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DE60009665D1 - Zusammensetzungen zur behandlung von entzündungsreaktionen - Google Patents

Zusammensetzungen zur behandlung von entzündungsreaktionen

Info

Publication number
DE60009665D1
DE60009665D1 DE60009665T DE60009665T DE60009665D1 DE 60009665 D1 DE60009665 D1 DE 60009665D1 DE 60009665 T DE60009665 T DE 60009665T DE 60009665 T DE60009665 T DE 60009665T DE 60009665 D1 DE60009665 D1 DE 60009665D1
Authority
DE
Germany
Prior art keywords
compositions
treating
ignition reactions
ignition
reactions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60009665T
Other languages
English (en)
Other versions
DE60009665T2 (de
Inventor
Joel M Linden
Gail W Sullivan
Ian J Sarembock
Timothy Macdonald
Mark Okusa
Irving L Kron
W Michael Scheld
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Virginia UVA
Original Assignee
University of Virginia UVA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/333,387 external-priority patent/US6232297B1/en
Application filed by University of Virginia UVA filed Critical University of Virginia UVA
Publication of DE60009665D1 publication Critical patent/DE60009665D1/de
Application granted granted Critical
Publication of DE60009665T2 publication Critical patent/DE60009665T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/167—Purine radicals with ribosyl as the saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE60009665T 1999-02-01 2000-01-31 Zusammensetzungen zur behandlung von entzündungsreaktionen Expired - Lifetime DE60009665T2 (de)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US11802999P 1999-02-01 1999-02-01
US118029P 1999-02-01
US12431699P 1999-03-12 1999-03-12
US124316P 1999-03-12
US13337499P 1999-05-10 1999-05-10
US133374P 1999-05-10
US13557399P 1999-05-24 1999-05-24
US135573P 1999-05-24
US09/333,387 US6232297B1 (en) 1999-02-01 1999-06-15 Methods and compositions for treating inflammatory response
US333387 1999-06-15
US15141299P 1999-08-30 1999-08-30
US151412P 1999-08-30
PCT/US2000/002324 WO2000044763A2 (en) 1999-02-01 2000-01-31 Compositions for treating inflammatory response

Publications (2)

Publication Number Publication Date
DE60009665D1 true DE60009665D1 (de) 2004-05-13
DE60009665T2 DE60009665T2 (de) 2004-08-19

Family

ID=27557920

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60009665T Expired - Lifetime DE60009665T2 (de) 1999-02-01 2000-01-31 Zusammensetzungen zur behandlung von entzündungsreaktionen

Country Status (25)

Country Link
EP (1) EP1150991B1 (de)
JP (1) JP4837831B2 (de)
KR (1) KR100668006B1 (de)
CN (1) CN1191266C (de)
AR (1) AR029332A1 (de)
AT (1) ATE263777T1 (de)
AU (2) AU778870B2 (de)
BR (1) BR0007864A (de)
CA (1) CA2361614C (de)
CZ (1) CZ296404B6 (de)
DE (1) DE60009665T2 (de)
DK (1) DK1150991T3 (de)
EE (1) EE05185B1 (de)
ES (1) ES2215609T3 (de)
HU (1) HU228937B1 (de)
IL (2) IL144188A0 (de)
MX (1) MXPA01007850A (de)
MY (1) MY129445A (de)
NO (1) NO321216B1 (de)
NZ (1) NZ513096A (de)
PL (1) PL199953B1 (de)
PT (1) PT1150991E (de)
SK (1) SK284877B6 (de)
UA (1) UA72912C2 (de)
WO (1) WO2000044763A2 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6514949B1 (en) 1994-07-11 2003-02-04 University Of Virginia Patent Foundation Method compositions for treating the inflammatory response
US6448235B1 (en) 1994-07-11 2002-09-10 University Of Virginia Patent Foundation Method for treating restenosis with A2A adenosine receptor agonists
US7427606B2 (en) 1999-02-01 2008-09-23 University Of Virginia Patent Foundation Method to reduce inflammatory response in transplanted tissue
US6232297B1 (en) 1999-02-01 2001-05-15 University Of Virginia Patent Foundation Methods and compositions for treating inflammatory response
US7378400B2 (en) 1999-02-01 2008-05-27 University Of Virginia Patent Foundation Method to reduce an inflammatory response from arthritis
US6322771B1 (en) 1999-06-18 2001-11-27 University Of Virginia Patent Foundation Induction of pharmacological stress with adenosine receptor agonists
IL133680A0 (en) 1999-09-10 2001-04-30 Can Fite Technologies Ltd Pharmaceutical compositions comprising an adenosine receptor agonist or antagonist
NZ532062A (en) * 2001-10-01 2006-09-29 Univ Virginia 2-propynyl adenosine analogues having A2 adenosine recepter agonist activity and compositions thereof to treat inflammatory responses
US20050033044A1 (en) 2003-05-19 2005-02-10 Bristol-Myers Squibb Pharma Company Methods for preparing 2-alkynyladenosine derivatives
US7217702B2 (en) * 2004-04-02 2007-05-15 Adenosine Therapeutics, Llc Selective antagonists of A2A adenosine receptors
WO2005107463A1 (en) * 2004-05-03 2005-11-17 University Of Virginia Patent Foundation Agonists of a2a adenosine receptors for treatment of diabetic nephropathy
WO2006028618A1 (en) 2004-08-02 2006-03-16 University Of Virginia Patent Foundation 2-polycyclic propynyl adenosine analogs with modified 5'-ribose groups having a2a agonist activity
WO2006023272A1 (en) 2004-08-02 2006-03-02 University Of Virginia Patent Foundation 2-polycyclic propynyl adenosine analogs having a2a agonist activity
JP5046930B2 (ja) * 2004-08-02 2012-10-10 ユニバーシティ オブ バージニア パテント ファウンデーション Ａ２ａアゴニスト活性を有する修飾５’−リボース基を備えた２−プロピニルアデノシン類似体
WO2007120972A2 (en) 2006-02-10 2007-10-25 University Of Virginia Patent Foundation Method to treat sickle cell disease
EP2021350B1 (de) 2006-03-21 2016-12-21 Rheinische Friedrich-Wilhelms-Universität Bonn Phosphorylierte adenosin-a2a-rezeptoragonisten
US8188063B2 (en) 2006-06-19 2012-05-29 University Of Virginia Patent Foundation Use of adenosine A2A modulators to treat spinal cord injury
NZ573308A (en) * 2006-06-27 2012-02-24 Biovitrum Ab Publ Adenosine derivatives for the treatment of pain
US8058259B2 (en) 2007-12-20 2011-11-15 University Of Virginia Patent Foundation Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists
SI2306971T1 (sl) * 2008-07-03 2015-07-31 University Of Virginia Patent Foundation Dozirna enota Apadenoson-a
MX2012000113A (es) 2009-06-30 2012-02-29 Forest Lab Holdings Ltd Compuestos alcoxi-carbonil-amino-alquinil-adenosina y derivados de los mismos como agonistas a2ar.
FR2960876B1 (fr) 2010-06-03 2012-07-27 Sanofi Aventis Derives de 3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1h)-dicarboxamide leur preparation et leur application en therapeutique.
JP2022538410A (ja) * 2019-06-21 2022-09-02 アカデミー オブ ミリタリー メディカル サイエンシズ Ａ２ａアデノシン受容体拮抗作用を有する小分子化合物

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3537228A1 (de) * 1985-10-19 1987-04-23 Huels Chemische Werke Ag Verfahren zur herstellung von cyclohexylverbindungen
JPS6299330A (ja) * 1985-10-25 1987-05-08 Yamasa Shoyu Co Ltd 抗高血圧剤
US5270304A (en) * 1988-11-15 1993-12-14 Yamasa Shoyu Kabushiki Kaisha Therapeutic 2-alkynyl adenosine agent for ischemic diseases of the heart or brain
US5283327A (en) * 1989-06-20 1994-02-01 Yamasa Shoyu Kabushiki Kaisha Tri-O-acetyl-2-alkynyladenosines
WO1991009864A1 (fr) * 1990-01-04 1991-07-11 Yamasa Shoyu Kabushiki Kaisha Medicament pour le traitement d'affections ischemiques du c×ur ou du cerveau
JPH03287537A (ja) * 1990-03-31 1991-12-18 Yamasa Shoyu Co Ltd 抗動脈硬化症剤
JP3025559B2 (ja) * 1990-07-19 2000-03-27 ヤマサ醤油株式会社 アデノシン誘導体
JP3025557B2 (ja) * 1991-06-28 2000-03-27 ヤマサ醤油株式会社 ２‐アルキニルアデノシン誘導体
JP3053908B2 (ja) * 1991-06-28 2000-06-19 ヤマサ醤油株式会社 ２‐アルキニルアデノシン誘導体
IT1254915B (it) * 1992-04-24 1995-10-11 Gloria Cristalli Derivati di adenosina ad attivita' a2 agonista
EP0983768A1 (de) * 1997-05-23 2000-03-08 Nippon Shinyaku Co., Ltd. Arzneimittel zur vorbeugung bzw. zur behandlung von leberleiden
WO1998057651A1 (en) * 1997-06-18 1998-12-23 Discovery Therapeutics, Inc. Compositions and methods for preventing restenosis following revascularization procedures
JPH11335302A (ja) * 1998-05-26 1999-12-07 Toa Eiyo Ltd 安定な医薬組成物
JP3619017B2 (ja) * 1998-06-24 2005-02-09 日本臓器製薬株式会社 新規アラビノシルアデニン誘導体
JP2002173427A (ja) * 1998-09-01 2002-06-21 Yamasa Shoyu Co Ltd 眼疾患治療用医薬組成物

Also Published As

Publication number Publication date
NO20013507D0 (no) 2001-07-13
JP4837831B2 (ja) 2011-12-14
DK1150991T3 (da) 2004-06-07
WO2000044763A2 (en) 2000-08-03
CZ20012781A3 (cs) 2002-01-16
AR029332A1 (es) 2003-06-25
SK10972001A3 (sk) 2002-01-07
WO2000044763A3 (en) 2000-12-14
SK284877B6 (sk) 2006-01-05
CA2361614C (en) 2008-08-26
CA2361614A1 (en) 2000-08-03
KR100668006B1 (ko) 2007-01-15
IL144188A (en) 2008-12-29
HUP0200224A2 (en) 2002-06-29
NO321216B1 (no) 2006-04-03
AU2005201255A1 (en) 2005-04-21
BR0007864A (pt) 2001-11-06
EE05185B1 (et) 2009-06-15
AU2005201255B2 (en) 2008-02-28
MXPA01007850A (es) 2002-08-20
CN1357002A (zh) 2002-07-03
PL199953B1 (pl) 2008-11-28
UA72912C2 (uk) 2005-05-16
EP1150991B1 (de) 2004-04-07
ATE263777T1 (de) 2004-04-15
KR20020013494A (ko) 2002-02-20
HUP0200224A3 (en) 2005-02-28
MY129445A (en) 2007-04-30
IL144188A0 (en) 2002-05-23
EE200100397A (et) 2002-08-15
EP1150991A2 (de) 2001-11-07
JP2002536300A (ja) 2002-10-29
CA2361614E (en) 2000-08-03
HU228937B1 (en) 2013-06-28
HK1047288A1 (en) 2003-02-14
CZ296404B6 (cs) 2006-03-15
CN1191266C (zh) 2005-03-02
NO20013507L (no) 2001-09-18
NZ513096A (en) 2003-01-31
DE60009665T2 (de) 2004-08-19
ES2215609T3 (es) 2004-10-16
AU2745400A (en) 2000-08-18
AU778870B2 (en) 2004-12-23
PT1150991E (pt) 2004-08-31

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition