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DE3781195D1 - Substituierte benzamidderivate, verfahren zu deren herstellung und diese enthaltende medikamente. - Google Patents

Substituierte benzamidderivate, verfahren zu deren herstellung und diese enthaltende medikamente.

Info

Publication number
DE3781195D1
DE3781195D1 DE8787106266T DE3781195T DE3781195D1 DE 3781195 D1 DE3781195 D1 DE 3781195D1 DE 8787106266 T DE8787106266 T DE 8787106266T DE 3781195 T DE3781195 T DE 3781195T DE 3781195 D1 DE3781195 D1 DE 3781195D1
Authority
DE
Germany
Prior art keywords
production
benzamide derivatives
substituted benzamide
medicines containing
medicines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8787106266T
Other languages
English (en)
Other versions
DE3781195T2 (de
Inventor
Tatsuya Kon
Shiro Kato
Toshiya Morie
Kazunori Ohno
Katsuhiko Hino
Tadahiko Karasawa
Naoyuki Yoshida
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Pharma Co Ltd
Original Assignee
Dainippon Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Pharmaceutical Co Ltd filed Critical Dainippon Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DE3781195D1 publication Critical patent/DE3781195D1/de
Publication of DE3781195T2 publication Critical patent/DE3781195T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D267/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D267/02—Seven-membered rings
    • C07D267/08—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D267/10—Seven-membered rings having the hetero atoms in positions 1 and 4 not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
DE8787106266T 1986-04-30 1987-04-29 Substituierte benzamidderivate, verfahren zu deren herstellung und diese enthaltende medikamente. Expired - Lifetime DE3781195T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP10155286 1986-04-30
JP31509086 1986-12-31

Publications (2)

Publication Number Publication Date
DE3781195D1 true DE3781195D1 (de) 1992-09-24
DE3781195T2 DE3781195T2 (de) 1993-02-18

Family

ID=26442419

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8787106266T Expired - Lifetime DE3781195T2 (de) 1986-04-30 1987-04-29 Substituierte benzamidderivate, verfahren zu deren herstellung und diese enthaltende medikamente.

Country Status (18)

Country Link
US (1) US4870074A (de)
EP (1) EP0243959B1 (de)
KR (1) KR870010030A (de)
AR (1) AR242953A1 (de)
AU (1) AU592177B2 (de)
CA (1) CA1291135C (de)
CZ (1) CZ284687B6 (de)
DE (1) DE3781195T2 (de)
DK (1) DK175281B1 (de)
ES (1) ES2043617T3 (de)
FI (1) FI87776C (de)
GR (1) GR3005934T3 (de)
HK (1) HK18194A (de)
HU (1) HU198193B (de)
NZ (1) NZ220120A (de)
PH (1) PH24049A (de)
SK (1) SK279058B6 (de)
SU (1) SU1597101A3 (de)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2640139A1 (fr) * 1988-12-14 1990-06-15 Delagrange Laboratoires Application de benzamides substitues comme gastromoteurs
US5395832A (en) * 1991-02-15 1995-03-07 Hokuriku Seiyaku Co., Ltd. Benzamide derivatives
TW243449B (de) * 1991-02-15 1995-03-21 Hokuriku Pharmaceutical
US5864039A (en) * 1994-03-30 1999-01-26 Yoshitomi Pharmaceutical Industries, Ltd. Benzoic acid compounds and use thereof as medicaments
WO1995026953A1 (en) * 1994-03-30 1995-10-12 Yoshitomi Pharmaceutical Industries, Ltd. Benzoic acid compound and use thereof as medicine
ATE208766T1 (de) * 1995-05-23 2001-11-15 Janssen Pharmaceutica Nv (2-morpholinylmethyl)benzamid-derivate
JP2001064177A (ja) * 1999-08-16 2001-03-13 Schering Ag ベンズアミド誘導体を有効成分とする製剤
CZ20031195A3 (cs) 2000-09-29 2003-09-17 Glaxo Group Limited Morfolinacetamidové deriváty
US6943160B2 (en) * 2000-11-28 2005-09-13 Smithkline Beecham Plc Morpholine derivatives as antagonists of orexin receptors
JP4829417B2 (ja) * 2001-03-26 2011-12-07 明夫 乾 インスリン抵抗性改善薬
MXPA04003002A (es) * 2001-10-08 2004-07-15 Sun Pharmaceutical Ind Ltd Un sistema de administracion espacial de farmacos para agentes antiespasmodicos.
GB0207447D0 (en) * 2002-03-28 2002-05-08 Glaxo Group Ltd Novel compounds
GB0207449D0 (en) * 2002-03-28 2002-05-08 Glaxo Group Ltd Novel compounds
GB0208158D0 (en) * 2002-03-28 2002-05-22 Glaxo Group Ltd Novel compounds
HUP0201980A3 (en) * 2002-06-13 2008-06-30 Richter Gedeon Nyrt Process for preparing a benzamide derivative and intermediates thereof
EP1695699A4 (de) * 2003-12-09 2012-08-22 Dainippon Sumitomo Pharma Co Arzneihaltige körner und die körner enthaltende feste zubereitung
US8138204B2 (en) * 2004-01-07 2012-03-20 Aryx Therapeutics, Inc. Stereoisomeric compounds and methods for the treatment of gastrointestinal and central nervous system disorders
PT2194053E (pt) 2004-01-07 2013-07-08 Armetheon Inc Derivados de metoxipiperidina para utilização no tratamento de distúrbios gastrointestinais e do sistema nervoso central
US8524736B2 (en) 2004-01-07 2013-09-03 Armetheon, Inc. Stereoisomeric compounds and methods for the treatment of gastrointestinal and central nervous system disorders
JP4970946B2 (ja) * 2004-09-08 2012-07-11 田辺三菱製薬株式会社 モルホリン化合物
KR20140000721A (ko) 2005-06-23 2014-01-03 어레이 바이오파마 인크. 벤즈이미다졸 화합물의 제조 방법
CA2620379C (en) * 2005-08-31 2015-02-24 Aryx Therapeutics, Inc. Synthetic methods and intermediates for stereoisomeric compounds useful for the treatment of gastrointestinal and central nervous system disorders
US20090042926A1 (en) * 2005-12-20 2009-02-12 Jason Imbriglio Niacin Receptor Agonists, Compositions Containing Such Compounds and Methods of Treatment
KR100750593B1 (ko) * 2006-03-16 2007-08-20 동우신테크 주식회사 치환된 벤즈아미드 유도체의 제조방법
WO2007149929A1 (en) * 2006-06-23 2007-12-27 Aryx Therapeutics, Inc. Piperidine derivatives for the treatment of gastrointestinal and cns disorders
AU2008242703B2 (en) * 2007-04-19 2011-08-18 Concert Pharmaceuticals Inc. Deuterated morpholinyl compounds
CN101402633A (zh) * 2007-09-11 2009-04-08 上海恒瑞医药有限公司 苯甲酰胺类衍生物、其制备方法及其在医药上的用途
JP4989733B2 (ja) 2008-02-13 2012-08-01 大日本住友製薬株式会社 口腔内崩壊錠
TWI423967B (zh) * 2008-02-21 2014-01-21 Dainippon Sumitomo Pharma Co 醯胺衍生物及含有其之醫藥組合物
WO2011019043A1 (ja) 2009-08-11 2011-02-17 大日本住友製薬株式会社 ２種以上の粒子を含有する口腔内速崩壊錠
WO2011107903A1 (en) 2010-03-04 2011-09-09 Ranbaxy Laboratories Limited Highly pure mosapride citrate dihydrate and processes for its preparation
IN2013MN01519A (de) 2011-02-25 2015-06-12 Yuhan Corp
KR101657616B1 (ko) 2013-05-24 2016-09-19 주식회사유한양행 피리미딘 고리를 포함하는 바이사이클릭 유도체 및 그의 제조방법
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
CN111349052B (zh) * 2020-04-07 2021-02-12 福建海西新药创制有限公司 一种枸橼酸莫沙必利的合成方法
CN114560822B (zh) * 2020-11-27 2024-05-28 鲁南制药集团股份有限公司 一种莫沙必利的二羧酸晶体
CN114591260B (zh) * 2020-12-05 2025-07-11 鲁南制药集团股份有限公司 一种莫沙必利有机酸盐
CN119241463A (zh) * 2024-10-22 2025-01-03 吉林修正药业新药开发有限公司 一种枸橼酸莫沙必利杂质化合物及其制备方法
CN119241464A (zh) * 2024-10-22 2025-01-03 吉林修正药业新药开发有限公司 一种枸橼酸莫沙必利杂质化合物及其制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH451142A (de) * 1965-01-19 1968-05-15 Sandoz Ag Verfahren zur Herstellung neuer basisch substituierter Benzoesäureamide
US4029786A (en) * 1972-08-11 1977-06-14 Imperial Chemical Industries Limited Morpholine derivatives for treating depression
US4323503A (en) * 1976-08-04 1982-04-06 Societe D'etudes Scientifiques Et Industrielles De L'ile-De-France Substituted 2,3-alkylene di (oxy) benzamides and derivatives
US4210754A (en) * 1977-02-01 1980-07-01 Hoffmann-La Roche Inc. Morpholino containing benzamides
US4692445A (en) * 1983-04-29 1987-09-08 Rorer Pharmaceutical Corporation Bicyclic benzenoid aminoalkylene ethers and thioethers, pharmaceutical compositions and use
FR2575158B1 (fr) * 1984-12-20 1987-10-02 Pf Medicament Arylalcoyloxymethyl-2 morpholines, leur preparation et leur application en tant que medicaments utiles dans le traitement des troubles du systeme nerveux central
JPH0390274A (ja) * 1989-08-28 1991-04-16 Furukawa Alum Co Ltd Ａｌ又はＡｌ合金の気相ろう付法

Also Published As

Publication number Publication date
EP0243959A1 (de) 1987-11-04
NZ220120A (en) 1989-06-28
DK175281B1 (da) 2004-08-09
FI87776C (fi) 1993-02-25
DK218787A (da) 1987-10-31
DE3781195T2 (de) 1993-02-18
US4870074A (en) 1989-09-26
PH24049A (en) 1990-03-05
CZ284687B6 (cs) 1999-02-17
FI87776B (fi) 1992-11-13
FI871828A7 (fi) 1987-10-31
HK18194A (en) 1994-03-11
SK289787A3 (en) 1998-06-03
AU592177B2 (en) 1990-01-04
AU7227587A (en) 1987-11-05
ES2043617T3 (es) 1994-01-01
CZ289787A3 (cs) 1998-11-11
SU1597101A3 (ru) 1990-09-30
KR870010030A (ko) 1987-11-30
DK218787D0 (da) 1987-04-29
AR242953A1 (es) 1993-06-30
FI871828A0 (fi) 1987-04-27
GR3005934T3 (de) 1993-06-07
HU198193B (en) 1989-08-28
HUT45514A (en) 1988-07-28
CA1291135C (en) 1991-10-22
SK279058B6 (sk) 1998-06-03
EP0243959B1 (de) 1992-08-19

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Legal Events

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