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DE102009035941B8 - Diagnostiksystem - Google Patents

Diagnostiksystem Download PDF

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Publication number
DE102009035941B8
DE102009035941B8 DE102009035941.9A DE102009035941A DE102009035941B8 DE 102009035941 B8 DE102009035941 B8 DE 102009035941B8 DE 102009035941 A DE102009035941 A DE 102009035941A DE 102009035941 B8 DE102009035941 B8 DE 102009035941B8
Authority
DE
Germany
Prior art keywords
diagnostic system
diagnostic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE102009035941.9A
Other languages
English (en)
Other versions
DE102009035941B4 (de
DE102009035941A1 (de
Inventor
Dr. Zilch Christian
Dr. Gerdes Wilhelm
Dr. Faber Sonya
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fraunhofer Gesellschaft zur Foerderung der Angewandten Forschung eV
Original Assignee
Fraunhofer Gesellschaft zur Foerderung der Angewandten Forschung eV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fraunhofer Gesellschaft zur Foerderung der Angewandten Forschung eV filed Critical Fraunhofer Gesellschaft zur Foerderung der Angewandten Forschung eV
Priority to DE102009035941.9A priority Critical patent/DE102009035941B8/de
Priority to US13/388,980 priority patent/US20120295366A1/en
Priority to EP10737854A priority patent/EP2462454A1/de
Priority to PCT/EP2010/060573 priority patent/WO2011015454A1/de
Publication of DE102009035941A1 publication Critical patent/DE102009035941A1/de
Publication of DE102009035941B4 publication Critical patent/DE102009035941B4/de
Application granted granted Critical
Publication of DE102009035941B8 publication Critical patent/DE102009035941B8/de
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06Fluid handling related problems
    • B01L2200/0673Handling of plugs of fluid surrounded by immiscible fluid
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00Moving or stopping fluids
    • B01L2400/04Moving fluids with specific forces or mechanical means
    • B01L2400/0403Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/043Moving fluids with specific forces or mechanical means specific forces magnetic forces
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502769Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
    • B01L3/502784Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for droplet or plug flow, e.g. digital microfluidics
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/0098Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor involving analyte bound to insoluble magnetic carrier, e.g. using magnetic separation
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10TTECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00Chemistry: analytical and immunological testing
    • Y10T436/25Chemistry: analytical and immunological testing including sample preparation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
DE102009035941.9A 2009-08-03 2009-08-03 Diagnostiksystem Expired - Fee Related DE102009035941B8 (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
DE102009035941.9A DE102009035941B8 (de) 2009-08-03 2009-08-03 Diagnostiksystem
US13/388,980 US20120295366A1 (en) 2009-08-03 2010-07-21 Diagnostic system
EP10737854A EP2462454A1 (de) 2009-08-03 2010-07-21 Diagnostiksystem
PCT/EP2010/060573 WO2011015454A1 (de) 2009-08-03 2010-07-21 Diagnostiksystem

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102009035941.9A DE102009035941B8 (de) 2009-08-03 2009-08-03 Diagnostiksystem

Publications (3)

Publication Number Publication Date
DE102009035941A1 DE102009035941A1 (de) 2011-02-17
DE102009035941B4 DE102009035941B4 (de) 2016-12-22
DE102009035941B8 true DE102009035941B8 (de) 2017-04-27

Family

ID=43015760

Family Applications (1)

Application Number Title Priority Date Filing Date
DE102009035941.9A Expired - Fee Related DE102009035941B8 (de) 2009-08-03 2009-08-03 Diagnostiksystem

Country Status (4)

Country Link
US (1) US20120295366A1 (de)
EP (1) EP2462454A1 (de)
DE (1) DE102009035941B8 (de)
WO (1) WO2011015454A1 (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102010041621B4 (de) 2010-09-29 2016-11-03 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. Verfahren zum Transport magnetischer Partikel
US20130004982A1 (en) * 2011-06-29 2013-01-03 The Regents Of The University Of California Method and apparatus for magnetic flow cytometry
WO2013009654A1 (en) * 2011-07-08 2013-01-17 Life Technologies Corporation Method and apparatus for automated sample manipulation
CA2872177A1 (en) 2012-05-08 2013-11-14 Quidel Corporation Device for isolating an analyte from a sample, and methods of use
EP2856167B1 (de) 2012-05-30 2018-07-11 Zhong Li Unmittelbarer nachweis von biomarkern und verwendungen davon
US10501735B2 (en) 2012-08-23 2019-12-10 Quidel Corporation Device with controlled fluid dynamics, for isolation of an analyte from a sample
TWI529402B (zh) * 2013-07-26 2016-04-11 財團法人工業技術研究院 磁性液滴控制裝置及磁性液滴的控制方法
US10202577B2 (en) * 2013-10-18 2019-02-12 The General Hospital Corporation Microfluidic sorting using high gradient magnetic fields
WO2015113047A2 (en) * 2014-01-27 2015-07-30 Brevitest Technologies, Llc Discontinuous fluidic systems for point-of-care analyte measurement
US10195609B2 (en) * 2016-10-25 2019-02-05 Fannin Partners, LLC Assay wells with hydrogel as a well-contents separator and a pigment-based temperature indicator
CN106660044B (zh) 2014-12-02 2019-04-23 皇家飞利浦有限公司 微流体系统和微流体系统中的磁性粒子的弥散和积聚方法
JP6506094B2 (ja) * 2015-04-30 2019-04-24 シスメックス株式会社 被検物質の検出方法および検体分析装置
EP3106229B1 (de) * 2015-06-17 2020-07-29 IMEC vzw Dynamische magnetische zellsortierung
LT3325159T (lt) * 2015-07-24 2021-10-25 Novel Microdevices, Inc. Mėginių apdorojimo įtaisas, apimantis magnetinius ir mechaninius aktyvinimo elementus, naudojant linijinį arba sukamąjį judėjimą
EP3634634A4 (de) * 2017-06-06 2021-03-10 Northwestern University Transschnittstellenmagnetische trennung
GB201711804D0 (en) * 2017-07-21 2017-09-06 Mast Group Ltd Apparatus for conducting an assay
US20210114036A1 (en) * 2018-04-30 2021-04-22 The Johns Hopkins University Disposable reagent scaffold for biochemical process integration
DE102018219091A1 (de) * 2018-11-08 2020-05-14 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. Vorrichtung und verfahren zum transport magnetischer partikel
CN114450090B (zh) * 2019-09-10 2024-07-23 深圳华大智造控股有限公司 磁珠子在微流控基板上的操作
JP7234393B2 (ja) * 2019-09-27 2023-03-07 富士フイルム株式会社 容器および検査キット
CN116121065A (zh) * 2023-01-12 2023-05-16 北京黑森智动科技有限公司 磁珠分离装置、控制方法及系统

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5981297A (en) * 1997-02-05 1999-11-09 The United States Of America As Represented By The Secretary Of The Navy Biosensor using magnetically-detected label
US20040021073A1 (en) * 2002-04-12 2004-02-05 California Institute Of Technology Apparatus and method for magnetic-based manipulation of microscopic particles
US20070184463A1 (en) * 2005-09-30 2007-08-09 Caliper Life Sciences, Inc. Microfluidic device for purifying a biological component using magnetic beads
US20080031787A1 (en) * 2006-08-02 2008-02-07 Industrial Technology Research Institute Magnetic bead-based sample separating device
US20080073546A1 (en) * 2006-03-13 2008-03-27 Gyros Patent Ab Enhanced magnetic particle steering
US20080166727A1 (en) * 2006-12-20 2008-07-10 The Board Of Trustees Of The Leland Stanford Junior University Heat and pH Measurement for Sequencing of DNA
EP1163052B1 (de) * 1999-02-23 2010-06-02 Caliper Life Sciences, Inc. Manipulation von mikroteilchen in mikrofluiden systemen

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4292920A (en) * 1976-04-26 1981-10-06 Smith Kendall O Magnetic attraction transfer devices for use in solid phase radioimmunoassays and in other assay methods
US6884357B2 (en) * 1995-02-21 2005-04-26 Iqbal Waheed Siddiqi Apparatus and method for processing magnetic particles
AU2001247478A1 (en) * 2000-03-16 2001-09-24 Sri International Microlaboratory devices and methods
WO2003039753A1 (en) * 2001-11-05 2003-05-15 President And Fellows Of Harvard College System and method for capturing and positioning particles
US20080314749A1 (en) * 2006-01-04 2008-12-25 Koninklijke Philips Electronics N.V. Microelectronic Device with Magnetic Excitation Wires
DE102006057300A1 (de) * 2006-12-05 2008-06-19 Siemens Ag Anordnung zur Aufbereitung einer Mehrzahl von Proben für eine Analyse

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5981297A (en) * 1997-02-05 1999-11-09 The United States Of America As Represented By The Secretary Of The Navy Biosensor using magnetically-detected label
EP1163052B1 (de) * 1999-02-23 2010-06-02 Caliper Life Sciences, Inc. Manipulation von mikroteilchen in mikrofluiden systemen
US20040021073A1 (en) * 2002-04-12 2004-02-05 California Institute Of Technology Apparatus and method for magnetic-based manipulation of microscopic particles
US20070184463A1 (en) * 2005-09-30 2007-08-09 Caliper Life Sciences, Inc. Microfluidic device for purifying a biological component using magnetic beads
US20080073546A1 (en) * 2006-03-13 2008-03-27 Gyros Patent Ab Enhanced magnetic particle steering
US20080031787A1 (en) * 2006-08-02 2008-02-07 Industrial Technology Research Institute Magnetic bead-based sample separating device
US20080166727A1 (en) * 2006-12-20 2008-07-10 The Board Of Trustees Of The Leland Stanford Junior University Heat and pH Measurement for Sequencing of DNA

Also Published As

Publication number Publication date
EP2462454A1 (de) 2012-06-13
WO2011015454A1 (de) 2011-02-10
US20120295366A1 (en) 2012-11-22
DE102009035941B4 (de) 2016-12-22
DE102009035941A1 (de) 2011-02-17

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Legal Events

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OP8 Request for examination as to paragraph 44 patent law
R016 Response to examination communication
R016 Response to examination communication
R018 Grant decision by examination section/examining division
R082 Change of representative

Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, DE

Representative=s name: MAIWALD PATENTANWALTS- UND RECHTSANWALTSGESELL, DE

R020 Patent grant now final
R119 Application deemed withdrawn, or ip right lapsed, due to non-payment of renewal fee