DE19852508A1 - Use of fat-soluble substance obtained from avocado oil as an antiphlogistic, antirheumatic, antimycotic or antiscabiotic agent, or as a toothpaste, lipstick, leather treatment agent or in bandages - Google Patents
Use of fat-soluble substance obtained from avocado oil as an antiphlogistic, antirheumatic, antimycotic or antiscabiotic agent, or as a toothpaste, lipstick, leather treatment agent or in bandagesInfo
- Publication number
- DE19852508A1 DE19852508A1 DE19852508A DE19852508A DE19852508A1 DE 19852508 A1 DE19852508 A1 DE 19852508A1 DE 19852508 A DE19852508 A DE 19852508A DE 19852508 A DE19852508 A DE 19852508A DE 19852508 A1 DE19852508 A1 DE 19852508A1
- Authority
- DE
- Germany
- Prior art keywords
- fat
- soluble substance
- soluble
- avocado oil
- lauraceae
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000126 substance Substances 0.000 title claims abstract description 63
- 235000021302 avocado oil Nutrition 0.000 title claims abstract description 22
- 239000008163 avocado oil Substances 0.000 title claims abstract description 22
- 239000002260 anti-inflammatory agent Substances 0.000 title claims abstract description 5
- 239000003435 antirheumatic agent Substances 0.000 title claims abstract description 5
- 239000003795 chemical substances by application Substances 0.000 title claims description 8
- 239000010985 leather Substances 0.000 title claims description 8
- 230000001741 anti-phlogistic effect Effects 0.000 title abstract 3
- -1 lipstick Substances 0.000 title abstract 2
- 230000001857 anti-mycotic effect Effects 0.000 title description 2
- 239000002543 antimycotic Substances 0.000 title description 2
- 239000000606 toothpaste Substances 0.000 title description 2
- 229940034610 toothpaste Drugs 0.000 title description 2
- 230000003356 anti-rheumatic effect Effects 0.000 title 1
- LGJMUZUPVCAVPU-UHFFFAOYSA-N beta-Sitostanol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(CC)C(C)C)C1(C)CC2 LGJMUZUPVCAVPU-UHFFFAOYSA-N 0.000 claims abstract description 21
- 244000025272 Persea americana Species 0.000 claims abstract description 14
- 229940068065 phytosterols Drugs 0.000 claims abstract description 14
- 239000011782 vitamin Substances 0.000 claims abstract description 12
- 235000013343 vitamin Nutrition 0.000 claims abstract description 12
- 229940088594 vitamin Drugs 0.000 claims abstract description 12
- 229930003231 vitamin Natural products 0.000 claims abstract description 12
- KZJWDPNRJALLNS-VPUBHVLGSA-N (-)-beta-Sitosterol Natural products O[C@@H]1CC=2[C@@](C)([C@@H]3[C@H]([C@H]4[C@@](C)([C@H]([C@H](CC[C@@H](C(C)C)CC)C)CC4)CC3)CC=2)CC1 KZJWDPNRJALLNS-VPUBHVLGSA-N 0.000 claims abstract description 11
- CSVWWLUMXNHWSU-UHFFFAOYSA-N (22E)-(24xi)-24-ethyl-5alpha-cholest-22-en-3beta-ol Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CC(CC)C(C)C)C1(C)CC2 CSVWWLUMXNHWSU-UHFFFAOYSA-N 0.000 claims abstract description 11
- KLEXDBGYSOIREE-UHFFFAOYSA-N 24xi-n-propylcholesterol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)CCC(CCC)C(C)C)C1(C)CC2 KLEXDBGYSOIREE-UHFFFAOYSA-N 0.000 claims abstract description 11
- LPZCCMIISIBREI-MTFRKTCUSA-N Citrostadienol Natural products CC=C(CC[C@@H](C)[C@H]1CC[C@H]2C3=CC[C@H]4[C@H](C)[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C)C(C)C LPZCCMIISIBREI-MTFRKTCUSA-N 0.000 claims abstract description 11
- ARVGMISWLZPBCH-UHFFFAOYSA-N Dehydro-beta-sitosterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)CCC(CC)C(C)C)CCC33)C)C3=CC=C21 ARVGMISWLZPBCH-UHFFFAOYSA-N 0.000 claims abstract description 11
- BTEISVKTSQLKST-UHFFFAOYSA-N Haliclonasterol Natural products CC(C=CC(C)C(C)(C)C)C1CCC2C3=CC=C4CC(O)CCC4(C)C3CCC12C BTEISVKTSQLKST-UHFFFAOYSA-N 0.000 claims abstract description 11
- MJVXAPPOFPTTCA-UHFFFAOYSA-N beta-Sistosterol Natural products CCC(CCC(C)C1CCC2C3CC=C4C(C)C(O)CCC4(C)C3CCC12C)C(C)C MJVXAPPOFPTTCA-UHFFFAOYSA-N 0.000 claims abstract description 11
- NJKOMDUNNDKEAI-UHFFFAOYSA-N beta-sitosterol Natural products CCC(CCC(C)C1CCC2(C)C3CC=C4CC(O)CCC4C3CCC12C)C(C)C NJKOMDUNNDKEAI-UHFFFAOYSA-N 0.000 claims abstract description 11
- SGNBVLSWZMBQTH-PODYLUTMSA-N campesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](C)C(C)C)[C@@]1(C)CC2 SGNBVLSWZMBQTH-PODYLUTMSA-N 0.000 claims abstract description 11
- KZJWDPNRJALLNS-VJSFXXLFSA-N sitosterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CC[C@@H](CC)C(C)C)[C@@]1(C)CC2 KZJWDPNRJALLNS-VJSFXXLFSA-N 0.000 claims abstract description 11
- 235000015500 sitosterol Nutrition 0.000 claims abstract description 11
- 229950005143 sitosterol Drugs 0.000 claims abstract description 11
- NLQLSVXGSXCXFE-UHFFFAOYSA-N sitosterol Natural products CC=C(/CCC(C)C1CC2C3=CCC4C(C)C(O)CCC4(C)C3CCC2(C)C1)C(C)C NLQLSVXGSXCXFE-UHFFFAOYSA-N 0.000 claims abstract description 11
- HCXVJBMSMIARIN-PHZDYDNGSA-N stigmasterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)/C=C/[C@@H](CC)C(C)C)[C@@]1(C)CC2 HCXVJBMSMIARIN-PHZDYDNGSA-N 0.000 claims abstract description 11
- BFDNMXAIBMJLBB-UHFFFAOYSA-N stigmasterol Natural products CCC(C=CC(C)C1CCCC2C3CC=C4CC(O)CCC4(C)C3CCC12C)C(C)C BFDNMXAIBMJLBB-UHFFFAOYSA-N 0.000 claims abstract description 11
- 150000003626 triacylglycerols Chemical class 0.000 claims abstract description 11
- OILXMJHPFNGGTO-UHFFFAOYSA-N (22E)-(24xi)-24-methylcholesta-5,22-dien-3beta-ol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CC(C)C(C)C)C1(C)CC2 OILXMJHPFNGGTO-UHFFFAOYSA-N 0.000 claims abstract description 10
- OQMZNAMGEHIHNN-UHFFFAOYSA-N 7-Dehydrostigmasterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CC(CC)C(C)C)CCC33)C)C3=CC=C21 OQMZNAMGEHIHNN-UHFFFAOYSA-N 0.000 claims abstract description 10
- SGNBVLSWZMBQTH-FGAXOLDCSA-N Campesterol Natural products O[C@@H]1CC=2[C@@](C)([C@@H]3[C@H]([C@H]4[C@@](C)([C@H]([C@H](CC[C@H](C(C)C)C)C)CC4)CC3)CC=2)CC1 SGNBVLSWZMBQTH-FGAXOLDCSA-N 0.000 claims abstract description 10
- HZYXFRGVBOPPNZ-UHFFFAOYSA-N UNPD88870 Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)=CCC(CC)C(C)C)C1(C)CC2 HZYXFRGVBOPPNZ-UHFFFAOYSA-N 0.000 claims abstract description 10
- 235000000431 campesterol Nutrition 0.000 claims abstract description 10
- 235000016831 stigmasterol Nutrition 0.000 claims abstract description 10
- 229940032091 stigmasterol Drugs 0.000 claims abstract description 10
- 239000000203 mixture Substances 0.000 claims description 15
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 11
- 241000218195 Lauraceae Species 0.000 claims description 10
- 235000011236 Persea americana var americana Nutrition 0.000 claims description 10
- 239000000654 additive Substances 0.000 claims description 10
- 150000003648 triterpenes Chemical class 0.000 claims description 10
- 230000003110 anti-inflammatory effect Effects 0.000 claims description 7
- 239000003921 oil Substances 0.000 claims description 6
- 235000019198 oils Nutrition 0.000 claims description 6
- 239000000463 material Substances 0.000 claims description 5
- 241000196324 Embryophyta Species 0.000 claims description 4
- 239000002674 ointment Substances 0.000 claims description 4
- 235000008673 Persea americana Nutrition 0.000 claims description 3
- 239000006071 cream Substances 0.000 claims description 3
- 235000013399 edible fruits Nutrition 0.000 claims description 3
- 239000011248 coating agent Substances 0.000 claims description 2
- 238000000576 coating method Methods 0.000 claims description 2
- 239000000551 dentifrice Substances 0.000 claims description 2
- 239000002657 fibrous material Substances 0.000 claims description 2
- 239000006210 lotion Substances 0.000 claims description 2
- 239000004753 textile Substances 0.000 claims description 2
- 239000007762 w/o emulsion Substances 0.000 claims description 2
- 230000000843 anti-fungal effect Effects 0.000 claims 1
- 229940121375 antifungal agent Drugs 0.000 claims 1
- 239000011505 plaster Substances 0.000 claims 1
- 239000002537 cosmetic Substances 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- 230000000694 effects Effects 0.000 description 5
- 230000002209 hydrophobic effect Effects 0.000 description 5
- 239000004480 active ingredient Substances 0.000 description 4
- 230000009286 beneficial effect Effects 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 230000029663 wound healing Effects 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- 230000000202 analgesic effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000000839 emulsion Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 125000005456 glyceride group Chemical group 0.000 description 2
- 230000000887 hydrating effect Effects 0.000 description 2
- 230000007803 itching Effects 0.000 description 2
- 235000013311 vegetables Nutrition 0.000 description 2
- 206010063409 Acarodermatitis Diseases 0.000 description 1
- 244000144927 Aloe barbadensis Species 0.000 description 1
- 235000002961 Aloe barbadensis Nutrition 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 208000012659 Joint disease Diseases 0.000 description 1
- 208000029578 Muscle disease Diseases 0.000 description 1
- 241000447727 Scabies Species 0.000 description 1
- 241000221095 Simmondsia Species 0.000 description 1
- 235000004433 Simmondsia californica Nutrition 0.000 description 1
- 208000028990 Skin injury Diseases 0.000 description 1
- 229930182558 Sterol Natural products 0.000 description 1
- NLDBCFRIELDMRO-UHFFFAOYSA-N Stigmasterin Natural products CCCC(CC)C=CC(C)C1CCC2C3CC=C4CC(O)CCC4(C)C3CCC12C NLDBCFRIELDMRO-UHFFFAOYSA-N 0.000 description 1
- 239000004904 UV filter Substances 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 235000011399 aloe vera Nutrition 0.000 description 1
- 230000001760 anti-analgesic effect Effects 0.000 description 1
- 230000001139 anti-pruritic effect Effects 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 210000004087 cornea Anatomy 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000003205 fragrance Substances 0.000 description 1
- 235000021588 free fatty acids Nutrition 0.000 description 1
- 230000002538 fungal effect Effects 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
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- 239000002324 mouth wash Substances 0.000 description 1
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- 239000003158 myorelaxant agent Substances 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 208000028169 periodontal disease Diseases 0.000 description 1
- 239000011814 protection agent Substances 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 238000007127 saponification reaction Methods 0.000 description 1
- 208000005687 scabies Diseases 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000010374 vitamin B1 Nutrition 0.000 description 1
- 239000011691 vitamin B1 Substances 0.000 description 1
- 235000019164 vitamin B2 Nutrition 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- 235000019166 vitamin D Nutrition 0.000 description 1
- 239000011710 vitamin D Substances 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Die Erfindung betrifft eine fettlösliche Substanz, zumindest teilweise bestehend aus dem unverseifbaren Anteil von Avocado-Öl (Persea gratissima, Lauraceae), insbesondere bestehend aus Triglyceriden, fettlöslichen Vitaminen, Triterpen-Alkohol und Phytosterinen, insbesondere Sitosterin, Campesterin und Stigmasterin, oder einer in Bezug auf die Hauptbestandteile identischen Zusammensetzung, wobei die fettlösliche Substanz zusätzlich die üblichen Hilfsstoffe und/oder Zusatzstoffe enthält.The invention relates to a fat-soluble substance, at least partially consisting of the unsaponifiable portion of avocado oil (Persea gratissima, Lauraceae), in particular consisting of triglycerides, fat-soluble vitamins, triterpene alcohol and phytosterols, especially sitosterol, campesterol and stigmasterol, or an identical composition with respect to the main components, the fat-soluble substance additionally contains the usual auxiliaries and / or additives.
Die Avocado (Persea gratissima, Lauraceae) ist eine grünschalige, birnenförmige und ca. 10 cm lange Frucht, die aus dem tropischen Mittelamerika stammt und einen Ölgehalt von 20 bis 25 Gew.-% aufweist, wobei der Ölgehalt von diesem Mittelwert je nach Sorte mehr oder weniger deutlich abweichen kann. Avocado-Öl findet u. a. in der Nahrungsmittelindustrie Anwendung, häufiger ist jedoch seine Verwendung in Kosmetika, da es sich durch gutes Eindringen in die Hornhaut und eine ausgesprochen hydratisierende Wirkung auszeichnet. Darüber hinaus hat es plastifizierende Eigenschaften, so daß die behandelte Haut weich und geschmeidig bleibt.The avocado (Persea gratissima, Lauraceae) is a green, pear-shaped and about 10 cm long fruit that comes from tropical Central America and one Has oil content of 20 to 25 wt .-%, the oil content depending on this average can vary more or less depending on the variety. Avocado oil finds a. in application in the food industry, but its use in Cosmetics because it is good penetration into the cornea and a very hydrating effect. It also has plastifying properties, so that the treated skin is soft and smooth remains.
Das Avocado-Öl enthält ca. 1,5% Unverseifbares, d. h. beispielsweise Kohlenwasserstoffe, Sterine, Vitamine und Fettalkohole, die der Verseifung bei der Fettsäure-Gewinnung widerstehen. Die unverseifbare Fraktion des Avocado-Öls besteht hauptsächlich aus Triglyceriden, fettlöslichen Vitaminen, Triterpen-Alkohol und Phytosterinen. Der hohe Anteil an Phytosterinen ist für die besonderen Eigenschaften des Unverseifbaren verantwortlich, wobei hauptsächlich Sitosterin, Campesterin und Stigmasterin vorliegen. Die Bestandteile des unverseifbaren Anteiles des Avocado-Öls, oder eine identische Zusammensetzung anderer pflanzlicher Herkunft, bilden in Verbindung mit den üblichen Hilfsstoffen und/oder Zusatzstoffen eine weiche, weiß-gelbliche und fettlösliche Substanz mit stark hydrophoben Eigenschaften und schwachem Duft, die nicht in Wasser oder Alkohol löslich ist. Diese fettlösliche Substanz ist Gegenstand der Erfindung. The avocado oil contains about 1.5% unsaponifiable, i.e. H. for example Hydrocarbons, sterols, vitamins and fatty alcohols, which are used in the saponification Resist fatty acid extraction. The unsaponifiable fraction of avocado oil consists mainly of triglycerides, fat-soluble vitamins, triterpene alcohol and phytosterols. The high proportion of phytosterols is for the special Properties of the unsaponifiable responsible, mainly sitosterol, Campesterin and Stigmasterin are available. The components of the unsaponifiable Share of avocado oil, or an identical composition of others of vegetable origin, form in conjunction with the usual auxiliaries and / or Additives a soft, white-yellowish and fat-soluble substance with strong hydrophobic properties and weak fragrance, not in water or alcohol is soluble. This fat-soluble substance is the subject of the invention.
Aus der US 4,560,568 ist ein Verfahren für die Gewinnung von Avocado-Öl und dem unverseifbaren Anteil in einem einzigen Extraktionsschritt beschrieben. Hierbei wird auf die Verwendung des unverseifbaren Anteiles in Cremes und medizinischen Salben hingewiesen. Bei der bisherigen Verwendung des unverseifbaren Anteils standen aber ausschließlich die plastifizierenden, hydratisierenden und antiphlogistischen Eigenschaften der Substanz im Vordergrund. Neben der Anwendung zu kosmetischen Zwecken ist dabei vor allem die Verwendung als wundheilendes und entzündungshemmendes Dermatikum bekannt, da das Unverseifbare des Avocado-Öls einen stimulierenden Effekt auf die proteolytische Aktivität des Bindegewebes hat und somit Hautentzündungen und -verletzungen heilen kann. Weitere besonders vorteilhafte Eigenschaften konnten dem unverseifbaren Anteil des Avocado-Öls bisher nicht zugewiesen werden, so daß dieser bisher nicht im nennenswerten Umfang verwendet wurde. Anwendung im Bereich der Kosmetika finden vielmehr hauptsächlich Jojoba- und Aloe vera-Öle, denen besonders hautpflegende Eigenschaften zugesprochen werden, während Anwendungen im medizinischen Bereich bisher fast völlig ausblieben.From US 4,560,568 is a process for the production of avocado oil and the unsaponifiable fraction described in a single extraction step. Here will on the use of the unsaponifiable portion in creams and medical Ointments pointed out. With the previous use of the unsaponifiable portion but only the plasticizing, hydrating and anti-inflammatory properties of the substance in the foreground. In addition to the Application for cosmetic purposes is primarily the use as wound healing and anti-inflammatory dermatological known because the Unsaponifiable avocado oil has a stimulating effect on the proteolytic Connective tissue activity and thus skin inflammation and injuries can heal. This could be further particularly advantageous properties unsaponifiable portion of avocado oil has not yet been allocated, so that this has not been used to any significant extent. Application in In the field of cosmetics, there are mainly jojoba and aloe vera oils, which are said to have special skin-care properties, while Applications in the medical field have so far been almost completely absent.
Der Erfindung liegt daher die Aufgabe zugrunde, den Anteil weiterer naturbelassener Substanzen für die Verwendung in kosmetischen, pharmazeutischen und sonstigen Produkten zu erhöhen.The invention is therefore based on the object, the proportion of other natural Substances for use in cosmetic, pharmaceutical and others Products.
In Lösung der Aufgabe konnten zahlreiche besonders vorteilhafte und neue Eigenschaften der fettlöslichen Substanz beschrieben werden. Bei Versuchen zeigte sich überraschender Weise, daß die Bestandteile des unverseifbaren Anteils von Avocado-Öl eine stark schmerzstillende und muskelrelaxierende Wirkung haben. Diese Eigenschaften machen die fettlösliche Substanz für die Verwendung als Bestandteil von antiphlogistischen oder antirheumatischen Mitteln sehr interessant. Dabei kann die fettlösliche Substanz alleine als Wirkstoff eingesetzt werden oder die Wirkung anderer Inhaltsstoffe ergänzen. In Verbindung mit der bereits bekannten antiphlogistischen Eigenschaft können durch Einreiben der betroffenen Körperstellen mit der fettlöslichen Substanz Schmerzen bei Muskel- und Gelenkerkrankungen, Weichteiltraumen und Rheuma effizient gemildert und so beispielsweise der therapeutische Effekt anderer Wirkstoffe sinnvoll ergänzt werden. In solving the task, numerous particularly advantageous and new ones were able Properties of the fat-soluble substance are described. In experiments showed surprisingly, that the components of the unsaponifiable portion of Avocado oil has a strong analgesic and muscle relaxant effect. These properties make the fat-soluble substance suitable for use as Part of anti-inflammatory or anti-rheumatic agents very interesting. The fat-soluble substance can be used alone as an active ingredient or the Complement the effect of other ingredients. In connection with the already known anti-inflammatory property can be achieved by rubbing the affected areas of the body with the fat-soluble substance pain in muscle and joint diseases, Efficiently softened soft tissue dreams and rheumatism, such as the therapeutic effect of other active ingredients can be supplemented in a meaningful way.
Eine weitere vorteilhafte Eigenschaft der fettlöslichen Substanz besteht in einer stark juckreizhemmenden Wirkung, die insbesondere die Verwendung als Bestandteil von antimycotischen oder antiscabiotischen Mitteln möglich macht. In ersten Versuchen hat sich gezeigt, daß durch direktes Auftragen der fettlöslichen Substanz auf mit Fußpilz befallene Haut der Juckreiz vollständig eliminiert werden konnte. Diese Eigenschaft macht die fettlösliche Substanz als Zusatzstoff von beispielsweise Salben gegen Pilzbefall oder Krätze besonders nützlich.Another advantageous property of the fat-soluble substance is a strong one antipruritic effect, in particular the use as a component of antimycotic or antiscabiotic agents. In the first attempts has been shown that by directly applying the fat-soluble substance on with Athlete's skin affected by the itching could be completely eliminated. This Property makes the fat-soluble substance as an additive for example Ointments for fungal or scabies are particularly useful.
Die fettlösliche Substanz hat ferner entgiftende Eigenschaften, so daß eine Verwendung als Bestandteil von detoxifizierenden Mitteln oder Hautschutzmitteln vorteilhaft ist. Die fettlösliche Substanz kann, als einziger Wirkstoff oder als Ergänzung zu weiteren Wirkstoffen, schädliche Stoffe von der Haut fernhalten und diese sogar teilweise der Haut wieder entziehen. Somit ist ein Einsatz nicht nur im kosmetischen oder medizinischen Bereich, sondern auch im Bereich des Arbeitsschutzes und des gewerblichen Hautschutzes möglich.The fat-soluble substance also has detoxifying properties, so that a Use as part of detoxifying agents or skin protection agents is advantageous. The fat-soluble substance can be used as the only active ingredient or as Supplement to other active ingredients, keep harmful substances away from the skin and partially remove them from the skin. So use is not only in cosmetic or medical field, but also in the field of Occupational safety and industrial skin protection possible.
Die fettlösliche Substanz ist vielseitig einsetzbar und kann sowohl im human- oder auch veterinärmedizinischen Bereich eingesetzt werden. Dabei kann diese in Form von Cremes, Ölen, Lotionen oder Salbe zum Einsatz kommen. Beim Auftragen auf die Haut in einer der genannten Anwendungsformen werden die Bestandteile der fettlöslichen Substanz von der Haut sehr gut aufgenommen und können so ihre vorteilhaften Wirkungen besonders gut entfalten.The fat-soluble substance is versatile and can be used in human or also be used in the veterinary field. This can take the form of creams, oils, lotions or ointment are used. When applying on the skin in one of the application forms mentioned are the components of fat-soluble substance is very well absorbed by the skin and so can its develop beneficial effects particularly well.
Die antiphlogistischen und schmerzstillenden Eigenschaften der fettlöslichen Substanz machen auch eine Verwendung als Bestandteil von Zahnpflegemitteln und Mitteln zur Mundhygiene, insbesondere Zahnpasta und Mundspülungen, besonders sinnvoll. Aufgrund der stark hydrophoben Eigenschaften kann die Substanz hier allerdings nur in geringen Konzentrationen, vorzugsweise 0,05 bis 5 Gew.-%, zugegeben werden. Wie Versuche zeigen, reicht allerdings bereits diese geringe Konzentration aus, um beispielsweise die Heilung von Parodontose vorteilhaft zu beeinflussen. The anti-inflammatory and analgesic properties of fat-soluble Substance also make use as an ingredient in dentifrices and Oral hygiene products, in particular toothpaste and mouthwashes, in particular sensible. Due to its highly hydrophobic properties, the substance can be used here however only in low concentrations, preferably 0.05 to 5% by weight, be added. As experiments show, this small one is enough Concentration to, for example, the healing of periodontal disease beneficial influence.
Die Verwendung der fettlöslichen Substanz als Bestandteil von Lippenpflegemitteln, insbesondere Lippenstiften, hat sich ebenfalls als besonders vorteilhaft herausgestellt, da aufgrund der hydrophoben und plastifizierenden Eigenschaften der "Long-Lasting-Effekt" solcher Produkte positiv beeinflußt wird. So haften beispielsweise Lippenstifte, die die fettlösliche Substanz enthalten, wesentlich länger auf den Lippen als herkömmliche Produkte. In diesem Zusammenhang ist sowohl die Verwendung im kosmetischen Bereich als auch in Verbindung mit Pflegestiften mit oder ohne UV-Filter vorgesehen.The use of the fat-soluble substance as a component of lip care products, especially lipsticks, has also proven to be particularly advantageous emphasized because of the hydrophobic and plasticizing properties the "long-lasting effect" of such products is positively influenced. So stick For example, lipsticks that contain the fat-soluble substance last much longer on the lips than conventional products. In this context, both the Use in the cosmetic area as well as in connection with care pencils or provided without a UV filter.
Besonders vorteilhaft ist ferner die Verwendung der fettlöslichen Substanz als Bestandteil von Lederpflege- und Lederschutzmitteln, wobei auch hier die stark hydrophoben Eigenschaften der Substanz vorteilhaft sind. Entsprechende Versuche haben gezeigt, daß Schuhe oder andere Lederprodukte nach direktem Auftragen der fettlöslichen Substanz vollständig vor einer Benetzung bzw. Aufnahme von Wasser geschützt werden konnten. Ferner sorgen die plastifizierenden Eigenschaften der Substanz dafür, daß das Leder weich und geschmeidig wird. Eine Verwendung als Zusatz von Schuhcreme ist daher sehr vorteilhaft und erleichtert darüber-hinaus die Aufnahme anderer Inhaltsstoffe, wie beispielsweise Farbstoffe oder Pflegestoffe, in das Leder.It is also particularly advantageous to use the fat-soluble substance as Part of leather care and leather protection products, although here too the strong hydrophobic properties of the substance are advantageous. Appropriate attempts have shown that shoes or other leather products after direct application of the fat-soluble substance completely before wetting or absorption of water could be protected. Furthermore, the plasticizing properties of Substance that the leather becomes soft and supple. Use as Adding shoe polish is therefore very beneficial and also makes it easier Inclusion of other ingredients, such as dyes or care substances, in the leather.
Als besonders vorteilhaft hat sich auch die Verwendung als Beschichtung von Textilien oder Faserstoffen, insbesondere Pflaster- und Verbandmaterial, Windelmaterial, Toilettenpapier und Pflegetüchern erwiesen. Bei diesen Verwendungsmöglichkeiten kann man sich einerseits die hydrophoben Eigenschaften und andererseits die wundheilenden und schmerzstillenden Eigenschaften der fettlöslichen Substanz zum Vorteil machen. Vor allem bei medizinischen Pflastern und Verbänden wird durch eine Beschichtung mit der fettlöslichen Substanz zum einen eine Verunreinigung der Wunde durch hydrophile Substanzen verhindert und zum anderen durch die bereits beschriebenen entzündungshemmenden Eigenschaften die Wundheilung gefördert sowie durch Eliminierung von Schmerzen und Juckreiz das Tragegefühl des Patienten verbessert. Die gleichen Vorteile können auch beim Einsatz von entsprechend behandelten Windeln erzielt werden. Im kosmetischen Bereich, beispielsweise bei Toilettenpapier und Pflegetüchern, wirken sich darüber hinaus die detoxifizierenden Eigenschaften der fettlöslichen Substanz positiv aus.Use as a coating of has also proven to be particularly advantageous Textiles or fibrous materials, especially plasters and bandages, Proven diaper material, toilet paper and wipes. With these One can use the hydrophobic on the one hand Properties and on the other hand the wound healing and analgesic Make the properties of the fat-soluble substance an advantage. Especially with medical plasters and bandages is coated with the fat-soluble substance on the one hand contamination of the wound by hydrophilic Prevents substances and secondly by those already described anti-inflammatory properties promote wound healing as well as through Eliminating pain and itching the patient's comfort improved. The same benefits can also be used accordingly treated diapers can be achieved. In the cosmetic field, for example at Toilet paper and wipes also have a detoxifying effect Properties of the fat-soluble substance positive.
In besonders vorteilhafter Verwendung der fettlöslichen Substanz ist vorgesehen, daß diese in einer Konzentration von 0,05 bis 50 Gew.-%, vorzugsweise 2 bis 12 Gew.-% in einer Wasser-in-Öl-Emulsion, angewendet wird. Die Konzentration, in der die fettlösliche Substanz eingesetzt wird, kann dabei in Abhängigkeit von der Art der Anwendung und der erwünschten Wirkung frei gewählt werden. In ersten Versuchen hat sich bei vielen Anwendungen eine Konzentration zwischen 2 und 12 Gew.-% als besonders vorteilhaft erwiesen, wobei Emulsionen durch die Zugabe der fettlöslichen Substanz stabilisiert werden. In Ausnahmefällen kann die fettlösliche Substanz auch unverdünnt in reiner Form eingesetzt werden, was jedoch aus Kostengründen in der Regel vermieden werden sollte. Es ist ferner die Verwendung in Wachsen, Öl-in-Wasser-Emulsionen und alkoholischen Lösungen möglich.In a particularly advantageous use of the fat-soluble substance, that these in a concentration of 0.05 to 50 wt .-%, preferably 2 to 12% by weight in a water-in-oil emulsion. The concentration in which the fat-soluble substance is used, depending on the type of Application and the desired effect can be chosen freely. In the first attempts has a concentration between 2 and 12 wt .-% as in many applications proven particularly advantageous, emulsions by adding the fat-soluble Substance to be stabilized. In exceptional cases, the fat-soluble substance can also are used undiluted in pure form, which, however, for reasons of cost Rule should be avoided. It is also used in waxes, Oil-in-water emulsions and alcoholic solutions possible.
Die fettlösliche Substanz besteht vorteilhafter Weise zu mindestens 25% aus dem unverseifbaren Anteil des Öles von Avocado-Früchten, insbesondere also aus Triglyceriden, fettlöslichen Vitaminen, Triterpen-Alkohol und besonderen Phytosterinen. Hierbei kommt es weniger auf die Herkunft der Substanz an, als auf die entsprechende Zusammensetzung. Die Glyceride enthalten den hohen Anteil von 75 bis 80 Gew.-% an ungesättigten Fettsäuren. Die Vitamine A, B1, B2, D, E und Biotin sind ebenfalls in hohen Konzentrationen enthalten. Als Phytosterine liegen vor allem Sitosterin, Campesterin und Stigmasterin vor, wobei die Phytosterine für die vorteilhaften Eigenschaften von besonderer Bedeutung sind. Alle Bestandteile bewirken in ihrer Gesamtheit die oben beschriebenen vorteilhaften Eigenschaften der fettlöslichen Substanz und sind in ihrer speziellen Zusammensetzung im unverseifbaren Anteil von Avocado-Öl enthalten. Darüber hinaus können zusätzlich Glyceride und freie Fettsäuren des Avocado-Öls enthalten sein. Alternativ ist es möglich, diese Bestandteile aus anderem pflanzlichen Material zu gewinnen und durch Mischen dieser Bestandteile aus anderen pflanzlichen Quellen, möglicherweise auch aus unterschiedlichen Pflanzen, zu der speziellen Zusammensetzung zu gelangen. Entscheidend für die Wirkung der fettlöslichen Substanz ist ihre Zusammensetzung, die in dieser Form ohne weitere Behandlung nur im unverseifbaren Anteil von Avocado-Öl vorliegt. Die vorteilhaften Eigenschaften der fettlöslichen Substanz und somit die beschriebenen Anwendungsmöglichkeiten sind nur in Verbindung mit den besonderen Bestandteilen in dieser speziellen Zusammensetzung gegeben.The fat-soluble substance advantageously consists of at least 25% of the unsaponifiable portion of the oil from avocado fruits, especially from Triglycerides, fat-soluble vitamins, triterpene alcohol and special Phytosterols. The origin of the substance is less important here than it is the corresponding composition. The glycerides contain the high proportion of 75 to 80% by weight of unsaturated fatty acids. Vitamins A, B1, B2, D, E and Biotin is also present in high concentrations. Are available as phytosterols especially sitosterol, campesterol and stigmasterol, whereby the phytosterols for the advantageous properties are of particular importance. All components in their entirety bring about the advantageous properties described above the fat-soluble substance and are in their special composition in contains unsaponifiable portion of avocado oil. In addition, additional Glycerides and free fatty acids from avocado oil can be included. Alternatively it is possible to extract these components from other plant material and by mixing these ingredients from other vegetable sources, possibly also from different plants, to the special one Composition to arrive. Crucial for the effect of fat-soluble Substance is its composition, in this form without further treatment only in the unsaponifiable portion of avocado oil. The beneficial Properties of the fat-soluble substance and thus the described Possible applications are only in connection with the special components given in this special composition.
Claims (12)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19852508A DE19852508C2 (en) | 1998-11-16 | 1998-11-16 | Use of the unsaponified components from avocado |
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| Application Number | Priority Date | Filing Date | Title |
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| DE19852508A DE19852508C2 (en) | 1998-11-16 | 1998-11-16 | Use of the unsaponified components from avocado |
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| Publication Number | Publication Date |
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| DE19852508A1 true DE19852508A1 (en) | 2000-05-18 |
| DE19852508C2 DE19852508C2 (en) | 2002-09-26 |
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| EP1063962A4 (en) * | 1998-02-26 | 2001-07-18 | Lawrence S Moy | Improved cosmetic formulation and method for amelioration of skin keratoses and striae distensae |
| WO2002096369A3 (en) * | 2001-05-31 | 2003-02-13 | Cognis Deutschland Gmbh | Haircare agent comprising natural oils |
| FR2869543A1 (en) * | 2004-04-30 | 2005-11-04 | Expanscience Laboratoires Sa | MEDICAMENT COMPRISING A PEPTIDE AVOCADO EXTRACT FOR THE TREATMENT AND PREVENTION OF DISEASES ASSOCIATED WITH A DEFICIENCY OF THE IMMUNE SYSTEM |
| FR2905270A1 (en) * | 2006-08-31 | 2008-03-07 | Expanscience Sa Lab | USE OF C7 SUGARS IN THE PREVENTION AND TREATMENT OF MYCOSES |
| US9089576B2 (en) | 2004-04-30 | 2015-07-28 | Laboratoires Expanscience | Medicament comprising a peptide extract of avocado, which is intended for the treatment and prevention of illnesses that are linked to an immune system deficiency or oxidative stress or skin ageing or dry skin |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1063962A4 (en) * | 1998-02-26 | 2001-07-18 | Lawrence S Moy | Improved cosmetic formulation and method for amelioration of skin keratoses and striae distensae |
| WO2002096369A3 (en) * | 2001-05-31 | 2003-02-13 | Cognis Deutschland Gmbh | Haircare agent comprising natural oils |
| FR2869543A1 (en) * | 2004-04-30 | 2005-11-04 | Expanscience Laboratoires Sa | MEDICAMENT COMPRISING A PEPTIDE AVOCADO EXTRACT FOR THE TREATMENT AND PREVENTION OF DISEASES ASSOCIATED WITH A DEFICIENCY OF THE IMMUNE SYSTEM |
| WO2005105123A1 (en) * | 2004-04-30 | 2005-11-10 | Laboratoires Expanscience | Medicament comprising a peptide extract of avocado, which is intended for the treatment and prevention of illnesses that are linked to an immune system deficiency |
| US7833554B2 (en) | 2004-04-30 | 2010-11-16 | Laboratoires Expanscience | Medicament comprising a peptide extract of avocado, which is intended for the treatment and prevention of illnesses that are linked to an immune system deficiency |
| US8349377B2 (en) | 2004-04-30 | 2013-01-08 | Laboratoires Expanscience | Medicament comprising a peptide extract of avocado, which is intended for the treatment and prevention of illnesses that are linked to an immune system deficiency |
| US9089576B2 (en) | 2004-04-30 | 2015-07-28 | Laboratoires Expanscience | Medicament comprising a peptide extract of avocado, which is intended for the treatment and prevention of illnesses that are linked to an immune system deficiency or oxidative stress or skin ageing or dry skin |
| FR2905270A1 (en) * | 2006-08-31 | 2008-03-07 | Expanscience Sa Lab | USE OF C7 SUGARS IN THE PREVENTION AND TREATMENT OF MYCOSES |
| WO2008025847A3 (en) * | 2006-08-31 | 2008-07-31 | Expanscience Lab | Use of c7 sugars in prevention and treatment of mycoses |
Also Published As
| Publication number | Publication date |
|---|---|
| DE19852508C2 (en) | 2002-09-26 |
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