DE60016786D1 - Bicyclische vasopressin-agoniste - Google Patents

Bicyclische vasopressin-agoniste

Info

Publication number: DE60016786D1
Authority: DE; Germany
Prior art keywords: alkyl; vasopressine; bicyclic; agonist; independently
Prior art date: 1999-10-20
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Expired - Lifetime

Application number

DE60016786T

Other languages

English (en)

Other versions

DE60016786T2 (de

Inventor

Doreen Mary Ashworth

Gary Robert William Pitt

Peter Hudson

Christopher Martyn Yea

Jeremy Franklin

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Vantia Ltd

Original Assignee

Ferring BV

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-20

Filing date

2000-10-20

Publication date

2005-01-20

2000-10-20 Application filed by Ferring BV filed Critical Ferring BV

2005-01-20 Publication of DE60016786D1 publication Critical patent/DE60016786D1/de

2005-12-22 Application granted granted Critical

2005-12-22 Publication of DE60016786T2 publication Critical patent/DE60016786T2/de

2020-10-21 Anticipated expiration legal-status Critical

Status Expired - Lifetime legal-status Critical Current

Links

239000000556 agonist Substances 0.000 title abstract 2
JLTCWSBVQSZVLT-CDIPANDDSA-N (2s)-n-[(2s)-6-amino-1-[(2-amino-2-oxoethyl)amino]-1-oxohexan-2-yl]-1-[(4r,7s,10s,13s,16s,19r)-19-amino-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-[(4-hydroxyphenyl)methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosan Chemical compound NCCCC[C@@H](C(=O)NCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H]1NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@H](CC=2C=CC(O)=CC=2)NC(=O)[C@@H](N)CSSC1.C([C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CSSC[C@@H](C(N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N1)=O)N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O)C1=CC=CC=C1 JLTCWSBVQSZVLT-CDIPANDDSA-N 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 2
102000004136 Vasopressin Receptors Human genes 0.000 abstract 1
108090000643 Vasopressin Receptors Proteins 0.000 abstract 1
230000002686 anti-diuretic effect Effects 0.000 abstract 1
229940124538 antidiuretic agent Drugs 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003805 procoagulant Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/12—Antidiuretics, e.g. drugs for diabetes insipidus
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D267/02—Seven-membered rings
- C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D267/12—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D267/14—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Diabetes (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Hematology (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

DE60016786T 1999-10-20 2000-10-20 Bicyclische vasopressin-agoniste Expired - Lifetime DE60016786T2 (de)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
GB9924836		1999-10-20
GB9924836A GB2355454A (en)	1999-10-20	1999-10-20	Antidiuretic agents
PCT/GB2000/004055 WO2001029005A1 (en)	1999-10-20	2000-10-20	Bicyclic vasopressin agonists

Publications (2)

Publication Number	Publication Date
DE60016786D1 true DE60016786D1 (de)	2005-01-20
DE60016786T2 DE60016786T2 (de)	2005-12-22

Family

ID=10863070

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE60016786T Expired - Lifetime DE60016786T2 (de)	1999-10-20	2000-10-20	Bicyclische vasopressin-agoniste

Country Status (22)

Country	Link
US (1)	US6664249B1 (de)
EP (1)	EP1226122B1 (de)
JP (1)	JP4694747B2 (de)
KR (1)	KR100725555B1 (de)
CN (1)	CN1144788C (de)
AT (1)	ATE284871T1 (de)
AU (1)	AU777092B2 (de)
CA (1)	CA2387886A1 (de)
CZ (1)	CZ304069B6 (de)
DE (1)	DE60016786T2 (de)
ES (1)	ES2234684T3 (de)
GB (1)	GB2355454A (de)
HK (1)	HK1044155B (de)
HU (1)	HU229357B1 (de)
IL (2)	IL148548A0 (de)
MX (1)	MXPA02003779A (de)
NO (1)	NO322920B1 (de)
NZ (1)	NZ517611A (de)
PL (1)	PL206211B1 (de)
PT (1)	PT1226122E (de)
RU (1)	RU2254332C2 (de)
WO (1)	WO2001029005A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB0000079D0 (en) *	2000-01-05	2000-02-23	Ferring Bv	Novel antidiuretic agents
GB0015601D0 (en) *	2000-06-26	2000-08-16	Ferring Bv	Novel antidiuretic agents
GB0210397D0 (en)	2002-05-07	2002-06-12	Ferring Bv	Pharmaceutical formulations
DE60305043T2 (de) *	2003-11-13	2006-11-30	Ferring B.V.	Blisterverpackung und feste Dosierungsform enthaltend Desmopressin
EP1632494A1 (de)	2004-08-24	2006-03-08	Ferring B.V.	Vasopressin v1a antagonisten
CA2616937A1 (en) *	2005-07-29	2007-02-08	F. Hoffman-La Roche Ag	Indol-3-yl-carbonyl-piperidin and piperazin derivatives
SE528446C2 (sv) *	2006-03-02	2006-11-14	Ferring Int Ct Sa	Farmaceutisk sammansättning innefattande desmopressin, kiseldioxid och stärkelse
RU2342949C1 (ru) *	2007-03-26	2009-01-10	Юрий Георгиевич Жуковский	Применение [дезамино-1, изолейцин-3, аргинин-8]вазопрессина в качестве средства для увеличения выведения почкой солей натрия и усиления обратного избирательного всасывания из почечных канальцев в кровь воды-растворителя
US8399410B2 (en)	2007-08-06	2013-03-19	Allergan, Inc.	Methods and devices for desmopressin drug delivery
SI3225250T1 (sl)	2008-05-21	2019-11-29	Ferring Bv	Orodisperzibilen dezmopresin za podaljšanje začetnega obdobja spanja, ki ga ne moti nokturija
US11963995B2 (en)	2008-05-21	2024-04-23	Ferring B.V.	Methods comprising desmopressin
US20100286045A1 (en)	2008-05-21	2010-11-11	Bjarke Mirner Klein	Methods comprising desmopressin
CN102942558B (zh) *	2012-05-18	2014-04-16	天津药物研究院	一种苯并氮杂卓衍生物的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE122009000062I2 (de) *	1989-10-20	2011-01-13	Otsuka Pharma Co Ltd	Benzoheterozyklische verbindungen
US5753677A (en) *	1989-10-20	1998-05-19	Otsuka Pharmaceutical Co., Ltd.	Benzoheterocyclic compounds
JP2905909B2 (ja) *	1991-04-19	1999-06-14	大塚製薬株式会社	バソプレシン拮抗剤
CA2066104C (en) *	1991-04-19	2003-05-27	Hidenori Ogawa	Benzazepine derivatives as vasopressin antagonists
JPH05320135A (ja) *	1992-05-19	1993-12-03	Yamanouchi Pharmaceut Co Ltd	テトラヒドロベンズアゼピン誘導体
AU657431B2 (en)	1992-08-20	1995-03-09	Otsuka Pharmaceutical Co., Ltd.	Benzoheterocyclic compounds as oxytocin and vasopressin antagonists
TW270927B (de) *	1992-10-16	1996-02-21	Otsuka Pharma Co Ltd
JP2913082B2 (ja) *	1992-10-16	1999-06-28	大塚製薬株式会社	バソプレシン拮抗剤及びオキシトシン拮抗剤
AU5533894A (en)	1992-11-25	1994-06-22	Yamanouchi Pharmaceutical Co., Ltd.	Benzanilide derivative
AU6219994A (en) *	1993-03-11	1994-09-26	Yamanouchi Pharmaceutical Co., Ltd.	Compound with vasopressin antagonism
RU2137760C1 (ru) *	1993-08-26	1999-09-20	Яманоути Фармасьютикал Ко., Лтд.	Производное бензазепина, фармацевтическая композиция, производное дифторбензазепина и производное (замещенного) аминобензоилдифторбензазепина
JP2926335B2 (ja) *	1997-06-13	1999-07-28	大塚製薬株式会社	医薬組成物

1999
- 1999-10-20 GB GB9924836A patent/GB2355454A/en not_active Withdrawn
2000
- 2000-10-20 WO PCT/GB2000/004055 patent/WO2001029005A1/en not_active Ceased
- 2000-10-20 PT PT00971534T patent/PT1226122E/pt unknown
- 2000-10-20 EP EP00971534A patent/EP1226122B1/de not_active Expired - Lifetime
- 2000-10-20 CN CNB008145563A patent/CN1144788C/zh not_active Expired - Fee Related
- 2000-10-20 CZ CZ20021339A patent/CZ304069B6/cs not_active IP Right Cessation
- 2000-10-20 ES ES00971534T patent/ES2234684T3/es not_active Expired - Lifetime
- 2000-10-20 US US10/111,007 patent/US6664249B1/en not_active Expired - Fee Related
- 2000-10-20 HK HK02105816.9A patent/HK1044155B/en not_active IP Right Cessation
- 2000-10-20 MX MXPA02003779A patent/MXPA02003779A/es active IP Right Grant
- 2000-10-20 AU AU10374/01A patent/AU777092B2/en not_active Ceased
- 2000-10-20 KR KR1020027003788A patent/KR100725555B1/ko not_active Expired - Fee Related
- 2000-10-20 NZ NZ517611A patent/NZ517611A/xx not_active IP Right Cessation
- 2000-10-20 AT AT00971534T patent/ATE284871T1/de active
- 2000-10-20 JP JP2001531805A patent/JP4694747B2/ja not_active Expired - Fee Related
- 2000-10-20 PL PL354044A patent/PL206211B1/pl unknown
- 2000-10-20 RU RU2002113097/04A patent/RU2254332C2/ru not_active IP Right Cessation
- 2000-10-20 CA CA002387886A patent/CA2387886A1/en not_active Abandoned
- 2000-10-20 DE DE60016786T patent/DE60016786T2/de not_active Expired - Lifetime
- 2000-10-20 HU HU0203622A patent/HU229357B1/hu unknown
- 2000-10-20 IL IL14854800A patent/IL148548A0/xx active IP Right Grant
2002
- 2002-03-06 IL IL148548A patent/IL148548A/en not_active IP Right Cessation
- 2002-04-19 NO NO20021879A patent/NO322920B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
AU1037401A (en)	2001-04-30
HU229357B1 (en)	2013-11-28
ES2234684T3 (es)	2005-07-01
KR20020029794A (ko)	2002-04-19
GB9924836D0 (en)	1999-12-22
JP4694747B2 (ja)	2011-06-08
IL148548A0 (en)	2002-09-12
WO2001029005A1 (en)	2001-04-26
JP2003512356A (ja)	2003-04-02
HUP0203622A2 (hu)	2003-02-28
CZ304069B6 (cs)	2013-09-18
NO20021879L (no)	2002-04-19
AU777092B2 (en)	2004-09-30
IL148548A (en)	2007-02-11
HUP0203622A3 (en)	2005-01-28
CN1144788C (zh)	2004-04-07
EP1226122B1 (de)	2004-12-15
EP1226122A1 (de)	2002-07-31
RU2254332C2 (ru)	2005-06-20
KR100725555B1 (ko)	2007-06-08
ATE284871T1 (de)	2005-01-15
US6664249B1 (en)	2003-12-16
HK1044155B (en)	2005-05-06
DE60016786T2 (de)	2005-12-22
HK1044155A1 (en)	2002-10-11
CN1382125A (zh)	2002-11-27
MXPA02003779A (es)	2002-09-30
NZ517611A (en)	2002-11-26
NO20021879D0 (no)	2002-04-19
CA2387886A1 (en)	2001-04-26
CZ20021339A3 (cs)	2002-09-11
PT1226122E (pt)	2005-04-29
PL206211B1 (pl)	2010-07-30
NO322920B1 (no)	2006-12-18
GB2355454A (en)	2001-04-25
PL354044A1 (en)	2003-12-15

Publication	Publication Date	Title
ATE135701T1 (de)	1996-04-15	Imidazolderivate, starke und selektive angiotensin-ii-rezeptor-antagonisten
IS6275A (is)	2002-02-18	Heteróhringa efnasambönd og notkun þeirra sem mótlyf efnaskiptaglútamatviðtaka
MY147451A (en)	2012-12-14	4-phenyl-pyridine derivatives and their use as nk-1 receptor antagonists
HRP20080666T3 (en)	2009-01-31	Cgrp receptor antagonists
TR200102839T2 (tr)	2002-04-22	LH agonistleri olarak faydalı bisiklik heteroaromatik bileşikler.
DE60016786D1 (de)	2005-01-20	Bicyclische vasopressin-agoniste
CA2037630A1 (en)	1991-09-08	Nitrogen-containing heterocylic compounds, their production and use
ATE139233T1 (de)	1996-06-15	Annelierte thiophen-derivate, ihre herstellung und verwendung
WO2000067735A3 (en)	2001-02-01	USE OF SELECTIVE ANTAGONISTS OF THE α1b-ADRENERGIC RECEPTOR FOR IMPROVEMENT OF SEXUAL DYSFUNCTION
EP0287339A3 (de)	1991-05-15	Piperidine als Opioid-Antagoniste
IL142893A0 (en)	2002-04-21	Fused polyclic heterocyclic compounds and pharmaceutical compositions containing the same
WO2001034601A3 (de)	2001-11-15	Imidazopyridinderivate als phosphodiesterase vii-hemmer
BR9503536A (pt)	1996-06-04	Composto processo para sua preparação seu uso e composição farmacêutica
IL125982A0 (en)	1999-04-11	2-(arylphenyl) amino-imidazoline derivatives
TR200101654T2 (tr)	2002-03-21	Vitronektin reseptr antagonistleri
ATE170851T1 (de)	1998-09-15	Guanidinothiazolederivate und ihre anwendung als h2-rezeptor-antagonisten
DE69812010D1 (de)	2003-04-17	4-Aminopyrrole (3,2-d) Pyrimidinen als Antagonisten des Neuropeptide Y Receptors
GB0130868D0 (en)	2002-02-06	New compounds
ATE151750T1 (de)	1997-05-15	3-(indol-3-yl) propensäurderivate, die als nmda- antagonisten nützlich sind
EA199900688A1 (ru)	2000-04-24	Хиноксалиндионы
TW200504054A (en)	2005-02-01	Heteroarylsulfonanilide derivative and pharmaceutical composition containing the same
YU38498A (sh)	2001-09-28	Derivati 2-(arilfenil)amino-imidazolina

Legal Events

Date	Code	Title	Description
2006-01-26	8364	No opposition during term of opposition
2010-08-19	8327	Change in the person/name/address of the patent owner	Owner name: VANTIA LTD., CHILWORTH, GB