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DE60017406D1 - Verfahren zur herstellung von in lipid verkapselten therapeutischen wirkstoffen - Google Patents

Verfahren zur herstellung von in lipid verkapselten therapeutischen wirkstoffen

Info

Publication number
DE60017406D1
DE60017406D1 DE60017406T DE60017406T DE60017406D1 DE 60017406 D1 DE60017406 D1 DE 60017406D1 DE 60017406 T DE60017406 T DE 60017406T DE 60017406 T DE60017406 T DE 60017406T DE 60017406 D1 DE60017406 D1 DE 60017406D1
Authority
DE
Germany
Prior art keywords
lipid
therapeutic agent
vesicles
preformed
destabilizing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60017406T
Other languages
English (en)
Other versions
DE60017406T2 (de
Inventor
Norbert Maurer
F Wong
R Cullis
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Inex Pharmaceuticals Corp
Original Assignee
Inex Pharmaceuticals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inex Pharmaceuticals Corp filed Critical Inex Pharmaceuticals Corp
Publication of DE60017406D1 publication Critical patent/DE60017406D1/de
Application granted granted Critical
Publication of DE60017406T2 publication Critical patent/DE60017406T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dispersion Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medical Preparation Storing Or Oral Administration Devices (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE60017406T 1999-07-15 2000-07-14 Verfahren zur herstellung von in lipid verkapselten therapeutischen wirkstoffen Expired - Lifetime DE60017406T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14397899P 1999-07-15 1999-07-15
US143978P 1999-07-15
PCT/CA2000/000843 WO2001005374A1 (en) 1999-07-15 2000-07-14 Methods for preparation of lipid-encapsulated therapeutic agents

Publications (2)

Publication Number Publication Date
DE60017406D1 true DE60017406D1 (de) 2005-02-17
DE60017406T2 DE60017406T2 (de) 2005-09-29

Family

ID=22506531

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60017406T Expired - Lifetime DE60017406T2 (de) 1999-07-15 2000-07-14 Verfahren zur herstellung von in lipid verkapselten therapeutischen wirkstoffen

Country Status (11)

Country Link
EP (2) EP1196145A1 (de)
JP (3) JP2003504390A (de)
CN (1) CN1228041C (de)
AT (1) ATE286719T1 (de)
AU (2) AU769357B2 (de)
BR (1) BR0012624B1 (de)
CA (2) CA2378430A1 (de)
DE (1) DE60017406T2 (de)
ES (1) ES2235916T3 (de)
IL (2) IL147089A0 (de)
WO (2) WO2001005374A1 (de)

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Also Published As

Publication number Publication date
WO2001005373A1 (en) 2001-01-25
ES2235916T3 (es) 2005-07-16
JP2011225618A (ja) 2011-11-10
CN1361681A (zh) 2002-07-31
BR0012624A (pt) 2002-04-02
CA2378430A1 (en) 2001-01-25
EP1196145A1 (de) 2002-04-17
AU6256100A (en) 2001-02-05
CA2378438A1 (en) 2001-01-25
WO2001005374A1 (en) 2001-01-25
JP2003504391A (ja) 2003-02-04
AU6256200A (en) 2001-02-05
JP2003504390A (ja) 2003-02-04
CN1228041C (zh) 2005-11-23
WO2001005373A9 (en) 2002-08-29
EP1194122B1 (de) 2005-01-12
ATE286719T1 (de) 2005-01-15
IL147089A (en) 2006-08-20
EP1194122A1 (de) 2002-04-10
BR0012624B1 (pt) 2011-08-09
AU769357B2 (en) 2004-01-22
DE60017406T2 (de) 2005-09-29
CA2378438C (en) 2010-05-04
JP5388395B2 (ja) 2014-01-15
IL147089A0 (en) 2002-08-14
AU771706B2 (en) 2004-04-01

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