DE3428543A1 - Neue p-phenylendiamin-peptide und diese enthaltende reagenzien zur bestimmung von proteasen des blutgerinnungssystems - Google Patents

Neue p-phenylendiamin-peptide und diese enthaltende reagenzien zur bestimmung von proteasen des blutgerinnungssystems

Info

Publication number: DE3428543A1
Authority: DE; Germany
Prior art keywords: group; proteases; compound according; amino acid; compound
Prior art date: 1984-08-02
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Withdrawn

Application number

DE19843428543

Other languages

German (de)

English (en)

Inventor

Knut Dr.rer.nat. 8121 Wilzhofen Bartl

Hans-Georg Dr.Rer.Nat. 8132 Tutzing Batz

Udo Dr.rer.nat. 3550 Marburg Becker

Herbert von der Dr.rer.nat. 8120 Weilheim Eltz

Helmut Dr.Rer.Nat. 8121 Wielenbach Lill

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Roche Diagnostics GmbH

Original Assignee

Boehringer Mannheim GmbH

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1984-08-02

Filing date

1984-08-02

Publication date

1986-02-13

1984-08-02 Application filed by Boehringer Mannheim GmbH filed Critical Boehringer Mannheim GmbH

1984-08-02 Priority to DE19843428543 priority Critical patent/DE3428543A1/de

1985-07-31 Priority to PCT/EP1985/000385 priority patent/WO1986001209A2/fr

1985-07-31 Priority to AU47238/85A priority patent/AU564556B2/en

1985-07-31 Priority to JP60503696A priority patent/JPS61501635A/ja

1985-07-31 Priority to EP85904101A priority patent/EP0190299A1/fr

1985-08-01 Priority to ZA855814A priority patent/ZA855814B/xx

1986-02-13 Publication of DE3428543A1 publication Critical patent/DE3428543A1/de

Status Withdrawn legal-status Critical Current

Links

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CBCKQZAAMUWICA-UHFFFAOYSA-N 1,4-phenylenediamine Chemical compound NC1=CC=C(N)C=C1 CBCKQZAAMUWICA-UHFFFAOYSA-N 0.000 title description 3
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GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 1
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IJKVHSBPTUYDLN-UHFFFAOYSA-N dihydroxy(oxo)silane Chemical compound O[Si](O)=O IJKVHSBPTUYDLN-UHFFFAOYSA-N 0.000 description 1
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YAGKRVSRTSUGEY-UHFFFAOYSA-N ferricyanide Chemical compound [Fe+3].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-] YAGKRVSRTSUGEY-UHFFFAOYSA-N 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- C07K14/675—Beta-endorphins
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
- C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2337/00—N-linked chromogens for determinations of peptidases and proteinases
- C12Q2337/10—Anilides
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/745—Assays involving non-enzymic blood coagulation factors
- G01N2333/755—Factors VIII, e.g. factor VIII C [AHF], factor VIII Ag [VWF]

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Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Biophysics (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
Medicinal Chemistry (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Wood Science & Technology (AREA)
Microbiology (AREA)
Immunology (AREA)
Biotechnology (AREA)
Analytical Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Physics & Mathematics (AREA)
Neurosurgery (AREA)
Hematology (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Peptides Or Proteins (AREA)

DE19843428543 1984-08-02 1984-08-02 Neue p-phenylendiamin-peptide und diese enthaltende reagenzien zur bestimmung von proteasen des blutgerinnungssystems Withdrawn DE3428543A1 (de)

Priority Applications (6)

Application Number	Priority Date	Filing Date	Title
DE19843428543 DE3428543A1 (de)	1984-08-02	1984-08-02	Neue p-phenylendiamin-peptide und diese enthaltende reagenzien zur bestimmung von proteasen des blutgerinnungssystems
PCT/EP1985/000385 WO1986001209A2 (fr)	1984-08-02	1985-07-31	NOUVEAUX PEPTIDES DE p-PHENYLENEDIAMINE ET REACTIFS LES CONTENANT POUR DETERMINER DES PROTEINASES DU SYSTEME DE COAGULATION DU SANG
AU47238/85A AU564556B2 (en)	1984-08-02	1985-07-31	New p-phenylenediamine peptides and reactance containing themfor the determination of proteases of the blood coagulation system
JP60503696A JPS61501635A (ja)	1984-08-02	1985-07-31	新規ｐ−フエニレンジアミン−ペプチド及びこれを含有する血液凝固系のプロテア−ゼを測定するための試薬
EP85904101A EP0190299A1 (fr)	1984-08-02	1985-07-31	NOUVEAUX PEPTIDES DE p-PHENYLENEDIAMINE ET REACTIFS LES CONTENANT POUR DETERMINER DES PROTEINASES DU SYSTEME DE COAGULATION DU SANG
ZA855814A ZA855814B (en)	1984-08-02	1985-08-01	New p-phenylenediamine-peptides and reagents containing these for the determination of proteases of the blood coagulation systems

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19843428543 DE3428543A1 (de)	1984-08-02	1984-08-02	Neue p-phenylendiamin-peptide und diese enthaltende reagenzien zur bestimmung von proteasen des blutgerinnungssystems

Publications (1)

Publication Number	Publication Date
DE3428543A1 true DE3428543A1 (de)	1986-02-13

Family

ID=6242223

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DE19843428543 Withdrawn DE3428543A1 (de)	1984-08-02	1984-08-02	Neue p-phenylendiamin-peptide und diese enthaltende reagenzien zur bestimmung von proteasen des blutgerinnungssystems

Country Status (6)

Country	Link
EP (1)	EP0190299A1 (fr)
JP (1)	JPS61501635A (fr)
AU (1)	AU564556B2 (fr)
DE (1)	DE3428543A1 (fr)
WO (1)	WO1986001209A2 (fr)
ZA (1)	ZA855814B (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1987005608A1 (fr) *	1986-03-21	1987-09-24	Kabivitrum Ab	Nouveaux derives de peptides
EP0228666A3 (fr) *	1986-01-06	1987-12-23	Orion Corporation Ltd	Substrats de type peptide et procédé pour la détermination quantitative d'endotoxine
EP0224830A3 (en) *	1985-12-03	1987-12-23	Miles Laboratories, Inc.	Gram negative bacteruria test
US4797472A (en) *	1986-03-21	1989-01-10	Kabivitrum Ab	New peptide derivatives
WO2000050446A1 (fr) *	1999-02-23	2000-08-31	Pentapharm Ag	Derives d'oligopeptides pour la mesure electrochimique de l'activite de proteases

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2644697B1 (fr) *	1989-03-24	1992-05-15	Poudres & Explosifs Ste Nale	Composes anesthesiques a duree d'action controlee et compositions pharmaceutiques les contenant
AU4634896A (en)	1995-01-10	1996-07-31	Hendrik Coenraad Hemker	Methods of determining endogenous thrombin potential (etp) and thrombin substrates for use in said methods
CN100591690C (zh) *	2004-10-12	2010-02-24	弗·哈夫曼-拉罗切有限公司	固相肽合成

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2497798A1 (fr) *	1981-01-09	1982-07-16	Pharmindustrie	Nouveaux peptides portant un fluorophore, procede pour leur preparation et leur application au dosage fluorimetrique des endotoxines
JPS57176940A (en) *	1981-04-25	1982-10-30	Wako Pure Chem Ind Ltd	Novel color-developing peptide derivative
JPS58172354A (ja) *	1982-04-05	1983-10-11	Dai Ichi Pure Chem Co Ltd	ペプチド誘導体
GB2118190B (en) *	1982-04-13	1985-05-01	Erba Farmitalia	Peptides with sauvagine-like activity
DE3244030A1 (de) *	1982-11-27	1984-05-30	Behringwerke Ag, 3550 Marburg	Chromogene verbindungen, verfahren zu ihrer herstellung und ihre verwendung
JPH08142597A (ja) *	1994-11-21	1996-06-04	Dainippon Printing Co Ltd	転写箔及びこれを用いた装飾ガラス

1984
- 1984-08-02 DE DE19843428543 patent/DE3428543A1/de not_active Withdrawn
1985
- 1985-07-31 WO PCT/EP1985/000385 patent/WO1986001209A2/fr not_active Ceased
- 1985-07-31 EP EP85904101A patent/EP0190299A1/fr not_active Withdrawn
- 1985-07-31 AU AU47238/85A patent/AU564556B2/en not_active Ceased
- 1985-07-31 JP JP60503696A patent/JPS61501635A/ja active Pending
- 1985-08-01 ZA ZA855814A patent/ZA855814B/xx unknown

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP0224830A3 (en) *	1985-12-03	1987-12-23	Miles Laboratories, Inc.	Gram negative bacteruria test
EP0228666A3 (fr) *	1986-01-06	1987-12-23	Orion Corporation Ltd	Substrats de type peptide et procédé pour la détermination quantitative d'endotoxine
WO1987005608A1 (fr) *	1986-03-21	1987-09-24	Kabivitrum Ab	Nouveaux derives de peptides
US4797472A (en) *	1986-03-21	1989-01-10	Kabivitrum Ab	New peptide derivatives
WO2000050446A1 (fr) *	1999-02-23	2000-08-31	Pentapharm Ag	Derives d'oligopeptides pour la mesure electrochimique de l'activite de proteases
US6495336B1 (en)	1999-02-23	2002-12-17	Pentapharm Ag	Oligopeptide derivatives for the electrochemical measurement of protease activity

Also Published As

Publication number	Publication date
WO1986001209A3 (fr)	1986-03-27
AU4723885A (en)	1986-03-07
AU564556B2 (en)	1987-08-13
EP0190299A1 (fr)	1986-08-13
ZA855814B (en)	1986-04-30
WO1986001209A2 (fr)	1986-02-27
JPS61501635A (ja)	1986-08-07

Publication	Publication Date	Title
EP0034122B1 (fr)	1983-09-21	Dérivés de tripeptides et leur utilisation dans la détermination d'enzymes
EP0012957B1 (fr)	1981-09-16	Moyen diagnostique pour la détermination d'enzymes protéolytiques et esters d'indoxyle ou de thioindoxyle appropriés comme chromogènes, procédé pour leur préparation et leur utilisation pour la préparation de moyens diagnostiques
EP0039880B2 (fr)	1987-06-03	Réactifs pour la détection des enzymes estérolytiques et/ou protéolytiques, esters d'acides phénoxy-amines ou de phénoxy-peptides appropriés comme substrats pour les enzymes, méthode pour la préparation des substrats et leur utilisation dans la production des réactifs
EP1157029B1 (fr)	2005-12-28	Derives d'oligopeptides pour la mesure electrochimique de l'activite de proteases
DE2724211C2 (de)	1987-03-05	Tripeptidderivate und deren Verwendung
DE3331588C2 (fr)	1989-03-23
HU180211B (en)	1983-02-28	Process for preparing a-guaiaconic acid and diagnostic composition containing thereof
EP0157360B1 (fr)	1991-08-14	Esters chromogènes d'aminoacides et de peptides, procédés pour leur préparation, utilisation de ces agents dans des méthodes analytiques et agents pour l'identification d'enzymes estérolytiques et/ou protéolytiques
DE3413078A1 (de)	1985-10-24	Chromogene aminosaeure- und peptidester, verfahren zu deren herstellung, verwendung dieser verbindungen in analysenverfahren sowie mittel zum nachweis esterolytischer und/oder proteolytischer enzyme
DE3428543A1 (de)	1986-02-13	Neue p-phenylendiamin-peptide und diese enthaltende reagenzien zur bestimmung von proteasen des blutgerinnungssystems
EP0158225A2 (fr)	1985-10-16	Méthode de dosage et agents pour détecter des enzymes estérolytiques et/ou protéolytiques
EP0034323B1 (fr)	1983-08-17	Esters d'aminoacides et de peptides de leuco-indoanilines, procédé pour leur préparation et agents contenant ces composés pour la détection d'enzymes protéolytiques
DE3327873A1 (de)	1984-02-09	Verfahren zur bestimmung der aktivitaet von enzymen
EP0253548A2 (fr)	1988-01-20	Procédé et compositions chimiques pour la détermination de sang occulte
EP0285000A2 (fr)	1988-10-05	Composés chromogènes, leur préparation et leur emploi comme substrat enzymatique
EP0408075B1 (fr)	1995-03-08	Méthode et réactif pour la détermination d'antithrombine III
DE3685724T2 (de)	1993-01-28	Synthetisches peptid-substrat fuer die bestimmung von trypsin und alpha-1-antitrypsin.
EP1684071B1 (fr)	2011-03-30	Réactif de test stable et chromogènes et son utilisation dans des tests diagnostiques de coagulation
DE3413120A1 (de)	1985-10-24	Analysenverfahren und mittel zum nachweis esterolytischer und/oder proteolytischer enzyme
DE3879406T2 (de)	1993-06-24	Bestimmung aktiver bestandteile der proteolyse.
CA2081870A1 (fr)	1993-05-16	Detection des substances a analyser dans la salive a l'aide d'epreuves peroxyde-peroxydase
DD279485A5 (de)	1990-06-06	Verfahren zur herstellung chromogener verbindungen und ihre verwendung
DD236114A1 (de)	1986-05-28	Verfahren zur bestimmung von bakterieninfektion in liquores
DE68915216T2 (de)	1994-09-29	Substrate zur Bestimmung der enzymatischen Aktivität.
DE3413119A1 (de)	1985-10-24	Analysenverfahren und mittel zum nachweis esterolytischer und/oder proteolytischer enzyme

Legal Events

Date	Code	Title	Description
1989-08-10	8139	Disposal/non-payment of the annual fee