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DE60033044D1 - COMPOSITION OF MORPHINE METHANSULPHONATE AND CHITOSAN FOR NASAL ADMINISTRATION - Google Patents

COMPOSITION OF MORPHINE METHANSULPHONATE AND CHITOSAN FOR NASAL ADMINISTRATION

Info

Publication number
DE60033044D1
DE60033044D1 DE60033044T DE60033044T DE60033044D1 DE 60033044 D1 DE60033044 D1 DE 60033044D1 DE 60033044 T DE60033044 T DE 60033044T DE 60033044 T DE60033044 T DE 60033044T DE 60033044 D1 DE60033044 D1 DE 60033044D1
Authority
DE
Germany
Prior art keywords
methansulphonate
morphine
chitosan
composition
nasal administration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60033044T
Other languages
German (de)
Other versions
DE60033044T2 (en
Inventor
Lisbeth Illum
Peter Watts
Alan Smith
Ian Lafferty
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyowa Kirin Services Ltd
Original Assignee
Archimedes Development Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Archimedes Development Ltd filed Critical Archimedes Development Ltd
Application granted granted Critical
Publication of DE60033044D1 publication Critical patent/DE60033044D1/en
Publication of DE60033044T2 publication Critical patent/DE60033044T2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
    • C07D489/04—Salts; Organic complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
DE60033044T 1999-10-20 2000-10-19 COMPOSITION OF MORPHINE METHANSULPHONATE AND CHITOSAN FOR NASAL ADMINISTRATION Expired - Lifetime DE60033044T2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9924797.5A GB9924797D0 (en) 1999-10-20 1999-10-20 Compound
GB9924797 1999-10-20
PCT/GB2000/004003 WO2001029046A2 (en) 1999-10-20 2000-10-19 A salt of morphine

Publications (2)

Publication Number Publication Date
DE60033044D1 true DE60033044D1 (en) 2007-03-08
DE60033044T2 DE60033044T2 (en) 2007-10-18

Family

ID=10863040

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60033044T Expired - Lifetime DE60033044T2 (en) 1999-10-20 2000-10-19 COMPOSITION OF MORPHINE METHANSULPHONATE AND CHITOSAN FOR NASAL ADMINISTRATION

Country Status (15)

Country Link
US (1) US6387917B1 (en)
EP (1) EP1224188B1 (en)
JP (1) JP4928037B2 (en)
AU (1) AU771616B2 (en)
CA (1) CA2388395C (en)
CY (1) CY1106352T1 (en)
DE (1) DE60033044T2 (en)
DK (1) DK1224188T3 (en)
ES (1) ES2282141T3 (en)
GB (1) GB9924797D0 (en)
NO (1) NO327145B1 (en)
NZ (1) NZ518481A (en)
PT (1) PT1224188E (en)
WO (1) WO2001029046A2 (en)
ZA (1) ZA200203100B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9707934D0 (en) * 1997-04-18 1997-06-04 Danbiosyst Uk Improved delivery of drugs to mucosal surfaces
US7022683B1 (en) * 1998-05-13 2006-04-04 Carrington Laboratories, Inc. Pharmacological compositions comprising pectins having high molecular weights and low degrees of methoxylation
US6777000B2 (en) * 2001-02-28 2004-08-17 Carrington Laboratories, Inc. In-situ gel formation of pectin
US7494669B2 (en) * 2001-02-28 2009-02-24 Carrington Laboratories, Inc. Delivery of physiological agents with in-situ gels comprising anionic polysaccharides
US20030181488A1 (en) * 2002-03-07 2003-09-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Administration form for the oral application of 3-[(2-{[4-(hexyloxycarbonylamino-imino-methyl)-phenylamino]-methyl}-1-methyl-1H-benzimidazol-5-carbonyl)-pyridin-2-yl-amino]-propionic acid ethyl ester and the salts thereof
US7666876B2 (en) * 2002-03-19 2010-02-23 Vernalis (R&D) Limited Buprenorphine formulations for intranasal delivery
JP2005537244A (en) * 2002-06-28 2005-12-08 ナステック・ファーマシューティカル・カンパニー・インコーポレーテッド Compositions and methods for modulating physiological function of epithelial junction adhesion molecules for enhancing mucosal delivery of therapeutic compounds
US20040102476A1 (en) * 2002-11-25 2004-05-27 Chan Tai Wah High concentration formulations of opioids and opioid derivatives
GB0300531D0 (en) 2003-01-10 2003-02-12 West Pharm Serv Drug Res Ltd Pharmaceutical compositions
AU2004235744A1 (en) * 2003-05-01 2004-11-18 Archimedes Development Limited Nasal administration of the LH-RH analog leuprolide
GB0315632D0 (en) * 2003-07-04 2003-08-13 West Pharm Serv Drug Res Ltd Pharmaceutical formulations
US20050129679A1 (en) 2003-12-15 2005-06-16 Nastech Pharmaceutical Company Inc. Method for opening tight junctions
US20050175679A1 (en) * 2004-02-10 2005-08-11 Michael Moshman Controlled release formulations
CN107260672A (en) 2011-05-13 2017-10-20 欧洲凯尔特公司 Intranasal pharmaceutical formulation comprising naloxone
WO2014140899A2 (en) * 2013-03-15 2014-09-18 Johnson Matthey Public Limited Company Morphine sulfate methanolic solvate, processes for making same and related compositions and methods for treating pain

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB343397A (en) * 1929-05-24 1931-02-19 Chem Fab Vormals Sandoz Process for the manufacture of easily soluble salts of benzyl morphine
US2665227A (en) 1950-06-30 1954-01-05 Nat Res Corp Apparatus and method of coating by vapor deposition
CH407120A (en) * 1961-03-06 1966-02-15 Boehringer Sohn Ingelheim Process for the preparation of new piperidine derivatives
DE1445518A1 (en) * 1964-01-24 1968-12-05 Boehringer Sohn Ingelheim Process for the preparation of new halogenallylpiperidines
US4334071A (en) 1981-02-02 1982-06-08 Miles Laboratories, Inc. 17-Cyclobutylmethyl-3-hydroxy-8β-methyl-6-methylene-morphinane methanesulfonate
US4464378A (en) 1981-04-28 1984-08-07 University Of Kentucky Research Foundation Method of administering narcotic antagonists and analgesics and novel dosage forms containing same
US4626539A (en) * 1984-08-10 1986-12-02 E. I. Dupont De Nemours And Company Trandermal delivery of opioids
GB9202464D0 (en) * 1992-02-05 1992-03-18 Danbiosyst Uk Composition for nasal administration
EP0689438B1 (en) * 1993-03-26 2003-06-04 Franciscus Wilhelmus Henricus Maria Merkus Pharmaceutical compositions for intranasal administration of apomorphine
ES2131083T3 (en) 1993-05-03 1999-07-16 Physion Srl NEW FORMULATIONS OF MORPHINE FOR ITS USE BY IONTOFORETIC ADMINISTRATION.
US5607940A (en) 1994-07-18 1997-03-04 Stephen; Robert L. Morphine formulations for use by electromotive administration
GB9416884D0 (en) * 1994-08-20 1994-10-12 Danbiosyst Uk Drug delivery compositions
JPH09208465A (en) 1996-02-07 1997-08-12 Takeda Chem Ind Ltd Morphine liquid for high-concentration injection
GB9700624D0 (en) * 1997-01-14 1997-03-05 Danbiosyst Uk Drug delivery composition
ES2174490T3 (en) 1997-09-25 2002-11-01 Lohmann Therapie Syst Lts SALTS OF ADDITION OF ALCALOID OF MORFINA AND ITS USE.
DE19834005A1 (en) * 1997-09-25 1999-04-01 Lohmann Therapie Syst Lts Acid addition salts of morphine alkaloids and their use
KR20020016831A (en) 1999-06-16 2002-03-06 나스텍 파마수티컬 컴퍼니 인코포레이티드 Pharmaceutical Formulation and Method Comprising Intranasal Morphine
WO2000076477A1 (en) 1999-06-16 2000-12-21 Nastech Pharmaceutical Co., Inc. Methods and compositions for treating breakthrough pain
AU6046900A (en) 1999-06-16 2001-01-02 Nastech Pharmaceutical Company, Inc Method for increasing the solubility of morphine and pharmaceutical compositionsprepared therefrom
US6225343B1 (en) 1999-06-16 2001-05-01 Nastech Pharmaceutical Company, Inc. Compositions and methods comprising morphine gluconate

Also Published As

Publication number Publication date
GB9924797D0 (en) 1999-12-22
EP1224188B1 (en) 2007-01-17
CY1106352T1 (en) 2011-10-12
NO20021815D0 (en) 2002-04-17
WO2001029046A3 (en) 2001-11-01
CA2388395A1 (en) 2001-04-26
AU771616B2 (en) 2004-04-01
JP2003512380A (en) 2003-04-02
EP1224188A2 (en) 2002-07-24
DK1224188T3 (en) 2007-04-02
PT1224188E (en) 2007-02-28
NZ518481A (en) 2004-10-29
NO327145B1 (en) 2009-05-04
WO2001029046A2 (en) 2001-04-26
US6387917B1 (en) 2002-05-14
AU7933500A (en) 2001-04-30
DE60033044T2 (en) 2007-10-18
CA2388395C (en) 2010-03-09
NO20021815L (en) 2002-06-14
ES2282141T3 (en) 2007-10-16
JP4928037B2 (en) 2012-05-09
ZA200203100B (en) 2003-09-23

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: STROHSCHAENK UND KOLLEGEN, 85521 OTTOBRUNN