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DE60120109D1 - PROCESS FOR THE PREPARATION OF OPTIC-PURE (R) - AND (S) - DIDESMETHYLSIBUTRAMINE - Google Patents

PROCESS FOR THE PREPARATION OF OPTIC-PURE (R) - AND (S) - DIDESMETHYLSIBUTRAMINE

Info

Publication number
DE60120109D1
DE60120109D1 DE60120109T DE60120109T DE60120109D1 DE 60120109 D1 DE60120109 D1 DE 60120109D1 DE 60120109 T DE60120109 T DE 60120109T DE 60120109 T DE60120109 T DE 60120109T DE 60120109 D1 DE60120109 D1 DE 60120109D1
Authority
DE
Germany
Prior art keywords
didesmethylsibutramine
optic
pure
preparation
racemic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60120109T
Other languages
German (de)
Other versions
DE60120109T2 (en
Inventor
H Senanayake
K Fang
Zhengxu Han
Dhileepkumar Krishnamurthy
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sunovion Pharmaceuticals Inc
Original Assignee
Sepracor Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sepracor Inc filed Critical Sepracor Inc
Publication of DE60120109D1 publication Critical patent/DE60120109D1/en
Application granted granted Critical
Publication of DE60120109T2 publication Critical patent/DE60120109T2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
    • C07C251/18—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to carbon atoms of rings other than six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/11—Aldehydes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C211/00—Compounds containing amino groups bound to a carbon skeleton
    • C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
    • C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
    • C07C211/29—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/44—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reduction and hydrolysis of nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/38—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings
    • C07C47/457—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings containing halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Addiction (AREA)
  • Gynecology & Obstetrics (AREA)
  • Child & Adolescent Psychology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Methods of making and using racemic and optically pure metabolites of sibutramine, and pharmaceutically acceptable salts, solvates, and clathrates thereof, are disclosed. Pharmaceutical compositions and dosage forms are also disclosed which comprise a dopamine reuptake inhibitor, such as a racemic or optically pure sibutramine metabolite, and optionally an additional pharmacologically active compound.
DE60120109T 2000-01-11 2001-01-10 METHOD FOR THE PRODUCTION OF OPTICALLY PURE (R) - AND (S) - DIDESMETHYLSIBUTRAMINE Expired - Fee Related DE60120109T2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/480,889 US6399826B1 (en) 1999-08-11 2000-01-11 Salts of sibutramine metabolites, methods of making sibutramine metabolites and intermediates useful in the same, and methods of treating pain
US480889 2000-01-11
PCT/US2001/000762 WO2001051453A1 (en) 2000-01-11 2001-01-10 Racemic and optically pure metabolites of sibutramine, their preparation, compositions comprising them and their use as dopamine reuptake inhibitors

Publications (2)

Publication Number Publication Date
DE60120109D1 true DE60120109D1 (en) 2006-07-06
DE60120109T2 DE60120109T2 (en) 2006-10-19

Family

ID=23909753

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60120109T Expired - Fee Related DE60120109T2 (en) 2000-01-11 2001-01-10 METHOD FOR THE PRODUCTION OF OPTICALLY PURE (R) - AND (S) - DIDESMETHYLSIBUTRAMINE

Country Status (12)

Country Link
US (2) US6399826B1 (en)
EP (2) EP1632471A1 (en)
JP (1) JP2003519675A (en)
AT (1) ATE327972T1 (en)
AU (1) AU782567B2 (en)
CA (1) CA2396950A1 (en)
CY (1) CY1106150T1 (en)
DE (1) DE60120109T2 (en)
DK (1) DK1246789T3 (en)
ES (1) ES2260195T3 (en)
PT (1) PT1246789E (en)
WO (1) WO2001051453A1 (en)

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KR20030077538A (en) * 2000-11-15 2003-10-01 탭 파마슈티칼 프로덕츠 인코포레이티드 Treatment of anti-depression drug-induced sexual dysfunction with apomorphine
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CN1659154B (en) * 2002-04-10 2012-05-30 艾普辛特姆有限责任公司 Preparation method of amine stereoisomer
RU2290924C2 (en) * 2002-10-05 2007-01-10 Ханми Фарм. Ко., Лтд. Pharmaceutical composition including crystalline sibutramine methanesulfonate hemihydrate
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US8604244B2 (en) 2010-07-02 2013-12-10 Reviva Pharmaceuticals, Inc. Compositions, synthesis, and methods of using cycloalkylmethylamine derivatives
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CN101555214B (en) 2008-04-08 2012-07-11 北京嘉事联博医药科技有限公司 Phenylcyclobutylamide derivatives and optical isomers, preparation methods and uses thereof
WO2010065889A2 (en) * 2008-12-06 2010-06-10 Auspex Pharmaceutical Cyclobutanemethanamine inhibitors of monomine reuptake
CN102791134B (en) 2009-12-04 2015-04-22 魄金莱默有限公司 Method of using dopamine reuptake inhibitors and their analogs for treating diabetes symptoms and delaying or preventing diabetes-associated pathologic conditions
CN104039753B (en) 2011-12-30 2016-09-14 雷维瓦药品公司 The compositions of phenylcycloalkyl methylamine derivative, synthesis and using method
GB202114564D0 (en) * 2021-10-12 2021-11-24 Actimed Therapeutics Ltd Oral formulation

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Also Published As

Publication number Publication date
AU782567B2 (en) 2005-08-11
WO2001051453A1 (en) 2001-07-19
JP2003519675A (en) 2003-06-24
CA2396950A1 (en) 2001-07-19
CY1106150T1 (en) 2011-06-08
US20020183281A1 (en) 2002-12-05
EP1246789B1 (en) 2006-05-31
DK1246789T3 (en) 2006-09-18
EP1632471A1 (en) 2006-03-08
AU2779301A (en) 2001-07-24
ATE327972T1 (en) 2006-06-15
ES2260195T3 (en) 2006-11-01
US6710087B2 (en) 2004-03-23
DE60120109T2 (en) 2006-10-19
PT1246789E (en) 2006-10-31
EP1246789A1 (en) 2002-10-09
US6399826B1 (en) 2002-06-04

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