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DE60117465D1 - Lipide mit aminoxygruppe - Google Patents

Lipide mit aminoxygruppe

Info

Publication number
DE60117465D1
DE60117465D1 DE60117465T DE60117465T DE60117465D1 DE 60117465 D1 DE60117465 D1 DE 60117465D1 DE 60117465 T DE60117465 T DE 60117465T DE 60117465 T DE60117465 T DE 60117465T DE 60117465 D1 DE60117465 D1 DE 60117465D1
Authority
DE
Germany
Prior art keywords
lipide
aminoxy group
group
aminoxy
acting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60117465T
Other languages
English (en)
Other versions
DE60117465T2 (de
Inventor
Michael Jorgensen
Michael Keller
Andrew David Miller
Eric Perouzel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Chemical Corp
Original Assignee
Mitsubishi Chemical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/GB2000/004767 external-priority patent/WO2001048233A1/en
Priority claimed from GB0113781A external-priority patent/GB2372502B/en
Application filed by Mitsubishi Chemical Corp filed Critical Mitsubishi Chemical Corp
Application granted granted Critical
Publication of DE60117465D1 publication Critical patent/DE60117465D1/de
Publication of DE60117465T2 publication Critical patent/DE60117465T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/87Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/13Amines
    • A61K31/15Oximes (>C=N—O—); Hydrazines (>N—N<); Hydrazones (>N—N=) ; Imines (C—N=C)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • A61P31/18Antivirals for RNA viruses for HIV
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J41/00Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07JSTEROIDS
    • C07J41/00Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0055Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/64General methods for preparing the vector, for introducing it into the cell or for selecting the vector-containing host
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • AIDS & HIV (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cell Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE60117465T 2000-12-12 2001-12-05 Lipide mit aminoxygruppe Expired - Lifetime DE60117465T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
WOPCT/GB00/04767 2000-12-12
PCT/GB2000/004767 WO2001048233A1 (en) 1999-12-23 2000-12-12 Viral core protein-cationic lipid-nucleic acid-delivery complexes
GB0113781 2001-06-06
GB0113781A GB2372502B (en) 2000-12-12 2001-06-06 Carbohydrate compounds containing cholesterol and their use
PCT/GB2001/005385 WO2002048170A1 (en) 2000-12-12 2001-12-05 Lipids comprising an aminoxy group

Publications (2)

Publication Number Publication Date
DE60117465D1 true DE60117465D1 (de) 2006-04-27
DE60117465T2 DE60117465T2 (de) 2006-11-02

Family

ID=26243759

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60117465T Expired - Lifetime DE60117465T2 (de) 2000-12-12 2001-12-05 Lipide mit aminoxygruppe

Country Status (10)

Country Link
EP (1) EP1351972B1 (de)
JP (2) JP2004520301A (de)
CN (2) CN1524125A (de)
AT (1) ATE318834T1 (de)
AU (3) AU2212802A (de)
CA (2) CA2431896A1 (de)
DE (1) DE60117465T2 (de)
ES (1) ES2259007T3 (de)
RU (2) RU2003120456A (de)
WO (2) WO2002048170A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0129121D0 (en) * 2001-12-05 2002-01-23 Ic Vec Ltd Compound
EP1877100A2 (de) * 2005-04-25 2008-01-16 GE Healthcare AS Liposomen
JP5069920B2 (ja) * 2007-02-08 2012-11-07 公益財団法人東京都医学総合研究所 マンノース6−リン酸−ポリエチレングリコール結合体
GB2458473A (en) 2008-03-17 2009-09-23 Imuthes Ltd 3'-O-allyl- and 3'-O-carboxymethyl- 2'-aminosaccharide derivatives, & amides thereof with peptides, as adjuvants
GB0908963D0 (en) 2009-05-22 2009-07-01 Imuthes Ltd Compositions
WO2012066896A1 (ja) 2010-11-19 2012-05-24 Kato Junji 組合わせ医薬製剤
CZ307452B6 (cs) * 2016-11-03 2018-09-05 Vysoká škola chemicko-technologická v Praze Aminooxylipidy pro konstrukci samoskladných liposomálních systémů umožňujících jejich následnou modifikaci biologicky funkčními molekulami

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL31160A0 (en) * 1967-12-04 1969-01-29 Bayer Ag Basically substituted oximes of 5h-dibenzo-(a,d)-10,11-dihydro-cyclohepten-5-one and their production
NL6818074A (de) * 1968-12-17 1970-06-19
CH574396A5 (de) * 1969-12-29 1976-04-15 Richter Gedeon Vegyeszet
US4189431A (en) * 1975-08-04 1980-02-19 The Board of Trustees of Leland Stanford Junior University Alkinyl terminating groups in biogenetic-like cyclizations to steroids
US5283185A (en) * 1991-08-28 1994-02-01 University Of Tennessee Research Corporation Method for delivering nucleic acids into cells
US5510510A (en) * 1994-05-10 1996-04-23 Bristol-Meyers Squibb Company Inhibitors of farnesyl protein transferase
DE69727384T2 (de) * 1996-05-24 2004-11-04 IC-VEC Ltd. Polykatonische sterin-derivate zur transfektion
ATE342911T1 (de) * 1996-12-24 2006-11-15 Sirna Therapeutics Inc Synthese von nukleosiden und polynukleotiden

Also Published As

Publication number Publication date
AU2002220894A1 (en) 2002-06-24
HK1057048A1 (en) 2004-03-12
RU2003120455A (ru) 2005-01-10
RU2290409C2 (ru) 2006-12-27
CN100482676C (zh) 2009-04-29
WO2002048380A2 (en) 2002-06-20
EP1351972A1 (de) 2003-10-15
ATE318834T1 (de) 2006-03-15
JP2004520301A (ja) 2004-07-08
DE60117465T2 (de) 2006-11-02
ES2259007T3 (es) 2006-09-16
WO2002048170A1 (en) 2002-06-20
AU2002222128B2 (en) 2007-06-21
CN1524125A (zh) 2004-08-25
WO2002048380A3 (en) 2002-10-24
JP2004522722A (ja) 2004-07-29
AU2212802A (en) 2002-06-24
CA2364392A1 (en) 2002-06-12
EP1351972B1 (de) 2006-03-01
CA2431896A1 (en) 2002-06-20
CN1489597A (zh) 2004-04-14
RU2003120456A (ru) 2005-01-27

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