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DE60033668D1 - N-substituierte d-aminosäuren enthaltende peptide, zur prävention der beta-strang assoziation - Google Patents

N-substituierte d-aminosäuren enthaltende peptide, zur prävention der beta-strang assoziation

Info

Publication number
DE60033668D1
DE60033668D1 DE60033668T DE60033668T DE60033668D1 DE 60033668 D1 DE60033668 D1 DE 60033668D1 DE 60033668 T DE60033668 T DE 60033668T DE 60033668 T DE60033668 T DE 60033668T DE 60033668 D1 DE60033668 D1 DE 60033668D1
Authority
DE
Germany
Prior art keywords
peptide
beta
strand
preventing
nalpha
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60033668T
Other languages
English (en)
Other versions
DE60033668T2 (de
Inventor
Kelvin Stott
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Senexis Ltd
Original Assignee
Senexis Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senexis Ltd filed Critical Senexis Ltd
Application granted granted Critical
Publication of DE60033668D1 publication Critical patent/DE60033668D1/de
Publication of DE60033668T2 publication Critical patent/DE60033668T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Neurology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Biomedical Technology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurosurgery (AREA)
  • Toxicology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE60033668T 1999-07-28 2000-07-28 N-substituierte d-aminosäuren enthaltende peptide, zur prävention der beta-strang assoziation Expired - Fee Related DE60033668T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9917725.5A GB9917725D0 (en) 1999-07-28 1999-07-28 Peptides
GB9917725 1999-07-28
PCT/GB2000/002923 WO2001007474A1 (en) 1999-07-28 2000-07-28 Peptides containing n-substituted d-amino acids for preventing beta-strand association

Publications (2)

Publication Number Publication Date
DE60033668D1 true DE60033668D1 (de) 2007-04-12
DE60033668T2 DE60033668T2 (de) 2007-06-21

Family

ID=10858097

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60033668T Expired - Fee Related DE60033668T2 (de) 1999-07-28 2000-07-28 N-substituierte d-aminosäuren enthaltende peptide, zur prävention der beta-strang assoziation

Country Status (13)

Country Link
US (1) US7060671B1 (de)
EP (1) EP1204679B1 (de)
JP (1) JP2003505470A (de)
AT (1) ATE355302T1 (de)
AU (1) AU767396B2 (de)
CA (1) CA2379241A1 (de)
DE (1) DE60033668T2 (de)
DK (1) DK1204679T3 (de)
ES (1) ES2282125T3 (de)
GB (1) GB9917725D0 (de)
NZ (1) NZ516442A (de)
PT (1) PT1204679E (de)
WO (1) WO2001007474A1 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60043616D1 (de) 1999-07-21 2010-02-11 Univ Pennsylvania Herstellung von verbindungen zur bestimmung der hypoxie
ES2180417B1 (es) * 2001-03-14 2004-05-16 Consejo Superior De Investigaciones Cientificas Nueva proteina sobreexpresada en cancer de prostata.
DE10117281A1 (de) * 2001-04-06 2002-10-24 Inst Molekulare Biotechnologie Peptid zur Diagnose und Therapie der Alzheimer-Demenz
DE10230141B4 (de) * 2002-07-04 2004-07-15 Priontype Gmbh Verfahren und Kit zur Anreicherung und zum Nachweis von veränderten Prion-Proteinen (PrPSc)
EP1380290A1 (de) * 2002-07-09 2004-01-14 Universitair Medisch Centrum Utrecht Cross-Beta-Strukturweg und seine therapeutische Relevanz
US8067187B2 (en) 2005-07-13 2011-11-29 Crossbeta Biosciences B.V. Cross-β structure binding compounds
US8114832B2 (en) 2005-07-13 2012-02-14 Crossbeta Biosciences B.V. Method for detecting and/or removing a protein comprising a cross-beta structure from a pharmaceutical composition
GB2432586B (en) * 2005-11-25 2010-01-13 Univ Open Treatment of neurodegenerative disorders
JP2007217330A (ja) * 2006-02-16 2007-08-30 Dainippon Sumitomo Pharma Co Ltd 新規ペプチド
WO2008070284A2 (en) 2006-10-16 2008-06-12 Johnnie B. Byrd, Sr. Alzheimer's Center And Research Institute Amyloid beta peptides and methods of uses thereof
WO2008106657A2 (en) * 2007-03-01 2008-09-04 Intezyne Technologies, Inc. Encapsulated amyloid-beta peptides
GB0716885D0 (en) * 2007-08-30 2007-10-10 United Arab Emirates Universit Diagnostic agent

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2214247C (en) * 1995-03-14 2004-02-10 Praecis Pharmaceuticals Incorporated Modulators of amyloid aggregation
US6034211A (en) * 1996-06-03 2000-03-07 Kelly; Jeffery W. β-sheet nucleating peptidomimetics
DE19725619A1 (de) 1997-06-17 1998-12-24 Fraunhofer Ges Forschung Peptide als Agonisten und/oder Inhibitoren der Amyloidbildung und Zytotoxizität sowie der Verwendung bei Alzheimer'schen Krankheit, beim Typ II Diabetes mellitus und bei spongiformen Encephalopathien
AU781292B2 (en) * 1999-03-04 2005-05-12 Praecis Pharmaceuticals Incorporated Modulators of beta-amyloid peptide aggregation comprising D-amino acids

Also Published As

Publication number Publication date
DK1204679T3 (da) 2007-04-02
EP1204679B1 (de) 2007-02-28
CA2379241A1 (en) 2001-02-01
PT1204679E (pt) 2007-05-31
ATE355302T1 (de) 2006-03-15
EP1204679A1 (de) 2002-05-15
DE60033668T2 (de) 2007-06-21
GB9917725D0 (en) 1999-09-29
ES2282125T3 (es) 2007-10-16
NZ516442A (en) 2003-10-31
AU767396B2 (en) 2003-11-06
JP2003505470A (ja) 2003-02-12
AU6300400A (en) 2001-02-13
WO2001007474A1 (en) 2001-02-01
US7060671B1 (en) 2006-06-13

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee