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DE19812366A1 - Injection unit for drug injection from perforation ampoules using commercial single-use cannulas - Google Patents

Injection unit for drug injection from perforation ampoules using commercial single-use cannulas

Info

Publication number
DE19812366A1
DE19812366A1 DE1998112366 DE19812366A DE19812366A1 DE 19812366 A1 DE19812366 A1 DE 19812366A1 DE 1998112366 DE1998112366 DE 1998112366 DE 19812366 A DE19812366 A DE 19812366A DE 19812366 A1 DE19812366 A1 DE 19812366A1
Authority
DE
Germany
Prior art keywords
piston
ampoules
receptacle
container
injection
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE1998112366
Other languages
German (de)
Inventor
Berno Spaeter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7861743&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE19812366(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Individual filed Critical Individual
Priority to DE1998112366 priority Critical patent/DE19812366A1/en
Priority to PCT/EP1999/001856 priority patent/WO1999048547A1/en
Publication of DE19812366A1 publication Critical patent/DE19812366A1/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31525—Dosing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
    • A61M5/31553—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe without axial movement of dose setting member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2403—Ampoule inserted into the ampoule holder
    • A61M2005/2407—Ampoule inserted into the ampoule holder from the rear
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
    • A61M2005/2485—Ampoule holder connected to rest of syringe
    • A61M2005/2488—Ampoule holder connected to rest of syringe via rotation, e.g. threads or bayonet
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
    • A61M5/204—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically connected to external reservoirs for multiple refilling
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31533—Dosing mechanisms, i.e. setting a dose
    • A61M5/31545—Setting modes for dosing
    • A61M5/31548—Mechanically operated dose setting member
    • A61M5/31563—Mechanically operated dose setting member interacting with a displaceable stop member

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

An injection unit comprises a piston portion, an ampoule container (6), and a two-part external housing (5) with a drug reception container (3) and a dose adjustment mechanism. A displaceable piston portion, comprises a piston (4) with a non-return valve (7) and a liquid passage hole (7a) is fixed to a tubular perforator (8), which has a liquid feed line (8a) and an air feed line (9) with an air filter (9a). The filter is fixed to and projects into the ampoule container (6). A piston rod (12) is fixed to the opposite side of the ampoule container, and a two-part external housing with a drug reception container is fitted with a non-return valve (2) at the outlet end, and a dose adjustment mechanism at the opposite end. An Independent claim is also included for a drug reception container for the above injection unit.

Description

Es ist bekannt, daß Patienten mit schlechtem Allgemeinzustand und Bewegungseinschränkungen als Thromboseprophylaxe Heparin subcutan injiziert bekommen. Diese Injektionen erfolgen bis zu 3× täglich mindestens jedoch einmal am Tag.It is known that patients with poor general condition and Movement restrictions as thrombosis prophylaxis, heparin injected subcutaneously to get. These injections are given up to 3 times a day, but at least once during the day.

Dabei ist es, dem Stand der Technik entsprechend, notwendig das Medikament in Einzeldosen mittels Einmalspritzen aus Stechampullen aufzuziehen. Dies nimmt Zudem erheblich Zeit in Anspruch.According to the state of the art, it is necessary to take the medication in Draw up single cans from single-dose syringes from ampoules. This takes It also takes a lot of time.

Der im Patentanspruch 1 angegebenen Erfindung liegt das Problem zugrunde, die Vielzahl der Einmalspritzen deutlich zu mindern und eine wesentliche Zeitersparnis im Umgang mit subcutanen Medikamenten zu erreichen.The invention specified in claim 1 is based on the problem that Significantly reduce the number of single-use syringes and an essential one To save time in dealing with subcutaneous medication.

Dieses Problem wird durch die im Patentanspruch 1 aufgeführten Rückschlagventile im Kolben und im Medikamentenaufnahmebehälter, dem Aufnahmebehälter für Stechampullen und der Mechanik für die Kolbensteuerung gelöst.This problem is caused by those listed in claim 1 Check valves in the piston and in the medication container, the Receptacle for ampoules and the mechanism for the piston control solved.

Die mit der Erfindung erzielten Vorteile bestehen insbesondere darin, daß eine Vielzahl von Einmalspritzen und deren Verpackung entfällt und nur die Einmalkanüle von Patient zu Patient bei selbem Gerät gewechselt werden muß. Dies ist zudem weniger zeitintensiv als einzelnes Aufziehen.The advantages achieved by the invention are in particular that a Many disposable syringes and their packaging are dispensed with and only that Disposable cannula must be changed from patient to patient with the same device. This is also less time-consuming than single winding.

Eine vorteilhafte Ausgestaltung der Erfindung ist im Patentanspruch 2 gegeben. Die Weiterbildung im Patentanspruch 2 verhindert einen Keimrückfluß in das Injektionsgerät und ermöglicht somit eine hygienisch sicherere Arbeitsweise als bei laufendem Wechsel von Einmalspritzen bei selber Stechampulle (Kontamination durch den Anwender), da sich das Medikament in einem geschlossenen System befindet. An advantageous embodiment of the invention is given in claim 2. The further development in claim 2 prevents a backflow of germs in the Injection device and thus enables a hygienically safer way of working than with continuous change of disposable syringes with own ampoule (contamination by the user) because the drug is in a closed system located.  

Das Injektionsgerät läßt sich durch Auseinanderschrauben des Aussengehäuses (5) und des Aufnahmebehälters für Stechampullen (6) in der Mitte trennen. Nun läßt sich in den Aufnahmebehälter für Stechampullen (6) ein handelsübliche Stech­ ampulle einführen und auf den Dorn (8), der in den Aufnahmebehälter einragt, aufstecken. Nach Zusammenschrauben des Injektionsgerätes ist das System ge­ schlossen. Durch erstes niederdrücken der Kolbenstange (12) wird der Medika­ mentenaufnahmebehälter (3) entlüftet.The injection device can be separated by unscrewing the outer housing ( 5 ) and the receptacle for puncture vials ( 6 ) in the middle. Now a commercially available ampoule can be inserted into the receptacle for piercing ampoules ( 6 ) and plugged onto the mandrel ( 8 ) which protrudes into the receptacle. After screwing the injection device together, the system is closed. By first depressing the piston rod ( 12 ), the medication container ( 3 ) is vented.

Da der Aufnahmebehälter für Stechampullen (6) direkt mit der Kolbenstange (12) und dem Dorn (8) mit Belüftungskanal (9) und Flüssigkeitskanal (8a), Kolben (4) mit Rückschlagventil (7) und Flüssigkeitsdurchtrittsloch (7a) verbunden ist, wird der Kolben (4) in den Medikamentenaufnahmebehälter (3) eingedrückt.Since the receptacle for piercing ampoules ( 6 ) is directly connected to the piston rod ( 12 ) and the mandrel ( 8 ) with ventilation channel ( 9 ) and liquid channel ( 8 a), piston ( 4 ) with check valve ( 7 ) and liquid passage hole ( 7 a) , the plunger ( 4 ) is pressed into the medication receptacle ( 3 ).

Anschließend wird durch Druck des Freigabeknopfes (15) der Kolbenrücklauf­ sperre (11) die Kolbenstange (12) freigegeben. Der Kolben (4) wird nun durch die Kolbenrückdruckfeder (14) aus dem Medikamentenaufnahmebehälter (3) zurück­ bewegt.Then the piston return lock ( 11 ), the piston rod ( 12 ) is released by pressing the release button ( 15 ). The piston ( 4 ) is now moved back out of the medication container ( 3 ) by the piston back pressure spring ( 14 ).

Rückschlagventil (2) ist geschlossen und Rückschlagventil (7) öffnet sich. Nun kann Flüssigkeit aus der Stechampulle über Flüssigkeitszuleitung (9) durch den Kolben (4) in den Medikamentenaufnahmebehälter (3) gelangen. Gleichzeitig strömt Luft durch den Luftfilter (9a) über die Luftzuleitung (9) des Dornes (8) in die Stechampulle um einen Unterdruck auszugleichen. Nach Aufstecken einer handelsüblichen Einmalkanüle 26 Gx ½ auf den Luer-Lock-Konus (1), ist das In­ jektionsgerät applikationsbereit. Nach erfolgter Applikation bei der sich, der unter Absatz 2 beschriebene Vorgang wiederholt, wird die Einmalkanüle gewechselt und nach Absatz 4 erneut verfahren.Check valve ( 2 ) is closed and check valve ( 7 ) opens. Now liquid from the puncture ampoule can reach the medication receptacle ( 3 ) via the liquid supply line ( 9 ) through the piston ( 4 ). At the same time, air flows through the air filter ( 9 a) via the air supply line ( 9 ) of the mandrel ( 8 ) into the lancing ampoule to compensate for a negative pressure. After a commercially available 26 Gx ½ disposable cannula is attached to the Luer-Lock cone ( 1 ), the injection device is ready for application. After the application has been repeated, the process described in paragraph 2 is repeated, the single-use cannula is changed and the procedure described in paragraph 4 is repeated.

Zur Dosisänderung wird am Einstellrad (13) die gewünschte Dosis eingestellt, wo­ bei die Gegendruckplatte der Kolbenrückdruckfeder (14) auf der Längsachse ver­ schoben wird.To change the dose, the desired dose is set on the setting wheel ( 13 ), where the back pressure plate of the piston back pressure spring ( 14 ) is pushed along the longitudinal axis.

Nach der Freigabe der Rasterzahnung durch Drücken des Freigabeknopfes (15), wird das Gerät erneut in applikationsbereiten Zustand gebracht.After the grid teeth have been released by pressing the release button ( 15 ), the device is brought back into the ready-to-use state.

Ferner verhindert die Kolbenrücklaufsperre (11) eine unbeabsichtigte Füllung des Medikamentenaufnahmebehälters (3).The piston backstop ( 11 ) also prevents the medication container ( 3 ) from being filled unintentionally.

Ein Ausführungsbeispiel der Erfindung ist in der Zeichnung dargestellt und wird im folgenden näher beschrieben.An embodiment of the invention is shown in the drawing and will described in more detail below.

Es zeigen:Show it:

Fig. 1 Darstellung des Geräteaufbaus im Längsschnitt. Fig. 1 representation of the device structure in longitudinal section.

Fig. 2 Injektionsgerät mit eingelegter Stechampulle. Fig. 2 injection device with inserted ampoule.

Fig. 3 1. Phase: Luftauspressung bei der Ventil (2) öffnet und Ventil (7) Geschlossen ist. Kolbenrücklaufsperre (11) hat gesichert. Fig. 3 1st phase: air squeeze when valve ( 2 ) opens and valve ( 7 ) is closed. Piston backstop ( 11 ) has secured.

Fig. 4 2. Phase: Kolbenrücklaufsperre ist per Knopfdruck freigegeben, Kolben wird im Medikamentenaufnahmebehälter zurückgezogen, Ventil (2) schlißt und Ventil (7) öffnet sich, Flüssigkeit strömt in den Medikamenten­ aufnahmebehälter und Luft strömt in die Stechampulle. Fig. 4 2nd phase: Piston backstop is released at the push of a button, piston is withdrawn in the medication container, valve ( 2 ) closes and valve ( 7 ) opens, liquid flows into the medication container and air flows into the ampoule.

Fig. 5 3. Phase: Kolbenschubstange (12) wird manuell niedergedrückt, Kolben schiebt sich in den Medikamentenaufnahmebehälter, Ventil (2) öffnet und Ventil (7) schlißt, Flüssigkeit wird appliziert. Fig. 5 3rd phase: piston push rod ( 12 ) is depressed manually, piston pushes into the medication container, valve ( 2 ) opens and valve ( 7 ) closes, liquid is applied.

Claims (2)

1. Injektionsgerät zur s.c. Injektion von Medikamenten in Stechampullen unter Verwendung handelsüblicher Einmalkanülen Gr. 26 Gx ½ die auf einen, dem Stand der Technik entsprechenden, Luer-Lock-Konus aufgesteckt werden, dadurch gekennzeichnet, daß das Injektionsgerät aus einem verschieblichen Kolbenanteil, bestehend aus Kolben mit Rückschlagventil und Flüssigkeitsdurchtrittsloch, fest verbunden mit einem röhrenförmigen Dorn, der eine Flüssigkeitszuleitung in Richtung Kolben und eine Luftzuleitung mit Luftfilter in Richtung Stechampulle aufweist und mit dem Aufnahmebehälter für Stechampullen fest verbunden ist und in diesen einragt, einer Kolbenstange, die am Aufnahmebehälter für Stechampullen auf der gegenüberliegenden Seite fest verbunden ist, und einem zweiteiligen Außengehäuse mit Medikamentenaufnahmebehälter, dem am Austrittsende ein Rückschlagventil eingefügt ist, ferner an der gegenüber liegenden Seite eine, dem zweiten Anteil, für die Dosiseinstellung notwendige, Mechanik eingesetzt ist.1. Injection device for sc injection of medication in ampoules using standard disposable cannulas Gr. 26 Gx ½ which are plugged onto a state-of-the-art Luer lock cone, characterized in that the injection device consists of a displaceable piston portion, consisting of a piston with a non-return valve and a liquid passage hole, firmly connected to a tubular mandrel which has a liquid supply line in the direction of the piston and an air supply line with an air filter in the direction of the ampoule and is firmly connected to the receptacle for puncture ampoules and projects into it, a piston rod which is firmly connected to the receptacle for puncture ampoules on the opposite side, and a two-part outer housing with medication receptacle, the a non-return valve is inserted at the outlet end, and on the opposite side a mechanism, the second part, required for dose adjustment, is inserted. 2. Medikamentenaufnahmebehälter nach Patentanspruch 1, dadurch gekennzeichnet, daß der Medikamentenaufnahmebehälter an der Austrittsöffnung mit einem Rückschlagventil versehen ist und daß der Kolben mit Rückschlagventil und Flüssigkeitsdurchtrittsloch mit einem röhrenförmigen Dorn fest verbunden ist, der eine Flüssigkeitsleitung zum Kolben und eine Luftleitung mit Luftfilter zum Aufnahmebehälter für Stechampullen aufweist und in diesen fest verbunden einragt.2. medicament receptacle according to claim 1, characterized, that the medication container at the outlet with a Check valve is provided and that the piston with check valve and Liquid passage hole is fixedly connected to a tubular mandrel which a liquid line to the piston and an air line with air filter to Has receptacles for ampoules and firmly connected in these protrudes.
DE1998112366 1998-03-20 1998-03-20 Injection unit for drug injection from perforation ampoules using commercial single-use cannulas Withdrawn DE19812366A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE1998112366 DE19812366A1 (en) 1998-03-20 1998-03-20 Injection unit for drug injection from perforation ampoules using commercial single-use cannulas
PCT/EP1999/001856 WO1999048547A1 (en) 1998-03-20 1999-03-19 Device for delivering, notably injecting, defined quantities of a fluid such as a medicine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE1998112366 DE19812366A1 (en) 1998-03-20 1998-03-20 Injection unit for drug injection from perforation ampoules using commercial single-use cannulas

Publications (1)

Publication Number Publication Date
DE19812366A1 true DE19812366A1 (en) 1999-09-23

Family

ID=7861743

Family Applications (1)

Application Number Title Priority Date Filing Date
DE1998112366 Withdrawn DE19812366A1 (en) 1998-03-20 1998-03-20 Injection unit for drug injection from perforation ampoules using commercial single-use cannulas

Country Status (2)

Country Link
DE (1) DE19812366A1 (en)
WO (1) WO1999048547A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2465557A1 (en) * 2010-12-17 2012-06-20 Weibel CDS AG Device for dispensing a liquid from a container

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AUPQ526200A0 (en) * 2000-01-25 2000-02-17 Ferrier International Limited Delivery system and apparatus thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19604838A1 (en) * 1996-02-12 1997-08-14 Alfred Von Schuckmann Device for dispensing liquid in divided quantities

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT303250B (en) * 1970-02-19 1972-11-10 Walter Stein Dr Injection syringe equipped with a drug depot
US3827601A (en) * 1973-03-23 1974-08-06 J Magrath Hand powered liquid dispenser of the metering type
DE59509695D1 (en) * 1995-11-09 2001-11-15 Disetronic Licensing Ag Injection device

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19604838A1 (en) * 1996-02-12 1997-08-14 Alfred Von Schuckmann Device for dispensing liquid in divided quantities

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2465557A1 (en) * 2010-12-17 2012-06-20 Weibel CDS AG Device for dispensing a liquid from a container
WO2012080309A1 (en) * 2010-12-17 2012-06-21 Weibel Cds Ag Device for dispensing a liquid from a container

Also Published As

Publication number Publication date
WO1999048547A1 (en) 1999-09-30

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