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DE19735800A1 - Triazine mit adenosinantagonistischer Wirkung - Google Patents

Triazine mit adenosinantagonistischer Wirkung

Info

Publication number
DE19735800A1
DE19735800A1 DE1997135800 DE19735800A DE19735800A1 DE 19735800 A1 DE19735800 A1 DE 19735800A1 DE 1997135800 DE1997135800 DE 1997135800 DE 19735800 A DE19735800 A DE 19735800A DE 19735800 A1 DE19735800 A1 DE 19735800A1
Authority
DE
Germany
Prior art keywords
phenyl
alkyl
hydrogen
pyridyl
furyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE1997135800
Other languages
German (de)
English (en)
Inventor
Ulrike Dr Kuefner-Muehl
Stefan Wolfgang Dr Scheuplein
Gerald Dr Pohl
Wolfgang Dr Gaida
Erich Dr Lehr
Joachim Dr Mierau
Christopher John Montagu Meade
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Original Assignee
Boehringer Ingelheim Pharma GmbH and Co KG
Boehringer Ingelheim Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma GmbH and Co KG, Boehringer Ingelheim Pharmaceuticals Inc filed Critical Boehringer Ingelheim Pharma GmbH and Co KG
Priority to DE1997135800 priority Critical patent/DE19735800A1/de
Priority to PCT/EP1998/005101 priority patent/WO1999011633A1/fr
Publication of DE19735800A1 publication Critical patent/DE19735800A1/de
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
    • C07D251/16—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom
    • C07D251/18—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom with nitrogen atoms directly attached to the two other ring carbon atoms, e.g. guanamines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
    • C07D251/22—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to two ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE1997135800 1997-08-18 1997-08-18 Triazine mit adenosinantagonistischer Wirkung Withdrawn DE19735800A1 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
DE1997135800 DE19735800A1 (de) 1997-08-18 1997-08-18 Triazine mit adenosinantagonistischer Wirkung
PCT/EP1998/005101 WO1999011633A1 (fr) 1997-08-18 1998-08-12 Triazines ayant un effet antagoniste vis-a-vis de l'adenosine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE1997135800 DE19735800A1 (de) 1997-08-18 1997-08-18 Triazine mit adenosinantagonistischer Wirkung

Publications (1)

Publication Number Publication Date
DE19735800A1 true DE19735800A1 (de) 1999-02-25

Family

ID=7839336

Family Applications (1)

Application Number Title Priority Date Filing Date
DE1997135800 Withdrawn DE19735800A1 (de) 1997-08-18 1997-08-18 Triazine mit adenosinantagonistischer Wirkung

Country Status (2)

Country Link
DE (1) DE19735800A1 (fr)
WO (1) WO1999011633A1 (fr)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1201661A4 (fr) * 1999-07-15 2002-10-23 Sumitomo Pharma Composes de cycles heteroaromatiques
US7208597B2 (en) * 2002-07-31 2007-04-24 Ciba Specialty Chemicals Corporation Pyridyl-triazine derivatives as microbiocidal active substances
JP2010523570A (ja) * 2007-04-03 2010-07-15 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー 置換ベンゼン殺菌・殺カビ剤
JP2020158450A (ja) * 2019-03-27 2020-10-01 大阪ガスケミカル株式会社 ２−アミノ−１，３，５−トリアジン化合物の製造方法
WO2021050900A1 (fr) 2019-09-13 2021-03-18 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Inhibiteurs du récepteur de la tyrosine kinase pour le traitement de maladie ou de trouble sensible à la modulation de la protéine kinase
US10961254B2 (en) 2014-06-13 2021-03-30 Yuma Therapeutics, Inc. Pyrimidine compounds and methods using the same

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MXPA04007590A (es) * 2002-02-05 2004-12-06 Yamanouchi Pharma Co Ltd Derivado de 2,4,6-triamino-1,3,5-triacina.
US7307079B2 (en) 2002-05-30 2007-12-11 Solvay Pharmaceuticals, B.V. 1,3,5-Triazine derivatives as ligands for human adenosine-A3 receptors
EP1513827A1 (fr) * 2002-05-30 2005-03-16 Solvay Pharmaceuticals B.V. Derives de 1,3,5-triazine comme ligands pour des recepteurs humains de l'adenosine a3
AU2003249369A1 (en) 2002-06-21 2004-01-06 Cellular Genomics, Inc. Certain amino-substituted monocycles as kinase modulators
EP1878733A1 (fr) * 2006-07-14 2008-01-16 Novartis AG Dérivés de pyrimidine comme inhibiteurs de ALK-5

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH419155A (de) * 1963-01-24 1966-08-31 Geigy Ag J R Verfahren zur Herstellung von o-Hydroxyphenyl-s-triazinen
GB1094858A (en) * 1964-12-11 1967-12-13 Bayer Ag 2,4-disubstituted 6-amino-1,3,5-triazines
BE793112A (fr) * 1971-12-22 1973-06-21 Ciba Geigy Pyridinium-s-triazines agissant sur la croissance des plantes
FR2262512A1 (en) * 1974-03-01 1975-09-26 Synthelabo 2,4,6-Tri-substd. -1,3,5-triazines - with analgesic and psychotropic activity
EP0563386A4 (en) * 1990-12-20 1994-06-01 Nippon Shinyaku Co Ltd Anticancer composition and compound
JPH04300874A (ja) * 1991-03-29 1992-10-23 Tsumura & Co 新規２，４−ジアミノ−１，３，５−トリアジン誘導体
AU703263B2 (en) * 1994-08-08 1999-03-25 Nippon Shinyaku Co. Ltd. Triazine derivative and medicine
CN1177298A (zh) * 1995-03-09 1998-03-25 日本新药株式会社 胰腺炎治疗剂

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1201661A4 (fr) * 1999-07-15 2002-10-23 Sumitomo Pharma Composes de cycles heteroaromatiques
US7208597B2 (en) * 2002-07-31 2007-04-24 Ciba Specialty Chemicals Corporation Pyridyl-triazine derivatives as microbiocidal active substances
AU2003254560B2 (en) * 2002-07-31 2009-05-28 Basf Se Pyridyl-triazine derivatives as microbicidal active substances
JP2010523570A (ja) * 2007-04-03 2010-07-15 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー 置換ベンゼン殺菌・殺カビ剤
US10961254B2 (en) 2014-06-13 2021-03-30 Yuma Therapeutics, Inc. Pyrimidine compounds and methods using the same
EP3154547B1 (fr) * 2014-06-13 2023-06-07 Yuma Therapeutics, Inc. Composés pyrimidiques et procédés les utilisant
JP2020158450A (ja) * 2019-03-27 2020-10-01 大阪ガスケミカル株式会社 ２−アミノ−１，３，５−トリアジン化合物の製造方法
JP7145802B2 (ja) 2019-03-27 2022-10-03 大阪ガスケミカル株式会社 ２－アミノ－１，３，５－トリアジン化合物の製造方法
WO2021050900A1 (fr) 2019-09-13 2021-03-18 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Inhibiteurs du récepteur de la tyrosine kinase pour le traitement de maladie ou de trouble sensible à la modulation de la protéine kinase

Also Published As

Publication number Publication date
WO1999011633A1 (fr) 1999-03-11

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Legal Events

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8139 Disposal/non-payment of the annual fee