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DE60026297D1 - Pyrrolotriazin kinasehemmer - Google Patents

Pyrrolotriazin kinasehemmer

Info

Publication number
DE60026297D1
DE60026297D1 DE60026297T DE60026297T DE60026297D1 DE 60026297 D1 DE60026297 D1 DE 60026297D1 DE 60026297 T DE60026297 T DE 60026297T DE 60026297 T DE60026297 T DE 60026297T DE 60026297 D1 DE60026297 D1 DE 60026297D1
Authority
DE
Germany
Prior art keywords
kinasehemmer
pyrrolotriazine
pyrrolotriazine kinasehemmer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60026297T
Other languages
English (en)
Other versions
DE60026297T2 (de
Inventor
T Hunt
S Bhide
M Borzilleri
Ligang Qian
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of DE60026297D1 publication Critical patent/DE60026297D1/de
Application granted granted Critical
Publication of DE60026297T2 publication Critical patent/DE60026297T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A—HUMAN NECESSITIES
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    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
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    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Obesity (AREA)
  • Virology (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Molecular Biology (AREA)
  • Child & Adolescent Psychology (AREA)
DE60026297T 1999-05-21 2000-05-16 Pyrrolotriazin kinasehemmer Expired - Lifetime DE60026297T2 (de)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US13526599P 1999-05-21 1999-05-21
US135265P 1999-05-21
US19372700P 2000-03-31 2000-03-31
US193727P 2000-03-31
PCT/US2000/013420 WO2000071129A1 (en) 1999-05-21 2000-05-16 Pyrrolotriazine inhibitors of kinases

Publications (2)

Publication Number Publication Date
DE60026297D1 true DE60026297D1 (de) 2006-04-27
DE60026297T2 DE60026297T2 (de) 2006-11-02

Family

ID=26833147

Family Applications (2)

Application Number Title Priority Date Filing Date
DE60042620T Expired - Lifetime DE60042620D1 (de) 1999-05-21 2000-05-16 Pyrrolotriazine als Kinase Hemmer.
DE60026297T Expired - Lifetime DE60026297T2 (de) 1999-05-21 2000-05-16 Pyrrolotriazin kinasehemmer

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE60042620T Expired - Lifetime DE60042620D1 (de) 1999-05-21 2000-05-16 Pyrrolotriazine als Kinase Hemmer.

Country Status (28)

Country Link
EP (1) EP1183033B1 (de)
JP (2) JP4649046B2 (de)
KR (1) KR100666514B1 (de)
CN (1) CN1351498B (de)
AR (1) AR043087A1 (de)
AT (1) ATE318603T1 (de)
AU (1) AU770377B2 (de)
BR (1) BR0010482A (de)
CA (1) CA2373990C (de)
CZ (1) CZ303660B6 (de)
DE (2) DE60042620D1 (de)
DK (1) DK1183033T3 (de)
EG (1) EG24027A (de)
ES (2) ES2258459T3 (de)
HK (1) HK1041599B (de)
HU (1) HUP0301005A3 (de)
IL (2) IL144977A0 (de)
MX (1) MXPA01011832A (de)
MY (1) MY128370A (de)
NO (1) NO322214B1 (de)
NZ (1) NZ516292A (de)
PE (1) PE20010126A1 (de)
PL (1) PL204437B1 (de)
RU (1) RU2331640C2 (de)
TR (1) TR200103352T2 (de)
TW (1) TWI238163B (de)
UY (1) UY26150A1 (de)
WO (1) WO2000071129A1 (de)

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JP2006502995A (ja) 2002-07-19 2006-01-26 メモリー・ファーマシューティカルズ・コーポレイション ホスホジエステラーゼ４阻害剤としての６−アミノ−１ｈ−インダゾール及び４−アミノベンゾフラン化合物
JP2006504656A (ja) 2002-07-19 2006-02-09 メモリー・ファーマシューティカルズ・コーポレイション Ｎ−置換されたアニリン及びジフェニルアミンアナログを含むホスホジエステラーゼ４インヒビター
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CN1351498B (zh) 2012-08-15
CA2373990A1 (en) 2000-11-30
KR20020015041A (ko) 2002-02-27
RU2331640C2 (ru) 2008-08-20
ES2258459T3 (es) 2006-09-01
BR0010482A (pt) 2002-04-23
EP1183033A4 (de) 2002-07-17
HUP0301005A3 (en) 2006-05-29
NO20015650L (no) 2001-11-20
EP1183033A1 (de) 2002-03-06
JP4649046B2 (ja) 2011-03-09
DK1183033T3 (da) 2006-06-06
CA2373990C (en) 2007-05-08
PL204437B1 (pl) 2010-01-29
KR100666514B1 (ko) 2007-02-28
DE60042620D1 (de) 2009-09-03
NO322214B1 (no) 2006-08-28
NZ516292A (en) 2004-01-30
JP2003500359A (ja) 2003-01-07
EP1183033B1 (de) 2006-03-01
AR043087A1 (es) 2005-07-20
ATE318603T1 (de) 2006-03-15
HK1041599A1 (en) 2002-07-12
IL144977A (en) 2006-12-10
TR200103352T2 (tr) 2005-03-21
PL351720A1 (en) 2003-06-02
HK1041599B (en) 2006-09-15
TWI238163B (en) 2005-08-21
NO20015650D0 (no) 2001-11-20
ES2328269T3 (es) 2009-11-11
CN1351498A (zh) 2002-05-29
WO2000071129A1 (en) 2000-11-30
CZ20014169A3 (cs) 2002-10-16
IL144977A0 (en) 2002-06-30
AU770377B2 (en) 2004-02-19
MY128370A (en) 2007-01-31
AU4852400A (en) 2000-12-12
EG24027A (en) 2008-03-26
UY26150A1 (es) 2000-12-29
HUP0301005A2 (hu) 2003-07-28
CZ303660B6 (cs) 2013-02-13
JP2011037878A (ja) 2011-02-24
DE60026297T2 (de) 2006-11-02
MXPA01011832A (es) 2002-06-21

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