DE60135504D1 - Isotop-kodierte ionisierung-förderende reagenzien zur hochdurchsatz protein identifikation und quantifikation mit massenspectrometrie - Google Patents
Isotop-kodierte ionisierung-förderende reagenzien zur hochdurchsatz protein identifikation und quantifikation mit massenspectrometrieInfo
- Publication number
- DE60135504D1 DE60135504D1 DE60135504T DE60135504T DE60135504D1 DE 60135504 D1 DE60135504 D1 DE 60135504D1 DE 60135504 T DE60135504 T DE 60135504T DE 60135504 T DE60135504 T DE 60135504T DE 60135504 D1 DE60135504 D1 DE 60135504D1
- Authority
- DE
- Germany
- Prior art keywords
- icier
- increase
- ionization
- maldi
- cysteine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 102000004169 proteins and genes Human genes 0.000 title abstract 4
- 108090000623 proteins and genes Proteins 0.000 title abstract 4
- 239000003153 chemical reaction reagent Substances 0.000 title abstract 2
- 238000004949 mass spectrometry Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 238000011002 quantification Methods 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 5
- 238000001906 matrix-assisted laser desorption--ionisation mass spectrometry Methods 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 235000018102 proteins Nutrition 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000004475 Arginine Substances 0.000 abstract 1
- 238000004458 analytical method Methods 0.000 abstract 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 abstract 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 abstract 1
- 235000018417 cysteine Nutrition 0.000 abstract 1
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 abstract 1
- 230000029087 digestion Effects 0.000 abstract 1
- 125000002795 guanidino group Chemical group C(N)(=N)N* 0.000 abstract 1
- 238000004811 liquid chromatography Methods 0.000 abstract 1
- 238000013507 mapping Methods 0.000 abstract 1
- 238000011084 recovery Methods 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6848—Methods of protein analysis involving mass spectrometry
- G01N33/6851—Methods of protein analysis involving laser desorption ionisation mass spectrometry
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2458/00—Labels used in chemical analysis of biological material
- G01N2458/15—Non-radioactive isotope labels, e.g. for detection by mass spectrometry
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/13—Tracers or tags
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/25125—Digestion or removing interfering materials
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Hematology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Optics & Photonics (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24264500P | 2000-10-23 | 2000-10-23 | |
| PCT/US2001/050744 WO2002046770A2 (en) | 2000-10-23 | 2001-10-22 | Isotope-coded ionization-enhancing reagents (icier) for high-throughput protein identification and quantitation using matrix-assisted laser desorption ionization mass spectrometry |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE60135504D1 true DE60135504D1 (de) | 2008-10-02 |
Family
ID=22915621
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60135504T Expired - Fee Related DE60135504D1 (de) | 2000-10-23 | 2001-10-22 | Isotop-kodierte ionisierung-förderende reagenzien zur hochdurchsatz protein identifikation und quantifikation mit massenspectrometrie |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6905879B2 (de) |
| EP (1) | EP1415161B1 (de) |
| JP (1) | JP4141834B2 (de) |
| AT (1) | ATE405839T1 (de) |
| AU (2) | AU2002241732B2 (de) |
| CA (1) | CA2426728A1 (de) |
| DE (1) | DE60135504D1 (de) |
| WO (1) | WO2002046770A2 (de) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE344456T1 (de) * | 2000-05-05 | 2006-11-15 | Purdue Research Foundation | Durch affinität ausgewählte unterschriftspeptide zur identifizierung und quantifizierung von proteinen |
| CA2426731A1 (en) * | 2000-10-23 | 2002-06-20 | Genetics Institute, Llc. | Acid-labile isotope-coded extractant (alice) and its use in quantitative mass spectrometric analysis of protein mixtures |
| CA2461587C (en) | 2001-09-27 | 2011-04-26 | Purdue Research Foundation | Materials and methods for controlling isotope effects during fractionation of analytes |
| EP2336763A1 (de) | 2002-02-14 | 2011-06-22 | Ajinomoto Co., Inc. | Methode zur Analyse von Substanzen, welche Aminogruppen enthalten und analytische Reagenzien dafür. |
| US7846748B2 (en) * | 2002-12-02 | 2010-12-07 | The University Of North Carolina At Chapel Hill | Methods of quantitation and identification of peptides and proteins |
| AU2004209401A1 (en) | 2003-01-30 | 2004-08-19 | Applied Biosystems, Llc. | Methods, mixtures, kits and compositions pertaining to analyte determination |
| GB0314209D0 (en) * | 2003-06-19 | 2003-07-23 | Amersham Biosciences Ab | Novel MS reagents |
| EP1651962B1 (de) * | 2003-07-29 | 2013-09-11 | Abbott Laboratories GmbH | Analytisches verfahren für pankreatische und ähnliche zusammensetzungen |
| WO2005052563A1 (en) * | 2003-11-20 | 2005-06-09 | Indiana University Research And Technology Corporation | Peptide derivatization for enhancing protein identification by mass spectrometry |
| EP1695090A1 (de) * | 2003-12-08 | 2006-08-30 | Oxford Gene Technology Ip Limited | Massenspektrometrie argininhaltiger peptide |
| US20050148087A1 (en) | 2004-01-05 | 2005-07-07 | Applera Corporation | Isobarically labeled analytes and fragment ions derived therefrom |
| DE602004015989D1 (de) * | 2004-02-10 | 2008-10-02 | Korea Basic Science Inst | Methode zur analyse phosphorylierter stellen und selektives markierungsmittel |
| BRPI0614746A2 (pt) * | 2005-08-09 | 2011-04-12 | University Of Sunderland | partìculas de sìlica hidrofóbicas, métodos de fabricação e uso das mesmas, assim como métodos de detecção e/ou identificação de uma impressão digital ou outra massa ou depósito hidrofóbico |
| KR101081053B1 (ko) * | 2008-07-18 | 2011-11-07 | 포항공과대학교 산학협력단 | 가변질량 라벨링제와 이를 이용한 아미노산 서열 및 단백질정량 동시 분석방법 |
| EP2755024B1 (de) * | 2011-09-09 | 2019-05-01 | Shimadzu Corporation | Hydrophile thiolsonde |
| CN102495127B (zh) * | 2011-11-11 | 2013-09-04 | 暨南大学 | 一种基于概率统计模型的蛋白质二级质谱鉴定方法 |
| US10035823B2 (en) * | 2014-09-29 | 2018-07-31 | The Regents Of The University Of California | Compositions for expanding regulatory T cells (TREG), and treating autoimmune and inflammatory diseases and conditions |
| KR101746535B1 (ko) | 2015-07-27 | 2017-06-13 | 서강대학교산학협력단 | Maldi-tof 질량분석방법을 이용한 고분자내 올리고머의 정량분석 방법 |
| CN112326852B (zh) * | 2020-11-06 | 2021-07-27 | 吉林大学 | 一种1-芘甲醛的应用及生物小分子的检测方法 |
| CN113267554A (zh) * | 2021-05-14 | 2021-08-17 | 谱天（天津）生物科技有限公司 | 一种用于评估蛋白质组还原烷基化效率的质控方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5045694A (en) | 1989-09-27 | 1991-09-03 | The Rockefeller University | Instrument and method for the laser desorption of ions in mass spectrometry |
| US4977320A (en) | 1990-01-22 | 1990-12-11 | The Rockefeller University | Electrospray ionization mass spectrometer with new features |
| US5288644A (en) | 1990-04-04 | 1994-02-22 | The Rockefeller University | Instrument and method for the sequencing of genome |
| US5245186A (en) | 1991-11-18 | 1993-09-14 | The Rockefeller University | Electrospray ion source for mass spectrometry |
| AU685055B2 (en) | 1992-05-29 | 1998-01-15 | Rockefeller University, The | Method and product for the sequence determination of peptides using a mass spectrometer |
| US5792664A (en) | 1992-05-29 | 1998-08-11 | The Rockefeller University | Methods for producing and analyzing biopolymer ladders |
| AU755334C (en) | 1998-08-25 | 2004-02-26 | University Of Washington | Rapid quantitative analysis of proteins or protein function in complex mixtures |
| US6629040B1 (en) * | 1999-03-19 | 2003-09-30 | University Of Washington | Isotope distribution encoded tags for protein identification |
| CA2411126A1 (en) * | 2000-06-09 | 2001-12-13 | Mds Proteomics, Inc. | Labeling of proteomic samples during proteolysis for quantitation and sample multiplexing |
| CA2426731A1 (en) | 2000-10-23 | 2002-06-20 | Genetics Institute, Llc. | Acid-labile isotope-coded extractant (alice) and its use in quantitative mass spectrometric analysis of protein mixtures |
-
2001
- 2001-10-22 WO PCT/US2001/050744 patent/WO2002046770A2/en not_active Ceased
- 2001-10-22 DE DE60135504T patent/DE60135504D1/de not_active Expired - Fee Related
- 2001-10-22 AU AU2002241732A patent/AU2002241732B2/en not_active Ceased
- 2001-10-22 AT AT01988424T patent/ATE405839T1/de not_active IP Right Cessation
- 2001-10-22 JP JP2002548456A patent/JP4141834B2/ja not_active Expired - Fee Related
- 2001-10-22 EP EP01988424A patent/EP1415161B1/de not_active Expired - Lifetime
- 2001-10-22 US US10/044,708 patent/US6905879B2/en not_active Expired - Fee Related
- 2001-10-22 AU AU4173202A patent/AU4173202A/xx active Pending
- 2001-10-22 CA CA002426728A patent/CA2426728A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP4141834B2 (ja) | 2008-08-27 |
| EP1415161A2 (de) | 2004-05-06 |
| WO2002046770A2 (en) | 2002-06-13 |
| US6905879B2 (en) | 2005-06-14 |
| US20030054570A1 (en) | 2003-03-20 |
| EP1415161B1 (de) | 2008-08-20 |
| CA2426728A1 (en) | 2002-06-13 |
| WO2002046770A3 (en) | 2004-02-26 |
| AU4173202A (en) | 2002-06-18 |
| ATE405839T1 (de) | 2008-09-15 |
| AU2002241732B2 (en) | 2007-07-12 |
| JP2004534205A (ja) | 2004-11-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |