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DE3364145D1 - Antihypertensive benzopyranols - Google Patents

Antihypertensive benzopyranols

Info

Publication number
DE3364145D1
DE3364145D1 DE8383301649T DE3364145T DE3364145D1 DE 3364145 D1 DE3364145 D1 DE 3364145D1 DE 8383301649 T DE8383301649 T DE 8383301649T DE 3364145 T DE3364145 T DE 3364145T DE 3364145 D1 DE3364145 D1 DE 3364145D1
Authority
DE
Germany
Prior art keywords
benzopyranols
hypertensive
hypertensive benzopyranols
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE8383301649T
Other languages
English (en)
Inventor
John Morris Evans
Robin Edwin Buckingham
Kenneth Willcocks
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Application granted granted Critical
Publication of DE3364145D1 publication Critical patent/DE3364145D1/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C07D311/70—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with two hydrocarbon radicals attached in position 2 and elements other than carbon and hydrogen in position 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE8383301649T 1982-04-08 1983-03-24 Antihypertensive benzopyranols Expired DE3364145D1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8210490 1982-04-08

Publications (1)

Publication Number Publication Date
DE3364145D1 true DE3364145D1 (de) 1986-07-24

Family

ID=10529622

Family Applications (1)

Application Number Title Priority Date Filing Date
DE8383301649T Expired DE3364145D1 (de) 1982-04-08 1983-03-24 Antihypertensive benzopyranols

Country Status (7)

Country Link
US (2) US4542149A (de)
EP (1) EP0091748B1 (de)
JP (1) JPS58188880A (de)
AU (1) AU1320683A (de)
DE (1) DE3364145D1 (de)
ES (1) ES521317A0 (de)
ZA (1) ZA832431B (de)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0139992B1 (de) * 1983-09-01 1988-12-28 Beecham Group Plc Chromanol-Derivate
GB8409745D0 (en) * 1984-04-14 1984-05-23 Beecham Group Plc Active compounds
DE3579390D1 (de) * 1984-06-22 1990-10-04 Beecham Group Plc Wirksame benzopyranverbindungen.
GB8419516D0 (en) * 1984-07-31 1984-09-05 Beecham Group Plc Treatment
GB8419515D0 (en) * 1984-07-31 1984-09-05 Beecham Group Plc Treatment
GB8513369D0 (en) * 1985-05-28 1985-07-03 Beecham Group Plc Treatment
DE3682331D1 (de) 1985-06-08 1991-12-12 Beecham Group Plc Pyrano(3,2-c)pyridinderivate, verfahren und zwischenprodukte zu ihrer herstellung und diese enthaltende pharmazeutische zubereitungen.
GB8521857D0 (en) * 1985-09-03 1985-10-09 Beecham Group Plc Active compounds
EP0218373B1 (de) * 1985-09-11 1990-03-07 Beecham Group Plc Chromanderivate und ähnliche Verbindungen mit blutdrucksenkender Wirkung
GB8625185D0 (en) * 1986-10-21 1986-11-26 Beecham Group Plc Active compounds
DE3703227A1 (de) * 1987-02-04 1988-08-18 Hoechst Ag Substituierte 3,4-dihydro-2h-benzopyrane, verfahren zu ihrer herstellung, ihre verwendung sowie pharmazeutische praeparate auf basis dieser verbindungen
CA1308108C (en) * 1987-10-27 1992-09-29 Dominick A. Quagliato Antihypertensive benzopyran derivatives
GB8800199D0 (en) * 1988-01-06 1988-02-10 Beecham Group Plc Pharmaceutical preparation
DE3811017A1 (de) * 1988-03-31 1989-10-19 Hoechst Ag Ungesaettigte n-benzopyranyllactame
DE3837809A1 (de) * 1988-11-08 1990-05-10 Merck Patent Gmbh Tetralinderivate
FR2639227A1 (fr) * 1988-11-23 1990-05-25 Sanofi Sa Utilisation de derives du chromane pour le traitement des etats depressifs
DE3918041A1 (de) * 1989-06-02 1990-12-06 Merck Patent Gmbh Chromanderivate
DE3926001A1 (de) * 1989-08-05 1991-02-07 Merck Patent Gmbh Chromanderivate
US5254555A (en) * 1989-10-30 1993-10-19 Beecham Group P.L.C. Amino pyrimidin-7-yl substituted benzopyrans for treatment of hypertension
GB8924373D0 (en) * 1989-10-30 1989-12-20 Beecham Group Plc Novel compounds
US5276168A (en) * 1990-06-18 1994-01-04 E. R. Squibb & Sons, Inc. Benzopyran derivatives and heterocyclic analogs thereof as antiischemic agents
JP3502403B2 (ja) * 1991-12-16 2004-03-02 アベンティス ファーマ株式会社 骨吸収抑制剤
US5540201A (en) * 1994-07-29 1996-07-30 Caterpillar Inc. Engine compression braking apparatus and method
US5869478A (en) * 1995-06-07 1999-02-09 Bristol-Myers Squibb Company Sulfonamido substituted benzopyran derivatives
US5612370A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phenylglycine and phenylalaninen amido benzopyran derivatives
US5612323A (en) * 1995-06-07 1997-03-18 Bristol-Myers Squibb Company Phosphinic ester substituted benzopyran derivatives
US5629429A (en) * 1995-06-07 1997-05-13 Bristol-Myers Squibb Company Process for preparing 4-arylamino-benzopyran and related compounds
SK7599A3 (en) * 1996-07-26 1999-07-12 Nissan Chemical Ind Ltd Chroman derivatives and pharmaceutical composition containing the same
AU3959099A (en) 1998-06-03 1999-12-20 Nissan Chemical Industries Ltd. Indan derivatives
EP1214307B1 (de) 1999-09-24 2004-04-07 Nissan Chemical Industries, Ltd. 4-oxybenzopyran derivate
US6677371B1 (en) 1999-10-05 2004-01-13 Nissan Chemical Industries, Ltd. 4-oxybenzopyran derivative
IL159218A0 (en) 2001-06-25 2004-06-01 Nissan Chemical Ind Ltd Substituted benzopyran derivatives against arrhythmia
US7038091B2 (en) * 2002-10-18 2006-05-02 Nissan Chemical Industries, Ltd. Process for producing acetylene compound
WO2007105658A1 (ja) 2006-03-10 2007-09-20 Nissan Chemical Industries, Ltd. 光学活性クロメンオキシド化合物の製造方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1495526A (en) * 1974-05-31 1977-12-21 Beecham Group Ltd Chroman derivatives
GB1548221A (en) * 1976-01-27 1979-07-04 Beecham Group Ltd Trans-4-heterocycyl-3,4-dihydro-2h-benzo pyran-3-ol esters
NZ183551A (en) * 1976-04-02 1978-09-20 Beecham Group Ltd Aminochromanols and pharmaceutical compositions containingthem
US4391815A (en) * 1976-04-02 1983-07-05 Beecham Group Limited Cyanobenzano[b]pyrans
GB1511187A (en) * 1976-04-02 1978-05-17 Beecham Group Ltd Chromans
GB1548222A (en) * 1976-12-17 1979-07-04 Beecham Group Ltd Trans-4-heterocyclyl-3,4-dihydro-2h-benzo pyarn-3-ol derivatives
EP0009912B1 (de) * 1978-10-04 1983-06-22 Beecham Group Plc Chromanol-Derivate, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zusammensetzungen
DE3064286D1 (en) * 1979-09-28 1983-08-25 Beecham Group Plc Chromanol derivatives, a process for their preparation and a pharmaceutical composition comprising them
DE3064285D1 (en) * 1979-09-28 1983-08-25 Beecham Group Plc Chromanol derivatives, a process for their preparation and a pharmaceutical composition comprising them
DE2950479A1 (de) * 1979-12-14 1981-06-19 A. Nattermann & Cie GmbH, 5000 Köln N-(3-alkylamino-2-hydroxypropoxy-phenyl)-lactame, deren herstellungsverfahren und arzneimitttel auf deren basis
DE3170604D1 (en) * 1980-08-21 1985-06-27 Beecham Group Plc Chromanol derivatives, their production and pharmaceutical compositions containing them
GB2107706A (en) * 1981-09-25 1983-05-05 Beecham Group Plc Benzopyrans
EP0093535B1 (de) * 1982-04-28 1986-12-30 Beecham Group Plc Chromenen und Chromanen

Also Published As

Publication number Publication date
ES8405393A1 (es) 1984-06-01
US4644070A (en) 1987-02-17
EP0091748B1 (de) 1986-06-18
JPS58188880A (ja) 1983-11-04
EP0091748A1 (de) 1983-10-19
US4542149A (en) 1985-09-17
AU1320683A (en) 1983-10-13
ES521317A0 (es) 1984-06-01
ZA832431B (en) 1984-03-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee