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DE60001657D1 - Verfahren zur herstellung von n-(4-cyan-3-trifluormethylphenyl)-3-(4-flurophenylsulfonyl)-2-hydroxy-2-methylpropionamid - Google Patents

Verfahren zur herstellung von n-(4-cyan-3-trifluormethylphenyl)-3-(4-flurophenylsulfonyl)-2-hydroxy-2-methylpropionamid

Info

Publication number
DE60001657D1
DE60001657D1 DE60001657T DE60001657T DE60001657D1 DE 60001657 D1 DE60001657 D1 DE 60001657D1 DE 60001657 T DE60001657 T DE 60001657T DE 60001657 T DE60001657 T DE 60001657T DE 60001657 D1 DE60001657 D1 DE 60001657D1
Authority
DE
Germany
Prior art keywords
methylpropionamide
hydroxy
flurophenylsulfonyl
trifluormethylphenyl
cyan
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60001657T
Other languages
English (en)
Other versions
DE60001657T2 (de
Inventor
Bela Soeroes
Zoltan Tuba
Gyoergy Galik
Adam Bor
Hu Rs
Adam Demeter
Ferenc Trischler
Janos Horvath
Janos Brlik
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Richter Gedeon Vegyeszeti Gyar Nyrt
Original Assignee
Richter Gedeon Vegyeszeti Gyar RT
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Richter Gedeon Vegyeszeti Gyar RT filed Critical Richter Gedeon Vegyeszeti Gyar RT
Publication of DE60001657D1 publication Critical patent/DE60001657D1/de
Application granted granted Critical
Publication of DE60001657T2 publication Critical patent/DE60001657T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/26—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids
    • C07C303/28—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of esters of sulfonic acids by reaction of hydroxy compounds with sulfonic acids or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/02—Preparation of sulfones; Preparation of sulfoxides by formation of sulfone or sulfoxide groups by oxidation of sulfides, or by formation of sulfone groups by oxidation of sulfoxides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/10—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms two oxygen atoms and one sulfur atom, e.g. cyclic sulfates

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE60001657T 1999-06-10 2000-05-26 Verfahren zur herstellung von n-(4-cyan-3-trifluormethylphenyl)-3-(4-flurophenylsulfonyl)-2-hydroxy-2-methylpropionamid Expired - Lifetime DE60001657T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU9901937A HU223950B1 (hu) 1999-06-10 1999-06-10 Eljárás a racém, valamint az R-(-)- és S-(+)-N-[4-ciano-3-(trifluor-metil)-fenil]-3-[(4-fluor-fenil)-szulfonil]-2-hidroxi-2-metil-propánsavamid előállítására
PCT/HU2000/000049 WO2001000608A1 (en) 1999-06-10 2000-05-26 Process for the synthesis of n-(4-cyano-3-trifluoromethylphenyl)-3-(4-fluorophenylsulfonyl)-2-hydroxy-2-methylpropionamide

Publications (2)

Publication Number Publication Date
DE60001657D1 true DE60001657D1 (de) 2003-04-17
DE60001657T2 DE60001657T2 (de) 2003-12-04

Family

ID=89998474

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60001657T Expired - Lifetime DE60001657T2 (de) 1999-06-10 2000-05-26 Verfahren zur herstellung von n-(4-cyan-3-trifluormethylphenyl)-3-(4-flurophenylsulfonyl)-2-hydroxy-2-methylpropionamid

Country Status (8)

Country Link
US (1) US7199257B1 (de)
EP (1) EP1189898B1 (de)
AT (1) ATE234294T1 (de)
AU (1) AU5239700A (de)
DE (1) DE60001657T2 (de)
ES (1) ES2188550T3 (de)
HU (1) HU223950B1 (de)
WO (1) WO2001000608A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1406855A4 (de) * 2001-06-13 2006-04-19 Teva Gyogyszergyar Reszvenytar Neues verfahren zur herstellung von rac-bicalutamid und dessen zwischenprodukten
US7102026B2 (en) 2001-06-13 2006-09-05 Teva Gyógyszergyár Zártkörüen Müködö Részvénytársaság Process for preparing and isolating rac-bicalutamide and its intermediates
KR100938188B1 (ko) * 2001-12-13 2010-01-21 스미또모 가가꾸 가부시키가이샤 비칼루타미드의 결정 및 그 제조 방법
DE10222104A1 (de) 2002-05-17 2003-12-04 Helm Ag Verfahren zur Herstellung von N-(4'-Cyano-3'-trifluormethyl)-3-(4"-fluorphenylsulfonyl)-2-hydroxy-2-methylpropionamid
US20040063782A1 (en) * 2002-09-27 2004-04-01 Westheim Raymond J.H. Bicalutamide forms
US6818766B2 (en) 2002-10-02 2004-11-16 Synthon Bv Process for making bicalutamide and intermediates thereof
AU2003209667A1 (en) * 2003-02-21 2004-09-09 Hetero Drugs Limited Bicalutamide polymorphs
US20050008691A1 (en) 2003-05-14 2005-01-13 Arturo Siles Ortega Bicalutamide compositions
JP2007521224A (ja) * 2003-06-25 2007-08-02 テバ ジョジセルジャール ザ−トケルエン ムケド レ−スベニュタ−ルシャシャ−グ Ｒａｃ−ビカルタミドの精製及び単離方法
JP4322621B2 (ja) 2003-10-16 2009-09-02 住友化学株式会社 ４’−シアノ−３−［（４−フルオロフェニル）スルホニル］−２−ヒドロキシ−２−メチル−３’−トリフルオロメチルプロピオンアニリドの製造方法
EP1863759A1 (de) * 2005-03-29 2007-12-12 Usv Limited Verfahren zur herstellung von bicalutamid
WO2007013094A2 (en) * 2005-04-15 2007-02-01 Sun Pharmaceutical Industries Limited A process for preparation of antiandrogen compound
CA2513356A1 (en) * 2005-07-26 2007-01-26 Apotex Pharmachem Inc. Process for production of bicalutamide
CA2635461A1 (en) 2005-12-27 2007-07-05 Dabur Pharma Limited An improved process for preparation of bicalutamide
CN101462988B (zh) * 2007-12-21 2014-01-01 中国医学科学院药物研究所 一种比卡鲁胺的合成工艺
US8895772B2 (en) 2010-09-29 2014-11-25 Shilpa Medicare Limited Process for preparing bicalutamide
CN102086167B (zh) * 2010-12-09 2013-05-08 济南大学 一种乙磺酰基乙腈的制备方法
CN102351762A (zh) * 2011-07-21 2012-02-15 宁波人健药业集团有限公司 用n-(4-氰基-3-三氟甲基苯基)-3-(4-氟苯硫基)-2-甲基-2-羟基丙酰胺制备比卡鲁胺的方法
CN102321000A (zh) * 2011-07-21 2012-01-18 宁波人健药业集团有限公司 氧化制备比卡鲁胺的方法
CN108069887B (zh) * 2016-11-17 2021-04-20 山西振东制药股份有限公司 一种(r)-比卡鲁胺中间体的制备方法
CN109336798B (zh) * 2018-11-19 2021-11-16 常州新星联生物科技有限公司 一种比卡鲁胺硫醚中间体的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
LU88769I2 (fr) 1982-07-23 1996-11-05 Zeneca Ltd Bicalutamide et ses sels et esters pharmaceutiquement acceptables (Casodex (R))
JPH09508125A (ja) 1994-01-21 1997-08-19 セプラコー，インコーポレイテッド 光学的純正ｒ−（−）−カソデックスを使用した男性ホルモン依存疾患治療のための方法と組成
AU7723198A (en) 1997-06-04 1998-12-21 University Of Tennessee Research Corporation, The Non-steroidal radiolabeled agonist/antagonist compounds and their use in prostate cancer imaging
KR100938188B1 (ko) * 2001-12-13 2010-01-21 스미또모 가가꾸 가부시키가이샤 비칼루타미드의 결정 및 그 제조 방법
US6818766B2 (en) * 2002-10-02 2004-11-16 Synthon Bv Process for making bicalutamide and intermediates thereof

Also Published As

Publication number Publication date
AU5239700A (en) 2001-01-31
HU9901937D0 (en) 1999-08-30
WO2001000608A1 (en) 2001-01-04
ES2188550T3 (es) 2003-07-01
HUP9901937A2 (hu) 2001-04-28
WO2001000608A8 (en) 2001-06-21
DE60001657T2 (de) 2003-12-04
HU223950B1 (hu) 2005-03-29
EP1189898B1 (de) 2003-03-12
US7199257B1 (en) 2007-04-03
ATE234294T1 (de) 2003-03-15
EP1189898A1 (de) 2002-03-27

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