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DE3586085D1 - Antitumor-4-hydroxy-2-zyklopentenonen. - Google Patents

Antitumor-4-hydroxy-2-zyklopentenonen.

Info

Publication number
DE3586085D1
DE3586085D1 DE8585307631T DE3586085T DE3586085D1 DE 3586085 D1 DE3586085 D1 DE 3586085D1 DE 8585307631 T DE8585307631 T DE 8585307631T DE 3586085 T DE3586085 T DE 3586085T DE 3586085 D1 DE3586085 D1 DE 3586085D1
Authority
DE
Germany
Prior art keywords
cyclopentenones
antitumor
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8585307631T
Other languages
English (en)
Inventor
Atsuo Hazato
Satoshi Sugiura
Seizi Kurozumi
Ryoji Noyori
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP59220475A external-priority patent/JPS61100542A/ja
Priority claimed from JP59220476A external-priority patent/JPS61100538A/ja
Priority claimed from JP60028429A external-priority patent/JPS61189245A/ja
Priority claimed from JP60130845A external-priority patent/JPH0635422B2/ja
Application filed by Teijin Ltd filed Critical Teijin Ltd
Application granted granted Critical
Publication of DE3586085D1 publication Critical patent/DE3586085D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
    • C07C405/0025—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing keto groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/18—Ethers having an ether-oxygen atom bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C43/188—Unsaturated ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
    • C07C45/292—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups with chromium derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
    • C07C45/66—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups by dehydration
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/673—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by change of size of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/707—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups a keto group being part of a three- to five-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/743—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups having unsaturation outside the rings, e.g. humulones, lupulones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE8585307631T 1984-10-22 1985-10-22 Antitumor-4-hydroxy-2-zyklopentenonen. Expired - Lifetime DE3586085D1 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP59220475A JPS61100542A (ja) 1984-10-22 1984-10-22 新規な４−ヒドロキシ−２−シクロペンテノン類およびその製造法
JP59220476A JPS61100538A (ja) 1984-10-22 1984-10-22 新規なシクロペンテンアルコ−ル類およびその製造法
JP60028429A JPS61189245A (ja) 1985-02-18 1985-02-18 ２−ハロ−４−ヒドロキシ−２−シクロペンテノン類およびその製造法
JP60130845A JPH0635422B2 (ja) 1985-06-18 1985-06-18 ２−ハロ−４−ヒドロキシ−２−シクロペンテノン類

Publications (1)

Publication Number Publication Date
DE3586085D1 true DE3586085D1 (de) 1992-06-25

Family

ID=27458880

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8585307631T Expired - Lifetime DE3586085D1 (de) 1984-10-22 1985-10-22 Antitumor-4-hydroxy-2-zyklopentenonen.

Country Status (3)

Country Link
US (1) US4711895A (de)
EP (1) EP0180399B1 (de)
DE (1) DE3586085D1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2608089B2 (ja) * 1988-03-09 1997-05-07 帝人株式会社 ４−ヒドロキシ−２−シクロペンテノン類およびそれを含有する薬剤組成物
US5216183A (en) * 1988-04-19 1993-06-01 Teijin Limited Cyclopentanone/cyclopentenone derivative
AU615534B2 (en) * 1988-04-19 1991-10-03 Teijin Limited 2-substituted-2-cyclopentenones
MA21706A1 (fr) * 1988-12-29 1990-07-01 Rhone Poulenc Agrochimie Benzolidene azolylmethylcycloalcane et utilisation comme fongicide.
FR2721510B1 (fr) * 1994-06-22 1996-07-26 Rhone Poulenc Rorer Sa Nanoparticules filtrables dans des conditions stériles.
IT1289250B1 (it) 1996-12-13 1998-09-29 Consiglio Nazionale Ricerche Impiego di 2 ciclopenten 1-one e suoi derivati come inibitori del fattore nf-kb
CA2366877A1 (en) * 1999-03-22 2000-09-28 Stanley Michael Roberts Chemical compounds and their uses
GB9929702D0 (en) * 1999-12-16 2000-02-09 Charterhouse Therapeutics Ltd Chemical compounds and their uses

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH648282A5 (de) * 1980-06-10 1985-03-15 Sumitomo Chemical Co Verfahren zur herstellung von oxocyclopentenen.
JPS604129A (ja) * 1983-06-22 1985-01-10 Fujisawa Pharmaceut Co Ltd 抗腫瘍剤
US4560703A (en) * 1982-09-27 1985-12-24 Fujisawa Pharmaceutical Co., Ltd. Clavulone derivatives, process for preparing the same, and use of said compounds
JPS5959646A (ja) * 1982-09-27 1984-04-05 Fujisawa Pharmaceut Co Ltd クラブロン誘導体
JPS59184159A (ja) * 1983-04-04 1984-10-19 Hokuriku Seiyaku Co Ltd ５−アシル−１−フエニル−２−インドリノン誘導体
DE3480197D1 (en) * 1983-07-06 1989-11-23 Teijin Ltd 5-alkylidene-2-halo-4-substituted-2-cyclopentenone and process for production thereof
JPS61501703A (ja) * 1984-02-14 1986-08-14 ハワイ　ユニバ−シテイ プナグランジン類及びその薬学的用途

Also Published As

Publication number Publication date
EP0180399A2 (de) 1986-05-07
EP0180399B1 (de) 1992-05-20
US4711895A (en) 1987-12-08
EP0180399A3 (en) 1987-06-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee