[go: up one dir, main page]

DE3679793D1 - 5-amino- und 5-hydroxy-6,8-difluorchinolone als antibakterielle wirkstoffe. - Google Patents

5-amino- und 5-hydroxy-6,8-difluorchinolone als antibakterielle wirkstoffe.

Info

Publication number
DE3679793D1
DE3679793D1 DE8686117250T DE3679793T DE3679793D1 DE 3679793 D1 DE3679793 D1 DE 3679793D1 DE 8686117250 T DE8686117250 T DE 8686117250T DE 3679793 T DE3679793 T DE 3679793T DE 3679793 D1 DE3679793 D1 DE 3679793D1
Authority
DE
Germany
Prior art keywords
difluorchinolone
hydroxy
amino
active substances
antibacterial active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE8686117250T
Other languages
English (en)
Inventor
Ashok K Trehan
Joseph P Sanchez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/808,122 external-priority patent/US4668680A/en
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Application granted granted Critical
Publication of DE3679793D1 publication Critical patent/DE3679793D1/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE8686117250T 1985-12-12 1986-12-11 5-amino- und 5-hydroxy-6,8-difluorchinolone als antibakterielle wirkstoffe. Expired - Fee Related DE3679793D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US06/808,122 US4668680A (en) 1985-12-12 1985-12-12 5-amino-6,8-difluoroquinolones as antibacterial agents
US06/918,568 US4977154A (en) 1985-12-12 1986-10-20 5-amino and 5-hydroxy-6-fluoroquinolones as antibacterial agents

Publications (1)

Publication Number Publication Date
DE3679793D1 true DE3679793D1 (de) 1991-07-18

Family

ID=27123084

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8686117250T Expired - Fee Related DE3679793D1 (de) 1985-12-12 1986-12-11 5-amino- und 5-hydroxy-6,8-difluorchinolone als antibakterielle wirkstoffe.

Country Status (16)

Country Link
US (1) US4977154A (de)
EP (1) EP0226961B1 (de)
KR (1) KR900000555B1 (de)
CN (1) CN1013114B (de)
AU (1) AU591732B2 (de)
DE (1) DE3679793D1 (de)
DK (1) DK166493B1 (de)
ES (1) ES2039198T3 (de)
FI (1) FI865004L (de)
GR (1) GR3002129T3 (de)
HU (1) HU203231B (de)
IE (1) IE59261B1 (de)
IL (1) IL80933A (de)
NO (1) NO865013L (de)
OA (1) OA08561A (de)
PT (1) PT83909B (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU594983B2 (en) * 1985-10-29 1990-03-22 Dainippon Pharmaceutical Co. Ltd. Novel quinoline derivatives and processes for preparation thereof
EP0242789A3 (de) * 1986-04-25 1990-09-05 Dainippon Pharmaceutical Co., Ltd. Chinolinderivate und Verfahren zu ihrer Herstellung
DE3711193A1 (de) * 1987-04-02 1988-10-13 Bayer Ag 5-substituierte chinolon- und naphthyridoncarbonsaeure-derivate
US4780468A (en) * 1987-08-07 1988-10-25 Warner-Lambert Company 8-trifluoromethyl quinolones as antibacterial agents
US4933335A (en) * 1987-08-07 1990-06-12 Warner-Lambert Company Quinolones as antibacterial agents
US4929613A (en) * 1987-08-26 1990-05-29 Warner-Lambert Company Antibacterial agents
EP0339406A1 (de) * 1988-04-19 1989-11-02 Hokuriku Pharmaceutical Co.,Ltd Derivate der Chinolin-3-carbonsäure, Verfahren zu ihrer Herstellung und diese Derivate enthaltende antibakterielle Zusammensetzung
JP2844079B2 (ja) * 1988-05-23 1999-01-06 塩野義製薬株式会社 ピリドンカルボン酸系抗菌剤
AU618823B2 (en) * 1988-07-20 1992-01-09 Sankyo Company Limited 4-oxoquinoline-3-carboxylic acid derivatives, their preparation and their use
JPH05506033A (ja) 1990-04-18 1993-09-02 ノーウィッチ、イートン、ファーマスーティカルズ、インコーポレーテッド 抗微生物性キノロニルラクタム類
DE4019023A1 (de) * 1990-06-14 1991-12-19 Bayer Ag Verfahren zur herstellung von chinolincarbonsaeuren
KR970704693A (ko) * 1994-07-18 1997-09-06 나가히로 마오미 트리플루오로메틸퀴놀린카르복실산 유도체(trifluoromethylquinolinecarboxylic acid derivative)
US5866150A (en) * 1996-03-20 1999-02-02 Aquaculture Technology Incorporated Antibacterially active extracts from the marine algae chaetoceros and methods of use
IN186245B (de) 1997-09-19 2001-07-14 Ranbaxy Lab Ltd
CN1091103C (zh) * 1999-04-02 2002-09-18 中国科学院上海药物研究所 一类喹诺酮类化合物及它的制备和其用途
US7176313B2 (en) * 2000-02-09 2007-02-13 Daiichi Pharmaceutical Co., Ltd. Anti acid-fast bacterial agent containing pyridonecarboxylic acids as active ingredient
DE102004035203A1 (de) * 2004-07-21 2006-02-16 Bayer Healthcare Ag Substituierte Chinolone
US8546423B2 (en) 2005-05-18 2013-10-01 Mpex Pharmaceuticals, Inc. Aerosolized fluoroquinolones and uses thereof
CN100415212C (zh) * 2006-07-21 2008-09-03 哈药集团制药总厂 一种含乳酸卡德沙星的口服制剂
US8629139B2 (en) 2008-10-07 2014-01-14 Mpex Pharmaceuticals, Inc. Topical use of Levofloxacin for reducing lung inflammation
HUE038428T2 (hu) 2008-10-07 2018-10-29 Horizon Orphan Llc Aeroszol fluorokinolon készítmények javított farmakokinetika érdekében
ES2739979T3 (es) 2009-09-04 2020-02-05 Horizon Orphan Llc Uso de levofloxacino en aerosol para el tratamiento de la fibrosis quística
CN104557896A (zh) * 2013-10-18 2015-04-29 沈敬山 布瑞哌唑、其关键中间体及其盐的制备方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2808070A1 (de) * 1978-02-24 1979-08-30 Bayer Ag Verfahren zur herstellung von 4-pyridon-3-carbonsaeuren und/oder deren derivaten
DE3248506A1 (de) * 1982-12-29 1984-07-05 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7(alkyl-1-piperazinyl)-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3574380D1 (en) * 1984-02-17 1989-12-28 Daiichi Seiyaku Co 1,8-naphthyridine derivatives
US4604401A (en) * 1984-07-20 1986-08-05 Warner-Lambert Company Antibacterial agents III
JPS61205258A (ja) * 1985-03-08 1986-09-11 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体及びその製造方法
AU594983B2 (en) * 1985-10-29 1990-03-22 Dainippon Pharmaceutical Co. Ltd. Novel quinoline derivatives and processes for preparation thereof

Also Published As

Publication number Publication date
CN86108942A (zh) 1987-11-04
KR900000555B1 (ko) 1990-01-31
PT83909A (en) 1987-01-01
DK590586A (da) 1987-06-13
EP0226961B1 (de) 1991-06-12
HU203231B (en) 1991-06-28
FI865004A0 (fi) 1986-12-08
FI865004A7 (fi) 1987-06-13
US4977154A (en) 1990-12-11
AU591732B2 (en) 1989-12-14
IL80933A (en) 1991-06-10
ES2039198T3 (es) 1993-09-16
GR3002129T3 (en) 1992-12-30
OA08561A (en) 1988-09-30
KR870006034A (ko) 1987-07-08
AU6587986A (en) 1987-06-18
IE863104L (en) 1987-06-12
FI865004L (fi) 1987-06-13
CN1013114B (zh) 1991-07-10
IE59261B1 (en) 1994-01-26
EP0226961A1 (de) 1987-07-01
IL80933A0 (en) 1987-03-31
HUT42470A (en) 1987-07-28
DK166493B1 (da) 1993-06-01
PT83909B (pt) 1989-05-12
NO865013D0 (no) 1986-12-11
NO865013L (no) 1987-06-15
DK590586D0 (da) 1986-12-09

Similar Documents

Publication Publication Date Title
DE3679793D1 (de) 5-amino- und 5-hydroxy-6,8-difluorchinolone als antibakterielle wirkstoffe.
FI861842A0 (fi) Makromerfoerstaerkt, tryckkaensligt hudlim.
FI863778A0 (fi) Tugg- och snuskompositioner, vilka innehaoller oerter.
FI860860A0 (fi) Stabiliserat, flytande tvaettmedel foer textiler.
FI861684A0 (fi) Imidazokinoliner, antitrombogena hjaertmediciner.
FI861058A7 (fi) Vaendskjutdoerr foer persontransportfordon, speciellt foer raelsfordon.
FI863532L (fi) Raekneanordning foer fiskar, i synnerhet fiskyngel.
FI854870A0 (fi) Oljekyld, flerdelad saenkkolv foer slagkolvsfoerbraenningsmotor.
FI863236A0 (fi) Filteranordning, saerskilt sugfilter.
FI853553A0 (fi) Kontinuerligt arbetande, tryckvalsfoersedd paorullningsanordning.
FI871692A0 (fi) Sorteringsmaskin, i synnerhet foer smaopaket.
FI863721L (fi) Skaeranordning foer skivmaterial, saerskilt faner.
FI864584A0 (fi) Koextruderad, biaxialt straeckt flerskiktsfolie.
FI860870L (fi) Antibakteriska foereningar, deras framstaellning och anvaendning.
FI861009L (fi) Hydroelastisk uppbaerningsanordning foer mobila, sjaelvlyftande borrplattformar.
ATE68471T1 (de) Gem-dihalo-1,8-diamino-4-aza-oktane.
FI855170A0 (fi) Sorterare, saerskilt vertikalsikt.
FI860454A7 (fi) Daeckregummeringsfoerfarande, varvid staolgoerdelskikt foernyas.
DE3763309D1 (de) Antibakterielle 3-halogenvinylglycinwirkstoffe.
ATE64385T1 (de) 5-amino- und 5-hydroxy-6,8-difluorchinolone als antibakterielle wirkstoffe.
FI863012A0 (fi) Bilslaepvagn, speciellt husvagn.
FI861244L (fi) Satsning- och demonteringsanordning foer en press, i synnerhet foer stolppress.
FI861494L (fi) Kristallinisk, vattenfri natrium-19 -deoxiaglykondianemycin.
DE3577436D1 (de) Optisch aktive, anti-kopf-zu-kopf-kumarondimerpolyamide.
MX9203337A (es) 5-aril-2,4-dialquil-3h- 1,2,4-triazol-3-tionas utiles como antidepresores.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee