-04-11	2012-04-05	Arena Pharmaceuticals, Inc.	Methods of using GPR119 receptor to identify compounds useful for increasing bone mass in an individual
WO2007148185A2 (en) *	2006-06-21	2007-12-27	Pfizer Products Inc.	Substituted 3 -amino- pyrrolidino-4 -lactams as dpp inhibitors
US8324383B2 (en)	2006-09-13	2012-12-04	Takeda Pharmaceutical Company Limited	Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile
TW200838536A (en) *	2006-11-29	2008-10-01	Takeda Pharmaceutical	Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor
JP2010120851A (ja) *	2007-02-09	2010-06-03	Kyorin Pharmaceut Co Ltd	二量化シクロ誘導体
US8093236B2 (en)	2007-03-13	2012-01-10	Takeda Pharmaceuticals Company Limited	Weekly administration of dipeptidyl peptidase inhibitors
JPWO2008114857A1 (ja) *	2007-03-22	2010-07-08	杏林製薬株式会社	アミノアセチルピロリジンカルボニトリル誘導体の製造方法
CN101652147B (zh) *	2007-04-03	2013-07-24	田边三菱制药株式会社	二肽基肽酶iv抑制化合物和甜味剂的并用
GB2465132B (en) *	2007-09-21	2012-06-06	Lupin Ltd	Compounds as dipeptidyl peptidase IV (DPP IV) inhibitors
EA201070839A1 (ru) *	2008-01-10	2010-12-30	Сан Фарма Адвансед Ресьёрч Компани Лимитед	Новые производные ацилцианопирролидинов
CL2008003653A1 (es) *	2008-01-17	2010-03-05	Mitsubishi Tanabe Pharma Corp	Uso de un inhibidor de sglt derivado de glucopiranosilo y un inhibidor de dppiv seleccionado para tratar la diabetes; y composicion farmaceutica.
US8278313B2 (en)	2008-03-11	2012-10-02	Abbott Laboratories	Macrocyclic spiro pyrimidine derivatives
US8436005B2 (en)	2008-04-03	2013-05-07	Abbott Laboratories	Macrocyclic pyrimidine derivatives
EP2108960A1 (de)	2008-04-07	2009-10-14	Arena Pharmaceuticals, Inc.	Verfahren zur Verwendung eines A G Protein-gekoppelten Rezeptors zur Identifikation von Peptid YY (PYY) Sekretagoga und nützliche Verbindungen zur Behandlung von durch (PYY) Sekretagoga modulierten Zuständen und nützliche Verbindungen zur Behandlung von Zuständen durch PYY
EP2322499A4 (de) *	2008-08-07	2011-12-21	Kyorin Seiyaku Kk	Verfahren zur herstellung eines bicyclo-[2,2,2]-octylaminderivats
US20110152342A1 (en) *	2008-08-14	2011-06-23	Hiroshi Uchida	Stabilized pharmaceutical composition
WO2010039124A1 (en) *	2008-09-30	2010-04-08	Mitsubishi Tanabe Pharma Corporation	Benzenesulfonic acid salt compounds
US7876263B2 (en) *	2009-02-24	2011-01-25	Raytheon Company	Asymmetrically thinned active array TR module and antenna architecture
US7965235B2 (en) *	2009-02-24	2011-06-21	Raytheon Company	Multi-channel thinned TR module architecture
WO2010146597A1 (en)	2009-06-18	2010-12-23	Lupin Limited	2-amino-2- [8-(dimethyl carbamoyl)- 8-aza- bicyclo [3.2.1] oct-3-yl]-exo- ethanoyl derivatives as potent dpp-iv inhibitors
AR077642A1 (es)	2009-07-09	2011-09-14	Arena Pharm Inc	Moduladores del metabolismo y el tratamiento de trastornos relacionados con el mismo
JP2013523819A (ja)	2010-04-06	2013-06-17	アリーナファーマシューティカルズ，インコーポレイテッド	Ｇｐｒ１１９レセプターのモジュレーターおよびそれに関連する障害の処置
PH12013500547A1 (en)	2010-09-22	2013-06-10	Arena Pharm Inc	Modulators of the gpr119 receptor and the treatment of disorders related thereto
US20140018371A1 (en)	2011-04-01	2014-01-16	Arena Pharmaceuticals, Inc.	Modulators Of The GPR119 Receptor And The Treatment Of Disorders Related Thereto
WO2012145361A1 (en)	2011-04-19	2012-10-26	Arena Pharmaceuticals, Inc.	Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2012145604A1 (en)	2011-04-22	2012-10-26	Arena Pharmaceuticals, Inc.	Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2012145603A1 (en)	2011-04-22	2012-10-26	Arena Pharmaceuticals, Inc.	Modulators of the gpr119 receptor and the treatment of disorders related thereto
WO2012170702A1 (en)	2011-06-08	2012-12-13	Arena Pharmaceuticals, Inc.	Modulators of the gpr119 receptor and the treatment of disorders related thereto
EP2729468A4 (de) *	2011-07-05	2015-03-18	Merck Sharp & Dohme	Tricyclische heterozyklen als dipeptidylpeptidase-iv-hemmer
WO2013055910A1 (en)	2011-10-12	2013-04-18	Arena Pharmaceuticals, Inc.	Modulators of the gpr119 receptor and the treatment of disorders related thereto
CN102875558A (zh) *	2012-11-05	2013-01-16	贵州大学	2-氯-4-取代-8-硝基苯并呋喃[3,2-d]嘧啶类化合物及其制备方法和用途
WO2014074668A1 (en)	2012-11-08	2014-05-15	Arena Pharmaceuticals, Inc.	Modulators of gpr119 and the treatment of disorders related thereto
NO2699580T3 (de) *	2014-01-24	2018-02-24
MY176401A (en)	2014-04-24	2020-08-05	Mitsubishi Tanabe Pharma Corp	Novel disubstituted 1,2,4-triazine compound
MX386778B (es)	2015-03-09	2025-03-19	Intekrin Therapeutics Inc	Métodos para el tratamiento de enfermedad de hígado graso no alcohólico y/o lipodistrofia.
CA3058806A1 (en)	2017-04-03	2018-10-11	Coherus Biosciences Inc.	Ppar.gamma. agonist for treatment of progressive supranuclear palsy
WO2019154859A1 (en) *	2018-02-06	2019-08-15	Universität Heidelberg	Fap inhibitor
CN108218865B (zh) *	2018-03-31	2020-06-26	济南市儿童医院	一种酰胺类衍生物及其在心脑血管方面的应用
CN108456207B (zh) *	2018-03-31	2020-11-20	浙江药苑生物科技有限公司	一种酰胺类衍生物及其在心脑血管方面的应用
US12286401B2 (en)	2018-07-31	2025-04-29	The Trustees Of The University Of Pennsylvania	Small molecules that sensitize HIV-1 infected cells to antibody dependent cellular cytotoxicity
JP7544965B2 (ja) *	2021-04-22	2024-09-03	住友電気工業株式会社	フレキシブルプリント回路基板及びフレキシブルプリント回路基板の製造方法
CN116650495B (zh) *	2021-12-10	2024-04-19	中南大学湘雅医院	芳香族化合物作为神经丛素蛋白-b2的激活剂以及在制备治疗骨质疏松症药物中的应用
US20250353833A1 (en)	2022-06-03	2025-11-20	Universiteit Antwerpen	Dpp9 binding compounds
CN120584108A (zh)	2023-01-06	2025-09-02	英斯梅德股份有限公司	新型可逆dpp1抑制剂及其用途

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6512481B1 (en) *	1996-10-10	2003-01-28	Teratech Corporation	Communication system using geographic position data
TW492957B (en)	1996-11-07	2002-07-01	Novartis Ag	N-substituted 2-cyanopyrrolidnes
US6011155A (en)	1996-11-07	2000-01-04	Novartis Ag	N-(substituted glycyl)-2-cyanopyrrolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV
US6316612B1 (en) *	1997-08-22	2001-11-13	Ribozyme Pharmaceuticals, Inc.	Xylofuranosly-containing nucleoside phosphoramidites and polynucleotides
US6484015B1 (en) *	1997-10-27	2002-11-19	Lucent Technologies Inc.	Portable telephone antenna
CO5150173A1 (es) *	1998-12-10	2002-04-29	Novartis Ag	Compuestos n-(glicilo sustituido)-2-cianopirrolidinas inhibidores de peptidasa de dipeptidilo-iv (dpp-iv) los cuales son efectivos en el tratamiento de condiciones mediadas por la inhibicion de dpp-iv
US6107317A (en) *	1999-06-24	2000-08-22	Novartis Ag	N-(substituted glycyl)-thiazolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV
US6110949A (en) *	1999-06-24	2000-08-29	Novartis Ag	N-(substituted glycyl)-4-cyanothiazolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV
JP3551122B2 (ja) *	2000-04-07	2004-08-04	日本電気株式会社	携帯電話装置
TW583185B (en)	2000-06-13	2004-04-11	Novartis Ag	N-(substituted glycyl)-2-cyanopyrrolidines and pharmaceutical composition for inhibiting dipeptidyl peptidase-IV (DPP-IV) or for the prevention or treatment of diseases or conditions associated with elevated levels of DPP-IV comprising the same
US6432969B1 (en) *	2000-06-13	2002-08-13	Novartis Ag	N-(substituted glycyl)-2 cyanopyrrolidines, pharmaceutical compositions containing them and their use in inhibiting dipeptidyl peptidase-IV
JPWO2002051836A1 (ja)	2000-12-27	2004-04-22	協和醗酵工業株式会社	ジペプチジルペプチダーゼ−ｉｖ阻害剤

2001
- 2001-10-05 AU AU2001294196A patent/AU2001294196B2/en not_active Ceased
- 2001-10-05 MX MXPA03003006A patent/MXPA03003006A/es active IP Right Grant
- 2001-10-05 KR KR10-2003-7004829A patent/KR100526091B1/ko not_active Expired - Fee Related
- 2001-10-05 AU AU2001294197A patent/AU2001294197C1/en not_active Ceased
- 2001-10-05 PT PT01974716T patent/PT1323710E/pt unknown
- 2001-10-05 CA CA002424964A patent/CA2424964C/en not_active Expired - Fee Related
- 2001-10-05 DK DK01974716T patent/DK1323710T3/da active
- 2001-10-05 CN CNB018169570A patent/CN1280269C/zh not_active Expired - Fee Related
- 2001-10-05 EP EP01974716A patent/EP1323710B1/de not_active Expired - Lifetime
- 2001-10-05 WO PCT/JP2001/008803 patent/WO2002030891A1/ja not_active Ceased
- 2001-10-05 MX MXPA03003007A patent/MXPA03003007A/es active IP Right Grant
- 2001-10-05 KR KR1020037004824A patent/KR100555014B1/ko not_active Expired - Fee Related
- 2001-10-05 DE DE60135862T patent/DE60135862D1/de not_active Expired - Lifetime
- 2001-10-05 NZ NZ524974A patent/NZ524974A/en unknown
- 2001-10-05 BR BR0114436-7A patent/BR0114436A/pt not_active IP Right Cessation
- 2001-10-05 AU AU9419701A patent/AU9419701A/xx active Pending
- 2001-10-05 CN CNB018166741A patent/CN1257891C/zh not_active Expired - Fee Related
- 2001-10-05 IL IL15489301A patent/IL154893A0/xx active IP Right Grant
- 2001-10-05 PL PL01362545A patent/PL362545A1/xx not_active Application Discontinuation
- 2001-10-05 ES ES01974716T patent/ES2312471T3/es not_active Expired - Lifetime
- 2001-10-05 DE DE60135764T patent/DE60135764D1/de not_active Expired - Lifetime
- 2001-10-05 AT AT01974716T patent/ATE407924T1/de not_active IP Right Cessation
- 2001-10-05 PT PT01974717T patent/PT1325910E/pt unknown
- 2001-10-05 WO PCT/JP2001/008802 patent/WO2002030890A1/ja not_active Ceased
- 2001-10-05 AT AT01974717T patent/ATE408597T1/de not_active IP Right Cessation
- 2001-10-05 HU HU0303391A patent/HUP0303391A3/hu unknown
- 2001-10-05 EP EP01974717A patent/EP1325910B1/de not_active Expired - Lifetime
- 2001-10-05 TW TWNITROGEN-A patent/TWI290919B/zh not_active IP Right Cessation
- 2001-10-05 US US10/398,485 patent/US7138397B2/en not_active Expired - Fee Related
- 2001-10-05 AU AU9419601A patent/AU9419601A/xx active Pending
- 2001-10-05 NZ NZ525630A patent/NZ525630A/en unknown
- 2001-10-05 US US10/398,486 patent/US6849622B2/en not_active Expired - Fee Related
- 2001-10-05 DK DK01974717T patent/DK1325910T3/da active
- 2001-10-05 ES ES01974717T patent/ES2312472T3/es not_active Expired - Lifetime
- 2001-10-05 CA CA002424600A patent/CA2424600C/en not_active Expired - Fee Related
2003
- 2003-03-12 IL IL154893A patent/IL154893A/en not_active IP Right Cessation
- 2003-04-02 NO NO20031490A patent/NO324519B1/no not_active IP Right Cessation
2004
- 2004-06-22 US US10/872,442 patent/US7160877B2/en not_active Expired - Fee Related
2006
- 2006-06-15 US US11/452,923 patent/US7332487B2/en not_active Expired - Fee Related
2007
- 2007-12-07 US US12/000,024 patent/US7666869B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
MXPA03003007A (es)	2003-07-14
WO2002030891A1 (en)	2002-04-18
NO20031490D0 (no)	2003-04-02
DK1323710T3 (da)	2008-12-01
IL154893A0 (en)	2003-10-31
EP1323710A4 (de)	2005-05-18
US6849622B2 (en)	2005-02-01
NZ525630A (en)	2004-10-29
HUP0303391A3 (en)	2004-04-28
EP1325910A1 (de)	2003-07-09
AU2001294197C1 (en)	2005-05-19
ES2312472T3 (es)	2009-03-01
AU9419601A (en)	2002-04-22
CA2424600C (en)	2008-12-02
MXPA03003006A (es)	2003-07-14
US20050054678A1 (en)	2005-03-10
ATE407924T1 (de)	2008-09-15
US7138397B2 (en)	2006-11-21
US7160877B2 (en)	2007-01-09
US20040229926A1 (en)	2004-11-18
US20060241146A1 (en)	2006-10-26
WO2002030890A1 (en)	2002-04-18
CA2424964C (en)	2007-12-04
PT1323710E (pt)	2008-11-25
CN1257891C (zh)	2006-05-31
NZ524974A (en)	2005-10-28
PL362545A1 (en)	2004-11-02
KR20030041148A (ko)	2003-05-23
CN1468216A (zh)	2004-01-14
CN1468217A (zh)	2004-01-14
KR100526091B1 (ko)	2005-11-08
NO20031490L (no)	2003-06-02
IL154893A (en)	2008-04-13
ATE408597T1 (de)	2008-10-15
WO2002030891A8 (en)	2002-05-16
WO2002030890A8 (en)	2002-05-16
AU9419701A (en)	2002-04-22
HUP0303391A2 (hu)	2004-03-01
AU2001294197B2 (en)	2004-09-16
CA2424600A1 (en)	2003-04-02
DE60135764D1 (de)	2008-10-23
HK1055302A1 (en)	2004-01-02
US7332487B2 (en)	2008-02-19
ES2312471T3 (es)	2009-03-01
CN1280269C (zh)	2006-10-18
EP1325910B1 (de)	2008-09-17
KR100555014B1 (ko)	2006-03-03
KR20030041149A (ko)	2003-05-23
US20040063935A1 (en)	2004-04-01
BR0114436A (pt)	2003-07-01
EP1325910A4 (de)	2005-05-18
AU2001294196B2 (en)	2005-11-17
US7666869B2 (en)	2010-02-23
PT1325910E (pt)	2008-10-27
DK1325910T3 (da)	2008-11-10
EP1323710A1 (de)	2003-07-02
EP1323710B1 (de)	2008-09-10
US20080153821A1 (en)	2008-06-26
NO324519B1 (no)	2007-11-12
HK1055301A1 (en)	2004-01-02
CA2424964A1 (en)	2002-04-18
TWI290919B (en)	2007-12-11

Publication	Publication Date	Title
DE60135764D1 (de)	2008-10-23	Stickstoffhaltige, fünfgliedrige ringverbindungen
DE69824194D1 (de)	2004-07-01	Substituierte kondensierte heterocyclische verbindungen
DK0870765T3 (da)	2004-02-23	Aminothiazolderivat, lægemiddel indeholdende samme og mellemprodukt til fremstilling af forbindelsen
IL147651A0 (en)	2002-08-14	Isoxazoline derivative and herbicide containing the same as the active ingredient
ATE368655T1 (de)	2007-08-15	Stickstoffhaltige heterocyclische verbindung und arzneimittel davon
AU3417501A (en)	2001-09-12	Novel cyclic amide derivatives
ATE271045T1 (de)	2004-07-15	Sauerstoffhaltige heterocyclische verbindungen
WO2001010834A3 (en)	2001-06-28	Antibacterial agents
EP1156031A4 (de)	2004-09-15	Verbindungen, aus der verbindung hergestelltes polymer und das polymer enthaltende mischung
AU9025601A (en)	2002-04-02	Cephem compounds and esbl-detecting reagents containing the same
EP0552489A3 (de)	1994-02-16
EA200101050A1 (ru)	2002-04-25	Замещенные бензолактамные соединения
ATE367377T1 (de)	2007-08-15	Bis(5-aryl-2-pyridyl)derivate
TW200510300A (en)	2005-03-16	Amino alcohol compounds
EP1391450A4 (de)	2005-08-17	N-(heterocyclylmethyl)alkylamin derivate, verfahren zu deren herstellung und bakterizid

Legal Events

Date	Code	Title	Description
2009-10-08	8364	No opposition during term of opposition