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DE60012131D1 - Intermediates for the production of citalopram - Google Patents

Intermediates for the production of citalopram

Info

Publication number
DE60012131D1
DE60012131D1 DE60012131T DE60012131T DE60012131D1 DE 60012131 D1 DE60012131 D1 DE 60012131D1 DE 60012131 T DE60012131 T DE 60012131T DE 60012131 T DE60012131 T DE 60012131T DE 60012131 D1 DE60012131 D1 DE 60012131D1
Authority
DE
Germany
Prior art keywords
citalopram
compound
following formula
production
intermediates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE60012131T
Other languages
German (de)
Other versions
DE60012131T2 (en
Inventor
Tetsuya Ikemoto
Wei-Guo Gao
Nobuhiro Arai
Masami Igi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumika Fine Chemicals Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26585589&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE60012131(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sumika Fine Chemicals Co Ltd filed Critical Sumika Fine Chemicals Co Ltd
Publication of DE60012131D1 publication Critical patent/DE60012131D1/en
Application granted granted Critical
Publication of DE60012131T2 publication Critical patent/DE60012131T2/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/36—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal
    • C07C29/38—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones
    • C07C29/40—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring increasing the number of carbon atoms by reactions with formation of hydroxy groups, which may occur via intermediates being derivatives of hydroxy, e.g. O-metal by reaction with aldehydes or ketones with compounds containing carbon-to-metal bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/40—Halogenated unsaturated alcohols
    • C07C33/46—Halogenated unsaturated alcohols containing only six-membered aromatic rings as cyclic parts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
    • C07C51/21—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation with molecular oxygen
    • C07C51/255—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation with molecular oxygen of compounds containing six-membered aromatic rings without ring-splitting
    • C07C51/265—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation with molecular oxygen of compounds containing six-membered aromatic rings without ring-splitting having alkyl side chains which are oxidised to carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
    • C07C51/373—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of functional groups containing oxygen only in doubly bound form

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Steroid Compounds (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)

Abstract

Citalopram can be industrially and economically produced and at a high yield by reacting a compound of the following formula ÄVIÜ with 3-(dimethylamino)propyl chloride in the presence of at least one of N,N,N',N'-tetramethylethylenediamine and 1,3-dimethyl-2-imidazolidinone and a condensing agent. The compound of the following formula ÄIIIÜ, which is a key compound for the production of citalopram, can be easily produced by subjecting the compound of the following formula ÄIIÜ to reduction and cyclization. <CHEM>
DE60012131T 2000-02-17 2000-09-06 Intermediates for the production of citalopram Expired - Fee Related DE60012131T2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2000039936 2000-02-17
JP2000039936 2000-02-17
JP2000065527 2000-03-09
JP2000065527 2000-03-09

Publications (2)

Publication Number Publication Date
DE60012131D1 true DE60012131D1 (en) 2004-08-19
DE60012131T2 DE60012131T2 (en) 2005-08-11

Family

ID=26585589

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60012131T Expired - Fee Related DE60012131T2 (en) 2000-02-17 2000-09-06 Intermediates for the production of citalopram

Country Status (10)

Country Link
US (5) US6433196B1 (en)
EP (2) EP1125907B1 (en)
AT (1) ATE271025T1 (en)
AU (1) AU777193B2 (en)
CA (1) CA2318701A1 (en)
DE (1) DE60012131T2 (en)
DK (1) DK1125907T3 (en)
ES (1) ES2220308T3 (en)
PT (1) PT1125907E (en)
SI (1) SI1125907T1 (en)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1173431E (en) * 1999-04-14 2003-09-30 Lundbeck & Co As H METHOD OF PREPARING CITALOPRAM
AR026063A1 (en) * 1999-11-01 2002-12-26 Lundbeck & Co As H METHOD FOR THE PREPARATION OF 5-CARBOXIFTALIDA.
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
IES20010143A2 (en) * 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
IES20010157A2 (en) 2000-03-03 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
GB0005477D0 (en) 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
WO2001068629A1 (en) * 2000-03-13 2001-09-20 H. Lundbeck A/S Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
CA2402388A1 (en) 2000-03-13 2001-09-20 Hans Petersen Method for the preparation of citalopram
GB2357762B (en) * 2000-03-13 2002-01-30 Lundbeck & Co As H Crystalline base of citalopram
IES20010206A2 (en) 2000-03-13 2002-03-06 Lundbeck & Co As H Method for the preparation of citalopram
AU2001239213A1 (en) 2000-03-14 2001-09-24 H Lundbeck A/S Method for the preparation of citalopram
SK14812002A3 (en) 2000-03-16 2003-02-04 H. Lundbeck A/S Method for the preparation of 5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
AR032455A1 (en) 2000-05-12 2003-11-12 Lundbeck & Co As H METHOD FOR THE PREPARATION OF CITALOPRAM, AN INTERMEDIARY EMPLOYED IN THE METHOD, A METHOD FOR THE PREPARATION OF THE INTERMEDIARY EMPLOYED IN THE METHOD AND PHARMACEUTICAL COMPOSITION ANTIDEPRESSIVE
EP1346989A1 (en) * 2002-03-21 2003-09-24 Jubilant Organosys Limited Improved process for the preparation of citalopram and its hydrobromide
ITMI20030479A1 (en) 2003-03-13 2004-09-14 Adorkem Technology S P A PROCEDURE FOR THE PREPARATION OF A CYAN-ISOBENZOFURANO.
AU2003223105A1 (en) * 2003-03-24 2004-10-18 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
US20040202717A1 (en) 2003-04-08 2004-10-14 Mehta Atul M. Abuse-resistant oral dosage forms and method of use thereof
AU2003238676A1 (en) * 2003-04-21 2004-11-19 Podile Khadgapathi An improved process for the preparation of citalopram hydrobromide
CA2575975A1 (en) * 2003-11-12 2005-05-26 Dr. Reddy's Laboratories, Inc. Preparation of escitalopram
EP1783108B1 (en) * 2004-08-05 2010-12-22 Sumitomo Chemical Company, Limited Method for producing halogen-substituted benzenedimethanol
CN102190641A (en) * 2011-03-23 2011-09-21 四川科伦药物研究有限公司 Method for preparing citalopram and key intermediate of escitalopram
CN104478690A (en) * 2014-11-18 2015-04-01 四川大学 Preparation method of 4,4'-dicarboxy diphenyl ketone

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US83508A (en) * 1868-10-27 Improved car-brake
US60640A (en) * 1866-12-18 peters
US134895A (en) * 1873-01-14 Improvement in folding-cribs
US114692A (en) * 1871-05-09 Improvement in chemical electric telegraphs
US4604A (en) * 1846-06-27 Apparatus for generating gas
US40153A (en) * 1863-10-06 Improvement in bullets for fire-arms
US109577A (en) * 1870-11-29 Improvement in machines for
GB1219609A (en) * 1968-07-19 1971-01-20 Koninklijke Pharma Fab Nv Diphenylmethoxyethylamino derivatives
US3642997A (en) 1969-06-25 1972-02-15 Merck & Co Inc Tricyclic carboxylic acids in the treatment of inflammation
US3835167A (en) 1972-12-18 1974-09-10 Syntex Inc Anthrone carboxylic acids and derivatives
US3959475A (en) * 1973-12-12 1976-05-25 American Hoechst Corporation Substituted 1,3-dihydrospiro(isobenzofuran)s
GB1526331A (en) 1976-01-14 1978-09-27 Kefalas As Phthalanes
ES8700647A1 (en) 1984-10-11 1986-11-16 Raychem Corp Preparation of aromatic carbonyl compounds.
US4940822A (en) * 1988-11-04 1990-07-10 Warner-Lambert Company Substituted benzenemethanol compounds, intermediates thereof, and preparation thereof
US5061810A (en) 1989-11-28 1991-10-29 Ethyl Corporation Substituted benzophenone dicarboxylic acids
EP0467435A3 (en) * 1990-07-19 1992-04-01 Akzo N.V. Benzhydryl derivatives having calmodulin inhibitor properties
US5198594A (en) * 1991-11-27 1993-03-30 Amoco Corporation Alkylation of alkylaromatics promoted by sonicated alkali metal
US5210313A (en) 1992-01-10 1993-05-11 Maxdem Incorporated Preparation of 2,5-dichlorobenzophenones
UA62985C2 (en) 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
EP1096926B1 (en) * 1998-07-13 2007-02-28 Nps Pharmaceuticals, Inc. Methods and compounds for treating depression
PT1173431E (en) 1999-04-14 2003-09-30 Lundbeck & Co As H METHOD OF PREPARING CITALOPRAM
US6310222B1 (en) * 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
IES20010143A2 (en) 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
FR2805812A1 (en) * 2000-02-24 2001-09-07 Lundbeck & Co As H PROCESS FOR THE PREPARATION OF CITALOPRAM
SK14812002A3 (en) 2000-03-16 2003-02-04 H. Lundbeck A/S Method for the preparation of 5-cyano-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
AR032455A1 (en) * 2000-05-12 2003-11-12 Lundbeck & Co As H METHOD FOR THE PREPARATION OF CITALOPRAM, AN INTERMEDIARY EMPLOYED IN THE METHOD, A METHOD FOR THE PREPARATION OF THE INTERMEDIARY EMPLOYED IN THE METHOD AND PHARMACEUTICAL COMPOSITION ANTIDEPRESSIVE
US20030109577A1 (en) 2000-10-27 2003-06-12 Ken Liljegren Pharmaceutical composition containing citalopram

Also Published As

Publication number Publication date
US6458975B1 (en) 2002-10-01
SI1125907T1 (en) 2004-12-31
US6946564B2 (en) 2005-09-20
US20020095051A1 (en) 2002-07-18
US20040138497A1 (en) 2004-07-15
EP1125907A3 (en) 2002-05-02
AU5656000A (en) 2001-08-23
ES2220308T3 (en) 2004-12-16
US6433196B1 (en) 2002-08-13
EP1125907A2 (en) 2001-08-22
ATE271025T1 (en) 2004-07-15
US20020062040A1 (en) 2002-05-23
DK1125907T3 (en) 2004-10-18
AU777193B2 (en) 2004-10-07
US7119215B2 (en) 2006-10-10
EP1428813A1 (en) 2004-06-16
CA2318701A1 (en) 2001-08-17
PT1125907E (en) 2004-10-29
US20040230066A1 (en) 2004-11-18
EP1125907B1 (en) 2004-07-14
DE60012131T2 (en) 2005-08-11

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Legal Events

Date Code Title Description
8327 Change in the person/name/address of the patent owner

Owner name: SUMITOMO CHEMICAL CO., LTD., TOKIO/TOKYO, JP

8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee