DE2130775A1 - Alkyl-bis-(2-hydroxylakyl or aralkyl or aryl)-sulphonium - sulphates - agents for the treatment of dermatoses - Google Patents
Alkyl-bis-(2-hydroxylakyl or aralkyl or aryl)-sulphonium - sulphates - agents for the treatment of dermatosesInfo
- Publication number
- DE2130775A1 DE2130775A1 DE19712130775 DE2130775A DE2130775A1 DE 2130775 A1 DE2130775 A1 DE 2130775A1 DE 19712130775 DE19712130775 DE 19712130775 DE 2130775 A DE2130775 A DE 2130775A DE 2130775 A1 DE2130775 A1 DE 2130775A1
- Authority
- DE
- Germany
- Prior art keywords
- alkyl
- dermatoses
- aryl
- aralkyl
- treatment
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000017520 skin disease Diseases 0.000 title claims abstract description 7
- 125000003710 aryl alkyl group Chemical group 0.000 title abstract 2
- 125000003118 aryl group Chemical group 0.000 title abstract 2
- 150000001450 anions Chemical class 0.000 claims abstract description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 6
- 125000004432 carbon atom Chemical group C* 0.000 claims description 4
- 150000001875 compounds Chemical group 0.000 claims description 2
- 150000007522 mineralic acids Chemical class 0.000 claims description 2
- 150000007524 organic acids Chemical class 0.000 claims description 2
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 2
- 208000007163 Dermatomycoses Diseases 0.000 abstract description 2
- 206010034016 Paronychia Diseases 0.000 abstract description 2
- 201000004681 Psoriasis Diseases 0.000 abstract description 2
- 230000001717 pathogenic effect Effects 0.000 abstract description 2
- 230000008929 regeneration Effects 0.000 abstract description 2
- 238000011069 regeneration method Methods 0.000 abstract description 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 206010040943 Skin Ulcer Diseases 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 238000009109 curative therapy Methods 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 201000004647 tinea pedis Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- -1 alkyl radical Chemical class 0.000 description 6
- 239000007921 spray Substances 0.000 description 3
- 239000000454 talc Substances 0.000 description 3
- 229910052623 talc Inorganic materials 0.000 description 3
- 125000000954 2-hydroxyethyl group Chemical group [H]C([*])([H])C([H])([H])O[H] 0.000 description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 235000019256 formaldehyde Nutrition 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 239000002674 ointment Substances 0.000 description 2
- 239000003380 propellant Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 235000003911 Arachis Nutrition 0.000 description 1
- 244000105624 Arachis hypogaea Species 0.000 description 1
- VOPWNXZWBYDODV-UHFFFAOYSA-N Chlorodifluoromethane Chemical compound FC(F)Cl VOPWNXZWBYDODV-UHFFFAOYSA-N 0.000 description 1
- 244000060011 Cocos nucifera Species 0.000 description 1
- 235000013162 Cocos nucifera Nutrition 0.000 description 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 239000013011 aqueous formulation Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 150000005840 aryl radicals Chemical class 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 230000001877 deodorizing effect Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 230000002070 germicidal effect Effects 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 239000006210 lotion Substances 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 239000007764 o/w emulsion Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q15/00—Anti-perspirants or body deodorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/46—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
- A61K8/466—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Mittel zur Behandlung von Dermatosen Es wurde gefunden, daß man Dermatosen erfolgreich behandeln kann, wenn man Mittel, die Verbindungen der folgenden allgemeinen Formel enthalten, auf der Haut zur Anwendung bringt in der bedeuten: R1 3 Alkylrest von 06 - 020 C-Atomen R2 = 2-Hydroxyalkylrest, niederer Alkylrest von C1 - C6 C-Atomen, Aralkylrest, Arylrest oder Alkenylrest R3 s R2 0 = Sauerstoffatom, n 3 1 oder null = = Anion einer beliebigen organischen od.er anorganischen Säure.Agents for Treating Dermatoses It has been found that dermatoses can be treated successfully when agents containing compounds of the following general formula are applied to the skin in which: R1 3 alkyl radical of 06-020 carbon atoms, R2 = 2-hydroxyalkyl radical, lower alkyl radical of C1 - C6 carbon atoms, aralkyl radical, aryl radical or alkenyl radical R3 s R2 0 = oxygen atom, n 3 1 or zero = = anion any organic or inorganic acid.
Die erfindungsgemäßen Wirkstoffe werden nach bekannten Verfahren hergestellt. DBP 1258 Ein besonderes Merkmal der neuen Mittel ist ihre sehr gute Hautverträglichkeit,neben einer starken baktericiden und.The active ingredients according to the invention are produced by known processes. DBP 1258 A special feature of the new products is their very good skin tolerance, besides a strong bactericidal and.
fungiziden Wirkung bei geringer Toxizität fUr den Menschen.fungicidal effect with low toxicity for humans.
Mittel, welche diese Wirkstoffe enthalten, entfalten eine kurative Wirkung bei Dermatosen der verschiendensten Genesis im Human- und veterinärmedizinischen Bereich. Besonders wirksam sind die erfindungsgemäßen Mittel bei der Behandlung der Psoriasis und von Ulcus oruris. Bei Dermatosen, die gleichzeitig eine Subinfektion von pathogenen Keimen aufweisen, kann dank der starken biociden Komponente d.er Mittel eine schnelle Abheilung des entzündlichen Geschehen erreicht werden. Auch Dermatomykosen sind d.er Behandlung sehr gut zugänglich. So kannen beispielsweise Pußpilzinfektionen (Finea ped.is) durch Boden in lösungen, welche diese Wirkstoffe enthalten, schnell zur Abheilung gebracht werden. Auch Entzündungen.des Nagelbetts (Panaritium) klingen durch Bäder bzw. durch direkten Kontakt mit höher konzentrierten lösungen der Wirkstoffe sehr schnell ab. Die Anwendung der Mittel erfolgt im allgemeinen in wässriger Lösung in Porm von Bädern bzw. Kopfbäder.n, feuchten Umschlägen od.er Kompressen. Die Anwendungskonzentration kann dabei von Fall zu Ball variiert werden von 5 bis 10 000 ppm. Häufig wird auch eine 0,5 - 50 %ige, vorzugsweise 5 - 20 %ige wässrige Einstellung direkt auf die erkrankten Hautstellen gebracht. Die Verwendung i.n Porm von Sprays mit fluorhaltigen Treibmitteln ist ebenfalls mUglich, wobei neben der kurativen Wirkung auch ein sehr guter deodorierender Effekt auf der Haut erreicht wird. Der kurative und hautschützende Effekt ist für den kosmetischen bzw.Means that contain these active ingredients develop a curative effect Effect on dermatoses of the most varied genesis in human and veterinary medicine Area. The agents according to the invention are particularly effective in treatment psoriasis and oruris ulcers. With dermatoses that are simultaneously a subinfection of pathogenic germs, thanks to the strong biocidal component of the d.er Means a quick healing of the inflammatory process achieved will. Dermatomycoses are also very accessible for treatment. So can For example, butt fungus infections (Finea ped.is) through soil in solutions, which contain these active ingredients, can be healed quickly. Inflammation too Nail beds (panaritium) sound higher through baths or through direct contact with concentrated solutions of the active ingredients disappear very quickly. The application of the means generally takes place in aqueous solution in the form of baths or head baths, moist compresses or compresses. The application concentration can be from Case by ball can be varied from 5 to 10,000 ppm. Often a 0.5 - 50 %, preferably 5 - 20% aqueous formulation directly on the diseased skin areas brought. The use in the form of sprays with fluorine-containing propellants is also possible, with a very good deodorizing effect in addition to the curative effect Effect on the skin is achieved. The curative and skin-protecting effect is for the cosmetic resp.
intimkosmetischen Bereich von nicht zu unterschätzendem Wert, da er eine Hauttherapie ohne Nebenwirkungen erlaubt, die häufig bei Verwendung von bakteriziden Wirkstoffen auftreten.intimate cosmetic area of value not to be underestimated, since he A skin therapy without side effects is allowed, which is often the case with the use of bactericides Active substances occur.
Von besonders hohem kurativem Wert sind die neuen Mittel bei d.er Behandlung von schweren und schwersten Verbrennungen. Durch die hohe germizide Wirkung dieser Mittel, wird.The new agents at d.er are of particularly high curative value Treatment of severe and very severe burns. Due to the high germicidal effect this means, will.
die verletzte bzw. verbrannte Hautatelle steril gehalten.the injured or burned skin area kept sterile.
Darüber hinaus regen die neuen Mittel die Haut zu einer schnellen Regeneration an, so daß Verbrennungen viel schneller und ohne Komplikationen abheilen können. Weitere Zubereitungsformen sind. galenisch zubereitete Schüttelmixturen, Salben und Anreibungen, die wahlweise angewendet werden können. Lotionen, Emulsionen und Dispersionen lassen sich dank der Tensidnatur der Wirkstoffe leicht herstellen, gegebenenfalls in Gegenwart and.erer Heilmittel oder Geruchsträger, wenn solche Effekte erzielt werden sollen. Für bestimmte therapeutische Zwecke werden die Wirkstoffe beispielsweise mit Talkum oder anderen neutralen Stäuben zu Pudern verarbeitet mit einem Wirkstoffgehalt von 0,1 bis 10 % neben Talkum.In addition, the new agents stimulate the skin quickly Regeneration so that burns heal much faster and without complications can. Other forms of preparation are. galenically prepared shaking mixtures, Ointments and rubs that can be used optionally. Lotions, emulsions and dispersions are easy to prepare thanks to the surfactant nature of the active ingredients, possibly in the presence of other remedies or odor carriers, if such Effects are to be achieved. The active ingredients are used for certain therapeutic purposes for example with talc or other neutral dusts Powder processed with an active ingredient content of 0.1 to 10% in addition to talc.
Beispiel 1: In einer 250 ml fassenden Spraydose werden eingefüllt: 5 Teile n-dodecyl - bis (2-hydroxyäthyl) sulfoniumsulfat 45 Teile Isopropanol 50 Teile Prigen Beispiel 2t 5 Teile n-Tetradecyl - bis (2-hydroxyäthyl) sulfoniumsulfat und 95 Teile Talkum worden in einer Kugelmühle bis zur Homogenität gemahlen.Example 1: A 250 ml spray can is filled with: 5 parts of n-dodecyl bis (2-hydroxyethyl) sulfonium sulfate 45 parts of isopropanol 50 Parts of Prigen Example 2t 5 parts of n-tetradecyl bis (2-hydroxyethyl) sulfonium sulfate and 95 parts of talc was ground in a ball mill until homogeneous.
Beispiel 3: Eine Salbe wird bereitet durch Mischen von 95 Teilen Weissöl und Kokosfett im Verhältnis 1 s 1 und 5 Teile C11 - 14 H23 - 29 - S-(CH2CH2OH)2] # # HOCH2 CH2O SO3 Beispiel 4: Ein öl in Wasser Emulsion bestehend aus 30 Teilen Arachisöl und 70 Teilen Wasser und 5 Teilen C11 - 14 H23 - 29 - S -(CH2CH2OH)2] # # HOCH2 CH2O SO3 Beispiel 5 In einer 250 ml Sprühdose werden eingefüllt: 8 Teile 2 Teile 20 Teile Äthanol 70 Teile Frigen # - Treibmittel 2 Teile GlycerinExample 3: An ointment is prepared by mixing 95 parts of white oil and coconut fat in a ratio of 1 s 1 and 5 parts of C11-14 H23-29-S- (CH2CH2OH) 2] # # HOCH2 CH2O SO3 Example 4: An oil in water emulsion consisting of 30 parts of arachis oil and 70 parts of water and 5 parts of C11-14 H23-29 - S - (CH2CH2OH) 2] # # HOCH2 CH2O SO3 Example 5 A 250 ml spray can is filled with: 8 parts 2 parts 20 parts of ethanol 70 parts of Frigen # propellant 2 parts of glycerine
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19712130775 DE2130775A1 (en) | 1971-06-22 | 1971-06-22 | Alkyl-bis-(2-hydroxylakyl or aralkyl or aryl)-sulphonium - sulphates - agents for the treatment of dermatoses |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19712130775 DE2130775A1 (en) | 1971-06-22 | 1971-06-22 | Alkyl-bis-(2-hydroxylakyl or aralkyl or aryl)-sulphonium - sulphates - agents for the treatment of dermatoses |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2130775A1 true DE2130775A1 (en) | 1972-12-28 |
Family
ID=5811385
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19712130775 Pending DE2130775A1 (en) | 1971-06-22 | 1971-06-22 | Alkyl-bis-(2-hydroxylakyl or aralkyl or aryl)-sulphonium - sulphates - agents for the treatment of dermatoses |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE2130775A1 (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2630995A1 (en) * | 1975-07-11 | 1977-01-20 | Aquitaine Petrole | ORGANIC COMPOUNDS WITH A SULFONIUM GROUP, METHOD FOR MANUFACTURING AND USING IT |
| US4056634A (en) * | 1975-02-19 | 1977-11-01 | Whitefin Holding S.A. | Dimercaptoethyl ether sulfonium compounds and use as antiinflammatory and antirheumatic agents |
| US4127654A (en) * | 1975-09-12 | 1978-11-28 | Kao Soap Co., Ltd. | Compositions and methods containing beta substituted allyl alcohols, sulfuric acid esters thereof, phosphoric acid esters thereof, alkanoyl esters thereof and alkylene oxide ethers thereof |
| US4251521A (en) * | 1979-02-07 | 1981-02-17 | Sandoz, Inc. | Alkyl diaryl sulfonium salts |
| FR2592302A1 (en) * | 1985-12-27 | 1987-07-03 | Oreal | COSMETIC COMPOSITIONS FOR THE TREATMENT OF FATTY SKIN AND HAIR, BASED ON DI (BETA-HYDROXYETHYL) SULFOXIDE, AND THEIR APPLICATION. |
-
1971
- 1971-06-22 DE DE19712130775 patent/DE2130775A1/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4056634A (en) * | 1975-02-19 | 1977-11-01 | Whitefin Holding S.A. | Dimercaptoethyl ether sulfonium compounds and use as antiinflammatory and antirheumatic agents |
| DE2630995A1 (en) * | 1975-07-11 | 1977-01-20 | Aquitaine Petrole | ORGANIC COMPOUNDS WITH A SULFONIUM GROUP, METHOD FOR MANUFACTURING AND USING IT |
| US4127654A (en) * | 1975-09-12 | 1978-11-28 | Kao Soap Co., Ltd. | Compositions and methods containing beta substituted allyl alcohols, sulfuric acid esters thereof, phosphoric acid esters thereof, alkanoyl esters thereof and alkylene oxide ethers thereof |
| US4251521A (en) * | 1979-02-07 | 1981-02-17 | Sandoz, Inc. | Alkyl diaryl sulfonium salts |
| FR2592302A1 (en) * | 1985-12-27 | 1987-07-03 | Oreal | COSMETIC COMPOSITIONS FOR THE TREATMENT OF FATTY SKIN AND HAIR, BASED ON DI (BETA-HYDROXYETHYL) SULFOXIDE, AND THEIR APPLICATION. |
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