DE2658725A1 - AGENT FOR CONTROLLING ANIMAL EECTOPARASITES WITH A STRONG RESIDUAL EFFECT - Google Patents

Description

Means for combating animal ectoparasols with strongly pronounced residual effect

The present invention relates to new means for Βετ fighting animal ectoparasites, preferably for fighting of insects, which have a pronounced recidual effect over a long period of time. The new agents preferably contain insecticides and / or repellents as constituents.

It isx. Tried repeatedly in the past been used in the case of insecticidal substances (e.g. phosphoric acid ester compounds) through special formulations over the period to extend the effectiveness, i.e. to achieve a good residual effect. This happened and is happening e.g. B. by microencapsulating volatile insecticidal compounds. Including insecticides in Polymers from which they evaporate over a longer period of time is carried out in practice, e.g. B. at

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SUBMITTED

Dog collars or fly strips with, for example, DDVP / ρ, Ο-dimethyl-O- (2,2-dichlorovinyl) -phosphoric acid ester as an active ingredient. For combating animal ectoparasites and especially insects on large animals (e.g. cattle, horses, sheep, etc.), such procedures have only rarely been used up to now.

Especially in cattle, the indication area is symbovine Flying has become of great concern lately. There are two main reasons for this:

a) New methods of mass rearing of cattle

(feed lots etc.),

b) Ban on the use of the substance DDT, which is highly effective against flies, in slaughterable animals.

Obwoi 1 a range of fly remedies for large animals Time available was the effective fight · the '"" " Symbovine flies in cattle are still an unsolved problem.

The cause is the insufficient residual effect of the preparations previously used against symbovine flies to search. Thus, the problem of controlling flies in cattle is less of a problem with the use of active ingredients rather than a suitable long-acting formulation. There are similar problems with other large animals.

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It has now been found that means for combating animal Ectoparatsiten consisting of an active ingredient with insecticidal and / or repellent effect, a pressure-sensitive adhesive and a solvent or solvent mixture and optionally other auxiliaries, a very pronounced one Exhibit residual effect.

It was surprising that insecticidal formulations were successful and / or to produce a repellent effect, which is an excellent and also for combating symbovin Flies have sufficient residual effect.

Polymers which are used as so-called "pressure-sensitive adhesives ¹¹ " are used to produce the agents according to the invention.

Such "pressure sensitive adhesives" are used, for example, in adhesive films, pressure-sensitive adhesive labels, adhesive plasters, etc.

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They are characterized by a soft, momentary and unspecific Gluing off.

According to R. Koehler: Adhäsion 1964 (4), page 160 f. Is the Ideally, to interpret the effect of pressure-sensitive adhesives by means of a hydrodynamic mechanism. Pressure sensitive adhesives show one Stickiness even though they do not contain any solvent or other liquid. Pressure sensitive adhesives are settings highly viscous polymers of various compositions ζ. B. natural rubber and synthetic rubbers such as e.g. Chlorinated rubber, polychlorobutadiene, butyl rubber, polyisobutylene, Polyvinyl ethers such as B. ethylene vinyl acetate copolymers, acrylic compounds such as butyl acrylate derivatives or polyester.

These adhesives ("pressure sensitive adhesives") are dissolved in solvents or solvent mixtures with the active ingredients optionally mixed with the addition of further auxiliaries and sprayed or sprayed onto the animal to be treated infused ·.

As added solvents, depending on the used adhesive both polar and nonpolar organic solvents or water, or mixtures of organic solvents or mixtures of organic solvents with water _t in question.

Examples of solvents to be used are:

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Halogenated hydrocarbons such as methylene chloride, chloroform, carbon tetrachloride, trichloroethane, aromatic Hydrocarbons such as B. benzene, toluene, aliphatic or cycloaliphatic hydrocarbons such as n-pentane, hexane, heptane, octane, or mixtures of the aforementioned solvents, furthermore cyclohexane, aliphatic Mono- or polyalcohols such as methanol, ethanol, n-propanol, i-propanol * ketones such as acetone, methyl isobutyl ketone, aliphatic esters, such as ethyl acetate ("ethyl acetate"), butyl acetate ("butyl acetate"); Amides such as dimethylformamide, sulfoxides such as ζ. Β, dimethyl sulfoxide.

The following are listed as active ingredients with insecticidal and / or repellant effects:

Phosphoric acid ester with insecticidal effect z. B. Coumaphos Diazinon, Chlorphenvos, Delnav, Ruelen, Bromophos, Bromophosäthyl, Dichlorvos, Naled, DDVP, Phosphamidon, Tetrachlorvinphos, Chlorfenvinphos, Crotoxyphos, Chlorpyriphos, Phoxim, Chlorphoxim, Fenthion, Iodofenphos, Fenchlorphos, MaIathion, Crufomat, Butonat and Trichlorfon, Famphur, DMP j (0,0-diethyl-0-3-methyl-4-methyl-mercapto-phenyl) thiophosphoric acid esterj Carbamates, e.g. Carbaryl, Propoxur, natural pyrethrum active ingredients, synthetic allethrins, etc.

Active ingredients with a certain vapor pressure, such as those used, for. B. also used in dog collars become: z. B. Propoxur, Carbaryl, DDVP. Repellents generally have a sufficiently high vapor pressure.

*) Ethylene glycol and their ether derivatives such. B. 2-ethoxyethanol

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Formulations with the aforementioned active ingredients are still effective after four weeks if an animal coat treated with them is brought into contact with flies.

The addition of a fly attractant can be improved in the formulations with insecticides, the effectiveness in a known manner, for. B. with indole, skatole
or vanillin. The flies come into contact with the active ingredient faster and are killed more quickly.

Other auxiliaries that may be added are used in question:

a) Surfactants (including emulsifiers and wetting agents):

e.g. 1) anion-active such as sodium lauryl sulfate or fatty alcohol ether sulfate,

2) cation-active such as cetyltrimethylammonium chloride

3) Ampholytic such as Di-Na-N-lauryl-ß-iminodipropionate or lecithin

4) non-ionic e.g. polyoxyethylated castor oil, polyoxyethylated sorbitan monooleate

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Monostearate, glycerin monostearate, poly-

oxyethylene stearate, alkylphenol polyglycol ether,

b) plasticizers ζ. B. phthalic acid esters such as phthalic acid dibutyl ester and also fatty acid esters and others. Plasticizers.

The agents according to the invention for combating animal ectoparasites have the following composition:

Active ingredient: 1 to 50 percent by weight, preferably 5 to 20 percent by weight.

Pressure sensitive adhesive: 1 to 50 percent by weight, preferably 5 to 30 percent by weight.

Other auxiliaries: 0 to 10 percent by weight, preferably

0 to 5 percent by weight.

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Solvent or

Solvent mixture: 40 to 98 percent by weight , preferably

60 to 90 percent by weight.

The following examples are intended to explain the principle according to the invention, but in no way have a restrictive effect, since many other formulations _K containing pressure-sensitive adhesives can also be used according to the invention.

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Example A.

Propoxur (active ingredient with insecticidal effect) 1O? O g

Ethylene vinyl acetate copolymers, vinyl acetate content

45%, glue) 15.0 g

Butyl acetate (solvent) ad 100.0 nil

The active ingredient is premixed in butyl acetate and this Solution processed with the adhesive to the final formulation.

Example B.

Propoxur '10.0 g

Acrylic acid butyl ester polymer 25 »0 g

(Pressure sensitive adhesive)

Ethyl acetate (solvent) ad 100.0 ml

Production according to example Ά.

Example C

Propoxur 10.0 g

20.0 g

cationic polymer made from dimethylaminoethyl methacrylate and other neutral methacrylic acid esters (Pressure sensitive adhesive)

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Isopropanol (solvent) ad 100.0 ml

Production according to Example A-

ExampleD

Couraaphos micronized (active ingredient with insecticidal io, o g

Effect)

acrylic ester containing carboxy groups »

copolymer pressure sensitive adhesive in aqueous 50.0 g

Suspension (solids content: 50 %)

Water (solvent) to 100.0 ml

The active ingredient is incorporated into water with a high-speed stirrer and further intensively Stir the glue in.

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Example ^

Coumaphos microns 10.0 g

low-molecular polyisobutylene (viscosity: 2 0.0 g (adhesive) ₅ .io ⁵ poise)

η-hexane (solvent) ac 100.0 ml

Production according to example d _#

Example E *

C Qomaphos micronized 10.0 g

Sodium lauryl sulphate (additional excipient) 0.03 g

30% aqueous dispersion of the 66.7 g

Polymers from Example C

Demineralized water (solvent) up to 100.00 ml

Production according to example D.

Example Q *

Fenthion active ingredient (active ingredient with insecticidal 10.0 g

Effect)

Acrylic acid butyl ester polymer 25.0 g

(Pressure sensitive adhesive)

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Ethyl acetate ad 100.0 ml

Active ingredient and glue are dissolved in the solvent » Example H.

Diethyltoluamide (active ingredient in repellent) 1O ₇ O g

Methyl vinyl maleic anhydride Copolymer (pressure sensitive adhesive) 20.0 g

Isopropanol (solvent) ad 10O ₇ O ml

Active ingredient and adhesive are stirred in the solvent solved.

The formulations Ά, B ₇ C ₇ D ₇ S wad. F were tested using the following test method.

1) Application of the formulations to large animals

The formulations A to F were each applied in a volume of 20 ml on the side of the coat at the level of the withers of the cattle is poured onto a marked area of skin so that the substance is on a spot that is about the the upper half of the shoulder blade, could distribute it.

Immediately after the treatment, the animals were exposed to the Pasture brought and kept under outdoor weather conditions for the entire duration of the experiment (36 days).

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2) Test procedure:

10 flies - adult Stomoxys calcitrans - are included Bovine hair samples in Petri dishes brought into contact with the active ingredients or formulations to be tested treated cattle originate. Samples are at certain times, a day before and 1, 4, 7 and 21 days etc. after application, taken from the cattle. The effectiveness check is carried out at 15, 30, 60, 90 and 180 minutes after placing the flies in Petri dishes. The criterion for the effect is entry of death in the flies brought into contact with the active substance.

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3) results;

Active ingredient example Percentage of dead flies
15 minutes after putting on
after application +7 + 14 +21 + 7 + 14 +21 (Stomoxys calcitrans)
on hair sample, days +35 +35 + 1 100 100 100 100 100 100 +28 0 50 Propoxur A. 100 100 100 100 100 100 100 0 100 100 B. 100 100 0 0 100 100 50 100 0 0 C. 100 percentage dead flies 100 100 0 0 (Stomoxys calcitrans) 100 Active ingredient example 180 minutes after putting on 100 100 0 on hair sample, days 50 after application 100 100 0 50 + 1 +28 100 0 Propoxur A. 100 100 B. 100 50 C. 100 0 Coumaphos D. 100 50 E. 100 0 F.

It turns out that a substance with a higher vapor pressure such as propoxur kills the flies after a shorter time than with a less volatile substance like Coumaphos longer contact time, the effectiveness of the Coumaphos formulation is comparable to that of the Propoxur formulation.

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Claims (11)

26 & Ö725 Claims 1 ". Agent for combating animal ectoparasites, characterized in that it has a pressure-sensitive adhesive as a component contains. 2. Means for combating animals. Ectoparasites, thereby characterized in that it is a pressure sensitive adhesive in addition to an ectoparasiticide or a repellent active ingredient Contains solvent or solvent mixture and optionally one or more other auxiliaries = 3. Means according to claim 2, characterized in that it is the ectoparasiticidal active ingredient is an insecticide. Agent according to Claim 2, characterized in that the ectoparasiticidal active ingredient is a repellent acts. 5ο means according to claim 2, characterized in that it contains the ectoparasiticidal or repellent active ingredient in a concentration of 1 to 50 percent by weight, the adhesive in a concentration of 1 to 50 percent by weight, the other auxiliaries in concentrations of 0 to 10 percent by weight and solvent Contains in concentrations of 40 to 98 percent by weight. 6. Agent according to claim 2, characterized in that it contains the ectoparasiticidal or repellent active ingredient a concentration of 5 to 20 percent by weight, the pressure sensitive adhesive in a concentration of 5 to 30 percent by weight, the other auxiliaries in concentrations of 0 to 5 percent by weight and solvents in concentrations Contains from 60 to 90 percent by weight. Le A 17 751 - 16 - 80982 "9 / 0U8 265872 * 7. Process for the preparation of means for controlling animal ectoparasites, characterized in that an ectoparasiticidal or a repellent active ingredient, a pressure sensitive adhesive, a solvent or solvent mixture and optionally one or several other auxiliaries mixed together. 8. A process for the preparation of agents for combating animal ectoparasites, characterized in that that 1 to 50 percent by weight of an ectoparasiticide or a repellent active ingredient, 1 to 50 Percent by weight of a pressure-sensitive adhesive, 0 to 10 percent by weight of one or more other auxiliaries and 40 to 98 percent by weight solvent mixed together. 9. A process for the preparation of agents for combating animal ectoparasites, characterized in that 5 to 20 percent by weight of ectoparasiticidal or repellent active ingredient, 5 to 30 percent by weight of pressure-sensitive adhesive, 0 to 5 percent by weight of one or more other auxiliaries and 60 to 90 percent by weight of one or several solvents mixed with one another. 10. methods of combating animal ectoparasites, characterized in that an agent according to claim 1 is applied to animals which are infected with ectoparasites To suffer. Le A 17 751 - 17 - 80982 ^ / 0148 11. Method of combating animal ectoparasites, thereby characterized in that an agent according to claim 2 is applied to animals which are infected with ectoparasites To suffer. 12 · Method of combating animal ectoparasites, thereby characterized in that an agent according to claim 3 is applied to animals which are infected with ectoparasites To suffer. Le A Xl 751 _: ". - 1 & - 80982? / 01