DE60119124D1 - Substituierte pyrazole - Google Patents

Substituierte pyrazole

Info

Publication number: DE60119124D1
Authority: DE; Germany
Prior art keywords: substituted pyrazole; methods; cathepsin; activity; manufacturing
Prior art date: 2000-08-14
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60119124T

Other languages

English (en)

Other versions

DE60119124T2 (de

Inventor

Hui Cai

P Edwards

P Meduna

A Pio

Jianmei Wei

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Janssen Pharmaceuticals Inc

Original Assignee

Ortho McNeil Pharmaceutical Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-08-14

Filing date

2001-08-10

Publication date

2006-06-01

2001-08-10 Application filed by Ortho McNeil Pharmaceutical Inc filed Critical Ortho McNeil Pharmaceutical Inc

2006-06-01 Publication of DE60119124D1 publication Critical patent/DE60119124D1/de

2006-11-30 Application granted granted Critical

2006-11-30 Publication of DE60119124T2 publication Critical patent/DE60119124T2/de

2021-08-11 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/275—Nitriles; Isonitriles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
Pulmonology (AREA)
Rheumatology (AREA)
Pain & Pain Management (AREA)
Transplantation (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Polysaccharides And Polysaccharide Derivatives (AREA)

DE60119124T 2000-08-14 2001-08-10 Substituierte pyrazole Expired - Lifetime DE60119124T2 (de)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US22517800P	2000-08-14	2000-08-14
US225178P		2000-08-14
US09/927,188 US6635633B2 (en)	2000-08-14	2001-08-10	Substituted pyrazoles
PCT/US2001/025180 WO2002014317A2 (en)	2000-08-14	2001-08-10	Substituted pyrazoles
US927188		2001-08-10

Publications (2)

Publication Number	Publication Date
DE60119124D1 true DE60119124D1 (de)	2006-06-01
DE60119124T2 DE60119124T2 (de)	2006-11-30

Family

ID=26919363

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60119124T Expired - Lifetime DE60119124T2 (de)	2000-08-14	2001-08-10	Substituierte pyrazole

Country Status (16)

Country	Link
US (6)	US6635633B2 (de)
EP (1)	EP1309592B9 (de)
JP (1)	JP4911864B2 (de)
CN (1)	CN1255405C (de)
AT (1)	ATE324372T1 (de)
AU (2)	AU8482301A (de)
CA (1)	CA2419550A1 (de)
CY (1)	CY1104912T1 (de)
DE (1)	DE60119124T2 (de)
DK (1)	DK1309592T3 (de)
ES (1)	ES2262674T3 (de)
HK (1)	HK1052705B (de)
MX (1)	MXPA03001420A (de)
NZ (1)	NZ524192A (de)
PT (1)	PT1309592E (de)
WO (1)	WO2002014317A2 (de)

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US20080207683A1 (en) *	2007-02-15	2008-08-28	Darin Allen	Biaryl-substituted tetrahydro-pyrazolo-pyridine modulators of cathepsin s
US20080269241A1 (en) *	2007-02-15	2008-10-30	Darin Allen	Bicyclic aminopropyl tetrahydro-pyrazolo-pyridine modulators of cathepsin s
US20090118274A1 (en) *	2007-02-15	2009-05-07	Darin Allen	Monocyclic aminopropyl tetrahydro-pyrazolo-pyridine modulators of cathepsin s
US20090099157A1 (en) *	2007-02-15	2009-04-16	Ameriks Michael K	Tetrahydro-pyrazolo-pyridine thioether modulators of cathepsin s
AR065804A1 (es)	2007-03-23	2009-07-01	Smithkline Beecham Corp	Compuesto de indol carboxamida, composicion farmaceutica que lo comprende y uso de dicho compuesto para preparar un medicamento
SG10201406263SA (en)	2008-06-20	2015-02-27	Novartis Ag	Paediatric compositions for treating multiple sclerosis
EP2406249A1 (de)	2009-03-10	2012-01-18	Glaxo Group Limited	Indolderivate als ikk2-inhibitoren
PH12015501678B1 (en)	2009-06-17	2022-07-06	Vertex Pharma	Inhibitors of influenza viruses replication
AU2011343642A1 (en)	2010-12-16	2013-05-02	Vertex Pharmaceuticals Incorporated	Inhibitors of influenza viruses replication
UA118010C2 (uk)	2011-08-01	2018-11-12	Вертекс Фармасьютікалз Інкорпорейтед	Інгібітори реплікації вірусів грипу
KR20140071361A (ko)	2011-08-12	2014-06-11	에프. 호프만-라 로슈 아게	피라졸로[3,4-c]피리딘 화합물 및 사용 방법
CA2890018A1 (en)	2012-11-05	2014-05-08	Nant Holdings Ip, Llc	Substituted indol-5-ol derivatives and their therapeutical applications
WO2014102594A2 (en)	2012-12-27	2014-07-03	Purdue Pharma L.P.	Substituted benzimidazole-type piperidine compounds and uses thereof
BR112015022307A2 (pt)	2013-03-15	2017-07-18	Nantbioscience Inc	derivados substituídos indol-5-ol e as suas aplicações terapêuticas
AU2014348752C1 (en)	2013-11-13	2019-11-21	Vertex Pharmaceuticals Incorporated	Methods of preparing inhibitors of influenza viruses replication
JP6615755B2 (ja)	2013-11-13	2019-12-04	バーテックスファーマシューティカルズインコーポレイテッド	インフルエンザウイルスの複製の阻害剤
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2001
- 2001-08-10 DE DE60119124T patent/DE60119124T2/de not_active Expired - Lifetime
- 2001-08-10 DK DK01963912T patent/DK1309592T3/da active
- 2001-08-10 CA CA002419550A patent/CA2419550A1/en not_active Withdrawn
- 2001-08-10 PT PT01963912T patent/PT1309592E/pt unknown
- 2001-08-10 ES ES01963912T patent/ES2262674T3/es not_active Expired - Lifetime
- 2001-08-10 AU AU8482301A patent/AU8482301A/xx active Pending
- 2001-08-10 AT AT01963912T patent/ATE324372T1/de not_active IP Right Cessation
- 2001-08-10 HK HK03105032.6A patent/HK1052705B/en not_active IP Right Cessation
- 2001-08-10 AU AU2001284823A patent/AU2001284823B2/en not_active Expired
- 2001-08-10 JP JP2002519457A patent/JP4911864B2/ja not_active Expired - Lifetime
- 2001-08-10 EP EP01963912A patent/EP1309592B9/de not_active Expired - Lifetime
- 2001-08-10 MX MXPA03001420A patent/MXPA03001420A/es active IP Right Grant
- 2001-08-10 CN CNB018170684A patent/CN1255405C/zh not_active Expired - Lifetime
- 2001-08-10 NZ NZ524192A patent/NZ524192A/en unknown
- 2001-08-10 US US09/927,188 patent/US6635633B2/en not_active Expired - Lifetime
- 2001-08-10 WO PCT/US2001/025180 patent/WO2002014317A2/en not_active Ceased
2003
- 2003-03-28 US US10/402,694 patent/US6936603B2/en not_active Expired - Lifetime
- 2003-03-28 US US10/401,486 patent/US6949540B2/en not_active Expired - Lifetime
- 2003-03-28 US US10/402,696 patent/US6951851B2/en not_active Expired - Lifetime
- 2003-08-08 US US10/638,032 patent/US20040044027A1/en not_active Abandoned
2005
- 2005-06-08 US US11/147,923 patent/US7265102B2/en not_active Expired - Lifetime
2006
- 2006-06-26 CY CY20061100866T patent/CY1104912T1/el unknown

Also Published As

Publication number	Publication date
US20040044027A1 (en)	2004-03-04
AU2001284823B2 (en)	2006-11-30
CN1468238A (zh)	2004-01-14
JP2004512273A (ja)	2004-04-22
JP4911864B2 (ja)	2012-04-04
US6635633B2 (en)	2003-10-21
MXPA03001420A (es)	2004-01-26
EP1309592B9 (de)	2007-02-28
US6951851B2 (en)	2005-10-04
US6936603B2 (en)	2005-08-30
AU8482301A (en)	2002-02-25
WO2002014317A2 (en)	2002-02-21
CA2419550A1 (en)	2002-02-21
NZ524192A (en)	2005-02-25
EP1309592A2 (de)	2003-05-14
US7265102B2 (en)	2007-09-04
CN1255405C (zh)	2006-05-10
ATE324372T1 (de)	2006-05-15
US20030229075A1 (en)	2003-12-11
US6949540B2 (en)	2005-09-27
DE60119124T2 (de)	2006-11-30
US20050234102A1 (en)	2005-10-20
US20020040019A1 (en)	2002-04-04
CY1104912T1 (el)	2009-11-04
HK1052705B (en)	2006-09-29
US20030225062A1 (en)	2003-12-04
DK1309592T3 (da)	2006-08-21
US20030225063A1 (en)	2003-12-04
EP1309592B1 (de)	2006-04-26
ES2262674T3 (es)	2006-12-01
WO2002014317A3 (en)	2002-07-04
PT1309592E (pt)	2006-07-31
HK1052705A1 (en)	2003-09-26

Publication	Publication Date	Title
ATE324372T1 (de)	2006-05-15	Substituierte pyrazole
DE60118004D1 (de)	2006-05-11	Substituierte pyrazole
WO2002014314A3 (en)	2002-06-06	Substituted pyrazoles
NO991732L (no)	1999-06-04	Nye heterocyklylmetylsubstituerte pyrazolderivater
BG66084B1 (bg)	2011-03-31	Циклопентаноиндоли, състави,съдържащи такива съединения и използването им
NO20030845D0 (no)	2003-02-24	Utvalgte fusjonerte pyrrolokarbazoler
MXPA02011320A (es)	2004-09-10	Derivados de pirazol triciclico como inhibidores de cinasa.
ATE532781T1 (de)	2011-11-15	5-(acylamino)indazol-derivate als kinase- inhibitoren
NO992400L (no)	1999-05-19	Nye substituerte pyrazolderivater
ATE433447T1 (de)	2009-06-15	Pyrimiidinverbindungen
BG66080B1 (bg)	2011-03-31	Заместени тиоацетамиди
ATE452896T1 (de)	2010-01-15	C3-cyanoepothilonderivate
DE60221425D1 (de)	2007-09-06	Substituierte tetrazyklische pyprolochinolonderivate als phosphodiesterase-inhibitoren
ATE383345T1 (de)	2008-01-15	Quinoxalin-3-on-verdindungen als orexin-rezeptor antagonisten.
MXPA03010766A (es)	2005-03-07	Nuevos compuestos y composiciones como inhibicores de las catepsinas.
DE60004340D1 (de)	2003-09-11	Substituierte 1,4-dihydroindeno[1,2-c]pyrazole als inhibitoren von tyrosinkinase
DE602004018811D1 (de)	2009-02-12	Pyrrolidinylharnstoffderivate als angiogeneseinhibitoren
ATE432936T1 (de)	2009-06-15	Imidazotriazin verbindungen zur behandlung von krebserkrankungen
ATE402694T1 (de)	2008-08-15	Verwendung von 1-phenyl-3-dimethylamino-propan- verbindungen zur therapie der harninkontinenz
YU34604A (sh)	2006-08-17	Oligopeptidi kao inhibitori katepsina s i kompozicije koje ih sadrže
ATE423780T1 (de)	2009-03-15	Makrozyclen zur behandlung von krebserkrankungen
CY1111290T1 (el)	2015-08-05	Παραγωγα 9-αλκυλαμινo-1-νιτρoακριδινης
UA87829C2 (en)	2009-08-25	Fused pyrrolocarbazoles
ECSP003336A (es)	2000-05-08	Acidos pirazolcarboxilicos sustituidos (lea 33524 - ec)

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2007-05-16	8364	No opposition during term of opposition