[go: up one dir, main page]

DE60031244D1 - Reinigung von biologischen substanzen - Google Patents

Reinigung von biologischen substanzen

Info

Publication number
DE60031244D1
DE60031244D1 DE60031244T DE60031244T DE60031244D1 DE 60031244 D1 DE60031244 D1 DE 60031244D1 DE 60031244 T DE60031244 T DE 60031244T DE 60031244 T DE60031244 T DE 60031244T DE 60031244 D1 DE60031244 D1 DE 60031244D1
Authority
DE
Germany
Prior art keywords
cleaning
biological substances
purifying
employing
types
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60031244T
Other languages
English (en)
Other versions
DE60031244T2 (de
Inventor
Henry Kopf
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NCSRT Inc
Original Assignee
NCSRT Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/255,186 external-priority patent/US6214221B1/en
Application filed by NCSRT Inc filed Critical NCSRT Inc
Publication of DE60031244D1 publication Critical patent/DE60031244D1/de
Application granted granted Critical
Publication of DE60031244T2 publication Critical patent/DE60031244T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
    • B01D15/3804—Affinity chromatography
    • B01D15/3809—Affinity chromatography of the antigen-antibody type, e.g. protein A, G or L chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Peptides Or Proteins (AREA)
  • Jellies, Jams, And Syrups (AREA)
DE60031244T 1999-02-22 2000-02-22 Reinigung von biologischen substanzen Expired - Lifetime DE60031244T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US255186 1994-06-07
US09/255,186 US6214221B1 (en) 1999-02-22 1999-02-22 Method and apparatus for purification of biological substances
US09/300,891 US6139746A (en) 1999-02-22 1999-04-28 Method and apparatus for purification of biological substances
PCT/US2000/040035 WO2000048703A1 (en) 1999-02-22 2000-02-22 Purification of biological substances
US300891 2002-11-21

Publications (2)

Publication Number Publication Date
DE60031244D1 true DE60031244D1 (de) 2006-11-23
DE60031244T2 DE60031244T2 (de) 2007-05-24

Family

ID=26944506

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60031244T Expired - Lifetime DE60031244T2 (de) 1999-02-22 2000-02-22 Reinigung von biologischen substanzen

Country Status (10)

Country Link
US (1) US6383380B1 (de)
EP (1) EP1154827B1 (de)
AT (1) ATE342112T1 (de)
AU (1) AU756832B2 (de)
CA (1) CA2361545C (de)
DE (1) DE60031244T2 (de)
DK (1) DK1154827T3 (de)
IL (1) IL144421A (de)
NZ (1) NZ513242A (de)
WO (1) WO2000048703A1 (de)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6214221B1 (en) * 1999-02-22 2001-04-10 Henry B. Kopf Method and apparatus for purification of biological substances
NO20002828D0 (no) * 2000-06-02 2000-06-02 Statens Inst For Folkehelse Proteinholdig vaksine mot Neisseria meningtidis serogruppe samt fremgangsmÕte ved fremstilling derav
AU2003235875A1 (en) * 2002-05-07 2003-11-11 Asahi Kasei Kabushiki Kaisha Method and system for obtaining cells of specific type from biological material
KR100473703B1 (ko) * 2002-08-23 2005-03-10 한미약품 주식회사 형질전환 동물의 젖으로부터 재조합 펩타이드 또는단백질의 정제 방법
JP2006515227A (ja) * 2003-02-24 2006-05-25 ジーティーシー バイオセラピューティックス インコーポレイテッド 十字流濾過の方法およびそのための装置
US8152999B2 (en) * 2004-05-21 2012-04-10 Wisconsin Alumni Research Foundation Membrane cascade-based separation
DK1786273T3 (en) 2004-08-20 2019-02-18 Prometic Biosciences Ltd SEQUENTIAL PROTEIN INSULATION AND PURIFICATION PLANS WITH AFFINITY CHROMATOGRAPHY
US20060218667A1 (en) * 2004-10-12 2006-09-28 Vojdani Fakhrieh S Plant-produced recombinant aprotinin and aprotinin variants
US7531632B2 (en) 2006-02-16 2009-05-12 Gtc Biotherapeutics, Inc. Clarification of transgenic milk using depth filtration
US10850235B2 (en) 2006-10-09 2020-12-01 Minnetronix, Inc. Method for filtering cerebrospinal fluid (CSF) including monitoring CSF flow
US10632237B2 (en) 2006-10-09 2020-04-28 Minnetronix, Inc. Tangential flow filter system for the filtration of materials from biologic fluids
ES2981635T3 (es) 2006-10-09 2024-10-09 Neurofluidics Inc Sistema de purificación de líquido cefalorraquídeo
CN101497649B (zh) * 2008-01-31 2011-06-08 上海依科赛生物制品有限公司 高融合率无噬菌体新生牛血清的生产工艺
FR2931838B1 (fr) 2008-06-02 2010-06-11 Millipore Corp Installation pour traiter un liquide biologique.
FR2940145B1 (fr) 2008-12-24 2011-03-25 Millipore Corp Chariot et installation de traitement d'un liquide biologique
WO2010090864A2 (en) * 2009-01-21 2010-08-12 Smartflow Technologies, Inc. Optimization of separation for viscous suspensions
FR2941385B1 (fr) 2009-01-23 2011-04-01 Millipore Corp Procede pour fournir un circuit pour liquide biologique et circuit obtenu.
US7988859B2 (en) * 2009-02-05 2011-08-02 Chromatan Inc. Countercurrent tangential chromatography methods, systems, and apparatus
KR20100102926A (ko) * 2009-03-12 2010-09-27 삼성전자주식회사 표적물질 정제를 위한 필터유닛 및 이를 채용한 미세유동장치
KR20100111097A (ko) * 2009-04-06 2010-10-14 삼성전자주식회사 표적물질 분리를 위한 미세유동장치 및 그 정제방법
WO2011066498A2 (en) 2009-11-28 2011-06-03 Smartflow Technologies, Inc. Portable filtration unit
FR2955119B1 (fr) 2010-01-13 2012-12-28 Millipore Corp Circuit pour liquide biologique
FR2960795B1 (fr) 2010-06-08 2012-07-27 Millipore Corp Dispositif pour une installation de traitement de liquide biologique
FR2960796B1 (fr) 2010-06-08 2014-01-24 Millipore Corp Dispositif pour une installation de traitement de liquide biologique
FR2960794B1 (fr) 2010-06-08 2012-07-27 Millipore Corp Dispositif pour une installation de traitement de liquide biologique
FR2961711B1 (fr) 2010-06-23 2012-08-17 Millipore Corp Poche pour circuit d'une installation de traitement de liquide biologique
FR2961713B1 (fr) 2010-06-23 2012-08-10 Millipore Corp Poche pour circuit d'une installation de traitement de liquide biologique
FR2963573B1 (fr) 2010-08-03 2012-08-31 Millipore Corp Chariot de pompage pour une installation de traitement de liquide biologique
EP2627428A4 (de) 2010-10-15 2016-08-31 Ge Healthcare Bio Sciences Einweg-ultrafiltrationssysteme und -verfahren mit grossem volumen
US8919385B2 (en) 2010-11-24 2014-12-30 Pall Corporation Manifold plates and fluid treatment arrangements including manifold plates
BR112013021344A2 (pt) 2011-02-21 2016-11-01 Smartflow Technologies Inc métodos e sistemas para isolamento e/ou separação de produtos de processos de produção
US10005697B1 (en) 2011-02-21 2018-06-26 Smartflow Technologies, Inc. Method and systems for isolation and/or separation of target products from animal produced waste streams
WO2012135042A1 (en) * 2011-03-25 2012-10-04 Receptors Llc Filtration article with microbial removal, micro-biocidal, or static growth capability
FR2973396B1 (fr) 2011-03-28 2013-05-10 Millipore Corp Installation de traitement de liquide biologique
US9284346B2 (en) * 2011-09-07 2016-03-15 Therapeutic Proteins International, LLC Preparative chromatography column and methods
US9783750B2 (en) 2012-02-16 2017-10-10 Smartflow Technologies, Inc. Biodiesel fuel production, separation methods and systems
EP2682168A1 (de) 2012-07-02 2014-01-08 Millipore Corporation Reinigung biologischer Moleküle
FR2993572B1 (fr) 2012-07-23 2016-04-15 Emd Millipore Corp Circuit pour liquide biologique comportant une vanne a pincement
US10786784B2 (en) 2012-09-06 2020-09-29 Smartflow Technologies, Inc. Permeate channel alterations for counter current filtration for use in cross-flow filtration modules useful in osmotic systems
AU2014285971A1 (en) 2013-07-05 2016-02-04 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Affinity chromatography matrix
US10324070B2 (en) 2014-04-23 2019-06-18 Chromatan Inc. High efficiency continuous countercurrent tangential chromatography
WO2015195452A2 (en) 2014-06-16 2015-12-23 Emd Millipore Corporation Single-pass filtration systems and processes
WO2015195453A2 (en) 2014-06-16 2015-12-23 Emd Millipore Corporation Methods for increasing the capacity of flow-through processes
KR101938948B1 (ko) 2014-06-25 2019-01-15 이엠디 밀리포어 코포레이션 밀집한 나권형 필터 엘리먼트, 모듈 및 시스템
WO2016033553A1 (en) 2014-08-29 2016-03-03 Emd Millipore Corporation Processes for filtering liquids using single pass tangential flow filtration systems and tangential flow filtration systems with recirculation of retentate
WO2016033546A1 (en) 2014-08-29 2016-03-03 Emd Millipore Corporation Single pass tangential flow filtration systems and tangential flow filtration systems with recirculation of retentate
US11147540B2 (en) 2015-07-01 2021-10-19 Minnetronix, Inc. Introducer sheath and puncture tool for the introduction and placement of a catheter in tissue
JP7166915B2 (ja) 2015-08-05 2022-11-08 ミネトロニクス， インコーポレイテッド 体液から物質を濾過する為の接線流フィルターシステム
ES2856599T3 (es) 2015-12-04 2021-09-27 Minnetronix Inc Sistemas de acondicionamiento de fluido cerebrospinal
US12226737B2 (en) 2016-06-09 2025-02-18 Emd Millipore Corporation Radial-path filter elements, systems and methods of using same
WO2018037244A1 (en) * 2016-08-26 2018-03-01 Puridify Ltd. Chromatography system
EP3781284B1 (de) 2018-04-17 2024-08-07 Smartflow Technologies, Inc. Filterkassettenartikel und filter damit
US11028124B2 (en) * 2018-05-07 2021-06-08 Repligen Corporation Methods, devices and systems for 3-stage filtration
CA3110039A1 (en) 2018-08-29 2020-03-05 Merck Biodevelopment S.A.S. New purification method
EP3852904A1 (de) 2018-09-21 2021-07-28 Cytiva Sweden AB Perfusionsbioverarbeitungssystem und betriebsverfahren dafür
BR112023000584A2 (pt) * 2020-07-15 2023-03-28 Nutrition & Biosciences Usa 1 Llc Bioprocesso com depósito de impurezas reduzido nas superfícies
WO2025019564A2 (en) * 2023-07-18 2025-01-23 Repligen Corporation System and methods for combined harvest and capture of a biologic

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4420398A (en) * 1981-08-13 1983-12-13 American National Red Cross Filteration method for cell produced antiviral substances
US4443231A (en) * 1982-02-02 1984-04-17 Exxon Research And Engineering Co. Continuous chromatographic separations in a magnetically stabilized fluidized bed
US4606825A (en) 1985-04-22 1986-08-19 J. T. Baker Chemical Company Purification of immunoglobulin G
US4748234A (en) 1985-06-26 1988-05-31 Cetus Corporation Process for recovering refractile bodies containing heterologous proteins from microbial hosts
US5593580A (en) * 1986-11-26 1997-01-14 Kopf; Henry B. Filtration cassette article, and filter comprising same
US5868930A (en) 1986-11-26 1999-02-09 Kopf; Henry B. Filtration cassette article and filter comprising same
DE3640513A1 (de) 1986-11-27 1988-06-09 Biotest Pharma Gmbh Verfahren zur herstellung eines virussicheren, lagerstabilen und intravenoes vertraeglichen immunglobulin-g-praeparates
US5049268A (en) 1987-10-02 1991-09-17 Kopf Henry B Filter plate, filter plate element, and filter comprising same
US4867876A (en) 1987-10-02 1989-09-19 Kopf Henry B Filter plate, filter plate element, and filter comprising same
US4882050A (en) 1987-10-02 1989-11-21 Kopf Henry B Filter plate, filter plate element, and filter comprising same
US5232589A (en) 1987-10-02 1993-08-03 Kopf Henry B Filter element and support
US5342517A (en) 1987-10-02 1994-08-30 Kopf Henry B Filtration cassette article, and filter comprising same
US5118796A (en) 1987-12-09 1992-06-02 Centocor, Incorporated Efficient large-scale purification of immunoglobulins and derivatives
US5077391A (en) 1989-12-01 1991-12-31 Raison Robert L Purification of immunoglobulin M
US5177194A (en) 1990-02-01 1993-01-05 Baxter International, Inc. Process for purifying immune serum globulins
US5505841A (en) * 1991-03-11 1996-04-09 Pirbazari; Massoud Microfiltration and adsorbent particle suspension for removing contaminants from water
US5259971A (en) 1992-03-02 1993-11-09 Cryolife, Inc. Method of preparing fibrinogen
AU667530B2 (en) * 1992-05-28 1996-03-28 New York Blood Center, Inc., The Removal of antibodies from blood-derived compositions while retaining coagulation factors
CA2090989C (en) * 1993-03-04 1995-08-15 Konstantin Volchek Removal of arsenic from aqueous liquids with selected alumina
CA2127605A1 (en) * 1993-12-23 1995-06-24 Peter J. Degen Affinity separation method
US6315900B1 (en) 1998-06-03 2001-11-13 Accurate Polymers Static separation method using non-porous cellulose beads
US6214221B1 (en) * 1999-02-22 2001-04-10 Henry B. Kopf Method and apparatus for purification of biological substances

Also Published As

Publication number Publication date
EP1154827A1 (de) 2001-11-21
EP1154827A4 (de) 2002-08-28
NZ513242A (en) 2003-10-31
WO2000048703A1 (en) 2000-08-24
IL144421A (en) 2004-12-15
US6383380B1 (en) 2002-05-07
DK1154827T3 (da) 2007-02-19
WO2000048703A9 (en) 2002-08-08
DE60031244T2 (de) 2007-05-24
CA2361545A1 (en) 2000-08-24
ATE342112T1 (de) 2006-11-15
CA2361545C (en) 2009-01-27
AU3008300A (en) 2000-09-04
EP1154827B1 (de) 2006-10-11
IL144421A0 (en) 2002-05-23
AU756832B2 (en) 2003-01-23
WO2000048703B1 (en) 2000-12-07

Similar Documents

Publication Publication Date Title
DE60031244D1 (de) Reinigung von biologischen substanzen
DK0923592T3 (da) Fremgangsmåder til rensning af nukleinsyrer
DE69421889D1 (de) Modifizierte Glasfasermembranen für Festphase-Extraktionsreinigung von DNA
DK0417829T4 (da) Fremgangsmåde til rensning af effluenten fra urinstofproduktionsanlæg
BRPI0410685B8 (pt) processos de purificação do 1,3-propanodiol e composição
BR0214084A (pt) Dispositivo e processo para separação de purificação de cristais de sua suspensão no banho cristalino impuro, uso de um dispositivo
DE60005143D1 (de) Herstellung von iodixanol
FR2603581B1 (fr) Procede pour isoler et purifier des aminoacides par chromatographie
IS5954A (is) Rafgreiningarbúnaður, aðferð til hreinsunar á vatnaskenndum lausnum og nýmyndun efna
EA200200274A1 (ru) Микробиологический фильтр для воды
EP0305316A3 (de) Verfahren und Anlage zur mehrstufigen Reinigung
DK0585347T3 (da) Fremgangsmåde til rensning af TiO2-malm
DK0891302T3 (da) Fremgangsmåde til biologisk rensning af spildevand
DE69502313D1 (de) Verfahren zur biologischen Reinigung von Gasströmen
DE69817818D1 (de) Einstufige vorrichtung und verfahren zur konzentration und säuberung biologischer moleküle
EP1115464A4 (de) Destillationsverfahren zur reinigung einer flüssigkeit
FR2801306B1 (fr) Procede de purification des monomeres (meth) acryliques par distillation
DE69400052D1 (de) Mikrodosierverfahren für Flüssigkeiten zur Erzielung nanovolumetrischer Lösungen
DE69604390D1 (de) Uv-reflektor, integriert in eine uv-anlage zur gas- oder flüssigkeitsreinigung, bevorzugt von wasser
EP1193281A4 (de) Verfahren zur reinigung einer polykarbonatlösung in einem organischen lösungsmittel und reinigungsgerät
DE69309106D1 (de) Prozess zur herstellung von (meth)acrylnitril durch ammoxidation
DK0999997T3 (da) Fremgangsmåde til affarvning af væsker
FR2716449B1 (fr) Procédé de purification du pentafluoroéthane.
DK1177164T3 (da) Fremgangsmåde til oprensning af diacerein
DE59903651D1 (de) Verfahren zur herstellung von [15 o]butanol und vorrichtung zur durchführung des verfahrens

Legal Events

Date Code Title Description
8364 No opposition during term of opposition