DE60002303D1 - Verfahren zur herstellung von paroxetin - Google Patents
Verfahren zur herstellung von paroxetinInfo
- Publication number
- DE60002303D1 DE60002303D1 DE60002303T DE60002303T DE60002303D1 DE 60002303 D1 DE60002303 D1 DE 60002303D1 DE 60002303 T DE60002303 T DE 60002303T DE 60002303 T DE60002303 T DE 60002303T DE 60002303 D1 DE60002303 D1 DE 60002303D1
- Authority
- DE
- Germany
- Prior art keywords
- paroxetine
- sesamol
- derivatisation
- dealkylation
- tetrahydropyridine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- AHOUBRCZNHFOSL-YOEHRIQHSA-N (+)-Casbol Chemical compound C1=CC(F)=CC=C1[C@H]1[C@H](COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-YOEHRIQHSA-N 0.000 title abstract 3
- AHOUBRCZNHFOSL-UHFFFAOYSA-N Paroxetine hydrochloride Natural products C1=CC(F)=CC=C1C1C(COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-UHFFFAOYSA-N 0.000 title abstract 3
- 229960002296 paroxetine Drugs 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 2
- UIOFUWFRIANQPC-JKIFEVAISA-N Floxacillin Chemical compound N([C@@H]1C(N2[C@H](C(C)(C)S[C@@H]21)C(O)=O)=O)C(=O)C1=C(C)ON=C1C1=C(F)C=CC=C1Cl UIOFUWFRIANQPC-JKIFEVAISA-N 0.000 abstract 1
- LUSZGTFNYDARNI-UHFFFAOYSA-N Sesamol Natural products OC1=CC=C2OCOC2=C1 LUSZGTFNYDARNI-UHFFFAOYSA-N 0.000 abstract 1
- ZSYVGBLSRONTAI-UHFFFAOYSA-N [4-(4-fluorophenyl)-1,2,3,6-tetrahydropyridin-3-yl]methanol Chemical class OCC1CNCC=C1C1=CC=C(F)C=C1 ZSYVGBLSRONTAI-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000006900 dealkylation reaction Methods 0.000 abstract 1
- 238000001212 derivatisation Methods 0.000 abstract 1
- 238000005984 hydrogenation reaction Methods 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- 238000010534 nucleophilic substitution reaction Methods 0.000 abstract 1
- 230000000707 stereoselective effect Effects 0.000 abstract 1
- 229910052723 transition metal Inorganic materials 0.000 abstract 1
- 150000003624 transition metals Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Pain & Pain Management (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI990364 | 1999-02-23 | ||
| IT1999MI000364A IT1308629B1 (it) | 1999-02-23 | 1999-02-23 | Processo per la produzione di paroxetina. |
| PCT/EP2000/001430 WO2000050422A1 (en) | 1999-02-23 | 2000-02-22 | Process for the production of paroxetine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60002303D1 true DE60002303D1 (de) | 2003-05-28 |
| DE60002303T2 DE60002303T2 (de) | 2004-04-01 |
Family
ID=11382007
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60002303T Expired - Fee Related DE60002303T2 (de) | 1999-02-23 | 2000-02-22 | Verfahren zur herstellung von paroxetin |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US6583287B1 (de) |
| EP (1) | EP1153023B1 (de) |
| JP (1) | JP2002537394A (de) |
| KR (1) | KR20010102366A (de) |
| CN (1) | CN1161353C (de) |
| AT (1) | ATE238295T1 (de) |
| AU (1) | AU759441B2 (de) |
| BR (1) | BR0008220A (de) |
| CA (1) | CA2361758A1 (de) |
| CZ (1) | CZ20012997A3 (de) |
| DE (1) | DE60002303T2 (de) |
| DK (1) | DK1153023T3 (de) |
| ES (1) | ES2195876T3 (de) |
| HK (1) | HK1040516B (de) |
| HR (1) | HRP20010608A2 (de) |
| HU (1) | HUP0105482A3 (de) |
| IL (1) | IL144883A (de) |
| IT (1) | IT1308629B1 (de) |
| MX (1) | MXPA01008502A (de) |
| NO (1) | NO319724B1 (de) |
| PL (1) | PL349358A1 (de) |
| PT (1) | PT1153023E (de) |
| RU (1) | RU2242473C2 (de) |
| SK (1) | SK12042001A3 (de) |
| TR (1) | TR200102441T2 (de) |
| TW (1) | TWI221473B (de) |
| WO (1) | WO2000050422A1 (de) |
| YU (1) | YU60801A (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2289650T3 (es) * | 2004-03-03 | 2008-02-01 | Chemi S.P.A. | Sal monosodica del acido 3-piridil-1-hidroxietiliden-1,1-bifosfonico amorfa y procedimiento para la preparacion de la misma. |
| US9138430B2 (en) * | 2007-12-27 | 2015-09-22 | Mylan Specialty L.P. | Formulation and method for the release of paroxetine in the large intestine |
| MX355654B (es) * | 2012-01-31 | 2018-04-26 | Eisai R&D Man Co Ltd | Derivado de paroxetina. |
| CN106831736A (zh) * | 2017-02-15 | 2017-06-13 | 浙江华海药业股份有限公司 | 一种制备帕罗西汀杂质的方法 |
| CN112521377A (zh) * | 2020-11-26 | 2021-03-19 | 北京福元医药股份有限公司 | 一种盐酸帕罗西汀的连续化制备方法 |
| CN115260153B (zh) * | 2022-07-21 | 2023-10-27 | 威尚（上海）生物医药有限公司 | 一种6取代手性纯二氟哌啶喹唑啉衍生物及其制备方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0757758B2 (ja) | 1988-10-24 | 1995-06-21 | 高砂香料工業株式会社 | ルテニウム―ホスフィン錯体 |
| DK715988D0 (da) * | 1988-12-22 | 1988-12-22 | Ferrosan As | Etherifikation og dealkylering af piperidin-derivater samt intermediater |
| US5233084A (en) * | 1989-06-22 | 1993-08-03 | Monsanto Company | Method for preparing α-arylpropionic acids |
| FR2651152B1 (fr) * | 1989-08-23 | 1991-11-29 | Elf Aquitaine | Perfectionnement a la preparation de catalyseurs chiraux a base de complexes du ruthenium et du phosphore. |
| GB9209687D0 (en) * | 1992-05-06 | 1992-06-17 | Smithkline Beecham Plc | Novel process |
| DE4422672A1 (de) * | 1994-06-30 | 1996-01-04 | Hoechst Ag | Halogenierte Biphenyl-2,2'-diyl-bis-diphenylphosphine, ihre Herstellung und ihre Verwendung |
| SK283608B6 (sk) * | 1995-02-06 | 2003-10-07 | Smithkline Beecham Plc | Bezvodý hydrochlorid paroxetínu, spôsob jeho výroby a použitie |
| EP0828735A1 (de) * | 1995-05-17 | 1998-03-18 | Novo Nordisk A/S | Verfahren zur herstellung von 4-arylpiperidin derivaten |
| HU221921B1 (hu) * | 1996-07-08 | 2003-02-28 | Richter Gedeon Vegyészeti Gyár Rt. | N-benzil-piperidin- és tetrahidropiridinszármazékok és eljárás azok előállítására |
| IL132170A0 (en) * | 1997-05-06 | 2001-03-19 | Novo Nordisk As | Novel heterocyclic compounds |
| ES2212287T3 (es) * | 1997-05-20 | 2004-07-16 | Firmenich Sa | Catalizadores de rutenio y su uso en la hidrogenacion asimetrica de sustratos debilmente coordinantes. |
-
1999
- 1999-02-23 IT IT1999MI000364A patent/IT1308629B1/it active
-
2000
- 2000-02-18 TW TW089102997A patent/TWI221473B/zh not_active IP Right Cessation
- 2000-02-22 EP EP00909228A patent/EP1153023B1/de not_active Expired - Lifetime
- 2000-02-22 HR HR20010608A patent/HRP20010608A2/hr not_active Application Discontinuation
- 2000-02-22 US US09/890,414 patent/US6583287B1/en not_active Expired - Fee Related
- 2000-02-22 PT PT00909228T patent/PT1153023E/pt unknown
- 2000-02-22 WO PCT/EP2000/001430 patent/WO2000050422A1/en not_active Ceased
- 2000-02-22 CA CA002361758A patent/CA2361758A1/en not_active Abandoned
- 2000-02-22 MX MXPA01008502A patent/MXPA01008502A/es active IP Right Grant
- 2000-02-22 TR TR2001/02441T patent/TR200102441T2/xx unknown
- 2000-02-22 YU YU60801A patent/YU60801A/sh unknown
- 2000-02-22 BR BR0008220-1A patent/BR0008220A/pt not_active IP Right Cessation
- 2000-02-22 PL PL00349358A patent/PL349358A1/xx not_active IP Right Cessation
- 2000-02-22 IL IL14488300A patent/IL144883A/en not_active IP Right Cessation
- 2000-02-22 DK DK00909228T patent/DK1153023T3/da active
- 2000-02-22 CZ CZ20012997A patent/CZ20012997A3/cs unknown
- 2000-02-22 DE DE60002303T patent/DE60002303T2/de not_active Expired - Fee Related
- 2000-02-22 CN CNB008041873A patent/CN1161353C/zh not_active Expired - Fee Related
- 2000-02-22 AT AT00909228T patent/ATE238295T1/de not_active IP Right Cessation
- 2000-02-22 RU RU2001125933/04A patent/RU2242473C2/ru not_active IP Right Cessation
- 2000-02-22 KR KR1020017010760A patent/KR20010102366A/ko not_active Ceased
- 2000-02-22 HK HK02101971.9A patent/HK1040516B/en not_active IP Right Cessation
- 2000-02-22 SK SK1204-2001A patent/SK12042001A3/sk unknown
- 2000-02-22 ES ES00909228T patent/ES2195876T3/es not_active Expired - Lifetime
- 2000-02-22 JP JP2000601002A patent/JP2002537394A/ja active Pending
- 2000-02-22 HU HU0105482A patent/HUP0105482A3/hu unknown
- 2000-02-22 AU AU31583/00A patent/AU759441B2/en not_active Ceased
-
2001
- 2001-08-22 NO NO20014078A patent/NO319724B1/no unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8328 | Change in the person/name/address of the agent |
Representative=s name: HANSMANN & VOGESER, 81369 MUENCHEN |
|
| 8327 | Change in the person/name/address of the patent owner |
Owner name: APOTECNIA, S.A., LLANERA-ASTURIAS, ES |
|
| 8339 | Ceased/non-payment of the annual fee |