DE60006665D1 - C17-ALKYL SUBSTITUTED STEROID COMPOUNDS WITH AN AROMATIC A-RING FOR THERAPEUTIC USE - Google Patents
C17-ALKYL SUBSTITUTED STEROID COMPOUNDS WITH AN AROMATIC A-RING FOR THERAPEUTIC USEInfo
- Publication number
- DE60006665D1 DE60006665D1 DE60006665T DE60006665T DE60006665D1 DE 60006665 D1 DE60006665 D1 DE 60006665D1 DE 60006665 T DE60006665 T DE 60006665T DE 60006665 T DE60006665 T DE 60006665T DE 60006665 D1 DE60006665 D1 DE 60006665D1
- Authority
- DE
- Germany
- Prior art keywords
- sup
- group
- hydrogen atom
- hydroxyl
- aromatic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- -1 STEROID COMPOUNDS Chemical class 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- 125000001931 aliphatic group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004450 alkenylene group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000004419 alkynylene group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 230000000125 calcaemic effect Effects 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 230000024245 cell differentiation Effects 0.000 abstract 1
- 230000010261 cell growth Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0072—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the A ring of the steroid being aromatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/18—Drugs for disorders of the endocrine system of the parathyroid hormones
- A61P5/20—Drugs for disorders of the endocrine system of the parathyroid hormones for decreasing, blocking or antagonising the activity of PTH
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Gynecology & Obstetrics (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Pregnancy & Childbirth (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Steroid Compounds (AREA)
Abstract
Formula (I) in which: R<SUP>1 </SUP>and R<SUP>2</SUP>, which may be the same or different, each represents a lower alkyl, alkenyl or alkynyl group; R<SUP>3 </SUP>represents a methyl group having alpha- or beta-configuration; R<SUP>4 </SUP>represents a hydrogen atom or an etherifying or esterifying group; R<SUP>5 </SUP>represents a hydrogen atom, a hydroxyl group or a lower alkoxy group; X represents a group OR<SUP>4</SUP>, or a group NR<SUP>6</SUP>R<SUP>7 </SUP>wherein R<SUP>6 </SUP>represents a hydrogen atom, an aliphatic or araliphatic group, or an acyl group comprising an aliphatic, araliphatic or aryl group linked to the nitrogen atom by way of a carbonyl group; and R<SUP>7 </SUP>is a hydrogen atom or a lower alkyl group; Y represents a lower alkylene, alkenylene or alkynylene group optionally substituted by a hydroxyl, etherified hydroxyl or esterified hydroxyl group; exhibit potent effects on modulation of cell growth and differentiation, while having low calcaemic activity.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9910934.0A GB9910934D0 (en) | 1999-05-11 | 1999-05-11 | Chemical compounds |
| PCT/GB2000/001813 WO2000068246A1 (en) | 1999-05-11 | 2000-05-11 | Steroid compounds with a c17-alkyl side chain and an aromatic a-ring for use in therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60006665D1 true DE60006665D1 (en) | 2003-12-24 |
| DE60006665T2 DE60006665T2 (en) | 2004-10-07 |
Family
ID=10853250
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60006665T Expired - Fee Related DE60006665T2 (en) | 1999-05-11 | 2000-05-11 | C17-ALKYL SUBSTITUTED STEROID COMPOUNDS WITH AN AROMATIC A-RING FOR THERAPEUTIC USE |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US6881730B1 (en) |
| EP (1) | EP1179005B1 (en) |
| JP (1) | JP2002544137A (en) |
| KR (1) | KR100690040B1 (en) |
| CN (1) | CN1158297C (en) |
| AT (1) | ATE254629T1 (en) |
| AU (1) | AU779743B2 (en) |
| CA (1) | CA2373443A1 (en) |
| CZ (1) | CZ297316B6 (en) |
| DE (1) | DE60006665T2 (en) |
| DK (1) | DK1179005T3 (en) |
| ES (1) | ES2207509T3 (en) |
| GB (1) | GB9910934D0 (en) |
| HK (1) | HK1046001B (en) |
| HU (1) | HUP0201047A3 (en) |
| IL (2) | IL146442A0 (en) |
| NO (1) | NO319949B1 (en) |
| NZ (1) | NZ515482A (en) |
| PT (1) | PT1179005E (en) |
| WO (1) | WO2000068246A1 (en) |
| ZA (1) | ZA200109272B (en) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6908910B2 (en) | 1993-08-06 | 2005-06-21 | The Children's Medical Center Corporation | Estrogenic compounds as anti-mitotic agents |
| GB9910934D0 (en) * | 1999-05-11 | 1999-07-14 | Res Inst Medicine Chem | Chemical compounds |
| US7087592B1 (en) | 1999-08-23 | 2006-08-08 | Entre Med, Inc. | Compositions comprising purified 2-methoxyestradiol and methods of producing same |
| NZ523042A (en) * | 2000-05-11 | 2004-05-28 | Res Inst Medicine Chem | 2-substituted pregna-1, 3, 5 (10) -triene and chola-1, 3, 5 (10)-triene derivatives and their biological activity |
| US6995278B2 (en) | 2000-08-18 | 2006-02-07 | Entre Med, Inc. | Antiangiogenic agents |
| US7135581B2 (en) | 2000-08-18 | 2006-11-14 | Entremed, Inc. | Antiangiogenic agents |
| JP2004537499A (en) * | 2000-11-27 | 2004-12-16 | エントレメッド インコーポレイテッド | Anti-angiogenic drugs |
| WO2002092100A1 (en) * | 2001-05-11 | 2002-11-21 | Marsden, John, Christopher | 17-(c(ch3) (ch2) o-3c (r4, r5) n (r6, r7))-substituted 19-nor-pregna-1, 3, 5(10)-triene derivatives and their medical use |
| AU2004275693A1 (en) | 2003-05-28 | 2005-04-07 | Entremed, Inc. | Antiangiogenic agents |
| JP2007529426A (en) | 2004-03-12 | 2007-10-25 | エントレメッド インコーポレイテッド | Anti-angiogenic drugs |
| CA2646065C (en) | 2006-03-20 | 2014-01-14 | Entremed, Inc. | Disease modifying anti-arthritic activity of 2-methoxyestradiol |
| NZ581081A (en) * | 2007-06-19 | 2012-12-21 | Kythera Biopharmaceuticals Inc | Synthetic deoxycholic acid (dca) or an ester, hydroxamale, or hydroxyamide thereof |
| US8242294B2 (en) | 2007-06-19 | 2012-08-14 | Kythera Biopharmaceuticals, Inc. | Synthetic bile acid compositions and methods |
| JOP20180077A1 (en) | 2007-06-19 | 2019-01-30 | Kythera Biopharmaceuticals Inc | Synthetic bile acid compositions and methods |
| US20080318870A1 (en) | 2007-06-19 | 2008-12-25 | Kythera Biopharmaceuticals, Inc. | Synthetic bile acid compositions and methods |
| WO2013036835A1 (en) * | 2011-09-08 | 2013-03-14 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
| RS67266B1 (en) | 2013-03-13 | 2025-10-31 | Sage Therapeutics Inc | Neuroactive steriods and methods of use thereof |
| WO2015195967A1 (en) | 2014-06-18 | 2015-12-23 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| BR112018000129B1 (en) | 2015-07-06 | 2024-01-09 | Sage Therapeutics, Inc | Oxysterol compounds, their uses and pharmaceutical composition |
| SMT202100476T1 (en) | 2015-07-06 | 2021-09-14 | Sage Therapeutics Inc | Oxysterols and methods of use thereof |
| JP6882996B2 (en) | 2015-07-06 | 2021-06-02 | セージ セラピューティクス， インコーポレイテッド | Oxysterols and how to use them |
| SI3436022T1 (en) | 2016-04-01 | 2022-08-31 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| WO2017193046A1 (en) | 2016-05-06 | 2017-11-09 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| ES2884071T3 (en) | 2016-07-07 | 2021-12-10 | Sage Therapeutics Inc | 11-substituted 24-hydroxysteroles for the treatment of NMDA-related conditions |
| MX392270B (en) | 2016-09-30 | 2025-03-24 | Sage Therapeutics Inc | C7-SUBSTITUTED OXYSTEROLS AND METHODS OF USING THEM. |
| EP4105223B1 (en) | 2016-10-18 | 2025-04-30 | Sage Therapeutics, Inc. | Oxysterols and methods of use thereof |
| CN110267966B (en) | 2016-10-18 | 2022-07-08 | 萨奇治疗股份有限公司 | Oxysterols and methods of using the same |
| CN115040524A (en) * | 2022-07-27 | 2022-09-13 | 深圳市中西医结合医院 | Use of 4-cholesten-3-ones for the treatment of multiple myeloma bone disease |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3562260A (en) * | 1965-08-23 | 1971-02-09 | Ormonoterapia Richter Spa | 2-carbonyl-estratrienes and method of their preparation |
| GB1267915A (en) * | 1968-05-24 | 1972-03-22 | Glaxo Lab Ltd | Ring a-substituted ring a-aromatic steroids |
| FR2528434B1 (en) * | 1982-06-11 | 1985-07-19 | Roussel Uclaf | NOVEL 19-NOR STEROIDS SUBSTITUTED IN 11B AND POSSIBLY IN 2, THEIR PREPARATION PROCESS AND THEIR APPLICATION AS A MEDICAMENT |
| JP2623285B2 (en) * | 1988-03-09 | 1997-06-25 | 雪印乳業株式会社 | Method for producing 2 (3-hydroxy-1,3,5 (10) -estrien-17-yl) propionic acid |
| GB9910934D0 (en) * | 1999-05-11 | 1999-07-14 | Res Inst Medicine Chem | Chemical compounds |
| US6967195B2 (en) * | 2000-05-11 | 2005-11-22 | Research Institute For Medicine And Chemistry, Inc. | 2-substituted pregna-1-3,5(10) triene and chola-1,3,5(10) triene derivatives and their biological activity |
-
1999
- 1999-05-11 GB GBGB9910934.0A patent/GB9910934D0/en not_active Ceased
-
2000
- 2000-05-11 CN CNB008095175A patent/CN1158297C/en not_active Expired - Fee Related
- 2000-05-11 HU HU0201047A patent/HUP0201047A3/en unknown
- 2000-05-11 DE DE60006665T patent/DE60006665T2/en not_active Expired - Fee Related
- 2000-05-11 NZ NZ515482A patent/NZ515482A/en unknown
- 2000-05-11 ES ES00927569T patent/ES2207509T3/en not_active Expired - Lifetime
- 2000-05-11 CA CA002373443A patent/CA2373443A1/en not_active Abandoned
- 2000-05-11 AU AU45960/00A patent/AU779743B2/en not_active Ceased
- 2000-05-11 EP EP00927569A patent/EP1179005B1/en not_active Expired - Lifetime
- 2000-05-11 CZ CZ20014049A patent/CZ297316B6/en not_active IP Right Cessation
- 2000-05-11 WO PCT/GB2000/001813 patent/WO2000068246A1/en not_active Ceased
- 2000-05-11 AT AT00927569T patent/ATE254629T1/en not_active IP Right Cessation
- 2000-05-11 KR KR1020017014382A patent/KR100690040B1/en not_active Expired - Fee Related
- 2000-05-11 PT PT00927569T patent/PT1179005E/en unknown
- 2000-05-11 JP JP2000616220A patent/JP2002544137A/en active Pending
- 2000-05-11 IL IL14644200A patent/IL146442A0/en active IP Right Grant
- 2000-05-11 HK HK02105910.4A patent/HK1046001B/en not_active IP Right Cessation
- 2000-05-11 DK DK00927569T patent/DK1179005T3/en active
-
2001
- 2001-11-09 ZA ZA200109272A patent/ZA200109272B/en unknown
- 2001-11-11 IL IL146442A patent/IL146442A/en not_active IP Right Cessation
- 2001-11-12 NO NO20015520A patent/NO319949B1/en not_active IP Right Cessation
-
2003
- 2003-05-11 US US09/926,491 patent/US6881730B1/en not_active Expired - Fee Related
-
2005
- 2005-02-11 US US11/055,620 patent/US20050171075A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU779743B2 (en) | 2005-02-10 |
| NZ515482A (en) | 2004-05-28 |
| JP2002544137A (en) | 2002-12-24 |
| EP1179005B1 (en) | 2003-11-19 |
| HK1046001B (en) | 2004-12-24 |
| US6881730B1 (en) | 2005-04-19 |
| DE60006665T2 (en) | 2004-10-07 |
| NO20015520D0 (en) | 2001-11-12 |
| NO319949B1 (en) | 2005-10-03 |
| CN1158297C (en) | 2004-07-21 |
| IL146442A0 (en) | 2002-07-25 |
| US20050171075A1 (en) | 2005-08-04 |
| AU4596000A (en) | 2000-11-21 |
| HK1046001A1 (en) | 2002-12-20 |
| ZA200109272B (en) | 2003-02-26 |
| GB9910934D0 (en) | 1999-07-14 |
| EP1179005A1 (en) | 2002-02-13 |
| KR20020013542A (en) | 2002-02-20 |
| HUP0201047A3 (en) | 2003-07-28 |
| KR100690040B1 (en) | 2007-03-09 |
| CZ20014049A3 (en) | 2002-04-17 |
| IL146442A (en) | 2006-10-05 |
| CZ297316B6 (en) | 2006-11-15 |
| CA2373443A1 (en) | 2000-11-16 |
| PT1179005E (en) | 2004-04-30 |
| WO2000068246A1 (en) | 2000-11-16 |
| CN1358193A (en) | 2002-07-10 |
| HUP0201047A2 (en) | 2002-08-28 |
| ES2207509T3 (en) | 2004-06-01 |
| ATE254629T1 (en) | 2003-12-15 |
| DK1179005T3 (en) | 2004-03-01 |
| NO20015520L (en) | 2002-01-09 |
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