[go: up one dir, main page]

DE60029561D1 - Immobilisierung von molekülen auf oberflächen über polymerbürsten - Google Patents

Immobilisierung von molekülen auf oberflächen über polymerbürsten

Info

Publication number
DE60029561D1
DE60029561D1 DE60029561T DE60029561T DE60029561D1 DE 60029561 D1 DE60029561 D1 DE 60029561D1 DE 60029561 T DE60029561 T DE 60029561T DE 60029561 T DE60029561 T DE 60029561T DE 60029561 D1 DE60029561 D1 DE 60029561D1
Authority
DE
Germany
Prior art keywords
immobilization
molecules
polymer
polymer brushes
surfaces over
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60029561T
Other languages
English (en)
Other versions
DE60029561T2 (de
Inventor
Holger Klapproth
Oswald Prucker
Juergen Ruehe
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
TDK Micronas GmbH
Original Assignee
TDK Micronas GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP99104278A external-priority patent/EP1035218A1/de
Application filed by TDK Micronas GmbH filed Critical TDK Micronas GmbH
Publication of DE60029561D1 publication Critical patent/DE60029561D1/de
Application granted granted Critical
Publication of DE60029561T2 publication Critical patent/DE60029561T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54353—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals with ligand attached to the carrier via a chemical coupling agent
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/544—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being organic
    • G01N33/545—Synthetic resin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00497—Features relating to the solid phase supports
    • B01J2219/00527—Sheets
    • B01J2219/00529—DNA chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00585—Parallel processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00596—Solid-phase processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00608—DNA chips
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00612—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports the surface being inorganic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00623—Immobilisation or binding
    • B01J2219/00626—Covalent
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00605—Making arrays on substantially continuous surfaces the compounds being directly bound or immobilised to solid supports
    • B01J2219/00632—Introduction of reactive groups to the surface
    • B01J2219/00637—Introduction of reactive groups to the surface by coating it with another layer
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00583—Features relative to the processes being carried out
    • B01J2219/00603—Making arrays on substantially continuous surfaces
    • B01J2219/00659—Two-dimensional arrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00718—Type of compounds synthesised
    • B01J2219/0072—Organic compounds
    • B01J2219/00722—Nucleotides
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00—Libraries per se, e.g. arrays, mixtures
    • C40B40/04—Libraries containing only organic compounds
    • C40B40/06—Libraries containing nucleotides or polynucleotides, or derivatives thereof

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Microbiology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Polymerisation Methods In General (AREA)
  • Polymerization Catalysts (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Materials For Medical Uses (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
DE60029561T 1999-01-25 2000-01-25 Immobilisierung von molekülen auf oberflächen über polymerbürsten Expired - Lifetime DE60029561T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP99101340 1999-01-25
EP99101340 1999-01-25
EP99104278A EP1035218A1 (de) 1999-03-03 1999-03-03 Immobilisierung von Molekülen an Oberflächen über verzweigte Polymerketten
EP99104278 1999-03-03
PCT/EP2000/000554 WO2000043539A2 (en) 1999-01-25 2000-01-25 Immobilization of molecules on surfaces via polymer brushes

Publications (2)

Publication Number Publication Date
DE60029561D1 true DE60029561D1 (de) 2006-09-07
DE60029561T2 DE60029561T2 (de) 2007-07-19

Family

ID=26152863

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60029561T Expired - Lifetime DE60029561T2 (de) 1999-01-25 2000-01-25 Immobilisierung von molekülen auf oberflächen über polymerbürsten

Country Status (8)

Country Link
US (1) US7250253B1 (de)
EP (1) EP1144677B1 (de)
JP (1) JP4970654B2 (de)
AT (1) ATE334226T1 (de)
AU (1) AU3150400A (de)
CA (1) CA2360027A1 (de)
DE (1) DE60029561T2 (de)
WO (1) WO2000043539A2 (de)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2377739A1 (en) 1999-07-02 2001-01-11 Symyx Technologies, Inc. Polymer brushes for immobilizing molecules to a surface or substrate, where the polymers have water-soluble or water-dispersible segments and probes bonded thereto
KR100608152B1 (ko) * 1999-07-07 2006-08-04 미러스 코포레이션 고체 지지체 상에 핵산을 고정시키기 위한 기판
US6994964B1 (en) 1999-09-01 2006-02-07 Affymetrix, Inc. Macromolecular arrays on polymeric brushes and methods for preparing the same
FR2802550B1 (fr) * 1999-12-17 2004-03-05 Centre Nat Rech Scient Biopuces, preparation et utilisations
ATE355525T1 (de) * 2000-07-27 2006-03-15 Micronas Holding Gmbh Auf einer oberfläche befestigte multifunktionelle polymere-netzwerke für sensorchips
ATE316581T1 (de) 2000-09-05 2006-02-15 Zeltz Patrick Dr Verfahren zur spezifischen bestimmung von dna- sequenzen mittels paralleler amplifikation
EP1202062B1 (de) * 2000-10-31 2007-02-28 Micronas GmbH Gemusterte Polymeroberflächen geeignet für Biokonjugationen und Verfahren zu ihrer Herstellung
US7205161B2 (en) 2001-01-10 2007-04-17 Symyx Technologies, Inc. Polymer brushes for immobilizing molecules to a surface or substrate having improved stability
US20030068317A1 (en) * 2001-04-20 2003-04-10 William Lee High capacity methods for separation, purification, concentration, immobilization and synthesis of compounds and applications based thereupon
US20050042612A1 (en) * 2001-07-30 2005-02-24 Hubbard Michael Anthony Graft polymer martrices
EP1421376A2 (de) * 2001-08-27 2004-05-26 Zeptosens AG Bionalytische erkennungsoberfläche mit optimierter dichte der erkennungselemente
US6867295B2 (en) 2001-09-07 2005-03-15 Dionex Corporation Ion exchange cryptands covalently bound to substrates
EP1463480A4 (de) * 2001-12-10 2008-08-27 Emembrane Inc Funktionalisierte materialien und bibliotheken davon
JP2003294742A (ja) * 2002-03-29 2003-10-15 Inst Of Physical & Chemical Res ハイブリダイゼーション用基板及びその使用方法
JP2005534942A (ja) * 2002-08-08 2005-11-17 シーメンス　アクチエンゲゼルシヤフト バイオセンサーテクノロジーのためのポリアクリルアミドをベースとするヒドロゲルからなる認識層
EP1530600B1 (de) * 2002-08-09 2007-03-14 Ottawa Health Research Institute Biosynthetische matrix und deren verwendung
AU2003270769A1 (en) * 2002-09-18 2004-04-08 Emembrane, Inc. Functionalized materials and methods of using same
DE10245435B4 (de) 2002-09-27 2006-03-16 Micronas Gmbh Vorrichtung zur Detektion mindestens eines in einer zu untersuchenden Probe enthaltenen Liganden
DE10328730B4 (de) 2003-06-25 2006-08-17 Micronas Gmbh Verfahren zum Herstellen eines Microarrays und Vorrichtung zum Versehen eines Trägers für ein Microarray mit Beschichtungsstoffen
US7354706B2 (en) 2003-09-09 2008-04-08 The Regents Of The University Of Colorado, A Body Corporate Use of photopolymerization for amplification and detection of a molecular recognition event
US20090163375A1 (en) 2003-09-09 2009-06-25 Bowman Christopher N Use of Photopolymerization for Amplification and Detection of a Molecular Recognition Event
DE102004010430A1 (de) 2004-03-01 2005-09-22 Rühe, Jürgen, Prof. Dr. Verfahren zur kovalenten Immobilisierung von Biomolekülen an organischen Oberflächen
US7514764B2 (en) * 2005-03-23 2009-04-07 Wisconsin Alumni Research Foundation Materials and methods for creating imaging layers
DE102005022782A1 (de) 2005-05-12 2006-11-16 Tesa Ag Haftklebemassen und Verfahren zu deren Herstellung
WO2006128644A1 (en) * 2005-05-30 2006-12-07 Giovanna Pirri Polymer coating and functionalization of solid surfaces
US8357433B2 (en) 2005-06-14 2013-01-22 Siemens Energy, Inc. Polymer brushes
US7862886B2 (en) * 2005-08-12 2011-01-04 Fujifilm Corporation Optical film, antireflection film, processes for producing the same, and polarizing plate and display employing the same
EP1811300B1 (de) 2005-12-23 2008-11-12 Micronas GmbH Sensorchip mit in einem Polymer-Netzwerk eingelagerten Rezeptoren
KR100838124B1 (ko) 2007-02-01 2008-06-13 포항공과대학교 산학협력단 생체적합성 지방족 브러쉬 고분자 및 그 제조 방법
DE102008032570A1 (de) 2008-07-11 2010-01-14 Tesa Se Haftklebemassen und Verfahren zu deren Herstellung
EP2192409B1 (de) 2008-11-26 2014-04-23 Corning Incorporated Biosensorzusammensetzung zur Marker-unabhängigen Erkennung und Verfahren dafür
DE102009060626A1 (de) 2009-12-24 2011-06-30 Klapproth, Holger, Dr., 79108 Kalibrierte Flusszelle zur IR-Analytik
US20130199692A1 (en) * 2010-07-30 2013-08-08 North Carolina State University Surface Functionalization of Polyester
CN103764671B (zh) 2011-02-01 2016-12-21 马哈希大亚纳德大学 酶共固定化的聚氯乙烯表面及其用途
EP2718691B1 (de) 2011-06-09 2017-12-13 QFood GmbH Verfahren und vorrichtung zum bestimmen der konzentration eines in einer flüssigen probe enthaltenen analyten
WO2014043644A1 (en) 2012-09-17 2014-03-20 Alltech Associates, Inc. Functionalized particulate support material and methods of making and using the same
JP6360482B2 (ja) 2012-09-17 2018-07-18 ダブリュー・アール・グレース・アンド・カンパニー−コーンＷ Ｒ Ｇｒａｃｅ ＆ Ｃｏ−Ｃｏｎｎ クロマトグラフィー担体及びデバイス
JP6453210B2 (ja) 2013-05-13 2019-01-16 国立研究開発法人科学技術振興機構 新規複合材料およびそれを用いるポリマー被覆材前駆体
WO2015085268A1 (en) 2013-12-05 2015-06-11 Centrillion Technology Holdings Corporation Modified surfaces
CN106460032B (zh) 2013-12-05 2019-12-24 生捷科技控股公司 图案化阵列的制备
EP3077545B1 (de) 2013-12-05 2020-09-16 Centrillion Technology Holdings Corporation Verfahren zur sequenzierung von nukleinsäuren
ES2887110T3 (es) 2014-01-16 2021-12-21 Grace W R & Co Medios para cromatografía de afinidad y dispositivos para cromatografía
US11060139B2 (en) 2014-03-28 2021-07-13 Centrillion Technology Holdings Corporation Methods for sequencing nucleic acids
US11389783B2 (en) 2014-05-02 2022-07-19 W.R. Grace & Co.-Conn. Functionalized support material and methods of making and using functionalized support material
CN107921407B (zh) 2015-06-05 2022-07-05 格雷斯公司 生物处理吸附澄清剂及其制备和使用方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63233360A (ja) * 1986-12-15 1988-09-29 Fuji Photo Film Co Ltd 電気泳動用媒体
SE8801070D0 (sv) * 1988-03-23 1988-03-23 Pharmacia Ab Method for immobilizing a dna sequence on a solid support
SE462454B (sv) * 1988-11-10 1990-06-25 Pharmacia Ab Maetyta foer anvaendning i biosensorer
US5143854A (en) * 1989-06-07 1992-09-01 Affymax Technologies N.V. Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
JPH05502585A (ja) * 1989-12-04 1993-05-13 ベクトン　ディッキンソン　アンド　カンパニー ポリマーに共有結合したオリゴヌクレオチドの利用により向上される標的核酸の捕獲
BR9206705A (pt) * 1991-11-01 1995-11-21 Adelaide Children S Hospital Processo de amplificação de fase sólida
US5624711A (en) * 1995-04-27 1997-04-29 Affymax Technologies, N.V. Derivatization of solid supports and methods for oligomer synthesis
SE9502608D0 (sv) * 1995-07-14 1995-07-14 Pharmacia Biosensor Ab Method for nucleic acid senquencing
EP0910570A4 (de) * 1995-11-14 2002-01-16 Baylor College Medicine Integrierte nukleinsaure-hybridisierung-vorrichtung auf der basis von aktiver-oberflachenchemie
US6132765A (en) * 1996-04-12 2000-10-17 Uroteq Inc. Drug delivery via therapeutic hydrogels
DK1005644T3 (da) * 1996-04-25 2003-06-23 Pence Inc Biosensoranordning og fremgangsmåde
US6130037A (en) * 1996-04-25 2000-10-10 Pence And Mcgill University Biosensor device and method
US6485703B1 (en) * 1998-07-31 2002-11-26 The Texas A&M University System Compositions and methods for analyte detection
JP3919958B2 (ja) * 1998-11-11 2007-05-30 独立行政法人科学技術振興機構 高分子薄膜の製造方法
WO2000030532A1 (en) * 1998-11-20 2000-06-02 University Of Connecticut Generic integrated implantable potentiostat telemetry unit for electrochemical sensors
US6413587B1 (en) * 1999-03-02 2002-07-02 International Business Machines Corporation Method for forming polymer brush pattern on a substrate surface

Also Published As

Publication number Publication date
EP1144677B1 (de) 2006-07-26
CA2360027A1 (en) 2000-07-27
JP4970654B2 (ja) 2012-07-11
JP2002535450A (ja) 2002-10-22
EP1144677A2 (de) 2001-10-17
WO2000043539A2 (en) 2000-07-27
DE60029561T2 (de) 2007-07-19
AU3150400A (en) 2000-08-07
ATE334226T1 (de) 2006-08-15
WO2000043539A3 (en) 2000-11-30
US7250253B1 (en) 2007-07-31

Similar Documents

Publication Publication Date Title
DE60029561D1 (de) Immobilisierung von molekülen auf oberflächen über polymerbürsten
CY1106984T1 (el) Νεα βιοσυγκολλητικη συνθεση που περιεχει μια βιοσυγκολλητικη πολυφαινολικη πρωτεϊνη, ενα πολυμερες που περιεχει ομαδες υδατανθρακα, φαρμακευτικως αποδεκτα λεπτα νηματα και οι χρησεις τους
BR0014703B1 (pt) dispersão polimérica aquosa, processo para preparação da mesma, substrato ligado, e, uso de uma dispersão polimérica aquosa.
DE69723369D1 (de) Mikrobieller Stamm, Verfahren zum biologischen Abbau von organischen Verbindungen und Verfahren zur Engiftung der Umwelt damit
BR9911084B1 (pt) processo de polimerização.
BR9805745B1 (pt) processo de construÇço de um pneu.
BR0017027B1 (pt) composição secada por spray e processo de polimerização.
DE69837543D1 (de) Gestell für den transport von rohrförmigen elementen
ES2066760T3 (es) Nucleotidos de alquinilamino.
DE69612772D1 (de) Bedrucken von Bibliotheken von Molekularketten
FI972333A7 (fi) Entsymaattiset DNA-molekyylit
FI20002539L (fi) Hepatosyyttiin kohdentuva polyetyleeniglykohaaroittunut poly-L-lysiinipolymeerigeenikantaja
DE59602960D1 (de) Federnde scharnieranordnung, z.b. für einteilig gespritzte kunststoffverschlüsse
ATE411116T1 (de) Funktionalisierte poröse siliziumoberflächen
EP1047711A4 (de) Nukleinsäuresequenzen, welche für capsaicin-rezeptoren kodieren
BR0313229B1 (pt) vernizes de eletroimersão e uso de tais vernizes
EP0964930A4 (de) Katalytische rna moleküle
ATE383172T1 (de) Oligonukleotide welche spezifisch retrovirale nukleokapsid-proteine binden
DE19882401B8 (de) Blockoligomere, enthaltend 1-Kohlenwasserstoffoxy-2,2,6,6-tetramethyl-4-piperidyl-Gruppen als Stabilisatoren für organische Materialien
WO2002010758A3 (de) Surface-
DE60039999D1 (de) Bindungsoberfläche
BR0311288A (pt) Processo para a ligação de polìmeros contendo grupo ácidos absorventes de água particulados em um material de suporte por meio de compostos compreendendo grupos amino, material de suporte, artigo de higiene, e, uso de compostos
BR0317288A (pt) Corrente de presilhas com presilhas internas e externas formadas de presilhas individuais
FI960375A0 (fi) Rakenneyksiköitä, joissa on nukleosidienvälisiä karbamaattisidoksia, ja niistä saatuja uusia oligonukleotideja
EP1083980A4 (de) Modulation molekularer wechselwirkungspositionen in rns und anderen biomolekülen

Legal Events

Date Code Title Description
8364 No opposition during term of opposition